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Circulation, Ahead of Print. The Physical Activity Guidelines for Americans supports sitting less and moving more. Growing evidence suggests that a waking behavior profile with less sedentary behavior and more light-intensity physical activity is associated with more favorable cardiovascular health. Remarkably, little is known about how these behaviors relate to cardiovascular health during pregnancy.
New research has uncovered a surprising culprit underlying cardiovascular diseases in obesity and diabetes -- not the presence of certain fats, but their suppression. The study challenges the conventional belief that a type of fat called ceramides accumulates in blood vessels causing inflammation and health risks. Instead, their findings reveal that when ceramides decrease in endothelial cells lining blood vessels, it can be damaging and cause chronic illnesses.
Nature Reviews Cardiology, Published online: 07 April 2025; doi:10.1038/s41569-025-01145-y To regenerate the injured heart, cardiomyocytes must proliferate to replace lost myocardial tissue, but this capacity is largely absent in adult mammals. In this Review, Koopmans and van Rooij explore the key pathways that drive cardiomyocyte maturation after birth and how targeted manipulation might reactivate the cell cycle in adult cardiomyocytes.
More than heart disease or cancer, dementia is the primary concern for many of the patients I see. Heart disease and cancer attack your body, but dementia attacks your mind and identity. It strips away the fabric of who a person is. That is why I believe people fear dementia so much. Thankfully, 45% of all dementia is preventable 1. Many factors make up that 45%, but one factor seems to impact the risk of dementia the most.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Casting doubt on value based cardiac care, a JAMA study found that outpatient cardiology practices enrolled in an accountable care organization (ACO) through the Medicare Shared Savings Program (MSSP) dont offer better care than non-ACO practices. MSSP was introduced in 2012 to improve care quality and lower Medicare costs by having ACOs assume responsibility for Medicare beneficiaries costs and care quality.
Circulation, Ahead of Print. Populations most affected by cardiovascular health disparities, including underrepresented populations with lower socioeconomic status, people with disabilities, and those living in underserved rural communities, are disproportionately exposed to adverse social determinants of health. Specifically, economic instability and suboptimal living conditions within the neighborhood and built environment directly determine access to resources and opportunities for healthful
Background Kuwait, one of the world’s hottest countries, faces increasing temperatures due to climate change. With a large migrant population predominantly employed in physically demanding jobs, the exact effects and burdens of temperature exposure on cardiovascular risk among this population remain unknown. This study aimed to investigate the relationship between temperature and myocardial infarction (MI) risk among migrants in Kuwait.
Background Kuwait, one of the world’s hottest countries, faces increasing temperatures due to climate change. With a large migrant population predominantly employed in physically demanding jobs, the exact effects and burdens of temperature exposure on cardiovascular risk among this population remain unknown. This study aimed to investigate the relationship between temperature and myocardial infarction (MI) risk among migrants in Kuwait.
tim.hodson Mon, 04/07/2025 - 16:15 April 4, 2025 Viz.ai has been named an Award Winner in the 2025 Edison Awards, for the third year in a row. Viz HCM, the companys AI software solution designed to detect and triage patients with signs of hypertrophic cardiomyopathy (HCM), was recognized in the Health Medical & Biotech category and Cardiovascular Health Diagnostics and Monitoring subcategory.
ObjectiveTo compare the image quality, radiation dose, and examination time between non-electrocardiogram (ECG)-gated coronary CT angiography (ECG-less CCTA) and conventional ECG-gated CCTA using wide-detector CT, and validate its clinical applicability.MethodsIn this prospective study, 109 patients with suspected coronary artery disease were divided into ECG-less (Group A, n=59) and ECG-gated (Group B, n=50) groups.
(MedPage Today) -- SAN DIEGO -- New data explored the potential beneficial impact that glucagon-like peptide-1 (GLP-1) receptor agonists may have on neurodegenerative diseases. In a plenary session at the annual American Academy of Neurology.
Objective To validate the prognostic utility of peak creatine kinase-myocardial band isoenzyme (CK-MB) level, left ventricular posterior wall diameter (LVPWD), and a score model for successful weaning from mechanical circulatory support (MCS) in fulminant myocarditis (FM). Furthermore, the severity of the histological data was stratified, and its relationship with the clinical findings was investigated.
Background Heart failure (HF) guidelines recommend routine testing for iron deficiency (ID) and, for those with ID, intravenous iron if the left ventricular ejection fraction is <50%. Guideline adherence to these recommendations by cardiologists in China is unknown. Methods and results An independent academic web-based survey was designed and distributed via social networks to cardiologists across China.
tim.hodson Wed, 04/09/2025 - 14:38 April 9, 2025 Idorsia Ltd recently announced that the US Food & Drug Administration (FDA), after having released Tryvio from its REMS (Risk Evaluation and Mitigation Strategy) requirement ( announced March 17, 2025 ), has now approved the updated label for Tryvio(aprocitentan). Tryvio is Idorsias dual endothelin receptor antagonist (ERA) indicated for the treatment of systemic hypertension in combination with other antihypertensives to lower blood pressure in
With the global impact of cardiovascular disease, there is a dire need to understand the mechanisms in the heart during injury and stress. It has been shown that the regulation of the extracellular matrix via cardiac fibroblasts plays a major role in the progression of heart failure and worsening function of the heart. Importantly, it has been suggested that crosstalk between other cardiac cells like cardiomyocytes, immune cells, and endothelial cells are influenced by the pathological function
(MedPage Today) -- As measles continues to spread through vulnerable communities in the U.S., HHS Secretary Robert F. Kennedy Jr. has suggested that there are long-term health benefits to contracting the virus, despite decades of data that suggest.
"Our medical language is filled with negativity and dehumanization." Dr. Colleen Christmas, Johns Hopkins University School of Medicine. Why doctors need to stop using words that hurt patients.
Since the first implementation in 2002 by Alain Cribier, transcatheter aortic valve replacement (TAVR) has become a standard procedure for high-risk and elderly patients with severe aortic valve stenosis. Recently, the use of TAVR has expanded to relatively younger patients with low to moderate surgical risk. Infective endocarditis (IE) after TAVR, first reported in medical literature in 2010, is a relatively new and extremely concerning complication. 1 Its incidence, reported as 1.1% per person
Prof. David Luria (left), Director of Electrophysiology at Hadassah Medical Center, and Ziv Menshes (right), CEO of CardioVia tim.hodson Tue, 04/08/2025 - 14:38 April 7, 2025 CardioVia, a medical device company specializing in advanced cardiac care solutions, has received U.S. Food and Drug Administration (FDA) clearance for its ViaOne system. This device is designed to enable safe and precise access to the hearts surface (pericardial space) for both diagnostic and therapeutic interventions wi
Unlike mammals, zebrafish can regenerate their heart after cardiac insult. There are several ways to perform cardiac injury in zebrafish, but cryoinjury most closely resembles human myocardial infarction (MI). Studies demonstrated that macrophages are essential cells from the beginning to later stages of cardiac injury throughout the regenerative process in zebrafish.
The International Journal of Cardiovascular Sciences (IJCS) is seeking a volunteer Assistant Editor to support the Editor-in-Chief in the journal’s editorial activities. This is an excellent opportunity for early-career individuals in the cardiovascular health field who wish to develop editorial skills and contribute to the advancement of science in this area, as well as engage in the journals outreach activities.
(MedPage Today) -- Comorbidities in midlife were associated with a modestly higher risk of cancer overall and more strongly associated with a risk for multiple individual cancer types, according to a secondary analysis of the prospective Prostate.
‘Real knowledge is to know the extent of one’s ignorance ’ Confucius This editorial refers to ‘Gaps in knowledge and management of iron deficiency in heart failure: a nationwide survey of cardiologists in China’, by Su et al. 1 Over the last 25 years, an accumulation of data has highlighted the prevalence of iron deficiency and the value of its correction in patients with heart failure and reduced (HFrEF) or mildly reduced ejection fraction (HFmrEF).
ObjectiveAdvanced glycation end-products (AGEs) may contribute to the pathogenesis of atherosclerotic cardiovascular disease (ASCVD), potentially influencing its development and progression differently at various life stages. This study aimed to elucidate the associations between AGEs and the risk of ASCVD across different age groups.MethodsIn this cross-sectional study, 1,240 subjects were enrolled and divided into three groups (Group , 2039 years old, n=468; Group , 4059 years old, n=471; Grou
Stroke, Ahead of Print. BACKGROUND:The National Institutes of Health Stroke Scale is used globally to rate neurological deficits in patients with acute stroke. Originally designed for research use, the scale uses idiosyncratic scoring rules and requires thorough training for proper use. Currently available training and certification systems are timeworn and limited in the range of demonstrated neurological findings.
Hypertension, Ahead of Print. BACKGROUND:Aberrant BMPR2 (bone morphogenetic protein receptor 2) signaling is associated with the pathogenesis of pulmonary hypertension. SMAD4 is an essential downstream effector of BMPR2 signaling, but whether and how it participates in pulmonary hypertension are unclear.METHODS:Globally and vascular cell-specifically inducible knockout mouse models were used to examine the role of SMAD4 deficiency in differential cell compartments in the development of pulmonary
ABSTRACT Background Sotalol is used for the maintenance of sinus rhythm among patients with atrial fibrillation. However, there is discretion regarding dosing of chronic therapy, and the target oral dose dictates infusion doses for intravenous sotalol loading. To date, use and outcomes by dose are not well-described. Methods In the Prospective Evaluation Analysis and Kinetics of IV Sotalol (PEAKS) Registry, we analyzed outcomes among patients undergoing elective IV sotalol load for atrial arrhyt
Cardio-kidney metabolic (CKM) syndrome represents a complex and circular interplay of cardiovascular, renal, and metabolic dysfunctions, significantly contributing to global morbidity and mortality. This expert opinion synthesizes insights from a panel of Italian specialists in cardiology, nephrology, and diabetology, advocating for a holistic and integrated framework for CKM management.
(MedPage Today) -- People taking medications for attention deficit-hyperactivity disorder (ADHD) showed small changes to their cardiovascular metrics -- and it wasn't just the stimulants to watch out for, a systematic review suggested. Based.
Circulation: Arrhythmia and Electrophysiology, Ahead of Print. BACKGROUND:Patients with arrhythmogenic cardiomyopathy due to pathogenic variants inPKP2, the gene for the desmosomal protein plakophilin-2, are being enrolled in gene therapy trials designed to replace the defective allele via adeno-associated viral transduction of cardiac myocytes. Evidence from experimental systems and patients indicates that ventricular myocytes inPKP2arrhythmogenic cardiomyopathy have greatly reduced electrical
This clinical study reports the incidence, severity and causes of hemolytic effects after PFA utilizing a novel hexaspline PFA catheter in an Chinese cohort, demonstrating a high rate (31.9%) of bilirubin elevation the next day post PFA, but returned to normal at 7th day without any signs of hemoglobin decline and renal failure. ABSTRACT Background and Aims Hemolysis-related renal failure after pulsed field ablation (PFA) has been described in recently published cases, we reported the incidence
Arteria lusoria (AL), an anomaly of the right subclavian artery, occurs in 2% of individuals and can cause symptoms such as dysphagia due to its retroesophageal course. Often associated with Kommerell's diverticulum (KD), a dilation at the artery's origin, this condition poses risks of rupture or dissection. Symptomatic cases and aneurysms necessitate surgical intervention, while asymptomatic cases may warrant observation.
Publication date: Available online 9 April 2025 Source: The American Journal of Cardiology Author(s): Alice Moroni, Andrea Mascaretti, Jo Dens, Paul Knaapen, Alexander Nap, Yvemarie B.O.
This paper aims to review and compare the mechanical and technical similarities and differences between the Arctic Front series cryoballoons from Medtronic and the next-generation cryoballoons, including POLARx and POLARx FIT from Boston Scientific and Nordica from Synaptic. As cryoballoon technology continues to evolve, the introduction of lower-pressure and selectable-size balloons presents new considerations for both safety and efficacy of cryoablation of atrial fibrillation.
Statement Highlights: Mobile health technologies, such as wearable devices, mobile health apps and telehealth or remote coaching, have shown potential to help people start and maintain heart-healthy behaviors, such as eating a healthy diet, increasing.
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