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Circulation, Ahead of Print. Cardiovascular disease remains a leading cause of morbidity and mortality in adults despite recent scientific advancements. Although people are living longer lives, there may be an adverse impact on quality of life, necessitating a greater need for palliative care services and support. Palliative care for adults with advanced cardiovascular disease has the potential to significantly improve quality of life for individuals living with cardiovascular disease and their
Building stronger evidence for AIs place in cardiology, this week brought several examples of how AI can improve ECG use cases and automate Echo for new disease detection methods. Starting with AI improving ECG for coronary revascularization , a deep learning ECG model outperformed both clinician-led ECG and troponin T testing in predicting which ED patients needed coronary revascularization.
tim.hodson Tue, 04/15/2025 - 15:54 April 15, 2025 DESKirecently announced FDA clearance for HeartFocus , its AI-enabled heart exam software that empowers any healthcare professional, including novices, to perform clinical-quality heart scans from any compatible device after just a few hours of training. The FDA also approved DESKis Predetermined Change Control Plan (PCCP) for HeartFocus growth opportunities.
Completing its pharma comeback story, Verve Therapeutics announced successful results from the Heart-2 Phase 1b Clinical Trial of its in-vivo base editing drug, VERVE-102, that targets the PCSK9 gene for reducing LDL-C. PCSK9 is a molecule that breaks down LDL receptors, so drugs that inhibit it force the bodys LDL receptors to work harder, which reduces LDL-C more efficiently.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
BackgroundAtrial fibrillation (AF) is a common arrhythmia associated with an increased risk of stroke, heart failure, and mortality. Immune infiltration plays a crucial role in AF pathogenesis, yet its mechanisms remain unclear. Lactylation, a novel post-translational modification, has been implicated in immune regulation, but its association with AF remains unexplored.
World Liver Day 2025 | A Global Call to Action for Liver Health through Nutrition A global coalition of leading health organizations unites to mark World Liver Day on Saturday, April 19, emphasizing the pivotal role of nutrition in supporting liver function and preventing disease. With the theme Food is Medicine, the campaign urges the global community to take action through sustainable lifestyle changes.
Experts discuss the challenges of identifying and diagnosing hypercortisolism, the reasons behind its often-delayed diagnosis, the impact of a wide spectrum of clinical signs and symptoms on clinicians ability to diagnose the condition, and recent data on the prevalence of hypercortisolism in at-risk populations, including those with difficult-to-control diabetes, hypertension, and cardiovascular disease.
Experts discuss the challenges of identifying and diagnosing hypercortisolism, the reasons behind its often-delayed diagnosis, the impact of a wide spectrum of clinical signs and symptoms on clinicians ability to diagnose the condition, and recent data on the prevalence of hypercortisolism in at-risk populations, including those with difficult-to-control diabetes, hypertension, and cardiovascular disease.
Cedars-Sinai investigators are using AI to analyze images from a common heart test to identify signs of valve disease. Photo: Getty. tim.hodson Wed, 04/16/2025 - 14:19 April 16, 2025 An artificial intelligence (AI) program trained to review images from a common medical test can detect early signs of tricuspid heart valve disease and may help doctors diagnose and treat patients sooner, according to research from the Smidt Heart Institute at Cedars-Sinai.
BackgroundGualou Xiebai Banxia Decoction (GXBD), a traditional Chinese medicine, is used to treat myocardial ischemia (MI). However, the molecular mechanisms underlying its effects remain unclear. This study integrated network pharmacology and experimental validation to investigate the efficacy and potential mechanisms of GXBD in MI treatment.MethodsNetwork pharmacology was used to predict the mechanism of action of GXBD in MI.
(MedPage Today) -- Hearing loss may play a bigger role in dementia than previously thought, data from a U.S. cohort study suggested. In a sample of nearly 3,000 older adults, up to 32% (95% CI 11.0%-46.5%) of incident dementia over 8 years could.
Research Highlights: Among adults ages 18-49 (median age of 41 years) who were born with a hole in the upper chambers of their heart known as patent foramen ovale (PFO), strokes of unknown cause were more strongly associated with nontraditional risk.
Dupilumab's approval marks the first new, targeted therapy for CSU in more than a decade and is the 7th indication for a disease with underlying type 2 inflammation.
CPT code 93296 is currently reimbursed based on 28 minutes of labor, yet delivering this service takes 84 minutes. Cardiac remote monitoring plays a vital role in proactive care, helping patients avoid complications and reduce hospital visits.1 As care standards evolve, aligning reimbursement with todays clinical reality is essential to uphold guideline-directed remote monitoring.
Background and AimHypertension (HTN) is a widespread global health challenge, and its increasing prevalence is attributed to individual and environmental risk factors. Persistent organic pollutants (POPs), especially polychlorinated biphenyls (PCBs), contribute to cardiovascular risk by accumulating in fatty tissues, which leads to oxidative stress and vascular inflammation.
(MedPage Today) -- After the Senate voted to confirm Robert F. Kennedy Jr. as Health and Human Services (HHS) secretary, supporters of his "Make America Healthy Again" (MAHA) movement cheered at having a champion in the federal government. Now.
Stroke, Ahead of Print. BACKGROUND:Branch atherosclerosis disease (BAD) is prone to early neurological deterioration (END). The purpose of this study was to assess the efficacy and safety of argatroban plus dual antiplatelet therapy (DAPT) for preventing END in high-risk branch atherosclerosis disease patients.METHODS:This multicenter, open-label, blinded end point, randomized controlled trial including branch atherosclerosis disease patients with mild stroke (National Institutes of Health Strok
Journal of the American Heart Association, Ahead of Print. BackgroundNonvitamin K oral anticoagulants prevent stroke and systemic embolism in patients with nonvalvular atrial fibrillation. However, potential drug interactions with concomitant medications may compromise their efficacy and escalate the risk of adverse effects.Methods and ResultsWe conducted a territorywide retrospective cohort study in Hong Kong, focusing on nonvalvular atrial fibrillation prescribed nonvitamin K oral anticoagulan
In this ECG Cases blog Dr. Jesse McLaren guides us through 6 illustrative cases delving into overall impression in identifying occlusion MI. He discusses how using multiple OMI findings such as acute Q wave, subtle STE, reciprocal STD, hyperacute T waves, and reciprocal TWI to contribute to your overall impression, can double the sensitivity of STEMI criteria for acute coronary occlusion.
BackgroundLeft ventricular hypertrophy (LVH) is often a complication of hypertension and an independent risk factor for cardiovascular events. In Ethiopia, there is a scarcity of data on the prevalence and associated factors of left ventricular hypertrophy among hypertensive adults. This study aimed to assess the prevalence and associated factors of left ventricular hypertrophy among adult patients with hypertension attending treatment at two public hospitals in Harar, Eastern Ethiopia from 20 D
(MedPage Today) -- The Supreme Court will hear oral arguments Monday in a case that could affect what kind of preventive care is covered at no charge under Americans' health insurance plans. The case, known as Kennedy v. Braidwood, involves Christian.
tim.hodson Mon, 04/21/2025 - 11:18 April 21, 2025 Stereotaxis, a provider of surgical robotics for minimally invasive endovascular intervention, will host a live demonstration of the GenesisX Robotic System at this years Heart Rhythm Symposium (HRS), taking place April 24-27 in San Diego, CA. This marks the first live, public demonstration of GenesisX, offering a glimpse into the robots clinical capabilities and weekend installation.
“I have high cholesterol, and I don’t know what to do about it.” This is one of the most common scenarios I encounter as a cardiologist focused on preventing heart disease. Unfortunately, many people do not understand cholesterol, and because of this, they wait too long to address the underlying problem. There is a very structured solution to this issue.
Greenspan offers tips in treating seasonal allergies in patients with pulmonary conditions, such as long-COVID, and provides his 2025 spring allergy prediction.
BackgroundChronic heart failure (CHF) is a complex cardiovascular disease caused by different pathological mechanisms. Modern medicine has made advancements in CHF treatment; however, there are still many challenges. Ershen Zhenwu Decoction (ESZWD) is a Xin'an medicine that has been clinically applied for years and had good efficacy against CHF; however, its underlying mechanisms remain undetermined.
Stroke, Ahead of Print. BACKGROUND:Stroke often results in significant impairments across various domains, including movement, language, cognition, and mood. Neurostimulants have been proposed as potential therapeutic interventions to enhance recovery in these areas.METHODS:This narrative literature review examines clinical trials investigating the efficacy of neurostimulants in poststroke recovery.
ABSTRACT Introduction Pulsed Field Cryoablation (PFCA) is a dual-energy cardiac ablation modality consisting of short-duration ultra-low temperature cryoablation (ULTC) followed immediately by pulsed field ablation (PFA) delivered from the same catheter. It is hypothesized that PFCA may improve contact stability during PFA, while maintaining lesion depth and effectiveness of ULTC.
This systematic review included seven studies that reported the outcomes of minimization or withdrawal of oral pharmacotherapy in chronic heart failure (HF) patients with improved myocardial function. There is a dearth of existing evidence, which supports only loop diuretic withdrawal and possibly carvedilol monotherapy. Unfavourable outcomes were observed following the minimization or withdrawal of reninangiotensin system inhibitors (RASi), mineralocorticoid receptor antagonists (MRA), or the c
This interview in the latest issue of The Respiratory Report features Divay Chandra, MD, MSc, discussing lithium's potential enhancement of alveolar repair after injury.
ObjectiveThe aim of this study was to examine the effectiveness of brief aerobic exercise on patients diagnosed with hyperlipidemia.MethodsSeventy patients diagnosed with hyperlipidemia were enrolled from community health centers between May 2023 and October 2023. They were randomly assigned into two groups: test and control group, each consisting of 35 patients.
(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.
ABSTRACT Introduction The role of corticosteroids in the management of ventricular tachyarrhythmia (VA) in cardiac sarcoidosis (CS) remains controversial. This study assessed the effect of early steroid initiation on VA recurrence rates in patients with CS and evaluated VA frequency before and after steroid therapy. Methods From a registry of 137 patients with CS with arrhythmias, those with VA and more than 60 days of follow-up were included.
If you frequently experience pain in the back of your legs when walking, it could be a sign of Peripheral Artery Disease (PAD). PAD (Peripheral Artery Disease) is a common circulatory condition affecting more than 10 million Americans. PAD causes a narrowing of the peripheral arteries due to fatty plaque buildup (or atherosclerosis) which restricts blood flow to the extremities.
Severe tricuspid regurgitation (TR) is a prevalent and challenging condition associated with poor survival outcomes and significant morbidity. Medical therapy alone often fails to provide adequate symptom relief, and stand-alone surgical intervention is linked to high mortality rates, making it a less favorable option unless combined with left-sided valve surgery.
Stroke, Ahead of Print. BACKGROUND:The international trial AVERT (A Very Early Rehabilitation Trial) found that very early mobilization (VEM; commenced <24 hours after stroke) negatively affected functional outcome (modified Rankin Scale [mRS]). The drivers of this effect remain unclear. One plausible mechanism is that high-dose upright activity worsens cerebral perfusion in patients with cerebral large vessel occlusion (LVO).
This multinational cohort study examined whether an artificial intelligence (AI) algorithm could predict heart failure risk from noisy single-lead electrocardiograms.
People with a certain heart valve abnormality are at increased risk of severe heart rhythm disorders, even after successful valve surgery. The condition is more common in women and younger patients with valve disorder and can, in the worst case, lead to sudden cardiac arrest.
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