2025, Outcomes and Thrombolysis - Cardiovascular Update

Bridging Innovation & Patient Care: The Growing Role of AI

Webinars

MORE WEBINARS

Abstract WP6: Associations between computed tomography biomarkers of cerebral small vessel disease and early outcomes after intravenous thrombolysis for acute ischemic stroke

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP6-AWP6, February 1, 2025. Background and Purpose:Whether imaging markers of cerebral small vessel disease on computed tomography (CT-CSVD) relates to early clinical outcomes after intravenous thrombolysis for acute ischemic stroke remains not well understood. 1.95, p = 0.019).Conclusion:This

Thrombolysis

Thrombolysis Outcomes Biomarkers Stroke

Abstract WP3: Large Vessel Recanalization with Thrombolysis Prior to Thrombectomy: Incidence, Outcomes, and Associations With Collateral Status

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP3-AWP3, February 1, 2025. Introduction:Large vessel recanalization (LVR) is a well described phenomenon following intravenous thrombolysis (IVT). The secondary endpoint was 90-day modified Rankin Scale (mRS) outcomes. 0.63], p<0.001 and OR 0.21 [95%CI 0.09-0.52],

Thrombolysis

Thrombolysis Outcomes Circulation Stroke

Abstract TP19: Intravenous thrombolysis before inter-facility transfer for thrombectomy

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP19-ATP19, February 1, 2025. The primary efficacy outcome was good 3-month functional outcome, defined as a modified Rankin scale (mRS) 0-2. Secondary efficacy outcomes were excellent 3-month functional outcome (mRS 0-1) and arterial recanalization during transfer.

Thrombolysis

Thrombolysis Outcomes Stroke Strokes

Abstract WP256: Cognitive Outcomes in Acute Ischemic Stroke with Large Vessel Occlusion After Treatment with Endovascular Thrombectomy with and without Intravenous Thrombolysis

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP256-AWP256, February 1, 2025. Introduction:In acute stroke patients who receive revascularization with endovascular thrombectomy (EVT) alone vs intravenous thrombolysis (IVT) followed by EVT, combination treatment has shown improved outcomes measured by the modified Rankin Scale (mRS).

Thrombolysis

Abstract TP11: Clinical Determinants of Decision-Making for Extended-Window Intravenous Thrombolysis

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP11-ATP11, February 1, 2025. Introduction:Current guidelines suggest using intravenous thrombolysis (IVT) for patients experiencing acute ischemic stroke within 4.5 The safety outcome was the rate of symptomatic intracranial hemorrhage (SICH).Results:We hours of symptom onset.

Thrombolysis

Thrombolysis Stroke Strokes Education

Abstract DP3: Thrombolysis for Ischemic Stroke after 4.5 hours without thrombectomy: A Meta-analysis of Randomized Controlled Trials

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP3-ADP3, February 1, 2025. hour window, and reperfusion through thrombolysis has been shown to enhance functional outcomes in patients with salvageable brain tissue beyond this timeframe.Objective:The aim of this study is to assess the efficacy and safety of thrombolysis administered more than 4.5

Thrombolysis

Abstract TP8: Prolonged Low-Dose Intravenous Thrombolysis in early recurrent Stroke: ESR-PROLONG Study

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP8-ATP8, February 1, 2025. A good clinical outcome (mRS 90day 2) was achieved by 61.4%. Introduction:Treatment of acute stroke has its clear rules and established standards. Improvement occurred in 70.5% of patients. Mortality was 15.9%. The incidence of intracerebral hemorrhage was 9.1%

Thrombolysis

Abstract 4: Thrombolysis with Tenecteplase in Minor Disabling versus Non-disabling Stroke: Secondary Analysis of the TEMPO-2 Trial

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A4-A4, February 1, 2025. Introduction:The tenecteplase versus standard of care for minor ischemic stroke with proven occlusion (TEMPO-2) trial showed that patients presenting with minor deficits up to 12 h do not benefit from intravenous thrombolysis. mg/kg) or non-thrombolytic standard of care.

Thrombolysis

Abstract WP9: IV Thrombolysis in Acute Stroke Management Secondary to Extracranial Artery Dissections: Systematic Review and Metanalysis

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP9-AWP9, February 1, 2025. The effectiveness and safety of intravenous thrombolysis (IVT) for acute ischemic stroke in these cases, particularly those involving large vessel occlusions, are debated. Background:Acute ischemic stroke can result from extracranial arterial dissection.

Thrombolysis

Abstract TP20: Intravenous thrombolysis versus early antiplatelet therapy in acute Ischemic Stroke with Small Artery Occlusion

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP20-ATP20, February 1, 2025. The primary outcome was 3-month functional outcome by modified Rankin scale (mRS). Additionally, 213 patients (18.9%) experienced END.

Thrombolysis

Thrombolysis Stroke Strokes Risk Factors

Abstract DP1: Intravenous thrombolysis for acute ischemic stroke patients with cerebral amyloid angiopathy

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP1-ADP1, February 1, 2025. Whether intravenous thrombolysis (IVT) is safe and effective for acute ischemic stroke (AIS) patients with CAA is largely unknown.Methods:This was an explorative analysis of a nationwide database of hospitalizations in the United States. 4.16], p=0.001).

Thrombolysis

Thrombolysis Stroke Strokes Cerebrovascular Disease

Abstract WP253: A Multicenter, Prospective, Randomized Controlled Trial of Endovascular Treatment with or without Intravenous ThromBolysis in Acute Ischemic Stroke of Basilar Artery Occlusion (BEST-BAO): Study Protocol

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP253-AWP253, February 1, 2025. Background and Aims:Endovascular treatment (EVT) alone has been confirmed to be non-inferior to intravenous thrombolysis (IVT) followed with EVT in acute ischemic stroke (AIS) due to large-vessel occlusion of the anterior circulation.

Thrombolysis

Thrombolysis Stroke Strokes Stents

Abstract TMP26: Acute Stroke Treatment Metrics and Outcomes in Telestroke vs Non-Telestroke Care within the Paul Coverdell Michigan Stroke-Registry

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP26-ATMP26, February 1, 2025. Introduction:Telestroke has the potential to revolutionize acute stroke treatment by improving access to optimal stroke care, including time-sensitive care such as thrombolysis. presented 4 hours of last known well, no contraindications to thrombolysis).

Stroke

Abstract TP259: Acute Ischemic Stroke Patient Factors Associated with Poor Outcomes in Patients with Favorable Collaterals and Successful Thrombectomy

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP259-ATP259, February 1, 2025. Despite successful reperfusion, many patients still have unfavorable outcomes even in the presence of favorable arterial collaterals. These patients were dichotomized into favorable (mRS 0-2) and unfavorable outcome (mRS 3-6) groups.

Outcomes

Outcomes Thrombolysis Stroke Strokes

Abstract 2: Endovascular thrombectomy plus intravenous thrombolysis versus endovascular thrombectomy alone in patients with large core infarct

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A2-A2, February 1, 2025. Conclusion:Our results indicate a beneficial impact of IVT on the clinical outcomes of EVT in AIS-LVO patients with LII regarding functional outcomes and early neurological improvement. More studies of larger sample sizes are needed to corroborate such results.

Thrombolysis

Thrombolysis Hemorrhage Outcomes Stroke

Abstract TP115: Differences in the Medical Management of Post-Stroke Sequelae Among Patients Treated with Mechanical Thrombectomy vs Intravenous Thrombolysis

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP115-ATP115, February 1, 2025. Background:Mechanical thrombectomy (MT) as treatment for acute ischemic stroke (AIS) has demonstrated superior functional outcomes compared to intravenous thrombolysis (IVT).

Thrombolysis

Thrombolysis Stroke Strokes Quality of Life

Abstract WP8: Targeted versus High-Intensity Monitoring Following Intravenous Thrombolysis in Acute Ischemic Stroke

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP8-AWP8, February 1, 2025. Introduction:Current guidelines recommend 24-hours of high-intensity monitoring (HIM) for acute ischemic stroke patients post-intravenous thrombolysis (IVT) due to risk of bleeding complications including symptomatic intracranial hemorrhage (sICH).

Thrombolysis

Thrombolysis ICU Stroke Strokes

Abstract TMP79: Post Thrombectomy Transcranial Doppler Parameters and Clinical Outcomes

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP79-ATMP79, February 1, 2025. Introduction:Previous evidence indicated that transcranial doppler (TCD) parameters were associated with functional outcome in large vessel occlusion stroke (LVOS) patients who undergo mechanical thrombectomy (MT).

Outcomes

Outcomes Thrombolysis Hypertension Stroke

Abstract TP87: Validation of Prognostic Scales for Functional Outcome in Ischemic Stroke Patients Treated with Intravenous Thrombolysis in a Rural Setting: a preliminary data analysis

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP87-ATP87, February 1, 2025. Background:Early prediction of functional outcome after rtPA helps clinicians in prognostic conversations with stroke patients and their families. modified Rankin Scale (mRS) at one month, classified into good (mRS 2) and poor (mRS 5) outcomes was noted.

Thrombolysis

Impact of Time to Catheter-Based Therapy on Outcomes in Acute Pulmonary Embolism

Circulation: Cardiovascular Interventions

JANUARY 20, 2025

Circulation: Cardiovascular Interventions, Volume 18, Issue 1 , Page e014499, January 1, 2025. BACKGROUND:The aim of this study was to examine the impact of early versus delayed catheter-based therapies (CBTs) on clinical outcomes in patients with acute intermediate-risk pulmonary embolism (PE).METHODS:This days;P=0.046).

Embolism

Embolism Pulmonary Outcomes Cardiac Arrest

Abstract HUP17: Insufficient Demographic and Data Collection Hinders Understanding the Health Outcomes in Patients with Limited English Proficiency

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AHUP17-AHUP17, February 1, 2025. Patients included in this study received either thrombolysis, thrombectomy, or both and were cared for at Methodist Hospital in Indianapolis, Indiana.Results:Between the years of 2019-2022, there were 2,815 ischemic stroke patients at Methodist Hospital.

Outcomes

Outcomes Thrombolysis Document Outpatient

Recanalization Does Not Always Equate to Reperfusion: No-Reflow Phenomenon After Successful Thrombectomy

Stroke Journal

DECEMBER 9, 2024

Stroke, Volume 56, Issue 1 , Page 183-189, January 1, 2025. We assessed the correlation of these parameters with infarct expansion, hemorrhagic transformation, and poor outcomes, defined as modified Rankin Scale scores of 4 to 6, at 3 months.RESULTS:A total of 65 cases were analyzed. Cerebral blood flow <45% (r=0.57;P<0.001)

Thrombolysis

Abstract TP190: Intracerebral Hemorrhage Laterality and Associations with Mood and Quality of Life Outcomes: A MISTIE III Substudy

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP190-ATP190, February 1, 2025. We aimed to determine the relationship between the affected hemisphere (right or left) and differences in non-motor outcomes (pain, mood) in patients with acute intracerebral hemorrhage (ICH).

Quality of Life

Quality of Life Hemorrhage Outcomes Thrombolysis

Abstract HUP1: Drivers of Disparities in Stroke Outcomes by Neighborhood Socioeconomic Status: A Causal Mediation Analysis

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AHUP1-AHUP1, February 1, 2025. Introduction:Identification of modifiable drivers of the disparity between neighborhood socioeconomic status (nSES) and stroke outcomes remains elusive. Variables were derived from BASIC, Redfin and the National Neighborhood Data Archive (NaNDA).

Stroke

Stroke Strokes Outcomes Quality of Life

Abstract DP53: Drivers of Disparities in Stroke Outcomes by Neighborhood Socioeconomic Status: A Causal Mediation Analysis

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP53-ADP53, February 1, 2025. Introduction:Identification of modifiable drivers of the disparity between neighborhood socioeconomic status (nSES) and stroke outcomes remains elusive. Variables were derived from BASIC, Redfin and the National Neighborhood Data Archive (NaNDA).

Stroke

Stroke Strokes Outcomes Quality of Life

Abstract TMP91: Acute Stroke Characteristics, Treatment and Outcomes in Children on Mechanical Circulatory Support

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP91-ATMP91, February 1, 2025. Demographic, clinical, radiographic, treatment and outcome data were collected via chart review and entered into a secure, HIPAA-compliant RedCAP database. Stroke presentation, treatment and outcomes are shown in Table 2.

Stroke

Stroke Strokes Outcomes Pediatrics

Abstract WP246: Predictors And Outcomes Of Excellent Recanalization Versus Successful Recanalization After Thrombectomy In Proximal And Distal Medium Vessel Occlusion Strokes: A Multinational Study

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP246-AWP246, February 1, 2025. This study aims to elucidate the outcomes and factors contributing to achieving excellent recanalization (mTICI 2c-3) versus successful recanalization (mTICI 2b) in MeVO stroke patients undergoing mechanical thrombectomy (MT).Methods:We

Stroke

Stroke Strokes Outcomes Thrombolysis

Abstract TP24: The Classification of Stroke Ambulance Dispatches in a Mixed Rural Urban Stroke Ambulance Program

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP24-ATP24, February 1, 2025. Introduction:Mobile Stroke Units (MSUs) are proven to shorten the time between stroke recognition and thrombolysis resulting to better patient outcomes and are deemed safe and cost-effective.

Stroke

Abstract 13: Intravenous Tirofiban as An Adjunct to Endovascular Therapy for Posterior Circulation Strokes with Tandem Lesions: One-Year Outcomes

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A13-A13, February 1, 2025. The primary efficacy outcome was favorable functional outcome, defined as modified Rankin Scale (mRS) scores of 0-3 at one year. The patients were divided into two groups based on whether they received adjunctive intravenous Tirofiban therapy or not.

Circulation

Circulation Outcomes Stroke Strokes

Abstract DP5: TNK is Non-Inferior to tPA in Patients Planned to Undergo Endovascular Thrombectomy in Real-World Practice

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP5-ADP5, February 1, 2025. Introduction:Outcomes after thrombolysis with alteplase (tPA) versus tenecteplase (TNK) prior to endovascular thrombectomy (EVT) have not been directly compared in real-world data (RWD). The rate of good functional outcomes was 35.1% The rate of ENI was 50.0%

Thrombolysis

Thrombolysis Hemorrhage Academic Outcomes

Abstract WP139: Telestroke service for Endovascular Stroke Treatment in Canada: Results from the OPTIMISE Registry

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP139-AWP139, February 1, 2025. Background:Telestroke allows rapid assessment of patients presenting with acute stroke symptoms for intravenous thrombolysis or endovascular thrombectomy (EVT). vs 3.1%), a lower rate for good functional outcome at 90-days (35.6%

Stroke

Abstract WMP53: Pre-hospital Arrival Times in 25 countries across regions: A Cross-Country Analysis from Registry of Stroke Care Quality (RES-Q)

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP53-AWMP53, February 1, 2025. Background:Treatment options and outcomes in stroke also depends on pre-hospital delays. Compared to the patients who reached by non-EMS mode, patients who reached by EMS mode were more likely to receive intravenous thrombolysis (16% vs 44%,).

Hospital

Hospital Stroke Strokes Thrombolysis

Abstract WP72: A Stroke System’s Implementation and Analysis After Transitioning to Tenecteplase, a Novel Thrombolytic

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP72-AWP72, February 1, 2025. The transition from Alteplase to Tenecteplase for AIS patients eligible for thrombolysis occurred on June 6, 2022. EHR Alteplase references were changed to thrombolysis. The percentage of door to thrombolysis<30 minutes improved from 23.3%

Stroke

Stroke Strokes Thrombolysis Nursing

Abstract TP84: Mapping the Access to Acute Stroke Care in Oklahoma - Preliminary Results of the MAPSTROKE Project

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP84-ATP84, February 1, 2025. We gathered data on the availability of critical resources like thrombolysis, computerized tomography (CT), and neurology services at over 200 facilities. In the U.S., In the U.S.,

Stroke

Stroke Strokes Thrombolysis ICU

Abstract TMP46: Comparison of Local and Centrally Adjudicated Modified Rankin Scores in the MOST Trial

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP46-ATMP46, February 1, 2025. Background:The modified Rankin Scale (mRS) is a key measure of functional outcomes in stroke trials. The primary outcome, the 90-day mRS score, was gathered through in-person video recordings by blinded local personnel. 0.95) for remote audio.

Thrombolysis

Abstract WMP5: Comparative analysis of methods to derive number needed to treat over the entire range of global disability on the modified Rankin Scale

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP5-AWMP5, February 1, 2025. Several methods have been described to derive NNT for ordinal outcomes. Overall, the magnitude of treatment effect estimates rendered by Permutation methods were substantially lower than by Joint Outcome methods Table methods.

Blood Pressure

Blood Pressure Thrombolysis Outcomes Stroke

Abstract WP245: Even minimal-dose intravenous heparin injection around mechanical thrombectomy would be related to higher incidence of early hemorrhagic conversion and distal migration without any clinical benefical effect.

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP245-AWP245, February 1, 2025. However, intravenous thrombolysis was performed more frequently in the non-user group than in the heparin group, and the apTT value after the procedure was higher in the heparin group than in the other groups(75.912.5 vs 21.3%, p=0.04).

Hemorrhage

Hemorrhage Thrombolysis Stroke Strokes

Abstract TP129: Both English and non-English speaking patients with large-vessel occlusion receive timely access to thrombectomy

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP129-ATP129, February 1, 2025. As such, patient factors associated with delays in care can influence outcomes after MT and lead to health inequities. Introduction:An equitable health system requires access to clinical advances across society. hours versus 8.1

Thrombolysis

Thrombolysis Stroke Strokes Hospital

Abstract WMP95: Endovascular Therapy Vs. Medical Management In Isolated Anterior Cerebral Artery Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Weighted Study

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP95-AWMP95, February 1, 2025. In light of context we aim in this investigation to assess the outcomes of these treatments.Methods:This multinational, multicenter study analyzed data from the Multicenter Analysis of Distal Medium Vessel Occlusions: Effect of Mechanical Thrombectomy (MAD-MT) registry.

Stroke

Stroke Strokes Hemorrhage Thrombolysis

Abstract WP248: Endovascular Thrombectomy for Acute Ischemic Stroke in Anticoagulated Patients

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP248-AWP248, February 1, 2025. Introduction:Endovascular thrombectomy (EVT) is effective in treating acute ischemic stroke, with research showing improved functional outcomes compared to medical treatment alone. Safety outcomes included ICH and 90 days mortality.

Stroke