Physiologically Speaking
MARCH 21, 2025
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.
Open Heart
MARCH 22, 2025
Background Mechanical stress on the heart is commonly considered the sole stimulus explaining the synthesis and release of circulating natriuretic peptides and their derivatives. While one of the most critical paradigms in cardiology is that mechanical load increases oxygen consumption, clinical studies on these peptides have neglected the relationship between mechanical stress and oxygen metabolism.
Science Daily - Heart Disease
MARCH 19, 2025
A new study reveals that encapsulated heating methods, an often-used heat simulation method, significantly increase heart rates and cardiac strain compared to natural heat exposure like those experienced during hot weathers. Understanding how extreme heat impacts heart function is crucial for developing effective strategies to protect vulnerable groups, especially as global temperatures continue to rise.
Frontiers in Cardiovascular Medicine
MARCH 20, 2025
ObjectiveThis study aimed to investigate the effects of Enhanced External Counterpulsation (EECP) on anxiety and depression in patients with Paroxysmal Atrial Fibrillation (PAF).MethodsA cohort of 100 patients diagnosed with PAF at the Fuzhou First Hospital between January 2023 and June 2024 were enrolled in this study. Patients were randomly assigned to either the control group (n=50) or the EECP group (n=50) in this randomized controlled trial.
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Nature Reviews - Cardiology
MARCH 19, 2025
Nature Reviews Cardiology, Published online: 20 March 2025; doi:10.1038/s41569-025-01142-1 In this Review, Ravindran and Gustafsson describe the mechanisms involved in regulating mitochondrial quality control in cardiomyocytes, discuss how these pathways are altered in cardiovascular disease and ageing, and highlight the therapeutic potential of targeting mitochondrial quality control pathways in cardiovascular disease.
Circulation
MARCH 19, 2025
Circulation, Ahead of Print. The field of cardio-oncology has expanded over the past 2 decades to address the ever-increasing issues related to cardiovascular disease in patients with cancer and survivors. There is increasing recognition that nearly all cancer treatments pose some short- or long-term risk for development of cardiovascular disease and that pediatric patients with cancer may be especially vulnerable to cardiovascular disease because of young age at treatment and expected long life
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
Open Heart
MARCH 22, 2025
Introduction Atrial fibrillation is the most prevalent sustained arrhythmia worldwide and is expected to increase substantially within the coming years. Although lifestyle changes and risk factor modification are now acknowledged as central components of atrial fibrillation management, the effects of exercise on disease-specific outcomes are still not extensively documented due to few high-quality randomised trials.
Frontiers in Cardiovascular Medicine
MARCH 20, 2025
BackgroundNeutrophil-to-lymphocyte ratio (NLR) has been presented as a possible indicator associated with the outcomes of growing patients and an available predictor of inflammation. Nevertheless, just a handful of researches shed light on the association between NLR and the consequences of critical patients with coronary artery disease (CAD). The study aimed to investigate the correlation between NLR and all-cause mortality of short-term and long-term in patients with CAD.MethodsWe obtained obj
Medical Xpress - Cardiology
MARCH 21, 2025
The coffee from most of the coffee machines in workplaces contains relatively high levels of cholesterol-elevating substances. There is a big difference in comparison to coffee made in regular paper filter coffee makers, which filter out most of these substances.
ADN Center of Excellence
MARCH 19, 2025
Over the past two days, interventional cardiologists from around the worldgathered at Freeman Hospital, Newcastle, for an intensive and enriching experience focused on tackling one of the most complex challenges in percutaneous coronary intervention (PCI): calcified coronary lesions.
CardiacWire
MARCH 19, 2025
Although theres still ongoing debate on who should receive LAAO devices, new five year results from the Amulet IDE trial confirm that both Abbotts Amulet occluder and Boston Scientifics Watchman 2.5 are safe and effective in the long run. LAAO (left atrial appendage occlusion) devices help prevent stroke in patients with AFib by sealing off the left atrial appendage where blood clots can form.
Open Heart
MARCH 22, 2025
Introduction and objectives Decision-making regarding prognosticating out-of-hospital cardiac arrest (OHCA) remains challenging at the front door. The MIRACLE2 score provides a simple and practical tool for early neuroprognostication to aid decision-making. The study aims to validate the MIRACLE2 score in a district general hospital (DGH). Material and methods This is a retrospective analysis of the patients with OHCA and return of spontaneous circulation (ROSC) in the community who attended the
Frontiers in Cardiovascular Medicine
MARCH 25, 2025
ObjectivesNoise pollution has become an increasingly severe environmental issue in modern society and has been recognized for its adverse effects on cardiovascular diseases. Hypertension induced by noise exposure has garnered significant research interest and a large quantity of studies have been conducted. This study aims to employ bibliometric methods to comprehensively review the literature on the relationship between noise exposure and hypertension and to analyze the current state of researc
DAIC
MARCH 25, 2025
tim.hodson Tue, 03/25/2025 - 16:19 March 25, 2025 Bayer plans to present data from 13 new analyses from across the KERENDIA (finerenone) comprehensive clinical trial program at the American College of Cardiology (ACC) 74 th Annual Scientific Session & Expo 2025 , in Chicago, IL, March 29-31, 2025. Ten presentations will feature new data from the pivotal Phase III FINEARTS-HF cardiovascular (CV) outcomes trial, which investigated KERENDIA for treatingt adult patients with heart failure (HF) wit
Journal of Cardiovascular Electrophysiology
MARCH 24, 2025
ABSTRACT Sudden cardiac death (SCD) is a major public health challenge, resulting in significant loss of life each year. Effective prevention relies on identifying individuals at elevated risk; however, accurate prediction of SCD has proven difficult. The current clinical strategy relies on a static risk assessment, primarily using left ventricular ejection fraction (LVEF)<35% as a key criterion.
Med Page Today
MARCH 20, 2025
(MedPage Today) -- Survivors of childhood cancer were much more likely to develop an aging-associated health condition before the age of 65, with earlier onset, compared with the general population, according to a modeling study. While 20% of.
Open Heart
MARCH 25, 2025
Background Cardiovascular disease (CVD) events triggered by inflammation are an underappreciated and poorly quantified cause of morbidity and mortality in patients with bloodstream infections (BSIs). We aimed to determine the risk of myocardial infarction (MI) and stroke after BSI. Methods This self-controlled case series study was conducted within the Secure Anonymised Information Linkage Databank, containing anonymised population-scale electronic health record data for Wales, UK.
Frontiers in Cardiovascular Medicine
MARCH 25, 2025
Cardio-cerebral infarction (CCI) is a rare clinical syndrome characterized by the simultaneous or sequential occurrence of acute myocardial infarction (AMI) and acute ischemic stroke (AIS). Despite its complex pathogenesis and more severe prognosis compared to isolated AMI or AIS, no consensus has been established regarding its definition, classification, epidemiology, treatment protocols, or prognostic management.
HCPLive
MARCH 24, 2025
Veeral Sheth, MD, is joined by the CEO of Neurotech to discuss the historic approval of revakinagene taroretcel (ENCELTO) for macular telangiectasia type 2.
DAIC
MARCH 24, 2025
tim.hodson Mon, 03/24/2025 - 15:48 March 24, 2025 Imperative Care, Inc. recently announced U.S. Food and Drug Administration (FDA) 510(k) clearance of the 82 cm version of its Symphony 16F catheter. The catheter is designed to elevate care for patients with venous thrombosis, a serious condition caused by a blood clot forming in the veins of the legs or abdomen that can have a life-threatening impact if left untreated.
Medical Xpress - Cardiology
MARCH 20, 2025
As a nurse working in a neurocritical care, I witnessed the sudden and devastating effects of stroke on survivors and their caregivers.
Open Heart
MARCH 25, 2025
Background Current pharmacological approaches for the treatment of orthostatic hypotension (OH) may detrimentally affect supine blood pressure (BP). This side effect is often unacceptable and limits the utility of medical management. Pyridostigmine has been proposed as a potential treatment alternative which may improve OH without worsening supine hypertension.
Frontiers in Cardiovascular Medicine
MARCH 25, 2025
ObjectiveThe influence of extreme sleep duration on coronary heart disease (CHD) risk across genders remains a debated topic.MethodsThis analysis gathers observational studies that explore association between varying sleep durations and CHD risks. Trend estimation employs generalized least squares, converting specific category risk estimates into relative risks (RR) per hour of sleep increase.
HCPLive
MARCH 24, 2025
Analgesic effects lasted up to week 8 while function improvements lasted until week 16 in a new randomized, controlled trial.
Med Page Today
MARCH 19, 2025
(MedPage Today) -- Changes in sleep patterns among cognitively unimpaired women in their 80s were associated with an increased risk of dementia, a longitudinal study showed. Compared with women who had stable sleep patterns, those who had increasing.
Medical Xpress - Cardiology
MARCH 20, 2025
For patients undergoing carotid endarterectomy, sonolysis is safe and results in a significant reduction in the composite incidence of ischemic stroke, transient ischemic attack, and death within 30 days, according to a study published online March 19 in The BMJ.
Open Heart
MARCH 25, 2025
Aim To assess the effectiveness and safety of strength training (ST) interventions in people with congenital heart disease (ConHD). Methods Participants included people of all ages diagnosed with all complexity of ConHD. Interventions included strength training or inspiratory muscle training (IMT) which were delivered in whole or as part of a more holistic programme.
Frontiers in Cardiovascular Medicine
MARCH 25, 2025
ObjectivesTo investigate the relationship between plasma aldosterone concentration (PAC) and the prevalence of peripheral artery disease (PAD) in hypertensive patients and to determine any potential threshold effects.MethodsThis cross-sectional study analyzed data from 13,157 hypertensive individuals from the People's Hospital of Xinjiang Uygur Autonomous Region, China.
HCPLive
MARCH 20, 2025
A study highlights how food allergies impact adults' mental health and social lives, revealing anxiety, isolation, and the need for better support systems.
Med Page Today
MARCH 21, 2025
(MedPage Today) -- For people with atrial fibrillation (Afib or AF), stopping oral anticoagulation (OAC) after a "successful" catheter ablation left them exposed to increased risk, according to a Japanese hospital's dataset. At Nagoya University.
Medical Xpress - Cardiology
MARCH 20, 2025
Affecting 1 in 500 people, hypertrophic cardiomyopathy is a condition in which the walls of the left ventricle, the heart's main pumping chamber, become abnormally thick. "HCM is one of the primary causes of sudden death among young, apparently healthy patients; it is also a frequent cause of heart failure requiring surgery or a transplant," says Dr.
Open Heart
MARCH 25, 2025
Background The COVID-19 pandemic necessitated major reallocation of healthcare services. Our aim was to assess the impact on paediatric congenital heart disease (CHD) procedures during different pandemic periods compared with the prepandemic period, to inform appropriate responses to future major health services disruptions. Methods and results We analysed 26 270 procedures from 17 860 children between 1 January 2018 and 31 March 2022 in England, linking them to primary/secondary care data.
Frontiers in Cardiovascular Medicine
MARCH 20, 2025
ObjectivesRegistered, prospective, multicenter study of the short-term clinical outcomes of a novel transcatheter aortic valve system (Xcor system, Saint Medical Technology, Inc., Nanjing) to evaluate its safety and efficacy.Methods130 high risk patients with symptomatic severe AS from 11 institutions were treated with the novel Xcor system. All patients were pre-TAVR assessed by transthoracic echocardiography and computed tomography of the aortic valve (AV) and relevant left cardiac and vascula
HCPLive
MARCH 19, 2025
XORTX is meeting with the FDA in a Type B meeting regarding a potential NDA for XORLO.
Med Page Today
MARCH 19, 2025
(MedPage Today) -- An automated insulin delivery (AID) system boosted glycemic control in insulin-treated adults with type 2 diabetes using continuous glucose monitoring (CGM), a randomized trial showed. Over 13 weeks, drops in HbA1c averaged.
Medical Xpress - Cardiology
MARCH 20, 2025
About 10% of Americans say they have chronic insomnia, and millions of others report poor sleep quality. Ongoing research has found that bad sleep could lead to numerous health problems, including heart disease.
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