Coupling Interval Counts in Ventricular Premature Depolarizations During Acute Ischemia
Circulation
MARCH 23, 2025
Circulation, Volume 151, Issue 12 , Page 884-886, March 25, 2025.
GE Healthcare Launches New Cardiac PET tracer
DAIC
MARCH 27, 2025
tim.hodson Thu, 03/27/2025 - 15:40 March 27, 2025 GE HealthCare is announcing theU.S.launch of Flyrcado(flurpiridaz F 18) injection at the 2025American College of Cardiology(ACC) AnnualScientific Session & Expo inChicago. Flyrcado is aunit dose positron emission tomography myocardial perfusion imaging (PET MPI) agent.
Abstract TP356: Nucleocytoplasmic shuttling of Sirt1 and Sirt2 during cerebral ischemia
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP356-ATP356, February 1, 2025. Background and Rationale:Acute hyperglycemia caused by cerebral ischemia occurs when there is a lack of oxygen, resulting in anaerobic glycolysis. We demonstrated that ischemia accelerates aging-like processes in the brain.
Ischemia 
40
40 
Abstract WP399: Effects of NLRP3 inhibitor on cerebral ischemia in chronic cerebral hypoperfusion model
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP399-AWP399, February 1, 2025. Background:The neuroinflammation triggered by acute cerebral ischemia can be mediated through inflammasome such as NLRP3 (NOD-like receptor family, pyrin domain containing 3) and ASC (apoptosis-associated speck-like protein). 17/Icr-Jcl mice in this experiment.
Ischemia 40
40 
Abstract WP371: Cranial bone marrow-derived polymorphonuclear neutrophils comprise a small fraction of infiltrating leukocytes within the ischemic cortex following ischemia/reperfusion injury.
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP371-AWP371, February 1, 2025. The significance of cranial bone marrow-derived leukocytes following ischemic stroke in the setting of ischemia/reperfusion remains uncertain. Mice underwent 90 min tMCAO with peripheral blood collection prior to and at 24 hours following ischemia/reperfusion.
Ischemia 40
40 
Abstract TP365: Understanding neutrophil recruitment and lifespan following ischemia/reperfusion using a novel tracking method
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP365-ATP365, February 1, 2025. Large vessel occlusion and reperfusion were simulated using the transient middle cerebral artery occlusion model (tMCAO, 90 minutes of ischemia followed by reperfusion). Infarct size was determined via triphenyl tetrazolium chloride staining.
Ischemia 40
40 
Abstract WP370: Platelet morphology but not coagulation markers predicts delayed cerebral ischemia after subarachnoid hemorrhage
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP370-AWP370, February 1, 2025. Approximately 30% of aneurysmal subarachnoid hemorrhage (aSAH) patients who survive the rupture develop delayed cerebral ischemia (DCI) 4 to 10 days following aSAH.
Ischemia 40
40 
Abstract TP357: Mitochondrial intercellular transfer via platelets after physical training exerts neuro-glial protection against cerebral ischemia.
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP357-ATP357, February 1, 2025. In cases of acute ischemia, training improved complications and reduced glial activation. Background:Despite the effectiveness of immediate treatment, such as thrombolytic therapy, after a stroke, many patients are unable to benefit due to time restrictions.
Ischemia 40
40 
Abstract WP35: Neutrophil Extracellular Traps As a Biomarker for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP35-AWP35, February 1, 2025. Following SAH, neutrophils cause vascular occlusion via neutrophil extracellular traps (NETs) and NETs have been identified as a therapeutic target to prevent delayed cerebral ischemia in mice (DCI) with SAH.
Aneurysm 40
40 
Abstract TP376: S-nitrosoglutathione Reduced Ischemia/reperfusion Injury by Relieving Thrombo-inflammation in Experimental Stroke Models
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP376-ATP376, February 1, 2025. The study was aimed to test the effects of GSNO in ischemia/reperfusion (I/R) Injury through relieving thrombo-inflammation.Methods:Male C57BL/6 mice (n=160) were 10-week-old (20-25 g) at the time of surgery.
Ischemia 40
40 
Abstract 157: Bio-orthogonal Amino Acid Tagging Identifies Nascent in vivo Astrocyte-specific Proteomic Alterations following Transient Global Ischemia
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page A157-A157, February 1, 2025. Experimental diffuse cortical ischemia was induced in Aldh1l1-Cre-ert2/MetRS-floxed mice via a 20-minute bilateral common carotid artery occlusion (BCCAO), followed by 3-week Anl water supplementation.
Ischemia 40
40 
Comments on: “Cardiovascular Prognosis in Limb Ischemia Patients with Heart Failure and Systolic Dysfunction Following Major Amputation”
The American Journal of Cardiology
FEBRUARY 6, 2025
Publication date: Available online 5 February 2025 Source: The American Journal of Cardiology Author(s): Sravani Modumudi, Chandana Padmanabham Reddy
Ischemia 40
40 
Abstract 113: Real-Time Detection of Cerebral Ischemia Using Optical Brain Pulse Monitoring in a Sheep Model of Stroke
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page A113-A113, February 1, 2025. Background:Early detection and intervention of cerebral ischemia is critical to improving patient outcomes. This method has the potential to identify ischemic changes and facilitate expeditious intervention.
Ischemia 40
40 
SCCT Awards Best Original Science of 19th Annual Scientific Meeting
DAIC
JULY 23, 2024
Dr. Yang is also winner of the SCCT Best Abstract Award for his submission, “Coronary CT Angiography-derived Precursors Of Acute Coronary Syndrome In Ischemia-causing Lesions.” and the Ma Family, who provided a $5,000 case prize for the winner.
Chest Pain 105
105 
Abstract WP372: Edaravone Dexborneol Protects Against Blood-brain Barrier Disruption Following Cerebral Ischemia/reperfusion By Activating The PDGFB/PDGFR-β Signaling Pathway To Inhibit Pericyte Injury
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP372-AWP372, February 1, 2025. Introduction:Recent advances in brain cytoprotection therapies following cerebral ischemia-reperfusion (I/R) injury have become an emerging interest.
Ischemia 40
40 
Abstract 90: Astrocytic Cluster of Differentiation 38 Contributes to Hippocampal Synaptic Plasticity Deficits following Focal Cerebral Ischemia
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page A90-A90, February 1, 2025. Introduction:Post-Stroke Cognitive Impairment (PSCI) is increasingly recognized as a major factor in long-term disability. Therefore, new therapies that enhance post-stroke brain function (plasticity) are appealing in translational research.
Ischemia 40
40 
Abstract TP392: Prior recurrent hypoglycemia exposure potentiates post-ischemic hypoperfusion in male insulin-treated diabetic rats.
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP392-ATP392, February 1, 2025. We have previously shown that RH exposure leads to severe post-ischemic hypoperfusion at least up to 80 minutes after ischemia and increases the extent of ischemic brain injury in insulin-treated diabetic (ITD) rats.
Diabetes 40
40 
Abstract DP29: A specific tRNA derived fragment, tRF-Gly-GCC, contributes to cerebral ischemic injury in both young and aged mice in an experimental stroke model
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ADP29-ADP29, February 1, 2025. To determine the role of tRF-Gly-GCC, tRF-Gly-GCC antisense inhibitors (antagomirs) were injected intracerebroventricularly.Results:tRF-Gly-GCC levels were significantly elevated in cerebral cortex after ischemia in both young and aged mice.
Ischemia 40
40 Abstract TP368: Targeted Lipid Nanoparticles to Modulate Blood-Brain Barrier Transcytosis in Acute Ischemic Stroke
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP368-ATP368, February 1, 2025. Thrombectomy, where occluded arteries are cannulated for mechanical clot removal, can restore blood flow and improve survival, but still leaves 1/3 of patients functionally dependent, largely due to secondary ischemia-reperfusion injury.
Stroke 40
40 Abstract TP367: Role of STAT1 and type I interferon signaling in ischemic preconditioning-induced microglial responses
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP367-ATP367, February 1, 2025. We also showed that exposure of primary microglia to either IFN-beta or ischemia/reperfusion-like conditions results in phosphorylation of STAT1, a key signaling kinase downstream of IFNAR1.
Ischemia 40
40 
Abstract TP233: Machine Learning Model to Predict Changes in Neuroimaging Profiles Following Delayed Transfer for Stroke Thrombectomy
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP233-ATP233, February 1, 2025. had ischemia progression (ASPECTS decay of 2 or more), and 16.1% 1.00) for imaging stability, ischemia progression, and vessel recanalization, respectively. hours from initial neuroimaging. of patients had stable imaging, 14.5% had vessel recanalization.
Stroke 40
40 
Will this case be flagged for Quality Improvement in the STEMI/NSTEMI Paradigm?
Dr. Smith's ECG Blog
MARCH 27, 2025
But it was interpreted as no acute ischemia and the patient was referred to cardiology as Non-STEMI. But clearly this 'Non-STEMI' patient with OMI would have benefited from immediate cath lab activation on arrival, when their first troponin was 11ng/L, rather than after after it rose to 12,000ng/L after 12 hours of refractory ischemia.
STEMI 80
80 Abstract WMP20: Enhanced Small Extracellular Vesicle Uptake By Activated Interneurons Improves Stroke Recovery In Mice
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP20-AWMP20, February 1, 2025. Western blot showed that adjunct CEC-sEVs with CNO (p<0.05) decreased ischemia-increased Drp1 and Mff, and elevated ischemia-reduced Mito oxidative phosphorylation (OXPHOS) protein, COX5A, vs CEC-sEVs or CNO alone.
Stroke 40
40 Abstract TP349: Deleted NLRP3 inflammasome improves functional outcome and improves cerebral blood flow in an experimental model of Vascular Cognitive Impairment and Dementia
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP349-ATP349, February 1, 2025. Background:Inflammation, a key player in both acute and chronic cerebral ischemia, is activated in brain tissues by bilateral carotid stenosis (BCAS)- induced chronic cerebral hypoperfusion.
Dementia 40
40 Abstract WMP115: Towards a Comprehensive Computational Model of Ischemic Stroke: Integrating Detailed Microvasculature With Advanced Model of Brain Tissue Metabolism
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP115-AWMP115, February 1, 2025. Results:Figure 2 shows timecourse of GLC, ATP, and Sodium in different compartments of the model through time in regions experiencing mild and severe ischemia. Brain metabolism was simulated for cases with no ischemic event, and after CBF was reduced by 80%.Results:Figure
Stroke 40
40 Abstract TP338: Functional recovery during the chronic phase after cerebral infarction via CSF-derived microRNA
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP338-ATP338, February 1, 2025. At 28 days after pMCAO, brains were harvested for ischemia volume calculation and immunofluorescence.(Result):miR-204-5p miR-204-5p mimic group showed a tendency of ameliorated functional dysfunction, smaller ischemia volume at 28 days after pMCAO.
Ischemia 40
40 Abstract WP366: Escape of Kdm6a from X Chromosome is Detrimental to Ischemic Brains via IRF5 Signaling
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP366-AWP366, February 1, 2025. Keywords:Stroke, Aging,Kdm6a/5c, Microglia, Epigenetics, Ischemia, IRF Introduction:The fundamental roles of chromatin biology and epigenetics in progression of diseases have been increasingly recognized.
Stroke 40
40 
Abstract WP193: Longitudinal Assessment of Vessel Wall Radiomics and Luminal Blood Flow During Evaluation of Intracranial Atherosclerotic Plaques
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP193-AWP193, February 1, 2025. Introduction:Intracranial atherosclerotic disease (ICAD) is a common cause of primary and secondary stroke.
Plaque 40
40 
Abstract TMP5: The Impact of Enteral Nimodipine on Endothelial Cell Apoptosis in an Animal Subarachnoid Hemorrhage Model
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATMP5-ATMP5, February 1, 2025. Background:Enteral nimodipine is the most evidence-based and widely used drug for the treatment of delayed cerebral ischemia and is known to have various neuroprotective functions.
Hemorrhage 40
40 Abstract WP359: Increased CCL4 and CCL5 following Mechanical Thrombectomy: A Plasma Biomarker Study in Ischemic Stroke Patients
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP359-AWP359, February 1, 2025. CCL4 and CCL5 may contribute to the post-ischemia reperfusion inflammatory response, potentially influencing outcomes after reperfusion therapies such as mechanical thrombectomy.
Biomarkers 40
40 Abstract WMP9: The Effect Of Remote Ischemic Conditioning On Acute Infarct Growth In Patients With Acute Ischemic Stroke - Subgroup Analysis From The RESIST Trial
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP9-AWMP9, February 1, 2025. Background:Remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is a safe and promising neuroprotective therapy in acute ischemic stroke (AIS).
Stroke 40
40 
Abstract WMP13: Cardiac Injury Potentially Contributes to Neuroinflammation via Extracellular Vesicles
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP13-AWMP13, February 1, 2025. Clinical and experimental evidence further suggest that 35%-65% of patients with myocardial ischemia are affected by CGI which include memory and global cognitive deficits.
Dementia 40
40 
Abstract TP247: Iatrogenic Cervical Artery Dissections during Endovascular Interventions
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP247-ATP247, February 1, 2025. Key factors influencing clinical decision-making include location, occlusion rate, pseudoaneurysm formation, intracranial extension, distal collateral circulation, and ischemia.
Stent 40
40 
Abstract DP28: NLRC5 Mediates Microglial Autophagy to Regulate Post-Stroke Neuroinflammation and its Mechanisms Study.
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ADP28-ADP28, February 1, 2025. Autophagy is crucial in inflammatory response after cerebral ischemia. Background:Microglia-mediated inflammatory response directly affects ischemic stroke outcome.
Stroke 40
40 
Abstract WP213: An experimental and theoretical study on electrical brain stimulation for post Intracerebral Hemorrhagic stroke rehabilitation.
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP213-AWP213, February 1, 2025. Intracerebral Hemorrhagic (ICH) stroke is the second most common type of stroke and its aftermath is often more severe than ischemia. Recent population data has shown increasing trends of ICH in middle aged people, contributing to the economic burden of society.
Hemorrhage 40
40 Abstract WP142: A Framework for Developing Prehospital Intracerebral Hemorrhage Recognition Scales and Technologies
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP142-AWP142, February 1, 2025. Introduction:INTEREACT 4 demonstrated lowering blood pressure in the prehospital setting improves outcomes for patients with intracerebral hemorrhage (ICH) but worsens outcomes for acute cerebral ischemia (ACI).
Technology 40
40 
Abstract WMP87: Determinants of proceduralist-associated differences in angiographic outcomes following stroke thrombectomy
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP87-AWMP87, February 1, 2025. Background:Complete recanalization, defined as modified Treatment in Cerebral Ischemia (mTICI) score of 2c or better, has been shown to be superior to mTICI 2b in terms of patient outcomes following stroke thrombectomy.
Stroke 40
40 
Abstract TP372: Establishing a Physiologically Variable Model of Ischemic Stroke to Recapitulate Patient Heterogeneity
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP372-ATP372, February 1, 2025. LSCI demonstrated a 2-to-5-fold increase in the area of profound ischemia (lowest quintile of pixel values) in the Koizumi model compared to the Longa model and with increasing ischemic duration.
Physiology 40
40 
Abstract TP337: Blocking insulin-like growth factor 1 receptor in the gut abrogates IGF-1 mediated long-term neuroprotection in middle-aged female rats
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP337-ATP337, February 1, 2025. Animals were subjected to endothelin-1 induced MCAo. Doxycycline was administered 4h later and IGF-1 was given ip at 4 and 24 h post-stroke.
Stroke 40
40 Abstract TP318: Comparison of Lipid-Lowering Therapies Regimens and LDL-C Profiles in Patients with Asymptomatic versus Acute Symptomatic Atherosclerotic Carotid Stenosis
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP318-ATP318, February 1, 2025. For this study, acute symptomatic was defined as hemispheric ischemic stroke or retinal ischemia ipsilateral to the carotid stenosis, with symptom onset within 24 hours of admission. Lipid-lowering therapies mitigate the risk of atherothrombotic events.
Stenosis 40
40 Abstract TP260: Utilization of Computed Tomography Perfusion in the Pediatric and Young Adult Population – A Nationwide Cohort Study
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP260-ATP260, February 1, 2025. Conclusion:This is the largest cohort of CTP studies done in the pediatric/ young adult population for suspected acute cerebral ischemia.
Pediatrics 40
40 Abstract TP163: Single- and Multi-Phase Computed Tomography Angiography Are Associated with Digital Subtraction Angiography and American Society of Interventional and Therapeutic Neuroradiology Collateral Score of Three or Greater
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP163-ATP163, February 1, 2025. Modified Treatment in Cerebral Ischemia (mTICI) score was used to determine reperfusion status, with mTICI > 2b considered successful. female) met inclusion criteria.
Document 40
40 
Abstract DP31: Effect of Hemoglobin and Blood Glucose Levels on CTP Ischemic Core Underestimation: a post-hoc analysis of the ESCAPE-NA1 trial
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ADP31-ADP31, February 1, 2025. Introduction:CT perfusion maps (CTP) can estimate the ischemic core in acute ischemic stroke based on distinctive cerebral blood flow (CBF) thresholds.
Ischemia 40
40 Abstract 34: White Matter Alteration after Stroke Is Correlated with Neuroinflammation: A Combined Fixel-based Diffusion MRI Analysis and 18F-THK-5351 PET Study
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page A34-A34, February 1, 2025. Tau PET demonstrated the highest uptake of 18F-THK-5351 at ischemia core. Introduction:Neuroinflammation plays a major role in post-stroke neuronal injury. Previous studies applied 18F-THK-5351 tau PET to identify the existence of neuroinflammation after infarction.
Stroke 40
40 
Let's personalize your content