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Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01110-1 In this Review, Dey and colleagues explore the pathobiology of coronary atherosclerotic plaques and perivascular adipose tissue, describe their phenotyping with computed tomography coronary angiography, and discuss potential future applications in clinical (..)
This case emphasises the importance of recognising plaque-associated CAS as a potential trigger for life-threatening arrhythmias, even in the absence of chest pain. The arrhythmias persisted despite initial medical management, including calcium channel blockers and intravenous glyceryl trinitrate.
Stroke, Volume 56, Issue Suppl_1 , Page ATP342-ATP342, February 1, 2025. Background:Previous research has suggested pericarotid fat density to be significantly linked to atherosclerotic plaque components and cerebrovascular events. Baseline demographics and clinical data of our population were extracted from electronic health records.
Stroke, Volume 56, Issue Suppl_1 , Page ATP296-ATP296, February 1, 2025. Introduction:Nonstenotic carotid plaque is found in some patients with otherwise cryptogenic stroke (CS) but also in normal individuals and patients with stroke of known cause (KS). 2.05) (Figure). and incidental in 47.3%.
Stroke, Volume 56, Issue Suppl_1 , Page AWP193-AWP193, February 1, 2025. Plaques were segmented on PD images from each time point. Plaques were compared between consecutive time points and classified as progressing, stable, or regressing, based on volume change (those <5mm3were excluded).
First runner-up for the YIA is Seokhun Yang, MD , of Seoul National University Hospital, for his abstract, “Prognostic Implications Of Coronary CT Angiography-derived Plaque And Hemodynamic Features On Acute Coronary Syndrome Across Varying Time Intervals: Emerald-ii Study.” and the Ma Family, who provided a $5,000 case prize for the winner.
Stroke, Volume 56, Issue Suppl_1 , Page AWP338-AWP338, February 1, 2025. Advancements in magnetic resonance angiography (MRA) with vessel wall imaging (VWI) have enabled the identification of vulnerable plaques, aiding in risk stratification for neurovascular events. Eleven plaques were vulnerable in preoperative MRI with VWI.
Nature Reviews Cardiology, Published online: 28 January 2025; doi:10.1038/s41569-025-01124-3 Inflammation is a new therapeutic target for the prevention of cardiovascular disease. Colchicine is a potential cheap option to target inflammation and prevent atherosclerotic plaque destabilization.
tim.hodson Mon, 02/03/2025 - 12:30 January 29, 2025 Roche announced today that the Tina-quant Lipoprotein (a) Gen.2 2 Molarity assay has received 510(k) clearance from the United States Food and Drug Administration (FDA). This will be the first 510(k) cleared test of its kind available in the U.S.
Stroke, Volume 56, Issue Suppl_1 , Page ATMP54-ATMP54, February 1, 2025. Although carotid plaques can be identified on CT angiography (CTA), interpretation is challenging for frontline physicians. Quantification of plaque volume/composition requires much manual effort. 0.76) for calcific plaque and 0.53 (0.49-0.57)
Stroke, Volume 56, Issue Suppl_1 , Page A38-A38, February 1, 2025. The primary outcomes were the percentage change in plaque burden and plaque response (plaque regression >5%) rate. The patients were divided into two groups: those with (evolucomab+) or without (evolocumab-) evolocumab add-on therapy.
Circulation, Volume 151, Issue 6 , Page 400-415, February 11, 2025. Lp(a) can enter the vessel wall, leading to the accumulation of oxidized phospholipids in the arterial intima, which are crucial for initiating plaque inflammation and triggering vascular disease progression.
Stroke, Volume 56, Issue Suppl_1 , Page A110-A110, February 1, 2025. Multiple immunofluorescence staining revealed that the plaque group exhibited a greater density of nerve fiber innervation compared to the control group.Conclusions:Our study provides evidence that human intracranial arteries are innervated by myelinated fibers.
Stroke, Volume 56, Issue Suppl_1 , Page AWP180-AWP180, February 1, 2025. Possible CWs were defined as filling defects 3-4.5cm from the bifurcation, not on the posterior wall, not seen on the axial view, or accompanied by atherosclerotic plaque/calcification in the proximity of the suspected web.
Stroke, Volume 56, Issue Suppl_1 , Page ATMP10-ATMP10, February 1, 2025. Recently, cilostazol plus other antiplatelet agents combined therapy (CT) has been reported to reduce recurrent stroke, and eicosapentaenoic acid (EPA) has been reported to reduce the risk of cardiovascular events and plaque progression. in the AA group, 13.8%
Stroke, Volume 56, Issue Suppl_1 , Page AWP205-AWP205, February 1, 2025. The bovine anatomical variation may alter the blood flow dynamics, potentially contributing to the formation and progression of carotid plaques.
Stroke, Volume 56, Issue Suppl_1 , Page ATP205-ATP205, February 1, 2025. Introduction:Alzheimers Disease (AD), characterized by extracellular deposition of amyloid beta (A) plaques in brain tissue, is often comorbid with cerebral amyloid angiopathy, which carries an elevated risk of intracranial hemorrhage.
Stroke, Volume 56, Issue Suppl_1 , Page ATP258-ATP258, February 1, 2025. p<0.0001), and ICA bulb plaque with high-risk features (87.9% Therefore, the differentiation between LAA and non-LAA LVO may be critical for selecting the ideal MT technique. p<0.0001), EF<35% (9.1% p<0.0001) (Table 1).
Stroke, Volume 56, Issue Suppl_1 , Page ATMP53-ATMP53, February 1, 2025. Amongst the seven cases which did not have a CAD on VW-MRI - two of them turned out to be artifactual, one of them was Fibromuscular Dysplasia (FMD), three showed atherosclerotic plaque and one was suggestive of a vasculitic process.
tim.hodson Mon, 03/31/2025 - 10:26 March 31, 2025 AGEPHA Pharma USA, LLC, has released clinical data that provides new information about how low-dose colchicine, 0.5 mg improved several measures of plaque volume changes over a period of 12 months in patients with stable coronary artery disease, Dr. Budoff continued.
tim.hodson Tue, 03/11/2025 - 10:25 March 11, 2025 Caristo Diagnosticshas received U.S. CaRi-Plaque builds on Caristoscore CaRi-Hearttechnology, which a Lancet 2024 study proved can reveal hidden, high-risk markers of CAD progression predicting heart attacks up to a decade before they strike. But with AI, we can change that.
tim.hodson Wed, 02/26/2025 - 10:24 Feb. 25, 2025 Heartflow, Inc. , Now Heartflow Plaque Analysis leverages AI to quantify and characterize the amount and type of plaque present in the arteries from a single CCTA scan. For more information on the company and and cardiovascular care, please visit www.heartflow.com.
A cardiac CT is a low-dose CT scan of your heart that assesses whether or not you have plaque in your coronary arteries and, if so, how much. In general, the more plaque you have, the higher your risk of a heart attack over the next 10 years. 2025 is a New Year. It is a fresh start. Time to hit reset and start again.
tim.hodson Mon, 03/31/2025 - 10:26 March 31, 2025 AGEPHA Pharma USA, LLC, has highlighted clinical data that provides new information about how low-dose colchicine, 0.5 mg improved several measures of plaque volume changes over a period of 12 months in patients with stable coronary artery disease, Dr. Budoff continued.
tim.hodson Tue, 02/04/2025 - 17:13 Feb. 3, 2025 Today, Peripheral Artery Disease (PAD)affects 10 million Americans and is the most common cause of limb amputation outside of trauma. Over time, this plaque can gradually narrow the arteries. Yet, 70 percent of Americans dont know what it is or what signs to look for.
Stone, MD Mount Sinai Health System tim.hodson Wed, 04/02/2025 - 15:26 March 31, 2025 Using intravascular imaging (IVI) to guide stent implantation during complex stenting procedures is safer and more effective for patients with severely calcified coronary artery disease than conventional angiography, the more commonly used technique.
Stroke, Volume 56, Issue Suppl_1 , Page ATP219-ATP219, February 1, 2025. We performed pathological analysis of plaque characteristics in carotid arteries and compared with patient characteristics.Results:Of the 508 specimens, 462 (90.9%) were from male patients and mean degree of stenosis was 73.816.4%.
Stroke, Volume 56, Issue Suppl_1 , Page ATP288-ATP288, February 1, 2025. After age standardization, the prevalence of cIMT, carotid plaque, and carotid stenosis was 23.24%, 16.75%, and 2.36%, respectively, with moderate to severe carotid stenosis observed in 0.49% of all participants.
Stroke, Volume 56, Issue Suppl_1 , Page ATP358-ATP358, February 1, 2025. Most dementia patients exhibit mixed brain pathologies, with histological evidence of ischemia and A plaque accumulation, observed at autopsy. Introduction:Stroke is a well-established independent risk factor for the development of dementia.
Inflammatory cytokines causing unstable plaques lead on to cardiovascular events [1]. 2025 Jan 6. Less quantities of healthier food may be consumed in the diet by those with higher intake of sugar sweetened beverages. Adiposity activates inflammatory cytokines, enhances risk of hypertension, dyslipidemia and diabetes mellitus.
Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01111-0 In this Review, Born and colleagues present insights into the role of apolipoprotein B-containing lipoproteins in atherogenesis, with an emphasis on the mechanisms leading to atherosclerotic plaque initiation and growth.
Provocative testing is very helpful for this Coronary Thrombus with lysis (one must do optical coherence tomography or at least intravascular ultrasound to find thes non-obstructive plaques that ruptured. I suspect this statement is still true 2 years later, in 2025. Embolism with lysis. Need to find an embolic source.
Welcome to 2025 and best wishes for a great academic journey to all readers. Top 10 Clinical Trials Preventive PCI on Stenosis With Functionally Insignificant Vulnerable Plaque PREVENT (ACC.24) Top 10 Clinical Trials Preventive PCI on Stenosis With Functionally Insignificant Vulnerable Plaque PREVENT (ACC.24)
Lancet Commission on Obesity: The Lancet Diabetes & Endocrinology journal has accepted the Lancet Commission on Obesity’s report for publication, scheduled for early 2025, announced Robert H. Eckel, MD, FAHA, FACC at the 19th Annual CMHC.
And in a study like COMPLETE or MULTISTARS AMI, you are stenting an acute plaque rupture (the culprit) and non-ruptured, non-culprit and hence essentially stable plaques. As per Dr. Frick use of intravascular imaging ( IVUS or OCT ) could have helped to find plaque rupture and identify the "true" culprit.
Angiogram: --"Suspected culprit for the patient's non-ST elevation myocardial infarction with refractory chest discomfort (although it had resolved prior to arrival to the cardiac catheterization lab), is a ruptured plaque in the distal circumflex with local embolic occlusion of the distal OM 3."
Influenza-like illness can also trigger plaque rupture. I do not accept the transfer." == MY Comment , by K EN G RAUER, MD ( 2/15 /2025 ): == Perhaps the most commonly overlooked infarction pattern is posterior OMI. Beware confusing the diagnosis of posterior STEMI by using posterior leads.
This was attributed to a "Type 2 MI", which is acute MI that is not due to ruptured plaque, but rather due to "supply demand oxygen mismatch". Most MINOCA is due to ruptured plaque with thrombus that lyses and does not leave behind a visible culprit. So there is a new inferior severe wall motion abnormality.
Nevertheless, the operator performed intravascular ultrasound and saw erupted calcium nodule consistent with plaque erosion. As you can see, the lesion is not very angiographically impressive , more on this below. Echocardiogram showed inferior hypokinesis. Troponin was rising when last checked, 8928 ng/L.
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