Science Daily - Heart Disease

JANUARY 2, 2025

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement. This study marks an important step toward regenerative therapies to prevent heart failure.

Heart Failure 98

Heart Failure Research 98

Medical Xpress - Cardiology

JANUARY 3, 2025

Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests.

Heart Disease 117

Heart Disease Stroke Strokes Diabetes 117

Ken Grauer, MD

DECEMBER 28, 2024

I was sent the ECG in Figure-1 told only that the patient was an older adult who reported dizziness with activity. QUESTIONS: What is the rhythm? ( HINT: There are at least 4 important findings that should be noted ). Is there AV block? Figure-1: The initial ECG in today's case. ( To improve visualization I've digitized the original ECG using PMcardio ).

Blog 171

Blog Ischemia Pacemaker 171

Med Page Today

DECEMBER 31, 2024

(MedPage Today) -- A three-step process underscores new clinical practice guidelines for primary and specialty care clinicians to evaluate patients who may have cognitive impairment or dementia due to Alzheimer's or a related disease. In broad.

Dementia 110

Dementia 110

HCPLive

JANUARY 1, 2025

Patients hospitalized for severe COVID-19 had an accelerated eGFR decline relative to those with pneumonia due to other infections.

COVID-19 105

COVID-19 Hospital 105

Dr. Smith's ECG Blog

JANUARY 2, 2025

By Smith with comments from our electrophysiologist, Rehan Karim. (And of course Ken's comments at the bottom) An elderly obese woman with cardiomyopathy, Left bundle branch block, and chronic hypercapnea presented hypoxic with altered mental status. She was intubated. Bedside cardiac ultrasound showed moderately decreased LV function. CT of the chest showed no pulmonary embolism but bibasilar infiltrates.

Tachycardia 86

Tachycardia Cardiomyopathy Blog Bradycardia 86

Nature Reviews - Cardiology

JANUARY 1, 2025

Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01104-z Endovascular renal denervation has been approved for the treatment of hypertension. In this Review, Fisher and Kirtane discuss the clinical trial data on its efficacy and safety and provide practical guidance on patient selection and clinical implementation of the procedure.

Hypertension 89

Hypertension 89

Med Page Today

DECEMBER 31, 2024

(MedPage Today) -- MedPage Today's enterprise and investigative team covers a lot of ground. We jump in when there's breaking news in healthcare. We write second-day stories on the implications of that news. We craft compelling feature stories.

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HCPLive

DECEMBER 30, 2024

Panelists discuss the new health measures relevant to chronic kidney disease (CKD) management and their significance in improving patient care and outcomes.

Kidney Disease 105

Kidney Disease Patient Care Outcomes 105

Science Daily - Stroke

JANUARY 3, 2025

Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests. Researchers drew this conclusion after studying proteins from blood samples taken from over 42,000 adults recruited to the UK Biobank.

Heart Disease 87

Heart Disease Stroke Strokes Diabetes 87

Nature Reviews - Cardiology

JANUARY 1, 2025

Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01109-8 In this Review, Lavine and colleagues describe the known subsets of cardiac macrophages, highlighting newly identified macrophage states and associated cellular neighbourhoods, and discuss the roles of cardiac macrophages in homeostasis and disease, including in inflammation, fibrosis, age-associated pathologies, mechanosensing, efferocytosis, angiogenesis, arrhythmias and transplant allograft survival.

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Transplant Arrhythmia 78

Medical Xpress - Cardiology

DECEMBER 31, 2024

The U.S. government's premier research body has made an important discovery that could help create new drugs to lower "bad" cholesterol, and hopefully prevent heart attacks and stroke.

Heart Attack 106

Heart Attack Heart attacks Cholesterol Technology 106

Med Page Today

DECEMBER 28, 2024

(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.

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HCPLive

DECEMBER 30, 2024

Panelists discuss how current treatments for IgA nephropathy often fall short in addressing the root cause, specifically abnormal IgA production and deposition, and highlight the consequences of prioritizing symptom management, such as proteinuria reduction, over targeting the diseases underlying pathology.

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105

ECG Guru

JANUARY 3, 2025

Here we see a 30 s long strip of a 1-leadECG, recorded with a modern Smartwatch (Apple watch). The ECG has been graphically processed for better visualization. The paper speed is 25 mm/s as usual. The lead shown corresponds to ECG lead I of the limb leads.

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85

Nature Reviews - Cardiology

JANUARY 1, 2025

Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01111-0 In this Review, Born and colleagues present insights into the role of apolipoprotein B-containing lipoproteins in atherogenesis, with an emphasis on the mechanisms leading to atherosclerotic plaque initiation and growth. They describe the causative role of LDL at the early stages of atherogenesis and discuss the relative atherogenicity of lipoprotein(a) and triglyceride-rich lipoproteins.

Plaque 97

Plaque 97

Medical Xpress - Cardiology

JANUARY 2, 2025

Walking in a winter wonderland may sound serene and peaceful, but shoveling your sidewalks to take that walk could quickly change delightful to deadly. According to the American Heart Association, the world's leading nonprofit organization focused on heart and brain health for all, research shows that the exertion of shoveling snow may lead to an increased risk of a heart attack or sudden cardiac arrest.

Heart Attack 87

Heart Attack Heart attacks Cardiac Arrest Research 87

Med Page Today

DECEMBER 28, 2024

(MedPage Today) -- In January, we reported on the FDA clearing GLP-1 receptor agonists of suicidality risk following a preliminary evaluation. In this report, we follow up on what has happened since. Not long after the FDA wrapped its preliminary.

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HCPLive

JANUARY 2, 2025

Although the oral navacaprant 80 mg failed to bring statistically significant improvements in depression symptoms, the study showed females respond better than males.

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Journal of Clinical Investigation - Cardiology

JANUARY 2, 2025

Cancer patients undergoing chemotherapy often experience anorexia and weight loss that substantially deteriorates overall health, reduces treatment tolerance and quality of life, and worsens oncologic outcomes. There are currently few effective therapeutic options to mitigate these side effects. The central melanocortin system, which plays a pivotal role in regulating appetite and energy homeostasis, presents a logical target for treating anorexia and weight loss.

Quality of Life 83

Quality of Life Cancer Outcomes 83

Nature Reviews - Cardiology

JANUARY 1, 2025

Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01110-1 In this Review, Dey and colleagues explore the pathobiology of coronary atherosclerotic plaques and perivascular adipose tissue, describe their phenotyping with computed tomography coronary angiography, and discuss potential future applications in clinical risk prediction and patient management.

Plaque 85

Plaque Atherosclerosis Biomarkers 85

ECG Guru

JANUARY 3, 2025

This ECG is from a 65-year-old woman who had previously had no cardiac abnormalities but has now suffered several syncopes within 2 weeks. During the last syncope she suffered a fracture of the left femur.

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Med Page Today

DECEMBER 30, 2024

(MedPage Today) -- Atherosclerosis progression was more than twice as common in younger people with systemic lupus erythematosus (SLE) than in healthy controls in a prospective study from Greece, but the rate difference narrowed substantially with.

Atherosclerosis 84

Atherosclerosis 84

Medical Xpress - Cardiology

JANUARY 2, 2025

Researchers from the Bakkers group at the Hubrecht Institute have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement.

Research 81

Research 81

Physiologically Speaking

JANUARY 3, 2025

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.

Physiology 63

Physiology Exercise Research Document 63

HCPLive

JANUARY 2, 2025

These data highlight long-term complications related to COVID-19 in terms of skin conditions, a continuing concern for many patients.

COVID-19 78

COVID-19 78

Heart Sisters

DECEMBER 29, 2024

Was this particular article the most popular of 2024 because my HEART SISTERS readers aren't getting clear jargon-free, patient-friendly answers from their doctors?

Article 75

Article 75

Med Page Today

DECEMBER 29, 2024

(MedPage Today) -- In March, we reported on back-to-back FDA approvals for two treatments in pulmonary arterial hypertension (PAH). In this report, we follow up on what has happened since. After the FDA approved both combination macitentan/tadalafil.

Pulmonary 79

Pulmonary Hypertension 79

The New England Journal of Medicine

JANUARY 1, 2025

A randomized trial of the factor XIa inhibitor asundexian was stopped early owing to a higher incidence of stroke or systemic embolism than with apixaban therapy among patients with atrial fibrillation.

Atrial Fibrillation 75

Atrial Fibrillation Embolism Stroke Strokes 75

Nature Reviews - Cardiology

JANUARY 1, 2025

Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01114-x In this Review, Heusch and Kleinbongard describe the deleterious and protective roles of the spleen in the inflammatory processes of atherosclerosis, myocardial infarction and heart failure, and highlight the translational potential of the cardioprotective functions of the spleen for the treatment of patients with ischaemic heart disease.

Heart Disease 98

Heart Disease Myocardial Infarction Atherosclerosis Heart Failure 98

Science Daily - Heart Disease

JANUARY 2, 2025

Patients diagnosed with late-stage or metastatic breast cancer have a statistically significant increased risk of pre-diagnosis cardiovascular disease (CVD) compared to those with early-stage cancer at diagnosis.

Cancer 68

Cancer Heart Disease Cardiovascular Disease 68

Medical Xpress - Cardiology

JANUARY 2, 2025

There's no question that exercise is good for the heart. Regular exercise lowers blood pressure and cholesterol and reduces the chances of having a heart attack or stroke.

Exercise 65

Exercise Blood Pressure Heart Attack Heart attacks 65

HCPLive

JANUARY 3, 2025

Zaheer discussed how this research may be used as a model to help study other therapy transitions as well.

Research 64

Research 64

The New England Journal of Medicine

JANUARY 1, 2025

Among patients with transthyretin amyloidosis with cardiomyopathy, the risk of death from any cause and recurrent cardiovascular events was lower with vutrisiran treatment than with placebo.

Cardiomyopathy 74

Cardiomyopathy 74

Nature Reviews - Cardiology

JANUARY 1, 2025

Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01103-0 Vascular cells are finely regulated by complex microenvironments, including biomechanical signals from the extracellular matrix. In this Review, Kong and colleagues describe the role of the extracellular matrix in vascular development, ageing and disease, and highlight the potential of novel therapies targeting this fine-tuned network.

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Dr. Paddy Barrett

DECEMBER 28, 2024

"Frustrated, lost and confused." That was the main feedback I got from thousands of readers when I asked them about their experience working with existing healthcare systems to implement a plan to prevent heart disease. This is not good. Heart disease is the leading cause of death worldwide, and with the right approaches, 80% or more can be prevented at an early age.

Heart Disease 54

Heart Disease Exercise 54

Dr. Smith's ECG Blog

DECEMBER 29, 2024

Dizziness is so unlikely to be OMI without an obvious ECG, that I am going to pretend that this patient presented with chest pain. The PMCardio Queen of Hearts app asks you, before giving an interpretation of OMI ("STEMI-Equivalent"), whether the patient's clinical presentation is high risk for OMI. If no, then she will tell you that the case is outside of the intended use group.

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Stents Stent Chest Pain Angina 70