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Women with blood pressure levels in a range considered clinically normal during pregnancy but no mid-pregnancy drop in blood pressure face an increased risk of developing hypertension in the five years after giving birth. These women -- about 12% of the population studied -- would not be flagged as high-risk by current medical guidelines, but the new findings could help identify them as candidates for early intervention.
The immune response plays a vital role in the development of cardiovascular diseases (CVDs). As a crucial component of the innate immune system, neutrophils are involved in the initial inflammatory response following cardiovascular injury, thereby inducing subsequent damage and promoting recovery. Neutrophils exert their functional effects in tissues through various mechanisms, including activation and the formation of neutrophil extracellular traps (NETs).
Background Mechanical stress on the heart is commonly considered the sole stimulus explaining the synthesis and release of circulating natriuretic peptides and their derivatives. While one of the most critical paradigms in cardiology is that mechanical load increases oxygen consumption, clinical studies on these peptides have neglected the relationship between mechanical stress and oxygen metabolism.
Nature Reviews Cardiology, Published online: 20 March 2025; doi:10.1038/s41569-025-01142-1 In this Review, Ravindran and Gustafsson describe the mechanisms involved in regulating mitochondrial quality control in cardiomyocytes, discuss how these pathways are altered in cardiovascular disease and ageing, and highlight the therapeutic potential of targeting mitochondrial quality control pathways in cardiovascular disease.
tim.hodson Mon, 03/17/2025 - 14:56 March 17, 2025 Being born with a heart defect may be associated with an increased cancer risk for babies and their moms, according to new research published today in the American Heart Associations flagship journal Circulation. According to the American Heart Association, the most common birth defects in the U.S. are forms of congenital heart defects (CHD).
A new study reveals that encapsulated heating methods, an often-used heat simulation method, significantly increase heart rates and cardiac strain compared to natural heat exposure like those experienced during hot weathers. Understanding how extreme heat impacts heart function is crucial for developing effective strategies to protect vulnerable groups, especially as global temperatures continue to rise.
ObjectiveThis study aimed to investigate the effects of Enhanced External Counterpulsation (EECP) on anxiety and depression in patients with Paroxysmal Atrial Fibrillation (PAF).MethodsA cohort of 100 patients diagnosed with PAF at the Fuzhou First Hospital between January 2023 and June 2024 were enrolled in this study. Patients were randomly assigned to either the control group (n=50) or the EECP group (n=50) in this randomized controlled trial.
Introduction Atrial fibrillation is the most prevalent sustained arrhythmia worldwide and is expected to increase substantially within the coming years. Although lifestyle changes and risk factor modification are now acknowledged as central components of atrial fibrillation management, the effects of exercise on disease-specific outcomes are still not extensively documented due to few high-quality randomised trials.
Introduction Atrial fibrillation is the most prevalent sustained arrhythmia worldwide and is expected to increase substantially within the coming years. Although lifestyle changes and risk factor modification are now acknowledged as central components of atrial fibrillation management, the effects of exercise on disease-specific outcomes are still not extensively documented due to few high-quality randomised trials.
Its not surprising that Alnylams Amvuttra (vutrisiran) received FDA approval for ATTR-CM last week, but what shocked many was Alnylams choice to price the drug at nearly half a million dollars per year in a segment where its incumbent competitors cost half as much. Amvuttra is now the third FDA-approved therapy for ATTR-CM, following Pfizers Vyndaqel and BridgeBios Attruby/Beyonttra.
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.
Circulation, Ahead of Print. The field of cardio-oncology has expanded over the past 2 decades to address the ever-increasing issues related to cardiovascular disease in patients with cancer and survivors. There is increasing recognition that nearly all cancer treatments pose some short- or long-term risk for development of cardiovascular disease and that pediatric patients with cancer may be especially vulnerable to cardiovascular disease because of young age at treatment and expected long life
BackgroundHeart failure (HF), a core component of cardiovascular diseases, is characterized by high morbidity and mortality worldwide. By collecting and analyzing routine blood data, machine learning models were built to identify the patterns of changes in blood indicators related to HF.MethodsWe conducted a statistical analysis of routine blood data from 226 patients who visited Zhejiang Provincial Hospital of Traditional Chinese Medicine (Hubin) between May 1, 2024, and June 30, 2024.
Introduction and objectives Decision-making regarding prognosticating out-of-hospital cardiac arrest (OHCA) remains challenging at the front door. The MIRACLE2 score provides a simple and practical tool for early neuroprognostication to aid decision-making. The study aims to validate the MIRACLE2 score in a district general hospital (DGH). Material and methods This is a retrospective analysis of the patients with OHCA and return of spontaneous circulation (ROSC) in the community who attended the
Although theres still ongoing debate on who should receive LAAO devices, new five year results from the Amulet IDE trial confirm that both Abbotts Amulet occluder and Boston Scientifics Watchman 2.5 are safe and effective in the long run. LAAO (left atrial appendage occlusion) devices help prevent stroke in patients with AFib by sealing off the left atrial appendage where blood clots can form.
Research Highlights: Newborns with congenital heart defects may have a higher risk of developing childhood cancer compared to children born without a heart abnormality. Congenital heart defects in newborns may also signal an elevated cancer risk for.
A new study has discovered what researchers say is the first drug to fully reproduce the effects of physical stroke rehabilitation in model mice, following from human studies.
Dilated cardiomyopathy (DCM) is a leading cause of heart failure, yet therapeutic options remain limited. While traditional research has focused on mechanisms such as energy deficits and calcium dysregulation, increasing evidence suggests that mitochondria-associated membranes (MAMs) could provide new insights into understanding and treating DCM. In this narrative review, we summarize the key role of MAMs, crucial endoplasmic reticulum (ER)-mitochondria interfaces, in regulating cellular process
Over the past two days, interventional cardiologists from around the worldgathered at Freeman Hospital, Newcastle, for an intensive and enriching experience focused on tackling one of the most complex challenges in percutaneous coronary intervention (PCI): calcified coronary lesions.
(MedPage Today) -- Statin use in patients with chronic liver disease was associated with a reduced risk of hepatocellular carcinoma (HCC) and hepatic decompensation, researchers found. In a cohort of 16,501 individuals with chronic liver disease.
BackgroundNeutrophil-to-lymphocyte ratio (NLR) has been presented as a possible indicator associated with the outcomes of growing patients and an available predictor of inflammation. Nevertheless, just a handful of researches shed light on the association between NLR and the consequences of critical patients with coronary artery disease (CAD). The study aimed to investigate the correlation between NLR and all-cause mortality of short-term and long-term in patients with CAD.MethodsWe obtained obj
Distribution Variance of Focal Atrial Tachycardia Foci and Long-Term Outcomes After Ablation. ABSTRACT Introduction The distribution of the origin of focal atrial tachycardia (FAT) in patients with different ages have not been clearly elucidated. We aimed to evaluate age differences in foci and factors influencing recurrence after radiofrequency catheter ablation in adult and juvenile patients with FAT.
Marijuana is now legal in many places, but is it safe? Two new studies add to mounting evidence that people who use cannabis are more likely to suffer a heart attack than people who do not use the drug, even among younger and otherwise healthy adults. The findings are from a retrospective study of over 4.6 million people and a meta-analysis of 12 previously published studies.
(MedPage Today) -- A preprint study suggested that GLP-1 receptor agonists may be associated with hair loss, though only in women. Using a random sample of 16 million patients, researchers found that women who newly initiated semaglutide (Ozempic.
A study highlights how food allergies impact adults' mental health and social lives, revealing anxiety, isolation, and the need for better support systems.
BackgroundAn undeflatable stent balloon following its inflation during percutaneous coronary intervention (PCI) is a rare and unpredictable complication that can lead to serious consequences. Currently, there is no standardized protocol for managing this issue.Case presentationAn 83-year-old man presented with chest pain. Coronary angiography showed a chronic total occlusion (CTO)-like lesion in the proximal left anterior descending coronary artery (LAD).
Journal of the American Heart Association, Ahead of Print. Blood culturenegative endocarditis has been associated with worse outcomes when compared with blood culturepositive endocarditis, because pathogendirected antimicrobial therapy and other management aspects have been difficult to achieve. Novel diagnostic tools, however, have changed the landscape of this syndrome and will likely improve patient outcomes.
(MedPage Today) -- Survivors of childhood cancer were much more likely to develop an aging-associated health condition before the age of 65, with earlier onset, compared with the general population, according to a modeling study. While 20% of.
ObjectivesRegistered, prospective, multicenter study of the short-term clinical outcomes of a novel transcatheter aortic valve system (Xcor system, Saint Medical Technology, Inc., Nanjing) to evaluate its safety and efficacy.Methods130 high risk patients with symptomatic severe AS from 11 institutions were treated with the novel Xcor system. All patients were pre-TAVR assessed by transthoracic echocardiography and computed tomography of the aortic valve (AV) and relevant left cardiac and vascula
The risk of cardiovascular disease (CVD) among individuals of South Asian (SA) ancestry is nearly twofold higher than in individuals of European ancestry.
Researchers have created an AI tool to accelerate the development of new disease treatments and demonstrated its potential by identifying an existing drug with the potential to prevent deadly heart failure.
(MedPage Today) -- An automated insulin delivery (AID) system boosted glycemic control in insulin-treated adults with type 2 diabetes using continuous glucose monitoring (CGM), a randomized trial showed. Over 13 weeks, drops in HbA1c averaged.
Latanya Benjamin, MD, and Lindsay Ackerman, MD, joins The Medical Sisterhood in a live recording at AAD 2025 to discuss advocacy, mentorship, and empowerment.
The coffee from most of the coffee machines in workplaces contains relatively high levels of cholesterol-elevating substances. There is a big difference in comparison to coffee made in regular paper filter coffee makers, which filter out most of these substances.
A simplified risk stratification model based on the cardiogenic shock (CS) classification system from the Society for Cardiovascular Angiography and Intervention (SCAI) effectively predicts in-hospital mortality in postcardiotomy (PC) patients, according to a retrospective, observational study.
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