Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A113-A113, February 1, 2025. Background:Early detection and intervention of cerebral ischemia is critical to improving patient outcomes. This method has the potential to identify ischemic changes and facilitate expeditious intervention.

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Ischemia Stroke Strokes Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP399-AWP399, February 1, 2025. Background:The neuroinflammation triggered by acute cerebral ischemia can be mediated through inflammasome such as NLRP3 (NOD-like receptor family, pyrin domain containing 3) and ASC (apoptosis-associated speck-like protein).

Ischemia 40

Ischemia Stenosis Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP357-ATP357, February 1, 2025. Background:Despite the effectiveness of immediate treatment, such as thrombolytic therapy, after a stroke, many patients are unable to benefit due to time restrictions. However, treadmill training protected against these damages.

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Ischemia Dementia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP395-ATP395, February 1, 2025. Introduction:Ischemic stroke is one of the leading causes of death in the United States and is a known risk factor for Alzheimers Disease (AD) development.

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Ischemia Risk Factors Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP370-AWP370, February 1, 2025. Approximately 30% of aneurysmal subarachnoid hemorrhage (aSAH) patients who survive the rupture develop delayed cerebral ischemia (DCI) 4 to 10 days following aSAH.

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Ischemia Hemorrhage Biomarkers Aneurysm 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A157-A157, February 1, 2025. Experimental diffuse cortical ischemia was induced in Aldh1l1-Cre-ert2/MetRS-floxed mice via a 20-minute bilateral common carotid artery occlusion (BCCAO), followed by 3-week Anl water supplementation.

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Ischemia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP368-ATP368, February 1, 2025. Ischemic stroke affects more than 600,000 Americans annually. Brain edema in the acute phase of ischemia-reperfusion primarily associates with early-stage neurovascular damage and plays a major role in poor outcomes of stroke.

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Stroke Strokes Ischemia Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP35-AWP35, February 1, 2025. Following SAH, neutrophils cause vascular occlusion via neutrophil extracellular traps (NETs) and NETs have been identified as a therapeutic target to prevent delayed cerebral ischemia in mice (DCI) with SAH. nucleosome.

Aneurysm 40

Aneurysm Biomarkers Ischemia Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP233-ATP233, February 1, 2025. While nearly all stroke patients undergo neuroimaging during acute triage, many patients do not initially present to EVT-capable centers, and interhospital transfer for the EVT procedure can result in significant time delays. had vessel recanalization.

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Stroke Strokes Ischemia Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP398-AWP398, February 1, 2025. Background:White matter or axonal injury is a key predictor of long-term functional outcome following ischemic stroke in humans. However, this type of injury is significantly understudied in animal stroke research.

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Stroke Strokes Ischemia Research 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP81-AWMP81, February 1, 2025. Background and purpose:Stroke as a world-wide prevalent disease, has brought a huge burden to health care and the national economy, accurate and fast stroke diagnosis can significantly increase reperfusion rate, mitigate disability, and reduce deaths.

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Stroke Strokes Ischemia Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP400-ATP400, February 1, 2025. Ischemic stroke is a leading cause of death and disability in the US, occurring when the blood supply to an area of the brain is disrupted. Using a combination of Gcamp voltage sensors and EEG. Using a combination of Gcamp voltage sensors and EEG.

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Stroke Strokes Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP29-ADP29, February 1, 2025. Introduction:The potential role of tRNA derived fragment (tRF&tiRNA) in ischemic stroke remains largely unknown. Small RNA sequencing analyses were conducted to explore the differentially expressed tRNA derived fragments.

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Ischemia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP20-AWMP20, February 1, 2025. Background:Neuronal circuitry remodeling which compromises excitatory and inhibitory neurons is critical to improve neurological outcome after stroke.

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Stroke Strokes Ischemia Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP372-AWP372, February 1, 2025. Introduction:Recent advances in brain cytoprotection therapies following cerebral ischemia-reperfusion (I/R) injury have become an emerging interest.

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Ischemia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP209-AWP209, February 1, 2025. Background:COVID-19, primarily a respiratory illness caused by SARS-CoV-2, is associated with vascular complications like ischemia due to endothelial injury, hypercoagulability, and inflammation.

COVID-19 40

COVID-19 Stroke Strokes Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP115-AWMP115, February 1, 2025. Intro:Resources for studying stroke are limited to clinical trials with sparse access to physiological and biochemical details, and pre-clinical animal studies with limited relation to humans. International Stroke Conference, February 7-9 2024, Phoenix2.

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Stroke Strokes Physiology Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP372-ATP372, February 1, 2025. Introduction:Ischemic stroke is highly heterogeneous, with patient-to-patient differences in infarct location, severity, and degree of reperfusion, among other factors.

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Physiology Stroke Strokes Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP26-ADP26, February 1, 2025. The function of these novel RNAs within the post-stroke brain remains virtually unexplored. Results:We discovered 46 eSINE-RNAs upregulated in the cortex following MCAO, 33 of which were unique to stroke and not detected in the sham group.

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Stroke Strokes Outcomes Ablation 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A90-A90, February 1, 2025. Introduction:Post-Stroke Cognitive Impairment (PSCI) is increasingly recognized as a major factor in long-term disability. Therefore, new therapies that enhance post-stroke brain function (plasticity) are appealing in translational research.

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Ischemia Stroke Strokes Research 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP359-AWP359, February 1, 2025. Background:Mechanical thrombectomy has been associated with improved outcomes in patients with acute ischemic stroke. Investigating the post-reperfusion inflammatory milieu could provide valuable insights into the mechanisms that influence stroke outcomes.

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Biomarkers Stroke Strokes Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP28-ADP28, February 1, 2025. Background:Microglia-mediated inflammatory response directly affects ischemic stroke outcome. Autophagy is crucial in inflammatory response after cerebral ischemia. Mass spectrometry was used to investigate the interaction of NLRC5 with other proteins.

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Stroke Strokes Ischemia Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP7-AWMP7, February 1, 2025. Background and objectives:Remote ischemic conditioning during cerebral ischemia ( PerRIC ) represents a new protection paradigm. Methods:Patients with suspected stroke < 8 hours of evolution and motor RACE > 0 were included.

COVID-19 40

COVID-19 Stroke Strokes Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP87-AWMP87, February 1, 2025. Background:Complete recanalization, defined as modified Treatment in Cerebral Ischemia (mTICI) score of 2c or better, has been shown to be superior to mTICI 2b in terms of patient outcomes following stroke thrombectomy.

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Stroke Strokes Outcomes Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP213-AWP213, February 1, 2025. Intracerebral Hemorrhagic (ICH) stroke is the second most common type of stroke and its aftermath is often more severe than ischemia. Neural activity (Electrophysiological) data is collected pre/post stroke and during stimulation.

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Hemorrhage Stroke Strokes Electrophysiology 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A162-A162, February 1, 2025. Background:Preceding respiratory tract infections (RTIs) caused by bacteria or viruses are associated with worse stroke outcomes, likely due to an exaggerated inflammatory immune response, endothelial dysfunction, platelet activation, and coagulopathy.

COVID-19 40

COVID-19 Stroke Strokes Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP402-AWP402, February 1, 2025. Background:Patients with hypertension (HTN) are almost 3 times more likely to have a stroke than non-hypertensive individuals. Middle Cerebral Artery Occlusion was used to induce focal ischemia/reperfusion injury (I/R). fold), IL-6 (3.3-fold),

Hypertension 40

Hypertension Stroke Strokes Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A34-A34, February 1, 2025. Introduction:Neuroinflammation plays a major role in post-stroke neuronal injury. Meanwhile, post-stroke microstructural degradation of white matter (WM) fibers can be observed using fixel-based analysis (FBA) of diffusion MRI (dMRI).

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Stroke Strokes Ischemia Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP392-ATP392, February 1, 2025. Diabetes is a widespread disease, and stroke is one of the serious complications of diabetes. Thus, we evaluated cerebral blood flow up to 7 days post-ischemia in RH-exposed ITD rats using laser speckle imaging.

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Diabetes Ischemia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP9-AWMP9, February 1, 2025. Background:Remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is a safe and promising neuroprotective therapy in acute ischemic stroke (AIS).

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Stroke Strokes Ischemia Hospital 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP367-ATP367, February 1, 2025. Elucidating the mechanisms of IPC is a critical challenge in the stroke field. We also provide data demonstrating how ischemia/reperfusion and innate immune signaling affect STAT1 phosphorylation signaling dynamics in microglia in vitro.

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Ischemia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP6-ATP6, February 1, 2025. According to our clinic observation, patients with acute ischemic stroke (AIS) treated with T1 to prevent/cure post-stroke infection display favorable stroke outcome.

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Ischemia Stroke Strokes Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP366-AWP366, February 1, 2025. Our previous studies have suggested that the X escapee genesKdm6aandKdm5cwere involved in microglial activation after stroke in aged mice. Infarct volume and behavioral deficits were quantified 3 days after stroke.

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Stroke Strokes Ischemia Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP338-ATP338, February 1, 2025. Background):Stroke has become a leading cause of mortality and disability worldwide. However, if specific components in CSF could contribute to functional recovery during chronic phase of ischemic stroke remains unclear.

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Ischemia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP337-ATP337, February 1, 2025. These data suggest that the gut may be implicated in IGF-1-mediated effects on stroke-induced cognitive impairment. Doxycycline was administered 4h later and IGF-1 was given ip at 4 and 24 h post-stroke.

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Stroke Strokes Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP93-AWMP93, February 1, 2025. Background:Chronic total internal carotid artery occlusion (CTO) can be associated with a high (22-25%) annual risk of stroke with limited therapeutic options. All TIA, stroke, death, and MI were recorded during follow-up. risk of restenosis.

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Outcomes Stents Stent Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP349-ATP349, February 1, 2025. Background:Inflammation, a key player in both acute and chronic cerebral ischemia, is activated in brain tissues by bilateral carotid stenosis (BCAS)- induced chronic cerebral hypoperfusion.

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Dementia Ischemia Stenosis Outcomes 40