CardiacWire
APRIL 18, 2025
Building stronger evidence for AIs place in cardiology, this week brought several examples of how AI can improve ECG use cases and automate Echo for new disease detection methods. Starting with AI improving ECG for coronary revascularization , a deep learning ECG model outperformed both clinician-led ECG and troponin T testing in predicting which ED patients needed coronary revascularization.
Frontiers in Cardiovascular Medicine
APRIL 21, 2025
BackgroundAtrial fibrillation (AF) is a common arrhythmia associated with an increased risk of stroke, heart failure, and mortality. Immune infiltration plays a crucial role in AF pathogenesis, yet its mechanisms remain unclear. Lactylation, a novel post-translational modification, has been implicated in immune regulation, but its association with AF remains unexplored.
Circulation
APRIL 17, 2025
Circulation, Ahead of Print. Cardiovascular disease remains a leading cause of morbidity and mortality in adults despite recent scientific advancements. Although people are living longer lives, there may be an adverse impact on quality of life, necessitating a greater need for palliative care services and support. Palliative care for adults with advanced cardiovascular disease has the potential to significantly improve quality of life for individuals living with cardiovascular disease and their
DAIC
APRIL 16, 2025
Cedars-Sinai investigators are using AI to analyze images from a common heart test to identify signs of valve disease. Photo: Getty. tim.hodson Wed, 04/16/2025 - 14:19 April 16, 2025 An artificial intelligence (AI) program trained to review images from a common medical test can detect early signs of tricuspid heart valve disease and may help doctors diagnose and treat patients sooner, according to research from the Smidt Heart Institute at Cedars-Sinai.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
CardiacWire
APRIL 16, 2025
Completing its pharma comeback story, Verve Therapeutics announced successful results from the Heart-2 Phase 1b Clinical Trial of its in-vivo base editing drug, VERVE-102, that targets the PCSK9 gene for reducing LDL-C. PCSK9 is a molecule that breaks down LDL receptors, so drugs that inhibit it force the bodys LDL receptors to work harder, which reduces LDL-C more efficiently.
Cardiometabolic Health Congress
APRIL 18, 2025
World Liver Day 2025 | A Global Call to Action for Liver Health through Nutrition A global coalition of leading health organizations unites to mark World Liver Day on Saturday, April 19, emphasizing the pivotal role of nutrition in supporting liver function and preventing disease. With the theme Food is Medicine, the campaign urges the global community to take action through sustainable lifestyle changes.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
Med Page Today
APRIL 17, 2025
(MedPage Today) -- Hearing loss may play a bigger role in dementia than previously thought, data from a U.S. cohort study suggested. In a sample of nearly 3,000 older adults, up to 32% (95% CI 11.0%-46.5%) of incident dementia over 8 years could.
Frontiers in Cardiovascular Medicine
APRIL 21, 2025
BackgroundGualou Xiebai Banxia Decoction (GXBD), a traditional Chinese medicine, is used to treat myocardial ischemia (MI). However, the molecular mechanisms underlying its effects remain unclear. This study integrated network pharmacology and experimental validation to investigate the efficacy and potential mechanisms of GXBD in MI treatment.MethodsNetwork pharmacology was used to predict the mechanism of action of GXBD in MI.
American Heart News - Heart News
APRIL 17, 2025
Research Highlights: Among adults ages 18-49 (median age of 41 years) who were born with a hole in the upper chambers of their heart known as patent foramen ovale (PFO), strokes of unknown cause were more strongly associated with nontraditional risk.
HCPLive
APRIL 18, 2025
Dupilumab's approval marks the first new, targeted therapy for CSU in more than a decade and is the 7th indication for a disease with underlying type 2 inflammation.
Vector Remote
APRIL 21, 2025
CPT code 93296 is currently reimbursed based on 28 minutes of labor, yet delivering this service takes 84 minutes. Cardiac remote monitoring plays a vital role in proactive care, helping patients avoid complications and reduce hospital visits.1 As care standards evolve, aligning reimbursement with todays clinical reality is essential to uphold guideline-directed remote monitoring.
Dr. Paddy Barrett
APRIL 22, 2025
Some people get heart disease early in life. But pretty much everyone gets heart disease at some point. We know that heart disease likely begins in childhood. Multiple studies have shown plaque build up in people from their teenage years onwards with significant amounts present by mid 20’s. I presume most of you who are reading this are well past your twenties.
Frontiers in Cardiovascular Medicine
APRIL 16, 2025
Background and AimHypertension (HTN) is a widespread global health challenge, and its increasing prevalence is attributed to individual and environmental risk factors. Persistent organic pollutants (POPs), especially polychlorinated biphenyls (PCBs), contribute to cardiovascular risk by accumulating in fatty tissues, which leads to oxidative stress and vascular inflammation.
Stroke Journal
APRIL 17, 2025
Stroke, Ahead of Print. BACKGROUND:Branch atherosclerosis disease (BAD) is prone to early neurological deterioration (END). The purpose of this study was to assess the efficacy and safety of argatroban plus dual antiplatelet therapy (DAPT) for preventing END in high-risk branch atherosclerosis disease patients.METHODS:This multicenter, open-label, blinded end point, randomized controlled trial including branch atherosclerosis disease patients with mild stroke (National Institutes of Health Strok
Journal of the American Heart Association
APRIL 17, 2025
Journal of the American Heart Association, Ahead of Print. BackgroundNonvitamin K oral anticoagulants prevent stroke and systemic embolism in patients with nonvalvular atrial fibrillation. However, potential drug interactions with concomitant medications may compromise their efficacy and escalate the risk of adverse effects.Methods and ResultsWe conducted a territorywide retrospective cohort study in Hong Kong, focusing on nonvalvular atrial fibrillation prescribed nonvitamin K oral anticoagulan
Med Page Today
APRIL 20, 2025
(MedPage Today) -- After the Senate voted to confirm Robert F. Kennedy Jr. as Health and Human Services (HHS) secretary, supporters of his "Make America Healthy Again" (MAHA) movement cheered at having a champion in the federal government. Now.
DAIC
APRIL 21, 2025
tim.hodson Mon, 04/21/2025 - 11:18 April 21, 2025 Stereotaxis, a provider of surgical robotics for minimally invasive endovascular intervention, will host a live demonstration of the GenesisX Robotic System at this years Heart Rhythm Symposium (HRS), taking place April 24-27 in San Diego, CA. This marks the first live, public demonstration of GenesisX, offering a glimpse into the robots clinical capabilities and weekend installation.
Frontiers in Cardiovascular Medicine
APRIL 16, 2025
BackgroundLeft ventricular hypertrophy (LVH) is often a complication of hypertension and an independent risk factor for cardiovascular events. In Ethiopia, there is a scarcity of data on the prevalence and associated factors of left ventricular hypertrophy among hypertensive adults. This study aimed to assess the prevalence and associated factors of left ventricular hypertrophy among adult patients with hypertension attending treatment at two public hospitals in Harar, Eastern Ethiopia from 20 D
Dr. Paddy Barrett
APRIL 19, 2025
“I have high cholesterol, and I don’t know what to do about it.” This is one of the most common scenarios I encounter as a cardiologist focused on preventing heart disease. Unfortunately, many people do not understand cholesterol, and because of this, they wait too long to address the underlying problem. There is a very structured solution to this issue.
HCPLive
APRIL 18, 2025
Greenspan offers tips in treating seasonal allergies in patients with pulmonary conditions, such as long-COVID, and provides his 2025 spring allergy prediction.
Med Page Today
APRIL 18, 2025
(MedPage Today) -- The Supreme Court will hear oral arguments Monday in a case that could affect what kind of preventive care is covered at no charge under Americans' health insurance plans. The case, known as Kennedy v. Braidwood, involves Christian.
Stroke Journal
APRIL 18, 2025
Stroke, Ahead of Print. BACKGROUND:Stroke often results in significant impairments across various domains, including movement, language, cognition, and mood. Neurostimulants have been proposed as potential therapeutic interventions to enhance recovery in these areas.METHODS:This narrative literature review examines clinical trials investigating the efficacy of neurostimulants in poststroke recovery.
Frontiers in Cardiovascular Medicine
APRIL 21, 2025
BackgroundChronic heart failure (CHF) is a complex cardiovascular disease caused by different pathological mechanisms. Modern medicine has made advancements in CHF treatment; however, there are still many challenges. Ershen Zhenwu Decoction (ESZWD) is a Xin'an medicine that has been clinically applied for years and had good efficacy against CHF; however, its underlying mechanisms remain undetermined.
Journal of Cardiovascular Electrophysiology
APRIL 16, 2025
ABSTRACT Introduction Pulsed Field Cryoablation (PFCA) is a dual-energy cardiac ablation modality consisting of short-duration ultra-low temperature cryoablation (ULTC) followed immediately by pulsed field ablation (PFA) delivered from the same catheter. It is hypothesized that PFCA may improve contact stability during PFA, while maintaining lesion depth and effectiveness of ULTC.
ECG Cases
APRIL 22, 2025
In this ECG Cases blog Dr. Jesse McLaren guides us through 6 illustrative cases delving into overall impression in identifying occlusion MI. He discusses how using multiple OMI findings such as acute Q wave, subtle STE, reciprocal STD, hyperacute T waves, and reciprocal TWI to contribute to your overall impression, can double the sensitivity of STEMI criteria for acute coronary occlusion.
European Journal of Heart Failure
APRIL 20, 2025
This systematic review included seven studies that reported the outcomes of minimization or withdrawal of oral pharmacotherapy in chronic heart failure (HF) patients with improved myocardial function. There is a dearth of existing evidence, which supports only loop diuretic withdrawal and possibly carvedilol monotherapy. Unfavourable outcomes were observed following the minimization or withdrawal of reninangiotensin system inhibitors (RASi), mineralocorticoid receptor antagonists (MRA), or the c
HCPLive
APRIL 18, 2025
This interview in the latest issue of The Respiratory Report features Divay Chandra, MD, MSc, discussing lithium's potential enhancement of alveolar repair after injury.
Stroke Journal
APRIL 18, 2025
Stroke, Ahead of Print. BACKGROUND:The international trial AVERT (A Very Early Rehabilitation Trial) found that very early mobilization (VEM; commenced <24 hours after stroke) negatively affected functional outcome (modified Rankin Scale [mRS]). The drivers of this effect remain unclear. One plausible mechanism is that high-dose upright activity worsens cerebral perfusion in patients with cerebral large vessel occlusion (LVO).
Journal of Cardiovascular Electrophysiology
APRIL 16, 2025
ABSTRACT Introduction The role of corticosteroids in the management of ventricular tachyarrhythmia (VA) in cardiac sarcoidosis (CS) remains controversial. This study assessed the effect of early steroid initiation on VA recurrence rates in patients with CS and evaluated VA frequency before and after steroid therapy. Methods From a registry of 137 patients with CS with arrhythmias, those with VA and more than 60 days of follow-up were included.
Frontiers in Cardiovascular Medicine
APRIL 22, 2025
BackgroundMarfan syndrome (MFS) is an autosomal dominant connective tissue disorder primarily affecting the cardiovascular, ocular, and skeletal systems. Cardiovascular complications are the leading cause of mortality in MFS. Mutations in the FBN1 gene, which encodes fibrillin-1, a critical extracellular matrix protein, are the predominant cause of the disorder.Case presentationOn March 11, 2024, we diagnosed a 30-year-old female proband with MFS based on the revised Ghent criteria, presenting w
Med Page Today
APRIL 21, 2025
(MedPage Today) -- Reducing hypertension dropped dementia risk by 15% in the open-label China Rural Hypertension Control phase III (CRHC-3) trial of nearly 34,000 people. At 48 months, all-cause dementia among people with high blood pressure was.
HCPLive
APRIL 21, 2025
Panelists discuss how differentiating between wild-type transthyretin amyloid cardiomyopathy (wATTR-CM) and hereditary transthyretin amyloid cardiomyopathy (hATTR-CM) is essential for accurate diagnosis, tailored treatment strategies, and better management of patient outcomes, given their distinct pathophysiologies, disease progression, and treatment options.
Stroke Journal
APRIL 21, 2025
Stroke, Ahead of Print. Secondary stroke prevention encompasses many approaches, including antithrombotic therapy, risk factor management, and a healthy lifestyle. Recommendations are typically based on the results of randomized clinical trials that provide evidence of benefit. However, in some situations, clinicians extrapolate the results of clinical trials into everyday practice, or trials have not provided sufficient information to make treatment decisions.
CTVS
APRIL 22, 2025
If you frequently experience pain in the back of your legs when walking, it could be a sign of Peripheral Artery Disease (PAD). PAD (Peripheral Artery Disease) is a common circulatory condition affecting more than 10 million Americans. PAD causes a narrowing of the peripheral arteries due to fatty plaque buildup (or atherosclerosis) which restricts blood flow to the extremities.
Circulation
APRIL 16, 2025
Circulation, Ahead of Print. The growing morbidity, mortality, and health care costs related to heart failure (HF) underscore the urgent need to prioritize its primary prevention. Whereas a risk-based approach for HF prevention remains in its infancy, several key opportunities exist to actualize this paradigm in clinical practice. First, the 2022 American Heart Association/American College of Cardiology/Heart Failure Society of America HF guidelines provided recommendations, for the first time,
Med Page Today
APRIL 19, 2025
(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.
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