2025, Dementia and Risk Factors - Cardiovascular Update

Abstract WP269: Predicting post-stroke all-cause dementia incidence using machine learning models and electronic health record data

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP269-AWP269, February 1, 2025. Introduction:All-cause dementia remains a significant public health concern, with stroke recognized as a key risk factor. The primary outcome was the incidence of all-cause dementia within one year post-stroke. The sample was 48.4%

Dementia

Dementia Stroke Strokes Blood Pressure

Abstract TP33: Microhemorrhages and Cortical Superficial Siderosis in Cognitively Impaired Patients: Prevalence and Risk Factors

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP33-ATP33, February 1, 2025. (1) The risk factors for cerebral MB and cSS and their relationship with cognitive decline are not well known.(2) The risk factors for cerebral MB and cSS and their relationship with cognitive decline are not well known.(2)

Risk Factors

Risk Factors Hypertension Dementia Hospital

Abstract DP22: The NOMAS-CBI Score: Development of a Risk Factor-Based Score to Detect Covert Brain Infarcts on MRI

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP22-ADP22, February 1, 2025. Introduction:Covert brain infarcts (CBIs) are associated with risk of stroke and dementia. It is unknown whether surveillance for CBIs and medical management can mitigate this risk. Exclusion criteria: missing information on risk-factor variables.

Risk Factors

Risk Factors Cardiovascular Disease Dementia Strokes

Webinars

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Abstract WMP117: SARS-CoV-2 infection worsens neuroinflammation and brain senescence in an endothelial nitric oxide synthase deficient model of vascular dementia.

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP117-AWMP117, February 1, 2025. Endothelial dysfunction, a key mechanism in COVID-19 illness, is also a major risk factor for vascular dementia (VaD). Introduction:SARS-CoV-2 causes various neurological sequelae in COVID-19 survivors including fatigue and cognitive dysfunction.

COVID-19

COVID-19 Dementia Risk Factors Pulmonary

Abstract WP44: Homocysteine mediates the impact of PFO shunt on vascular cognitive impairment

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP44-AWP44, February 1, 2025. Background:Patent foramen ovale (PFO) is an independent risk factor for neurovascular injury such as stroke. We previously found that large PFO shunt is associated with increased long-term risk of vascular dementia.

Dementia

Dementia Risk Factors Echocardiogram Circulation

Abstract TP252: Modulation of Piezo1 Channels Improves Cerebral Blood Flow in a Mouse Model of Alzheimer's Disease.

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP252-ATP252, February 1, 2025. Alzheimers Disease (AD) is the most common form of dementia and is characterized by progressive neurodegeneration and cognitive decline.

Dementia

Dementia Risk Factors Strokes Stroke

Abstract 139: Association between Cerebral Amyloid Angiopathy and Non-Traumatic Subdural Hemorrhage

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A139-A139, February 1, 2025. Using Cox regression analyses, we compared the risk of incident SDH among the three groups after adjustment for demographics and comorbidities. In pre-specified sensitivity analyses, patients with a diagnosis of dementia at baseline were excluded.Results:Among 8.5

Hemorrhage

Hemorrhage Cerebrovascular Disease Dementia Document

Abstract DP15: Increased Severity of Blood-Brain Barrier Disruption is Associated with Greater Burden of Cerebrovascular Disease in Asymptomatic Patients

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP15-ADP15, February 1, 2025. Background:White matter hyperintensities (WMH) of presumed vascular origin can be associated with vascular cognitive impairment and dementia. However, WMH are also seen in asymptomatic subjects. FLAIR/T1 images were segmented to create WMH masks.

Cerebrovascular Disease

Cerebrovascular Disease Dementia Risk Factors Cardiovascular Disease

Abstract WP319: Reliability and validity of self-reported risk factors for stroke and dementia

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP319-AWP319, February 1, 2025. Introduction:Stroke and dementia are among the leading causes of mortality globally. This can be mitigated through targeting modifiable risk factors.

Risk Factors

Risk Factors Dementia Stroke Strokes

Abstract WMP18: The Association between Cerebral Microbleed Patterns and Incident Dementia: The ARIC-Neurocognitive Study

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP18-AWMP18, February 1, 2025. Background:Cerebral microbleeds (CMBs) are associated with incident dementia, but the impact of specific CMB patterns is unclear. Compared to individuals with no CMBs, presence of any CMBs was associated with an increased risk of dementia (Table 2).

Dementia

Dementia Certification Atherosclerosis Risk Factors

Abstract TP358: Stroke Exacerbates Respiratory Function and Cognition in Mice with Dementia

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP358-ATP358, February 1, 2025. Introduction:Stroke is a well-established independent risk factor for the development of dementia. Most dementia patients exhibit mixed brain pathologies, with histological evidence of ischemia and A plaque accumulation, observed at autopsy.

Dementia

Dementia Stroke Strokes Risk Factors

Socioeconomic Disparities in Rate of Poststroke Dementia: A Nationwide Cohort Study

Stroke Journal

DECEMBER 5, 2024

Stroke, Volume 56, Issue 1 , Page 65-73, January 1, 2025. We aimed to investigate whether socioeconomic status was associated with the rate of poststroke dementia (PSD).METHODS:This PSD was defined as a dementia diagnosis in the National Patient Registry or a dispensed prescription of dementia medication after a stroke.

Dementia

Dementia Education Stroke Strokes

Abstract WP285: Lifelong trends in vascular risk factors and cerebral small vessel disease

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP285-AWP285, February 1, 2025. Introduction:Cerebral small vessel disease (CSVD) is linked to stroke and dementia risk, often predating clinical events for years to decades.

Risk Factors

Risk Factors Blood Pressure Dementia Strokes

Abstract DP12: Leukocyte Telomere Length as a Predictor of Age-Related Brain Diseases: Evidence from the UK Biobank

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP12-ADP12, February 1, 2025. Introduction:Stroke, dementia, and late-life depression (LLD) are age-related brain diseases that pose significant public health challenges. 0.92); dementia HRs were 0.86 (95%CI: 0.81-0.91) We used a modified 19-point BCS adapted to available UKB data.

Dementia

Dementia Public Health Strokes Stroke

Abstract TP42: Chronic cerebral hypoperfusion impairs brain iron metabolism in aged mice

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP42-ATP42, February 1, 2025. Introduction:Aging and chronic cerebral hypoperfusion (CCH) are major risk factors for Vascular contribution to cognitive impairment and dementia (VCID), which is a heterogeneous group of disorders characterized by cognitive deficits secondary to cerebrovascular pathology.

Dementia

Dementia Stenosis Risk Factors Stroke

Abstract WP310: Midlife Vascular Risk Factors, Dementia, and Parkinson's Disease-Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP310-AWP310, February 1, 2025. Background:Vascular risk factors, particularly in midlife, are associated with an increased risk of dementia, and smoking has been inversely associated with Parkinson's disease (PD) risk, but the role of these factors in PD-dementia (PDD) is less clear.

Dementia

Dementia Risk Factors Atherosclerosis Obesity

Abstract TP378: Malondialdehyde as a Clinical Indicator for Oxidative Stress: Associations with Age, BMI, and Cognitive Impairment

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP378-ATP378, February 1, 2025. Accumulation of oxidative stress has been shown to trigger the initiation and progression of cognitive deficits, including mild cognitive impairment (MCI) and Alzheimers Dementia (AD).

BMI

BMI Biomarkers Dementia Strokes

The legal case – naming a few names

Dr. Malcolm Kendrick

OCTOBER 30, 2024

(2022-25) Swiss Reinsurance Company: £645K China Kadoorie Biobank (2002-ongoing) AstraZeneca: $300K Bayer AG: £300K GlaxoSmithKline: £3.6M Elinogrel feasibility trial (2010-2011) Novartis: £500K EMPA-KIDNEY (2017-ongoing) Boehringer Ingelheim: £106.3M Establishing Fuwai-Oxford research centre (2010-ongoing) Merck: £1.1M

Cholesterol

Cholesterol Article Research Diet

Abstract WP269: Predicting post-stroke all-cause dementia incidence using machine learning models and electronic health record data

Abstract TP33: Microhemorrhages and Cortical Superficial Siderosis in Cognitively Impaired Patients: Prevalence and Risk Factors

Abstract DP22: The NOMAS-CBI Score: Development of a Risk Factor-Based Score to Detect Covert Brain Infarcts on MRI

Webinars

Abstract WMP117: SARS-CoV-2 infection worsens neuroinflammation and brain senescence in an endothelial nitric oxide synthase deficient model of vascular dementia.

Abstract WP44: Homocysteine mediates the impact of PFO shunt on vascular cognitive impairment

Abstract TP252: Modulation of Piezo1 Channels Improves Cerebral Blood Flow in a Mouse Model of Alzheimer's Disease.

Abstract 139: Association between Cerebral Amyloid Angiopathy and Non-Traumatic Subdural Hemorrhage

Abstract DP15: Increased Severity of Blood-Brain Barrier Disruption is Associated with Greater Burden of Cerebrovascular Disease in Asymptomatic Patients

Abstract WP319: Reliability and validity of self-reported risk factors for stroke and dementia

Abstract WMP18: The Association between Cerebral Microbleed Patterns and Incident Dementia: The ARIC-Neurocognitive Study

Abstract TP358: Stroke Exacerbates Respiratory Function and Cognition in Mice with Dementia

Socioeconomic Disparities in Rate of Poststroke Dementia: A Nationwide Cohort Study

Abstract WP285: Lifelong trends in vascular risk factors and cerebral small vessel disease

Abstract DP12: Leukocyte Telomere Length as a Predictor of Age-Related Brain Diseases: Evidence from the UK Biobank

Abstract TP42: Chronic cerebral hypoperfusion impairs brain iron metabolism in aged mice

Abstract WP310: Midlife Vascular Risk Factors, Dementia, and Parkinson's Disease-Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort

Abstract TP378: Malondialdehyde as a Clinical Indicator for Oxidative Stress: Associations with Age, BMI, and Cognitive Impairment

The legal case – naming a few names

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