Trending Articles

article thumbnail

Zebrafish protein unlocks dormant genes for heart repair

Science Daily - Heart Disease

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement. This study marks an important step toward regenerative therapies to prevent heart failure.

article thumbnail

Loneliness linked to higher risk of heart disease, stroke and susceptibility to infection

Medical Xpress - Cardiology

Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests.

article thumbnail

Phase 3 KOASTAL-1 Trial Fails to Show Navacaprant Significantly Improves MDD

HCPLive

Although the oral navacaprant 80 mg failed to bring statistically significant improvements in depression symptoms, the study showed females respond better than males.

119
119
article thumbnail

New Guidelines Update Alzheimer's and Dementia Evaluations

Med Page Today

(MedPage Today) -- A three-step process underscores new clinical practice guidelines for primary and specialty care clinicians to evaluate patients who may have cognitive impairment or dementia due to Alzheimer's or a related disease. In broad.

Dementia 115
article thumbnail

Torsade in a patient with left bundle branch block: is there a long QT? (And: Left Bundle Pacing).

Dr. Smith's ECG Blog

By Smith with comments from our electrophysiologist, Rehan Karim. (And of course Ken's comments at the bottom) An elderly obese woman with cardiomyopathy, Left bundle branch block, and chronic hypercapnea presented hypoxic with altered mental status. She was intubated. Bedside cardiac ultrasound showed moderately decreased LV function. CT of the chest showed no pulmonary embolism but bibasilar infiltrates.

article thumbnail

Loneliness linked to higher risk of heart disease and stroke and susceptibility to infection

Science Daily - Stroke

Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests. Researchers drew this conclusion after studying proteins from blood samples taken from over 42,000 adults recruited to the UK Biobank.

article thumbnail

Cellular interactions help explain vascular complications due to COVID-19 virus infection

Medical Xpress - Cardiology

COVID-19 is a respiratory disease primarily affecting the lungs. However, the SARS-CoV-2 virus that causes COVID-19 surprised doctors and scientists by causing an unusually large percentage of patients to experience vascular complicationsissues related to blood flow, such as blood clots, heart attacks, and strokes.

COVID-19 123

More Trending

article thumbnail

Meta-analysis of MitraClip and PASCAL for transcatheter mitral edge-to-edge repair

Journal of Cardiothoracic Surgery

Despite the promising results of both MitraClip and PASCAL systems for the treatment of mitral regurgitation (MR), there is limited data on the comparison of both systems regarding their safety and efficacy. W.

article thumbnail

Overlooked Stories of 2024

Med Page Today

(MedPage Today) -- MedPage Today's enterprise and investigative team covers a lot of ground. We jump in when there's breaking news in healthcare. We write second-day stories on the implications of that news. We craft compelling feature stories.

95
article thumbnail

What if we call them “self-care promises” instead of resolutions?

Heart Sisters

Why are 80% of New Year’s resolutions abandoned by the second week of February?

article thumbnail

Zebrafish protein unlocks dormant genes for heart repair

Medical Xpress - Cardiology

Researchers from the Bakkers group at the Hubrecht Institute have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement.

Research 103
article thumbnail

Steven W. Pipe, MD: Supporting Gene Therapy Implementation for Hemophilia

HCPLive

Pipe discussed a symposium at ASH 2024 about practical implementation of gene therapy in the field.

105
105
article thumbnail

Renal denervation for hypertension

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01104-z Endovascular renal denervation has been approved for the treatment of hypertension. In this Review, Fisher and Kirtane discuss the clinical trial data on its efficacy and safety and provide practical guidance on patient selection and clinical implementation of the procedure.

article thumbnail

Melanocortin-4 receptor antagonist TCMCB07 alleviates chemotherapy-induced anorexia and weight loss in rats

Journal of Clinical Investigation - Cardiology

Cancer patients undergoing chemotherapy often experience anorexia and weight loss that substantially deteriorates overall health, reduces treatment tolerance and quality of life, and worsens oncologic outcomes. There are currently few effective therapeutic options to mitigate these side effects. The central melanocortin system, which plays a pivotal role in regulating appetite and energy homeostasis, presents a logical target for treating anorexia and weight loss.

article thumbnail

Smartwatch-ECG

ECG Guru

Here we see a 30 s long strip of a 1-leadECG, recorded with a modern Smartwatch (Apple watch). The ECG has been graphically processed for better visualization. The paper speed is 25 mm/s as usual. The lead shown corresponds to ECG lead I of the limb leads.

85
article thumbnail

New technology 'sees' how cholesterol causes heart attacks

Medical Xpress - Cardiology

The U.S. government's premier research body has made an important discovery that could help create new drugs to lower "bad" cholesterol, and hopefully prevent heart attacks and stroke.

article thumbnail

COVID-19 Infection Linked to Faster Kidney Function Decline Than Pneumonia

HCPLive

Patients hospitalized for severe COVID-19 had an accelerated eGFR decline relative to those with pneumonia due to other infections.

COVID-19 105
article thumbnail

Functional diversity of cardiac macrophages in health and disease

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01109-8 In this Review, Lavine and colleagues describe the known subsets of cardiac macrophages, highlighting newly identified macrophage states and associated cellular neighbourhoods, and discuss the roles of cardiac macrophages in homeostasis and disease, including in inflammation, fibrosis, age-associated pathologies, mechanosensing, efferocytosis, angiogenesis, arrhythmias and transplant allograft survival.

article thumbnail

Physiology Friday #251: Does Our Body Have a ‘Muscle Memory’ for Aerobic Exercise?

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.

article thumbnail

SICK-SINUS-SYNDROME

ECG Guru

This ECG is from a 65-year-old woman who had previously had no cardiac abnormalities but has now suffered several syncopes within 2 weeks. During the last syncope she suffered a fracture of the left femur.

84
article thumbnail

Just two hours of exercise a week can bring you huge cardiovascular health benefits

Medical Xpress - Cardiology

There's no question that exercise is good for the heart. Regular exercise lowers blood pressure and cholesterol and reduces the chances of having a heart attack or stroke.

article thumbnail

Elevated HDL-C Efflux Capacity Could Protect Cognitive Function in Adults

HCPLive

Higher levels of small-particle HDL were linked with greater gray matter volume and higher cognitive capacity among middle-aged adults.

104
104
article thumbnail

Apolipoprotein B-containing lipoproteins in atherogenesis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01111-0 In this Review, Born and colleagues present insights into the role of apolipoprotein B-containing lipoproteins in atherogenesis, with an emphasis on the mechanisms leading to atherosclerotic plaque initiation and growth. They describe the causative role of LDL at the early stages of atherogenesis and discuss the relative atherogenicity of lipoprotein(a) and triglyceride-rich lipoproteins.

Plaque 97
article thumbnail

What's With All the UFH Infusions for Acute Pulmonary Embolism?

Med Page Today

(MedPage Today) -- Despite guidelines recommending other anticoagulants for people hospitalized with acute pulmonary embolism (PE), old habits and misconceptions have kept unfractionated heparin (UFH) the initial choice for many physicians in the.

article thumbnail

Asundexian versus Apixaban in Patients with Atrial Fibrillation

The New England Journal of Medicine

A randomized trial of the factor XIa inhibitor asundexian was stopped early owing to a higher incidence of stroke or systemic embolism than with apixaban therapy among patients with atrial fibrillation.

article thumbnail

Beware the snowstorm: Shoveling could trigger heart attacks, expert says

Medical Xpress - Cardiology

Walking in a winter wonderland may sound serene and peaceful, but shoveling your sidewalks to take that walk could quickly change delightful to deadly. According to the American Heart Association, the world's leading nonprofit organization focused on heart and brain health for all, research shows that the exertion of shoveling snow may lead to an increased risk of a heart attack or sudden cardiac arrest.

article thumbnail

Psychiatry Month in Review: December 2024

HCPLive

This Psychiatry Month in Review features promising phase 3 data, what is moving in the pipeline, and where the psychiatry field is heading into 2025.

104
104
article thumbnail

Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01110-1 In this Review, Dey and colleagues explore the pathobiology of coronary atherosclerotic plaques and perivascular adipose tissue, describe their phenotyping with computed tomography coronary angiography, and discuss potential future applications in clinical risk prediction and patient management.

Plaque 85
article thumbnail

Get A Look At What's Inside The Heart Health Formula

Dr. Paddy Barrett

What is inside the Heart Health Formula? A step-step guide to: - Understanding Heart Disease. - Defining Heart Disease Risk. - Reducing Heart Disease Risk. When I set out on my journey over a decade ago to put together a system to do this comprehensively, it did not exist in a way that I found useful. So, I created a system myself. The Heart Health Formula is made up of 3 main modules.

article thumbnail

Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy

The New England Journal of Medicine

Among patients with transthyretin amyloidosis with cardiomyopathy, the risk of death from any cause and recurrent cardiovascular events was lower with vutrisiran treatment than with placebo.

article thumbnail

Study challenges traditional risk factors for brain health in the oldest-old

Science Daily - Heart Disease

A study has found cardiovascular conditions such as high blood pressure and diabetes, which are known to contribute to brain blood vessel damage in younger populations, not to be associated with an increased risk of such harm in individuals 90 and older.

68
article thumbnail

Current Kidney Failure Mortality Prediction Models Miss the Mark for Clinical Use

HCPLive

Systematic review findings point to bias and insufficient clinical applicability with current mortality risk models in patients with kidney failure.

103
103
article thumbnail

The spleen in ischaemic heart disease

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01114-x In this Review, Heusch and Kleinbongard describe the deleterious and protective roles of the spleen in the inflammatory processes of atherosclerosis, myocardial infarction and heart failure, and highlight the translational potential of the cardioprotective functions of the spleen for the treatment of patients with ischaemic heart disease.

article thumbnail

ACC Announces 2025 Distinguished Award Recipients

American College of Cardiology

The ACC is pleased to announce the recipients of its 2025 Distinguished Awards. This year's honorees represent an inspiring group of individuals who have made, and continue to make, significant contributions to advancing the Colleges Vision of a world where science, knowledge, and innovation enhance the care and outcomes of cardiovascular patients globally.

article thumbnail

Artificial Intelligence–Enhanced Electrocardiography for Hypertension

JAMA Cardiology

This prognostic study evaluates the ability of an electrocardiography-based artificial intelligence risk estimator to predict incident hypertension and stratify risk for hypertension-associated adverse events.

article thumbnail

Patients with heart disease may be at increased risk for advanced breast cancer

Science Daily - Heart Disease

Patients diagnosed with late-stage or metastatic breast cancer have a statistically significant increased risk of pre-diagnosis cardiovascular disease (CVD) compared to those with early-stage cancer at diagnosis.

Cancer 68
article thumbnail

Organic Food Consumption May Protect Against Allergic Sensitization

HCPLive

This analysis highlights the connection between organic food consumption and respiratory/allergic morbidity among those of school age.

101
101