Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP370-AWP370, February 1, 2025. Approximately 30% of aneurysmal subarachnoid hemorrhage (aSAH) patients who survive the rupture develop delayed cerebral ischemia (DCI) 4 to 10 days following aSAH.

Ischemia 40

Ischemia Hemorrhage Biomarkers Aneurysm 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP368-ATP368, February 1, 2025. Ischemic stroke affects more than 600,000 Americans annually. Brain edema in the acute phase of ischemia-reperfusion primarily associates with early-stage neurovascular damage and plays a major role in poor outcomes of stroke.

Strokes 40

Strokes Stroke Ischemia Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A157-A157, February 1, 2025. Experimental diffuse cortical ischemia was induced in Aldh1l1-Cre-ert2/MetRS-floxed mice via a 20-minute bilateral common carotid artery occlusion (BCCAO), followed by 3-week Anl water supplementation.

Ischemia 40

Ischemia Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP35-AWP35, February 1, 2025. Following SAH, neutrophils cause vascular occlusion via neutrophil extracellular traps (NETs) and NETs have been identified as a therapeutic target to prevent delayed cerebral ischemia in mice (DCI) with SAH. nucleosome.

Aneurysm 40

Aneurysm Biomarkers Ischemia Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP233-ATP233, February 1, 2025. While nearly all stroke patients undergo neuroimaging during acute triage, many patients do not initially present to EVT-capable centers, and interhospital transfer for the EVT procedure can result in significant time delays. had vessel recanalization.

Strokes 40

Strokes Stroke Ischemia Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP29-ADP29, February 1, 2025. Introduction:The potential role of tRNA derived fragment (tRF&tiRNA) in ischemic stroke remains largely unknown. Small RNA sequencing analyses were conducted to explore the differentially expressed tRNA derived fragments.

Ischemia 40

Ischemia Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP20-AWMP20, February 1, 2025. Background:Neuronal circuitry remodeling which compromises excitatory and inhibitory neurons is critical to improve neurological outcome after stroke.

Strokes 40

Strokes Stroke Ischemia Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP372-AWP372, February 1, 2025. Introduction:Recent advances in brain cytoprotection therapies following cerebral ischemia-reperfusion (I/R) injury have become an emerging interest.

Ischemia 40

Ischemia Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP115-AWMP115, February 1, 2025. Intro:Resources for studying stroke are limited to clinical trials with sparse access to physiological and biochemical details, and pre-clinical animal studies with limited relation to humans. International Stroke Conference, February 7-9 2024, Phoenix2.

Strokes 40

Strokes Stroke Physiology Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP372-ATP372, February 1, 2025. Introduction:Ischemic stroke is highly heterogeneous, with patient-to-patient differences in infarct location, severity, and degree of reperfusion, among other factors.

Physiology 40

Physiology Strokes Stroke Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP26-ADP26, February 1, 2025. The function of these novel RNAs within the post-stroke brain remains virtually unexplored. Results:We discovered 46 eSINE-RNAs upregulated in the cortex following MCAO, 33 of which were unique to stroke and not detected in the sham group.

Strokes 40

Strokes Stroke Outcomes Ablation 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP359-AWP359, February 1, 2025. Background:Mechanical thrombectomy has been associated with improved outcomes in patients with acute ischemic stroke. Investigating the post-reperfusion inflammatory milieu could provide valuable insights into the mechanisms that influence stroke outcomes.

Biomarkers 40

Biomarkers Strokes Stroke Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A90-A90, February 1, 2025. Introduction:Post-Stroke Cognitive Impairment (PSCI) is increasingly recognized as a major factor in long-term disability. Therefore, new therapies that enhance post-stroke brain function (plasticity) are appealing in translational research.

Ischemia 40

Ischemia Strokes Stroke Research 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP28-ADP28, February 1, 2025. Background:Microglia-mediated inflammatory response directly affects ischemic stroke outcome. Autophagy is crucial in inflammatory response after cerebral ischemia. Mass spectrometry was used to investigate the interaction of NLRC5 with other proteins.

Strokes 40

Strokes Stroke Ischemia Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP87-AWMP87, February 1, 2025. Background:Complete recanalization, defined as modified Treatment in Cerebral Ischemia (mTICI) score of 2c or better, has been shown to be superior to mTICI 2b in terms of patient outcomes following stroke thrombectomy.

Strokes 40

Strokes Stroke Outcomes Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP213-AWP213, February 1, 2025. Intracerebral Hemorrhagic (ICH) stroke is the second most common type of stroke and its aftermath is often more severe than ischemia. Neural activity (Electrophysiological) data is collected pre/post stroke and during stimulation.

Hemorrhage 40

Hemorrhage Strokes Stroke Electrophysiology 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A162-A162, February 1, 2025. Background:Preceding respiratory tract infections (RTIs) caused by bacteria or viruses are associated with worse stroke outcomes, likely due to an exaggerated inflammatory immune response, endothelial dysfunction, platelet activation, and coagulopathy.

COVID-19 40

COVID-19 Strokes Stroke Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP402-AWP402, February 1, 2025. Background:Patients with hypertension (HTN) are almost 3 times more likely to have a stroke than non-hypertensive individuals. Middle Cerebral Artery Occlusion was used to induce focal ischemia/reperfusion injury (I/R). fold), IL-6 (3.3-fold),

Hypertension 40

Hypertension Strokes Stroke Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A34-A34, February 1, 2025. Introduction:Neuroinflammation plays a major role in post-stroke neuronal injury. Meanwhile, post-stroke microstructural degradation of white matter (WM) fibers can be observed using fixel-based analysis (FBA) of diffusion MRI (dMRI).

Strokes 40

Strokes Stroke Ischemia Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP392-ATP392, February 1, 2025. Diabetes is a widespread disease, and stroke is one of the serious complications of diabetes. Thus, we evaluated cerebral blood flow up to 7 days post-ischemia in RH-exposed ITD rats using laser speckle imaging.

Diabetes 40

Diabetes Ischemia Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP9-AWMP9, February 1, 2025. Background:Remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is a safe and promising neuroprotective therapy in acute ischemic stroke (AIS).

Strokes 40

Strokes Stroke Ischemia Hospital 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP367-ATP367, February 1, 2025. Elucidating the mechanisms of IPC is a critical challenge in the stroke field. We also provide data demonstrating how ischemia/reperfusion and innate immune signaling affect STAT1 phosphorylation signaling dynamics in microglia in vitro.

Ischemia 40

Ischemia Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP366-AWP366, February 1, 2025. Our previous studies have suggested that the X escapee genesKdm6aandKdm5cwere involved in microglial activation after stroke in aged mice. Infarct volume and behavioral deficits were quantified 3 days after stroke.

Strokes 40

Strokes Stroke Ischemia Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP338-ATP338, February 1, 2025. Background):Stroke has become a leading cause of mortality and disability worldwide. However, if specific components in CSF could contribute to functional recovery during chronic phase of ischemic stroke remains unclear.

Ischemia 40

Ischemia Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP337-ATP337, February 1, 2025. These data suggest that the gut may be implicated in IGF-1-mediated effects on stroke-induced cognitive impairment. Doxycycline was administered 4h later and IGF-1 was given ip at 4 and 24 h post-stroke.

Strokes 40

Strokes Stroke Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP349-ATP349, February 1, 2025. Background:Inflammation, a key player in both acute and chronic cerebral ischemia, is activated in brain tissues by bilateral carotid stenosis (BCAS)- induced chronic cerebral hypoperfusion.

Dementia 40

Dementia Ischemia Stenosis Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP163-ATP163, February 1, 2025. Introduction:Imaging features are increasingly relevant for predicting response to endovascular treatment in acute ischemic stroke (AIS) patients. female) met inclusion criteria. female) met inclusion criteria.

Document 40

Document Circulation Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP193-AWP193, February 1, 2025. Introduction:Intracranial atherosclerotic disease (ICAD) is a common cause of primary and secondary stroke.

Plaque 40

Plaque Ischemia Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP318-ATP318, February 1, 2025. For this study, acute symptomatic was defined as hemispheric ischemic stroke or retinal ischemia ipsilateral to the carotid stenosis, with symptom onset within 24 hours of admission.

Stenosis 40

Stenosis Atherosclerosis Cholesterol Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP31-ADP31, February 1, 2025. Introduction:CT perfusion maps (CTP) can estimate the ischemic core in acute ischemic stroke based on distinctive cerebral blood flow (CBF) thresholds.

Ischemia 40

Ischemia Hemorrhage Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP13-AWMP13, February 1, 2025. Clinical and experimental evidence further suggest that 35%-65% of patients with myocardial ischemia are affected by CGI which include memory and global cognitive deficits.

Dementia 40

Dementia Myocardial Infarction Ischemia Cardiovascular Disease 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP5-ATMP5, February 1, 2025. Background:Enteral nimodipine is the most evidence-based and widely used drug for the treatment of delayed cerebral ischemia and is known to have various neuroprotective functions.

Hemorrhage 40

Hemorrhage Arterioles Ischemia Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP260-ATP260, February 1, 2025. Introduction:Computer Tomography Perfusion (CTP) has become widely implemented into workflow models for adults presenting with acute stroke.

Pediatrics 40

Pediatrics Ischemia Hemorrhage Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP242-AWP242, February 1, 2025. Except for one patient in the right TRA group who developed transient ischemia, no patients experienced symptomatic stroke or other procedural complications.Conclusions:Both right and left TRA-CAS were successfully performed with a high success rate.

Stents 40

Stents Stent Aortic Interventional Cardiology 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP247-ATP247, February 1, 2025. Key factors influencing clinical decision-making include location, occlusion rate, pseudoaneurysm formation, intracranial extension, distal collateral circulation, and ischemia.

Stents 40

Stents Stent Angioplasty Aneurysm 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A48-A48, February 1, 2025. Introduction:Supratentorial intracerebral hemorrhage (ICH) is a devastating stroke subtype with high mortality and morbidity, and hematoma clearance is a critical therapeutic target.

Hemorrhage 40

Hemorrhage Outcomes Ischemia Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP142-AWP142, February 1, 2025. Introduction:INTEREACT 4 demonstrated lowering blood pressure in the prehospital setting improves outcomes for patients with intracerebral hemorrhage (ICH) but worsens outcomes for acute cerebral ischemia (ACI).

Technology 40

Technology Hemorrhage Blood Pressure Ischemia 40