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Circulation, Ahead of Print. The Physical Activity Guidelines for Americans supports sitting less and moving more. Growing evidence suggests that a waking behavior profile with less sedentary behavior and more light-intensity physical activity is associated with more favorable cardiovascular health. Remarkably, little is known about how these behaviors relate to cardiovascular health during pregnancy.
More than heart disease or cancer, dementia is the primary concern for many of the patients I see. Heart disease and cancer attack your body, but dementia attacks your mind and identity. It strips away the fabric of who a person is. That is why I believe people fear dementia so much. Thankfully, 45% of all dementia is preventable 1. Many factors make up that 45%, but one factor seems to impact the risk of dementia the most.
New research has uncovered a surprising culprit underlying cardiovascular diseases in obesity and diabetes -- not the presence of certain fats, but their suppression. The study challenges the conventional belief that a type of fat called ceramides accumulates in blood vessels causing inflammation and health risks. Instead, their findings reveal that when ceramides decrease in endothelial cells lining blood vessels, it can be damaging and cause chronic illnesses.
Nature Reviews Cardiology, Published online: 14 April 2025; doi:10.1038/s41569-025-01150-1 In this Review, Liu, Yang and He explore the diverse mechanisms by which various post-translational protein acylations, and the dynamic interactions between them, contribute to cardiac hypertrophy. The authors also discuss the therapeutic potential of targeting acylations to modulate their effects on chromatin architecture, enzyme activity and metabolic pathways.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
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Casting doubt on value based cardiac care, a JAMA study found that outpatient cardiology practices enrolled in an accountable care organization (ACO) through the Medicare Shared Savings Program (MSSP) dont offer better care than non-ACO practices. MSSP was introduced in 2012 to improve care quality and lower Medicare costs by having ACOs assume responsibility for Medicare beneficiaries costs and care quality.
ObjectiveAortic dissection (AD) is a life-threatening cardiovascular emergency. Delayed diagnosis frequently leads to treatment delays, elevated mortality, and complications. This study investigates the factors contributing to the misdiagnosis of AD and proposes strategies for improving its early diagnosis.MethodsA retrospective analysis of 801 patients with AD identified 219 cases for inclusion, which were split into a training set (131 cases) and a validation set (88 cases).
Background Kuwait, one of the world’s hottest countries, faces increasing temperatures due to climate change. With a large migrant population predominantly employed in physically demanding jobs, the exact effects and burdens of temperature exposure on cardiovascular risk among this population remain unknown. This study aimed to investigate the relationship between temperature and myocardial infarction (MI) risk among migrants in Kuwait.
Background Kuwait, one of the world’s hottest countries, faces increasing temperatures due to climate change. With a large migrant population predominantly employed in physically demanding jobs, the exact effects and burdens of temperature exposure on cardiovascular risk among this population remain unknown. This study aimed to investigate the relationship between temperature and myocardial infarction (MI) risk among migrants in Kuwait.
(MedPage Today) -- As measles continues to spread through vulnerable communities in the U.S., HHS Secretary Robert F. Kennedy Jr. has suggested that there are long-term health benefits to contracting the virus, despite decades of data that suggest.
tim.hodson Wed, 04/09/2025 - 14:38 April 9, 2025 Idorsia Ltd recently announced that the US Food & Drug Administration (FDA), after having released Tryvio from its REMS (Risk Evaluation and Mitigation Strategy) requirement ( announced March 17, 2025 ), has now approved the updated label for Tryvio(aprocitentan). Tryvio is Idorsias dual endothelin receptor antagonist (ERA) indicated for the treatment of systemic hypertension in combination with other antihypertensives to lower blood pressure in
Objective To validate the prognostic utility of peak creatine kinase-myocardial band isoenzyme (CK-MB) level, left ventricular posterior wall diameter (LVPWD), and a score model for successful weaning from mechanical circulatory support (MCS) in fulminant myocarditis (FM). Furthermore, the severity of the histological data was stratified, and its relationship with the clinical findings was investigated.
Cardiovascular disease (CVD) remains a global health burden despite advances in prevention and treatment. Conventional biomarkers, while effective for a number of patient groups, fail to provide personalized diagnosis and prognosis, necessitating the exploration of novel markers. Advancements in sequencing technology have unveiled the role of cell-free DNA (cfDNA) as a reservoir of genetic information from all cells within the body, and associations between elevated cfDNA levels and CVD risk fac
Background Heart failure (HF) guidelines recommend routine testing for iron deficiency (ID) and, for those with ID, intravenous iron if the left ventricular ejection fraction is <50%. Guideline adherence to these recommendations by cardiologists in China is unknown. Methods and results An independent academic web-based survey was designed and distributed via social networks to cardiologists across China.
Dr. Prateek Bhatnagar, the best cardiac surgeon in India, operated a 68-year-old gentleman from Bengal, who had been refused coronary bypass surgery by leading cardiac centers across India, due to the high-risk nature of his condition. The patient had a critically low pumping of heart (left ventricular ejection fraction) of just 22%, indicating severely compromised heart function.
Prof. David Luria (left), Director of Electrophysiology at Hadassah Medical Center, and Ziv Menshes (right), CEO of CardioVia tim.hodson Tue, 04/08/2025 - 14:38 April 7, 2025 CardioVia, a medical device company specializing in advanced cardiac care solutions, has received U.S. Food and Drug Administration (FDA) clearance for its ViaOne system. This device is designed to enable safe and precise access to the hearts surface (pericardial space) for both diagnostic and therapeutic interventions wi
The International Journal of Cardiovascular Sciences (IJCS) is seeking a volunteer Assistant Editor to support the Editor-in-Chief in the journal’s editorial activities. This is an excellent opportunity for early-career individuals in the cardiovascular health field who wish to develop editorial skills and contribute to the advancement of science in this area, as well as engage in the journals outreach activities.
Chronic heart failure (CHF) combined with depression represents a significant clinical challenge due to the mutual exacerbation of physical and psychological symptoms. This study investigated the therapeutic effects of Zhigancao decoction, a traditional Chinese medicine, in combination with conventional Western treatments in patients with CHF and depression.
Since the first implementation in 2002 by Alain Cribier, transcatheter aortic valve replacement (TAVR) has become a standard procedure for high-risk and elderly patients with severe aortic valve stenosis. Recently, the use of TAVR has expanded to relatively younger patients with low to moderate surgical risk. Infective endocarditis (IE) after TAVR, first reported in medical literature in 2010, is a relatively new and extremely concerning complication. 1 Its incidence, reported as 1.1% per person
Stroke, Ahead of Print. BACKGROUND:The National Institutes of Health Stroke Scale is used globally to rate neurological deficits in patients with acute stroke. Originally designed for research use, the scale uses idiosyncratic scoring rules and requires thorough training for proper use. Currently available training and certification systems are timeworn and limited in the range of demonstrated neurological findings.
Statement Highlights: While the strongest evidence exists that getting sufficient sleep (duration of sleep) is important for overall health , other components of sleep health, such as consistent bedtime, uninterrupted sleep, daytime functioning and.
BackgroundHeart failure (HF) is a multifaceted clinical condition, and our comprehension of its genetic pathogenesis continues to be significantly limited. Consequently, identifying specific genes for HF at the transcriptomic level may enhance early detection and allow for more targeted therapies for these individuals.MethodsHF datasets were acquired from the Gene Expression Omnibus (GEO) database (GSE57338), and through the application of bioinformatics and machine-learning algorithms.
‘Real knowledge is to know the extent of one’s ignorance ’ Confucius This editorial refers to ‘Gaps in knowledge and management of iron deficiency in heart failure: a nationwide survey of cardiologists in China’, by Su et al. 1 Over the last 25 years, an accumulation of data has highlighted the prevalence of iron deficiency and the value of its correction in patients with heart failure and reduced (HFrEF) or mildly reduced ejection fraction (HFmrEF).
Hypertension, Ahead of Print. BACKGROUND:Aberrant BMPR2 (bone morphogenetic protein receptor 2) signaling is associated with the pathogenesis of pulmonary hypertension. SMAD4 is an essential downstream effector of BMPR2 signaling, but whether and how it participates in pulmonary hypertension are unclear.METHODS:Globally and vascular cell-specifically inducible knockout mouse models were used to examine the role of SMAD4 deficiency in differential cell compartments in the development of pulmonary
(MedPage Today) -- BOSTON -- After living kidney donation, projection of renal function may vary by gender, a retrospective cohort study of 174,311 living kidney donors suggested. Over a median 6.7 months, the incidence rate of worsening post.
ObjectiveTo compare the image quality, radiation dose, and examination time between non-electrocardiogram (ECG)-gated coronary CT angiography (ECG-less CCTA) and conventional ECG-gated CCTA using wide-detector CT, and validate its clinical applicability.MethodsIn this prospective study, 109 patients with suspected coronary artery disease were divided into ECG-less (Group A, n=59) and ECG-gated (Group B, n=50) groups.
ABSTRACT Background Sotalol is used for the maintenance of sinus rhythm among patients with atrial fibrillation. However, there is discretion regarding dosing of chronic therapy, and the target oral dose dictates infusion doses for intravenous sotalol loading. To date, use and outcomes by dose are not well-described. Methods In the Prospective Evaluation Analysis and Kinetics of IV Sotalol (PEAKS) Registry, we analyzed outcomes among patients undergoing elective IV sotalol load for atrial arrhyt
Relaxation techniques may help lower high blood pressureat least in the short termbut the longer-term effects are unclear, finds a pooled data analysis of the existing research published in the open-access journal BMJ Medicine.
Circulation: Arrhythmia and Electrophysiology, Ahead of Print. BACKGROUND:Patients with arrhythmogenic cardiomyopathy due to pathogenic variants inPKP2, the gene for the desmosomal protein plakophilin-2, are being enrolled in gene therapy trials designed to replace the defective allele via adeno-associated viral transduction of cardiac myocytes. Evidence from experimental systems and patients indicates that ventricular myocytes inPKP2arrhythmogenic cardiomyopathy have greatly reduced electrical
Unlike mammals, zebrafish can regenerate their heart after cardiac insult. There are several ways to perform cardiac injury in zebrafish, but cryoinjury most closely resembles human myocardial infarction (MI). Studies demonstrated that macrophages are essential cells from the beginning to later stages of cardiac injury throughout the regenerative process in zebrafish.
(MedPage Today) -- The link between narcolepsy and cardiovascular disease (CVD) was strengthened by new evidence that the relationship applied to subclinical disease and was apparent early in life, based on a retrospective cohort study. Across.
This clinical study reports the incidence, severity and causes of hemolytic effects after PFA utilizing a novel hexaspline PFA catheter in an Chinese cohort, demonstrating a high rate (31.9%) of bilirubin elevation the next day post PFA, but returned to normal at 7th day without any signs of hemoglobin decline and renal failure. ABSTRACT Background and Aims Hemolysis-related renal failure after pulsed field ablation (PFA) has been described in recently published cases, we reported the incidence
A study led by researchers at Mass General Brigham suggests that, when it comes to cardiovascular health, food timing could be a bigger risk factor than sleep timing.
Publication date: Available online 9 April 2025 Source: The American Journal of Cardiology Author(s): Alice Moroni, Andrea Mascaretti, Jo Dens, Paul Knaapen, Alexander Nap, Yvemarie B.O.
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