Coupling Interval Counts in Ventricular Premature Depolarizations During Acute Ischemia
Circulation
MARCH 23, 2025
Circulation, Volume 151, Issue 12 , Page 884-886, March 25, 2025.
GE Healthcare Launches New Cardiac PET tracer
DAIC
MARCH 27, 2025
tim.hodson Thu, 03/27/2025 - 15:40 March 27, 2025 GE HealthCare is announcing theU.S.launch of Flyrcado(flurpiridaz F 18) injection at the 2025American College of Cardiology(ACC) AnnualScientific Session & Expo inChicago. Flyrcado is aunit dose positron emission tomography myocardial perfusion imaging (PET MPI) agent.
Abstract TP356: Nucleocytoplasmic shuttling of Sirt1 and Sirt2 during cerebral ischemia
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP356-ATP356, February 1, 2025. Background and Rationale:Acute hyperglycemia caused by cerebral ischemia occurs when there is a lack of oxygen, resulting in anaerobic glycolysis. We demonstrated that ischemia accelerates aging-like processes in the brain.
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Abstract TP354: The role of organelle-specific autophagy in rodent models of brain ischemia
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP354-ATP354, February 1, 2025. Cell death was examined by histopathology.Results:Autophagic flux was impaired in hippocampal CA1 neurons destined to die after brain ischemia, as indicated by the buildup of p62 and ubiquitinated proteins, depletion of NSF, and buildup of endolysosomal structures.
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Abstract WP399: Effects of NLRP3 inhibitor on cerebral ischemia in chronic cerebral hypoperfusion model
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP399-AWP399, February 1, 2025. Background:The neuroinflammation triggered by acute cerebral ischemia can be mediated through inflammasome such as NLRP3 (NOD-like receptor family, pyrin domain containing 3) and ASC (apoptosis-associated speck-like protein). 17/Icr-Jcl mice in this experiment.
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Abstract WP395: Mapping the Spatial Distribution of Neutrophils in a Murine Model of Ischemia/Reperfusion Injury
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP395-AWP395, February 1, 2025. Introduction:Polymorphonuclear Neutrophils (PMNs) are the first blood-derived immune cells to respond in ischemia/reperfusion injury (I/RI). Mice were subject to 60 min or 90 min of ischemia to model strokes of varying severity.
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Abstract WP371: Cranial bone marrow-derived polymorphonuclear neutrophils comprise a small fraction of infiltrating leukocytes within the ischemic cortex following ischemia/reperfusion injury.
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP371-AWP371, February 1, 2025. The significance of cranial bone marrow-derived leukocytes following ischemic stroke in the setting of ischemia/reperfusion remains uncertain. Mice underwent 90 min tMCAO with peripheral blood collection prior to and at 24 hours following ischemia/reperfusion.
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Abstract TP365: Understanding neutrophil recruitment and lifespan following ischemia/reperfusion using a novel tracking method
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP365-ATP365, February 1, 2025. Large vessel occlusion and reperfusion were simulated using the transient middle cerebral artery occlusion model (tMCAO, 90 minutes of ischemia followed by reperfusion). Infarct size was determined via triphenyl tetrazolium chloride staining.
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Abstract WP370: Platelet morphology but not coagulation markers predicts delayed cerebral ischemia after subarachnoid hemorrhage
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP370-AWP370, February 1, 2025. Approximately 30% of aneurysmal subarachnoid hemorrhage (aSAH) patients who survive the rupture develop delayed cerebral ischemia (DCI) 4 to 10 days following aSAH.
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Abstract TP395: Alzheimer's Disease model APP/PS1 mice exhibit motor deficits following 15-minute focal ischemia.
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP395-ATP395, February 1, 2025. Therefore, further studies are warranted to assess the interaction between ischemia and -amyloid peptide on histological injury and functional recovery.
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Abstract TP357: Mitochondrial intercellular transfer via platelets after physical training exerts neuro-glial protection against cerebral ischemia.
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP357-ATP357, February 1, 2025. In cases of acute ischemia, training improved complications and reduced glial activation. Background:Despite the effectiveness of immediate treatment, such as thrombolytic therapy, after a stroke, many patients are unable to benefit due to time restrictions.
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Abstract WP35: Neutrophil Extracellular Traps As a Biomarker for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP35-AWP35, February 1, 2025. Following SAH, neutrophils cause vascular occlusion via neutrophil extracellular traps (NETs) and NETs have been identified as a therapeutic target to prevent delayed cerebral ischemia in mice (DCI) with SAH.
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New Dodero Center at UH will Revolutionize Limb Salvage
DAIC
FEBRUARY 14, 2025
Lorraine and Bill Dodero tim.hodson Fri, 02/14/2025 - 15:33 Feb. 10, 2025 A generous gift of $5 million from Lorraine and Bill Dodero will establish the Lorraine and Bill Dodero Limb Preservation Center at University Hospitals Harrington Heart & Vascular Institute in Cleveland, Ohio. When we save a limb, we save a life.
Abstract TP376: S-nitrosoglutathione Reduced Ischemia/reperfusion Injury by Relieving Thrombo-inflammation in Experimental Stroke Models
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP376-ATP376, February 1, 2025. The study was aimed to test the effects of GSNO in ischemia/reperfusion (I/R) Injury through relieving thrombo-inflammation.Methods:Male C57BL/6 mice (n=160) were 10-week-old (20-25 g) at the time of surgery.
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Abstract 157: Bio-orthogonal Amino Acid Tagging Identifies Nascent in vivo Astrocyte-specific Proteomic Alterations following Transient Global Ischemia
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page A157-A157, February 1, 2025. Experimental diffuse cortical ischemia was induced in Aldh1l1-Cre-ert2/MetRS-floxed mice via a 20-minute bilateral common carotid artery occlusion (BCCAO), followed by 3-week Anl water supplementation.
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Comments on: “Cardiovascular Prognosis in Limb Ischemia Patients with Heart Failure and Systolic Dysfunction Following Major Amputation”
The American Journal of Cardiology
FEBRUARY 6, 2025
Publication date: Available online 5 February 2025 Source: The American Journal of Cardiology Author(s): Sravani Modumudi, Chandana Padmanabham Reddy
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40 Abstract 113: Real-Time Detection of Cerebral Ischemia Using Optical Brain Pulse Monitoring in a Sheep Model of Stroke
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page A113-A113, February 1, 2025. Background:Early detection and intervention of cerebral ischemia is critical to improving patient outcomes. This method has the potential to identify ischemic changes and facilitate expeditious intervention.
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Abstract WP367: Attenuating Post-stroke Ischemia Reperfusion Injury: Establishing the Efficacy of Disodium Malonate in a Clinically Relevant Sheep Model
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP367-AWP367, February 1, 2025. A pivotal role of the citric acid cycle intermediate succinate has been identified in driving RET post-reperfusion, whereby succinate accumulated during ischemia is rapidly reoxidized following reperfusion leading to a burst of ROS.
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Abstract WP372: Edaravone Dexborneol Protects Against Blood-brain Barrier Disruption Following Cerebral Ischemia/reperfusion By Activating The PDGFB/PDGFR-β Signaling Pathway To Inhibit Pericyte Injury
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP372-AWP372, February 1, 2025. Introduction:Recent advances in brain cytoprotection therapies following cerebral ischemia-reperfusion (I/R) injury have become an emerging interest.
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Patients Undergo First Doses of New Cardiac PET tracer
DAIC
MARCH 3, 2025
tim.hodson Mon, 03/03/2025 - 16:07 Feb. 25, 2025 GE HealthCare has delivered the first patient doses of Flyrcado(flurpiridaz F 18) injection, a unit dose positron emission tomography myocardial perfusion imaging (PET MPI) agent for detecting coronary artery disease (CAD), at early adopter imaging centers in the US.
Abstract 90: Astrocytic Cluster of Differentiation 38 Contributes to Hippocampal Synaptic Plasticity Deficits following Focal Cerebral Ischemia
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page A90-A90, February 1, 2025. Introduction:Post-Stroke Cognitive Impairment (PSCI) is increasingly recognized as a major factor in long-term disability. Therefore, new therapies that enhance post-stroke brain function (plasticity) are appealing in translational research.
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Abstract TP392: Prior recurrent hypoglycemia exposure potentiates post-ischemic hypoperfusion in male insulin-treated diabetic rats.
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP392-ATP392, February 1, 2025. We have previously shown that RH exposure leads to severe post-ischemic hypoperfusion at least up to 80 minutes after ischemia and increases the extent of ischemic brain injury in insulin-treated diabetic (ITD) rats.
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Abstract DP29: A specific tRNA derived fragment, tRF-Gly-GCC, contributes to cerebral ischemic injury in both young and aged mice in an experimental stroke model
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ADP29-ADP29, February 1, 2025. To determine the role of tRF-Gly-GCC, tRF-Gly-GCC antisense inhibitors (antagomirs) were injected intracerebroventricularly.Results:tRF-Gly-GCC levels were significantly elevated in cerebral cortex after ischemia in both young and aged mice.
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40 Abstract TP368: Targeted Lipid Nanoparticles to Modulate Blood-Brain Barrier Transcytosis in Acute Ischemic Stroke
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP368-ATP368, February 1, 2025. Thrombectomy, where occluded arteries are cannulated for mechanical clot removal, can restore blood flow and improve survival, but still leaves 1/3 of patients functionally dependent, largely due to secondary ischemia-reperfusion injury.
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40 Abstract TP367: Role of STAT1 and type I interferon signaling in ischemic preconditioning-induced microglial responses
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP367-ATP367, February 1, 2025. We also showed that exposure of primary microglia to either IFN-beta or ischemia/reperfusion-like conditions results in phosphorylation of STAT1, a key signaling kinase downstream of IFNAR1.
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Abstract TP233: Machine Learning Model to Predict Changes in Neuroimaging Profiles Following Delayed Transfer for Stroke Thrombectomy
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP233-ATP233, February 1, 2025. had ischemia progression (ASPECTS decay of 2 or more), and 16.1% 1.00) for imaging stability, ischemia progression, and vessel recanalization, respectively. hours from initial neuroimaging. of patients had stable imaging, 14.5% had vessel recanalization.
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40 Abstract WP398: Synaptic origin of axonal injury in the mouse stroke model
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP398-AWP398, February 1, 2025. The regional cerebral blood flow (rCBF) was monitored with a laser doppler flowmetry (LDF) needle probe and maintained below 10% of the pre-ischemia level via, when needed, adjusting the monofilament occluder position during the MCAO period.
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40 Abstract WMP20: Enhanced Small Extracellular Vesicle Uptake By Activated Interneurons Improves Stroke Recovery In Mice
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP20-AWMP20, February 1, 2025. Western blot showed that adjunct CEC-sEVs with CNO (p<0.05) decreased ischemia-increased Drp1 and Mff, and elevated ischemia-reduced Mito oxidative phosphorylation (OXPHOS) protein, COX5A, vs CEC-sEVs or CNO alone.
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Abstract TP400: Defining The Role Of Cortical Disinhibition In The Development Of Post-stroke Neurologic Complications
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP400-ATP400, February 1, 2025. However, each of these is comprised of circuitry involving multiple neuronal cell types, each with stratified metabolic requirements and distinct firing patterns that impact susceptibility to ischemia.
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40 Abstract TP349: Deleted NLRP3 inflammasome improves functional outcome and improves cerebral blood flow in an experimental model of Vascular Cognitive Impairment and Dementia
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP349-ATP349, February 1, 2025. Background:Inflammation, a key player in both acute and chronic cerebral ischemia, is activated in brain tissues by bilateral carotid stenosis (BCAS)- induced chronic cerebral hypoperfusion.
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40 Abstract WMP115: Towards a Comprehensive Computational Model of Ischemic Stroke: Integrating Detailed Microvasculature With Advanced Model of Brain Tissue Metabolism
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP115-AWMP115, February 1, 2025. Results:Figure 2 shows timecourse of GLC, ATP, and Sodium in different compartments of the model through time in regions experiencing mild and severe ischemia. Brain metabolism was simulated for cases with no ischemic event, and after CBF was reduced by 80%.Results:Figure
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40 Abstract TP338: Functional recovery during the chronic phase after cerebral infarction via CSF-derived microRNA
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP338-ATP338, February 1, 2025. At 28 days after pMCAO, brains were harvested for ischemia volume calculation and immunofluorescence.(Result):miR-204-5p miR-204-5p mimic group showed a tendency of ameliorated functional dysfunction, smaller ischemia volume at 28 days after pMCAO.
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40 Abstract TP6: Thymosin alpha 1 promotes neuron survival by enhancing mitophagy after AIS
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP6-ATP6, February 1, 2025. Bothin vivoandex vivoexperiments revealed that T1 directly inhibited ischemia-induced neuronal death. Background:Thymosin alpha 1 (T1) had been used in kinds of inflammatory and immunodeficiency diseases as an immunomodulator.
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40 Abstract WP366: Escape of Kdm6a from X Chromosome is Detrimental to Ischemic Brains via IRF5 Signaling
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP366-AWP366, February 1, 2025. Keywords:Stroke, Aging,Kdm6a/5c, Microglia, Epigenetics, Ischemia, IRF Introduction:The fundamental roles of chromatin biology and epigenetics in progression of diseases have been increasingly recognized.
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Abstract WP193: Longitudinal Assessment of Vessel Wall Radiomics and Luminal Blood Flow During Evaluation of Intracranial Atherosclerotic Plaques
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP193-AWP193, February 1, 2025. Introduction:Intracranial atherosclerotic disease (ICAD) is a common cause of primary and secondary stroke.
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40 Abstract WMP81: A ChatGLM-based stroke diagnosis and prediction tool
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP81-AWMP81, February 1, 2025. in other 2 external test cohorts), distinguish ischemia and hemorrhage (100.0% However, there exists a great discrepancy in acute stroke diagnosis and treatment due to the diverse medical information for making decisions. in validation dataset, 99.1%
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Abstract WMP7: Comprehensive safety and efficacy analysis of the full remote ischemic perconditioning among acute ischemic stroke patients in Catalonia (REMOTECAT) study cohort
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP7-AWMP7, February 1, 2025. Background and objectives:Remote ischemic conditioning during cerebral ischemia ( PerRIC ) represents a new protection paradigm. We present the safety and efficacy analysis of the entire patient cohort of the multicenter double-blind REMOTECAT trial (.Methods:Patients
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Abstract TMP5: The Impact of Enteral Nimodipine on Endothelial Cell Apoptosis in an Animal Subarachnoid Hemorrhage Model
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATMP5-ATMP5, February 1, 2025. Background:Enteral nimodipine is the most evidence-based and widely used drug for the treatment of delayed cerebral ischemia and is known to have various neuroprotective functions.
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40 Abstract WP359: Increased CCL4 and CCL5 following Mechanical Thrombectomy: A Plasma Biomarker Study in Ischemic Stroke Patients
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP359-AWP359, February 1, 2025. CCL4 and CCL5 may contribute to the post-ischemia reperfusion inflammatory response, potentially influencing outcomes after reperfusion therapies such as mechanical thrombectomy.
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Abstract WP209: Comparative Functional Outcomes for Ischemic Stroke Patients with and without COVID-19
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP209-AWP209, February 1, 2025. Background:COVID-19, primarily a respiratory illness caused by SARS-CoV-2, is associated with vascular complications like ischemia due to endothelial injury, hypercoagulability, and inflammation.
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40 Abstract WMP93: Long-term Outcomes of Total endovascular Reconstruction of Symptomatic Internal Carotid Artery Chronic Total Occlusions: An 18-year Experience
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP93-AWMP93, February 1, 2025. Patients were selected based on the presence of angiographically proven symptomatic carotid occlusion, adequate landing zone and concurrent impairment of cerebrovascular reserve or recurrent ischemia despite maximal medical therapy.
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40 Abstract WMP9: The Effect Of Remote Ischemic Conditioning On Acute Infarct Growth In Patients With Acute Ischemic Stroke - Subgroup Analysis From The RESIST Trial
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP9-AWMP9, February 1, 2025. Background:Remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is a safe and promising neuroprotective therapy in acute ischemic stroke (AIS).
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Abstract WMP13: Cardiac Injury Potentially Contributes to Neuroinflammation via Extracellular Vesicles
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP13-AWMP13, February 1, 2025. Clinical and experimental evidence further suggest that 35%-65% of patients with myocardial ischemia are affected by CGI which include memory and global cognitive deficits.
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Abstract TP247: Iatrogenic Cervical Artery Dissections during Endovascular Interventions
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP247-ATP247, February 1, 2025. Key factors influencing clinical decision-making include location, occlusion rate, pseudoaneurysm formation, intracranial extension, distal collateral circulation, and ischemia.
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