Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP11-ATP11, February 1, 2025. Introduction:Current guidelines suggest using intravenous thrombolysis (IVT) for patients experiencing acute ischemic stroke within 4.5 The safety outcome was the rate of symptomatic intracranial hemorrhage (SICH).Results:We hours of symptom onset.

Thrombolysis 40

Thrombolysis Stroke Strokes Education 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP19-ATP19, February 1, 2025. Safety outcomes were any intracerebral hemorrhage (ICH) and symptomatic ICH (sICH) at 24-36hrs. The primary efficacy outcome was good 3-month functional outcome, defined as a modified Rankin scale (mRS) 0-2.

Thrombolysis 40

Thrombolysis Outcomes Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP222-AWP222, February 1, 2025. Background and Aims:Machine learning models have shown promising potential for automated hemorrhage detection and segmentation, alleviating highly time-consuming manual contouring and facilitating rapid clinical diagnosis. 93.7%) and accuracy of 87.4%

Hemorrhage 40

Hemorrhage Thrombolysis Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A4-A4, February 1, 2025. Introduction:The tenecteplase versus standard of care for minor ischemic stroke with proven occlusion (TEMPO-2) trial showed that patients presenting with minor deficits up to 12 h do not benefit from intravenous thrombolysis. mg/kg) or non-thrombolytic standard of care.

Thrombolysis 40

Thrombolysis Stroke Strokes Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP9-AWP9, February 1, 2025. The effectiveness and safety of intravenous thrombolysis (IVT) for acute ischemic stroke in these cases, particularly those involving large vessel occlusions, are debated. Background:Acute ischemic stroke can result from extracranial arterial dissection.

Thrombolysis 40

Thrombolysis Stroke Strokes Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP20-ATP20, February 1, 2025. The primary outcome was 3-month functional outcome by modified Rankin scale (mRS).

Thrombolysis 40

Thrombolysis Stroke Strokes Risk Factors 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP245-AWP245, February 1, 2025. Background and Aims:Previous studies indicated the usual dose heparin(5000 IU bolus followed by 500~1250 IU/h) during mechanical thrombectomy(MT) is associated with an increased risk of hemorrhagic conversion without beneficial effect. vs 21.3%, p=0.04).

Hemorrhage 40

Hemorrhage Thrombolysis Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP253-AWP253, February 1, 2025. Background and Aims:Endovascular treatment (EVT) alone has been confirmed to be non-inferior to intravenous thrombolysis (IVT) followed with EVT in acute ischemic stroke (AIS) due to large-vessel occlusion of the anterior circulation.

Thrombolysis 40

Thrombolysis Stroke Strokes Stent 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP190-ATP190, February 1, 2025. Background:The prognostic significance of the affected hemisphere in hemorrhagic stroke remains uncertain.

Quality of Life 40

Quality of Life Hemorrhage Outcomes Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP242-ATP242, February 1, 2025. Background:Symptomatic intracranial hemorrhage (sICH) is the most dreaded complication after reperfusion therapy for acute ischemic stroke. 2.07; P = 0.037). 2.07; P = 0.037). Risk of sICH was comparable between the MT and MT+IVT groups (RR: 0.77; 95%CI: 0.57-1.03;

Hemorrhage 40

Hemorrhage Thrombolysis Circulation Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP72-AWMP72, February 1, 2025. Direct-to-angiography workflow relies on CBCT to exclude intracranial hemorrhage (ICH) to determine treatment eligibility for intravenous thrombolysis (IVT) and/or mechanical thrombectomy (MT).

Hemorrhage 40

Hemorrhage Stroke Strokes Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP8-AWP8, February 1, 2025. Introduction:Current guidelines recommend 24-hours of high-intensity monitoring (HIM) for acute ischemic stroke patients post-intravenous thrombolysis (IVT) due to risk of bleeding complications including symptomatic intracranial hemorrhage (sICH).

Thrombolysis 40

Thrombolysis ICU Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A30-A30, February 1, 2025. Background and objective:Perfusion imaging studies consistently show a substantially increased risk of hemorrhagic transformation (HT) in severely hypoperfused tissue.

Hemorrhage 40

Hemorrhage Stroke Strokes Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP225-AWP225, February 1, 2025. Background:Intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) are the standard of care for select stroke patients with acute large vessel occlusion (LVO).

Hemorrhage 40

Hemorrhage Thrombolysis Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A2-A2, February 1, 2025. Lastly, our subgroup analysis did not favor any of the two groups across different types of intracranial hemorrhage (ICH).Conclusion:Our A few randomized trials have investigated EVT in AIS-LVO with large ischemic infarcts (LII).

Thrombolysis 40

Thrombolysis Hemorrhage Outcomes Stroke 40

Stroke Journal

DECEMBER 9, 2024

Stroke, Volume 56, Issue 1 , Page 183-189, January 1, 2025. We assessed the correlation of these parameters with infarct expansion, hemorrhagic transformation, and poor outcomes, defined as modified Rankin Scale scores of 4 to 6, at 3 months.RESULTS:A total of 65 cases were analyzed.

Thrombolysis 68

Thrombolysis Stroke Strokes Hemorrhage 68

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP9-ATP9, February 1, 2025. Introduction:Tenecteplase (TNK) is now an accepted alternative to Alteplase (ALT) for intravenous thrombolysis (IVT) in acute ischemic stroke (AIS).

Hemorrhage 40

Hemorrhage Diabetes Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP5-ADP5, February 1, 2025. Introduction:Outcomes after thrombolysis with alteplase (tPA) versus tenecteplase (TNK) prior to endovascular thrombectomy (EVT) have not been directly compared in real-world data (RWD). for the tPA+EVT group and 33.8%

Thrombolysis 40

Thrombolysis Hemorrhage Academic Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP72-AWP72, February 1, 2025. The transition from Alteplase to Tenecteplase for AIS patients eligible for thrombolysis occurred on June 6, 2022. EHR Alteplase references were changed to thrombolysis. The percentage of door to thrombolysis<30 minutes improved from 23.3%

Stroke 40

Stroke Strokes Thrombolysis Nursing 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP139-AWP139, February 1, 2025. Background:Telestroke allows rapid assessment of patients presenting with acute stroke symptoms for intravenous thrombolysis or endovascular thrombectomy (EVT).

Stroke 40

Stroke Strokes Thrombolysis Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP95-AWMP95, February 1, 2025. Safety outcomes assessed hemorrhagic complications.Results:Of the 108 patients, 36 received BMM and 72 underwent EVT. Nonetheless, EVT achieved high procedural success and low rates of symptomatic hemorrhage, indicating its safety.

Stroke 40

Stroke Strokes Hemorrhage Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A13-A13, February 1, 2025. We also evaluated procedural outcomes, including successful reperfusion, defined as modified Thrombolysis in Cerebral Infarction (mTICI) grade 2b-3, and complete reperfusion, defined as mTICI 3.Results:Among 4.03], P=0.19). 0.59], P=0.001).Conclusion:Intravenous

Circulation 40

Circulation Outcomes Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A127-A127, February 1, 2025. Secondary outcome evaluated symptomatic intracranial hemorrhage (sICH) post thrombolysis comparing APP versus neurology residents using Fishers exact test.

Academic 40

Academic Thrombolysis Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP83-AWP83, February 1, 2025. Background:Stroke centers across the country followadhere to established best practice timeframes for stroke care delivery, such as door-to-doctor, door-to-CT, and door-to-needle times.

Stroke 40

Stroke Strokes Best Practices Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A58-A58, February 1, 2025. While intravenous thrombolysis is recommended within 4.5 Background:Acute ischemic stroke (AIS) is a leading cause of disability worldwide. hours of symptom onset, many patients present beyond this window.

Stroke 40

Stroke Strokes Thrombolysis Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP248-AWP248, February 1, 2025. In such a population, the safety and efficacy of EVT remain uncertain, with emphasis on the risk of intracranial hemorrhage (ICH).Method:We Oral anticoagulants (OAC) are often prescribed for stroke prevention. Safety outcomes included ICH and 90 days mortality.

Stroke 40

Stroke Strokes Thrombolysis Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP24-AWP24, February 1, 2025. Introduction:Because of the risk of infarcted tissue leading to symptomatic intracerebral hemorrhage (sICH) after intravenous thrombolysis for acute ischemic stroke, patients are monitored for at least 24 hours in a critical care setting.

Thrombolysis 40

Thrombolysis Hemorrhage Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP4-ATP4, February 1, 2025. Introduction:Current guidelines exclude patients with recent NOAC use from thrombolysis, even if they present during the 4.5hr timeframe. of last known well.

Thrombolysis 40

Thrombolysis Stroke Strokes AFIB 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP175-ATP175, February 1, 2025. Secondary outcomes included mRS 0-1 at 90 days, symptomatic intracranial hemorrhage (sICH), and death.Results:A total of 704 patients (mean age 7513 years, 52% women) were included in the study, with 214 having no CBF core (0 mL) and 490 having a CBF core.

Stroke 40

Stroke Strokes Thrombolysis Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP186-ATP186, February 1, 2025. Methods:AIS data was retrieved from the Norwegian Cognitive Impairment After Stroke study (Nor-COAST; NOR) and the Registry for Neurological Endpoints among patients with Ischemic and Hemorrhagic Stroke(REINAH; US).

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Stroke Strokes Thrombolysis Atrial Fibrillation 40