2025, Circulation and Thrombolysis - Cardiovascular Update

Abstract WP13: Determining Eligible Thrombolysis Candidates for Isolated Dizziness

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP13-AWP13, February 1, 2025. Introduction:Strokes affecting the posterior circulation (PCS) account for 20% of all ischemic strokes. The number of stroke mimics presenting with isolated dizziness who received thrombolysis was 11 in 2021, 16 in 2022, 9 in 2023, and 11 in 2024.

Thrombolysis

Thrombolysis Stroke Strokes Circulation

Abstract TP19: Intravenous thrombolysis before inter-facility transfer for thrombectomy

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP19-ATP19, February 1, 2025. Background:Patients with acute ischemic stroke and a large vessel occlusion (LVO) admitted to primary stroke centers (PSC) often require inter-facility transfer for thrombectomy.

Thrombolysis

Thrombolysis Outcomes Stroke Strokes

Abstract WP253: A Multicenter, Prospective, Randomized Controlled Trial of Endovascular Treatment with or without Intravenous ThromBolysis in Acute Ischemic Stroke of Basilar Artery Occlusion (BEST-BAO): Study Protocol

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP253-AWP253, February 1, 2025. Background and Aims:Endovascular treatment (EVT) alone has been confirmed to be non-inferior to intravenous thrombolysis (IVT) followed with EVT in acute ischemic stroke (AIS) due to large-vessel occlusion of the anterior circulation.

Thrombolysis

Thrombolysis Stroke Strokes Stents

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

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Abstract WP3: Large Vessel Recanalization with Thrombolysis Prior to Thrombectomy: Incidence, Outcomes, and Associations With Collateral Status

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP3-AWP3, February 1, 2025. Introduction:Large vessel recanalization (LVR) is a well described phenomenon following intravenous thrombolysis (IVT). Better collateral circulation was independently associated with both higher odds of LVR, as well as lower odds of infarct progression.

Thrombolysis

Thrombolysis Outcomes Circulation Stroke

Abstract 13: Intravenous Tirofiban as An Adjunct to Endovascular Therapy for Posterior Circulation Strokes with Tandem Lesions: One-Year Outcomes

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A13-A13, February 1, 2025. We also evaluated procedural outcomes, including successful reperfusion, defined as modified Thrombolysis in Cerebral Infarction (mTICI) grade 2b-3, and complete reperfusion, defined as mTICI 3.Results:Among 4.03], P=0.19).

Circulation

Circulation Outcomes Stroke Strokes

Abstract WP354: Neuroinflammatory Factor Response in Acute Ischemic Stroke Correlates with Lesion Volume and Stroke Severity: Circulating Blood from a Mobile Stroke Unit and during Hospitalization

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP354-AWP354, February 1, 2025. Twenty-three (88%) patients received IV thrombolysis and 7 (27%) had mechanical thrombectomy. Background:Circulating neuroinflammatory factors change rapidly in acute stroke, but the association with ischemic lesion size and stroke severity is unknown.

Stroke

Stroke Strokes Circulation Hospital

Abstract TP242: Risk of symptomatic intracranial hemorrhage after mechanical thrombectomy in randomized clinical trials: A systematic review and meta-analysis

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP242-ATP242, February 1, 2025. Results:MT in the anterior circulation was associated with a significantly higher risk of sICH as compared with no-MT (RR: 1.46; 95%CI: 1.03-2.07; The sICH risk for MT in the posterior circulation (RR: 7.48; 95%CI: 2.27-24.61) 2.07; P = 0.037).

Hemorrhage

Hemorrhage Thrombolysis Circulation Stroke

Abstract TP87: Validation of Prognostic Scales for Functional Outcome in Ischemic Stroke Patients Treated with Intravenous Thrombolysis in a Rural Setting: a preliminary data analysis

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP87-ATP87, February 1, 2025. 12% of the cohort (n=34) had posterior circulation stroke. Background:Early prediction of functional outcome after rtPA helps clinicians in prognostic conversations with stroke patients and their families. Of those, 43% (n=119) were male.

Thrombolysis

Thrombolysis Stroke Strokes Outcomes

Abstract TP140: The Blood Proteome Profiling Identifies Biomarkers Associated With Ischemic Stroke Prognosis

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP140-ATP140, February 1, 2025. Blackground:Due to the narrow therapeutic time window and strict indications, there are still a large number of patients unable to receive thrombolysis and endovascular therapy, resulting in a poor long-term functional prognosis.

Biomarkers

Biomarkers Stroke Strokes Technology

Abstract WP260: The Role of Fibrinogen in the Pathogenesis of Intracranial Atherosclerosis-Related Large Vessel Occlusion Strokes

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP260-AWP260, February 1, 2025. L), intravenous thrombolysis was associated with a reduced number of thrombectomy device passes.Conclusions:Fibrinogen plays a significant role in facilitating thrombosis and the occurrence of LVOS in patients with ICAS.

Atherosclerosis

Atherosclerosis Stroke Strokes Atrial Fibrillation

Impact of Time to Catheter-Based Therapy on Outcomes in Acute Pulmonary Embolism

Circulation: Cardiovascular Interventions

JANUARY 20, 2025

Circulation: Cardiovascular Interventions, Volume 18, Issue 1 , Page e014499, January 1, 2025. years; 44% women; 29% catheter-directed thrombolysis; 68% mechanical thrombectomy; and 3% both). Inverse probability of treatment weighting was used to balance covariates.RESULTS:A total of 133 patients were included (mean age, 58.3

Embolism

Embolism Pulmonary Outcomes Cardiac Arrest

Abstract TP175: Hidden Core: Unveiling the Clinical Impact of CTP-Invisible Ischemic Lesions in Large Vessel Occlusion Stroke Treated with Thrombectomy

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP175-ATP175, February 1, 2025. Anterior circulation AIS patients with large vessel occlusion were grouped based on the presence of a CBF core, defined as either 0 mL or greater than 0 mL, with a relative CBF less than 30% of normally perfused tissue on CT perfusion imaging. 2.25, p=0.04).Conclusions:Stroke

Stroke

Stroke Strokes Thrombolysis Outcomes

Abstract WP13: Determining Eligible Thrombolysis Candidates for Isolated Dizziness

Abstract TP19: Intravenous thrombolysis before inter-facility transfer for thrombectomy

Abstract WP253: A Multicenter, Prospective, Randomized Controlled Trial of Endovascular Treatment with or without Intravenous ThromBolysis in Acute Ischemic Stroke of Basilar Artery Occlusion (BEST-BAO): Study Protocol

Webinars

Abstract WP3: Large Vessel Recanalization with Thrombolysis Prior to Thrombectomy: Incidence, Outcomes, and Associations With Collateral Status

Abstract 13: Intravenous Tirofiban as An Adjunct to Endovascular Therapy for Posterior Circulation Strokes with Tandem Lesions: One-Year Outcomes

Abstract WP354: Neuroinflammatory Factor Response in Acute Ischemic Stroke Correlates with Lesion Volume and Stroke Severity: Circulating Blood from a Mobile Stroke Unit and during Hospitalization

Abstract TP242: Risk of symptomatic intracranial hemorrhage after mechanical thrombectomy in randomized clinical trials: A systematic review and meta-analysis

Abstract TP87: Validation of Prognostic Scales for Functional Outcome in Ischemic Stroke Patients Treated with Intravenous Thrombolysis in a Rural Setting: a preliminary data analysis

Abstract TP140: The Blood Proteome Profiling Identifies Biomarkers Associated With Ischemic Stroke Prognosis

Abstract WP260: The Role of Fibrinogen in the Pathogenesis of Intracranial Atherosclerosis-Related Large Vessel Occlusion Strokes

Impact of Time to Catheter-Based Therapy on Outcomes in Acute Pulmonary Embolism

Abstract TP175: Hidden Core: Unveiling the Clinical Impact of CTP-Invisible Ischemic Lesions in Large Vessel Occlusion Stroke Treated with Thrombectomy

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