Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP8-ATP8, February 1, 2025. There were also no other complications.Conclusion:Rescue therapy in the form of prolonged low-dose thrombolysis seems to be an effective and safe alternative to therapeutic nihilism in ultra-early stroke recurrence. The incidence of intracerebral hemorrhage was 9.1%

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Thrombolysis Stroke Strokes Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP11-ATP11, February 1, 2025. Introduction:Current guidelines suggest using intravenous thrombolysis (IVT) for patients experiencing acute ischemic stroke within 4.5 hours of symptom onset. Nevertheless, recent clinical trials have explored the possibility of extending the IVT treatment window.

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Thrombolysis Stroke Strokes Education 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP19-ATP19, February 1, 2025. Background:Patients with acute ischemic stroke and a large vessel occlusion (LVO) admitted to primary stroke centers (PSC) often require inter-facility transfer for thrombectomy.

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Thrombolysis Outcomes Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AHUP6-AHUP6, February 1, 2025. Introduction:Prior studies have demonstrated social determinants of health (SDoH) are associated with reduced rates of intravenous thrombolysis (IVT) for acute ischemic stroke (AIS), including in disadvantaged populations.

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Thrombolysis Stroke Strokes Research 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP299-ATP299, February 1, 2025. Introduction:Prior studies have demonstrated social determinants of health (SDH) are associated with reduced rates of intravenous thrombolysis (IVT) for acute ischemic stroke (AIS), including in disadvantaged populations.

Thrombolysis 40

Thrombolysis Stroke Strokes Research 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP3-ADP3, February 1, 2025. hour window, and reperfusion through thrombolysis has been shown to enhance functional outcomes in patients with salvageable brain tissue beyond this timeframe.Objective:The aim of this study is to assess the efficacy and safety of thrombolysis administered more than 4.5

Thrombolysis 40

Thrombolysis Stroke Strokes Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A4-A4, February 1, 2025. Introduction:The tenecteplase versus standard of care for minor ischemic stroke with proven occlusion (TEMPO-2) trial showed that patients presenting with minor deficits up to 12 h do not benefit from intravenous thrombolysis. mg/kg) or non-thrombolytic standard of care.

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Thrombolysis Stroke Strokes Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP9-AWP9, February 1, 2025. The effectiveness and safety of intravenous thrombolysis (IVT) for acute ischemic stroke in these cases, particularly those involving large vessel occlusions, are debated. Background:Acute ischemic stroke can result from extracranial arterial dissection.

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Thrombolysis Stroke Strokes Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP1-ADP1, February 1, 2025. Whether intravenous thrombolysis (IVT) is safe and effective for acute ischemic stroke (AIS) patients with CAA is largely unknown.Methods:This was an explorative analysis of a nationwide database of hospitalizations in the United States.

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Thrombolysis Stroke Strokes Cerebrovascular Disease 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP20-ATP20, February 1, 2025.

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Thrombolysis Stroke Strokes Risk Factors 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP253-AWP253, February 1, 2025. Background and Aims:Endovascular treatment (EVT) alone has been confirmed to be non-inferior to intravenous thrombolysis (IVT) followed with EVT in acute ischemic stroke (AIS) due to large-vessel occlusion of the anterior circulation.

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Thrombolysis Stroke Strokes Stent 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP6-AWP6, February 1, 2025. Background and Purpose:Whether imaging markers of cerebral small vessel disease on computed tomography (CT-CSVD) relates to early clinical outcomes after intravenous thrombolysis for acute ischemic stroke remains not well understood. 1.02; score 2: OR 0.46, 95%CI 0.26-0.83;

Thrombolysis 40

Thrombolysis Outcomes Biomarkers Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP8-AWP8, February 1, 2025. Introduction:Current guidelines recommend 24-hours of high-intensity monitoring (HIM) for acute ischemic stroke patients post-intravenous thrombolysis (IVT) due to risk of bleeding complications including symptomatic intracranial hemorrhage (sICH).

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Thrombolysis ICU Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP14-AWP14, February 1, 2025. Introduction:The use of IV thrombolysis (IVT) in acute ischemic stroke patients presenting with an NIHSS of 5 has failed to demonstrate benefit, particularly when the symptoms are considered non-disabling.

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Thrombolysis Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP3-AWP3, February 1, 2025. Introduction:Large vessel recanalization (LVR) is a well described phenomenon following intravenous thrombolysis (IVT).

Thrombolysis 40

Thrombolysis Outcomes Circulation Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP19-AWP19, February 1, 2025. We aim to assess the ability of ChatGPT to guide the decision for intravenous thrombolysis (IVT) in patients with acute ischemic strokes (AIS).Methods:The Introduction:Artificial intelligence is emerging as an adjunct promising tool in medicine.

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Thrombolysis Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A2-A2, February 1, 2025. Background:For patients meeting eligibility criteria, endovascular thrombectomy (EVT) remains the gold standard treatment for acute ischemic stroke (AIS) caused by large vessel occlusion (LVO).

Thrombolysis 40

Thrombolysis Hemorrhage Outcomes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP115-ATP115, February 1, 2025. Background:Mechanical thrombectomy (MT) as treatment for acute ischemic stroke (AIS) has demonstrated superior functional outcomes compared to intravenous thrombolysis (IVT).

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Thrombolysis Stroke Strokes Quality of Life 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP256-AWP256, February 1, 2025. Introduction:In acute stroke patients who receive revascularization with endovascular thrombectomy (EVT) alone vs intravenous thrombolysis (IVT) followed by EVT, combination treatment has shown improved outcomes measured by the modified Rankin Scale (mRS).

Thrombolysis 40

Thrombolysis Stroke Strokes Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP26-ATMP26, February 1, 2025. Introduction:Telestroke has the potential to revolutionize acute stroke treatment by improving access to optimal stroke care, including time-sensitive care such as thrombolysis. presented 4 hours of last known well, no contraindications to thrombolysis).

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Stroke Strokes Thrombolysis Outcomes 40

Stroke Journal

DECEMBER 9, 2024

Stroke, Volume 56, Issue 1 , Page 183-189, January 1, 2025. BACKGROUND:Thrombectomy for acute large vessel occlusion is a well-established treatment for stroke prevention. However, futile recanalization cases, where no-reflow occurs despite successful recanalization, have been reported.

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Thrombolysis Stroke Strokes Hemorrhage 68

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP87-ATP87, February 1, 2025. Background:Early prediction of functional outcome after rtPA helps clinicians in prognostic conversations with stroke patients and their families. Three prognostic tools have been developed in this regard: DRAGON, MRI-DRAGON, and S-TPI scales.

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Thrombolysis Stroke Strokes Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP259-ATP259, February 1, 2025. In a multivariable regression analysis, intravenous thrombolysis administration (OR 3.27 [95% CI: 1.04-10.33]; Background:Endovascular treatment (EVT) is an effective treatment for acute ischemic stroke in anterior large vessel occlusions.

Outcomes 40

Outcomes Thrombolysis Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP72-AWP72, February 1, 2025. The transition from Alteplase to Tenecteplase for AIS patients eligible for thrombolysis occurred on June 6, 2022. EHR Alteplase references were changed to thrombolysis. The percentage of door to thrombolysis<30 minutes improved from 23.3%

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Stroke Strokes Thrombolysis Nursing 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP84-ATP84, February 1, 2025. We gathered data on the availability of critical resources like thrombolysis, computerized tomography (CT), and neurology services at over 200 facilities. In the U.S., In the U.S.,

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Stroke Strokes Thrombolysis ICU 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP242-ATP242, February 1, 2025. Concomitant use of intravenous thrombolysis and the use of MT in the extended therapeutic window do not raise the risk of sICH. 2.07; P = 0.037). 2.07; P = 0.037). Risk of sICH was comparable between the MT and MT+IVT groups (RR: 0.77; 95%CI: 0.57-1.03;

Hemorrhage 40

Hemorrhage Thrombolysis Circulation Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP108-AWP108, February 1, 2025. We defined optimal destination according to the ASA algorithm, which recommends bypass for patients within 24 of last known well if large vessel occlusion suspected and bypass will not delay thrombolysis.

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Stroke Strokes Thrombolysis Hospital 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP5-ADP5, February 1, 2025. Introduction:Outcomes after thrombolysis with alteplase (tPA) versus tenecteplase (TNK) prior to endovascular thrombectomy (EVT) have not been directly compared in real-world data (RWD).

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Thrombolysis Hemorrhage Academic Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP91-AWP91, February 1, 2025. received thrombolysis and 53.6% Introduction:Education campaigns have previously successfully informed the public regarding stroke symptoms and the need for urgent evaluation of suspected stroke. million).

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Stroke Strokes Thrombolysis Education 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP245-AWP245, February 1, 2025. However, intravenous thrombolysis was performed more frequently in the non-user group than in the heparin group, and the apTT value after the procedure was higher in the heparin group than in the other groups(75.912.5 vs 21.3%, p=0.04).

Hemorrhage 40

Hemorrhage Thrombolysis Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AHUP17-AHUP17, February 1, 2025. Patients included in this study received either thrombolysis, thrombectomy, or both and were cared for at Methodist Hospital in Indianapolis, Indiana.Results:Between the years of 2019-2022, there were 2,815 ischemic stroke patients at Methodist Hospital.

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Outcomes Thrombolysis Document Outpatient 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP139-AWP139, February 1, 2025. Background:Telestroke allows rapid assessment of patients presenting with acute stroke symptoms for intravenous thrombolysis or endovascular thrombectomy (EVT).

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Stroke Strokes Thrombolysis Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP1-ATP1, February 1, 2025. Similarly, a longer time from LKN to thrombolysis was associated with a lower probability of reperfusion (continuous variable: OR=0.996, P=0.020,Figure 2; categorical variable: OR=0.043, P=0.005,Figure 3).

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Stroke Strokes Thrombolysis Hospital 40

Stroke Journal

DECEMBER 19, 2024

Stroke, Volume 56, Issue 1 , Page 170-182, January 1, 2025. We subsequently showcase the proposed method by monitoring therapeutic effects of thrombolysis in stroke (n=6), further performing cross-strain comparison of perfusion dynamics (n=6) and monitoring the therapeutic effects of sensory stimulationbased treatment (n=11).RESULTS:Quantitative

Thrombolysis 40

Thrombolysis Stroke Strokes Research 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP165-AWP165, February 1, 2025. Although we cannot definitively attribute the increased eligibility and administration of thrombolysis solely to the improved imaging times in the Post-FBS-CT group, our data demonstrates a substantial reduction in door-to-eMRI times following protocol implementation.

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Stroke Strokes Thrombolysis Academic 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP60-AWMP60, February 1, 2025. We compared protocol deviations between participants consented using conventional paper informed consent documents (ICDs) versus electronic informed consent (eConsent).Methods:MOST Methods:MOST began in 2019 and was completed in 2023.

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Stroke Strokes Thrombolysis Document 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP129-ATP129, February 1, 2025. hours, p = 0.110), were more likely to receive thrombolysis (33% versus 14%, p < 0.001), and had higher rates of hypertension (63% versus 44%, p < 0.008) and lower rates of congestive heart failure (12% versus 30%, p = 0.005). hours versus 8.1

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Thrombolysis Stroke Strokes Hospital 40