Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP227-AWP227, February 1, 2025. Introduction:Intracerebral hemorrhage (ICH) is commonly associated with poor neurologic outcomes. Early intervention has been shown to improve patient prognosis, highlighting the necessity of sensitive biomarkers. Specifically, functional parameters (i.e.,

Biomarkers 40

Biomarkers Physiology Hemorrhage Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP32-AWMP32, February 1, 2025. Our outcomes were differentially expressed protein (DEP) levels between patients with acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), transient ischemic attack (TIA), and stroke mimics (MIM). Results:We included 100 patients (mean age 58.6

Biomarkers 40

Biomarkers Stroke Strokes Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP341-ATP341, February 1, 2025. Introduction:Peripheral blood-based biomarker development for neurological diseases such as ischemic stroke has traditionally focused on measuring alterations in leukocyte number and composition.

Biomarkers 40

Biomarkers Stroke Strokes Outcomes 40

DAIC

MARCH 25, 2025

tim.hodson Tue, 03/25/2025 - 16:19 March 25, 2025 Bayer plans to present data from 13 new analyses from across t he KERENDIA (finerenone) comprehensive clinical trial program at the American College of Cardiology (ACC) 74 th Annual Scientific Session & Expo 2025 , in Chicago, IL, March 29-31, 2025. Additional ACC.25

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Preserved Ejection Fraction Heart Failure Research Academic 52

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP359-AWP359, February 1, 2025. Background:Mechanical thrombectomy has been associated with improved outcomes in patients with acute ischemic stroke. However, not all patients with successful reperfusion experience good functional outcomes.

Biomarkers 40

Biomarkers Stroke Strokes Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP35-AWP35, February 1, 2025. Neutrophils are reported to be critical mediators of to poor outcome after subarachnoid hemorrhage (SAH). Finally, as neutrophil counts (and the ratio of neutrophils to lymphocytes) are reported to be a biomarker for DCI, we assessed these measures too.

Aneurysm 40

Aneurysm Biomarkers Ischemia Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP6-AWP6, February 1, 2025. Background and Purpose:Whether imaging markers of cerebral small vessel disease on computed tomography (CT-CSVD) relates to early clinical outcomes after intravenous thrombolysis for acute ischemic stroke remains not well understood.

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Thrombolysis Outcomes Biomarkers Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP232-AWP232, February 1, 2025. Accurate prediction of the clinical outcomes in ICH patients is essential for effective clinical management. Results:We included 29 studies comprising 4,597 patients, with a mortality and poor functional outcomes rates of 21.2% and 47.8%, respectively.

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Hemorrhage Outcomes Biomarkers Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP343-ATP343, February 1, 2025. We generated the co-expression networks using the Weighted Gene Co-Expression Network Analysis (WGCNA) package to determine modules (groups of co-expressed genes) associated with 90-day SAH outcome.

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Hemorrhage Outcomes Biomarkers Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP112-ATMP112, February 1, 2025. Introduction:Both histological and transcriptomic analyses of acute ischemic stroke (AIS) clots have identified features associated with mechanical thrombectomy (MT) outcome. Expression of DEGs was able to separate clots by FP outcome.

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Outcomes Stroke Strokes Biomarkers 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP320-ATP320, February 1, 2025. The primary outcome of this study was KYN, and the secondary outcome were TRP, kynurenine/tryptophan ratio (KYN/TRP), and kynurenic acid (KYNA).

Stroke 40

Stroke Strokes Biomarkers Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP16-ADP16, February 1, 2025. Our outcome was differentially expressed levels of proteins in AIS patients classified by NIHSS scores. Introduction:The National Institutes of Health Stroke Scale (NIHSS) provides a clinical measure of stroke severity. to classify mild NIHSS, 0.66

Stroke 40

Stroke Strokes Biomarkers Hospital 40

Cardiometabolic Health Congress

OCTOBER 25, 2024

Attendees dove into cutting-edge topics, including FDA updates, resistant hypertension, and cardiac biomarkers. “I Morris, MD, led discussions on LDL-lowering therapy, Martha Gulati, MD, MS, FACC, FAHA, FASPC , FESC, presented on cardiovascular outcomes in women, and Christie M. Ballantyne, MD , explored Lipoprotein(a).

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CME Innovation Education Atherosclerosis 64

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP54-ADP54, February 1, 2025. The outcome was ischemic stroke during follow up. Background:Randomized trials and observational of patients with cervical artery dissection showed no significant difference in ischemic stroke risk with anticoagulation versus antiplatelet therapy.

Stroke 40

Stroke Strokes Biomarkers Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP4-ATMP4, February 1, 2025. This study aims to identify serum protein biomarkers specifically targeting cerebral edema in EBI and cell-specific interventional targets.Methods:This study is based on a prospective observational cohort at a single tertiary referral center. 35% had severe edema.

Aneurysm 40

Aneurysm Hemorrhage Biomarkers Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP79-AWMP79, February 1, 2025. Background and Purpose:The inflammatory response after ischemic and hemorrhagic stroke is associated with worse clinical outcomes through immune mediated production of pro- inflammatory cytokines.

Exercise 40

Exercise Hemorrhage Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP272-AWP272, February 1, 2025. The study outcome was atrial cardiopathy, defined as a left atrial volume index 35 mL/m2as determined by echocardiography. Background:Cancer is associated with an increased risk for atrial fibrillation. The study exposure was active cancer.

Cancer 40

Cancer Stroke Strokes Atrial Fibrillation 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP385-ATP385, February 1, 2025. Emerging research suggests that Vitamin D3 might help protect against brain damage caused by ischemic stroke, as a deficiency in Vitamin D3 can worsen the severity and outcomes of a stroke.

Diet 40

Diet Stroke Strokes Biomarkers 40

Circulation: Cardiovascular Quality & Outcomes

SEPTEMBER 2, 2024

Circulation: Cardiovascular Quality and Outcomes, Volume 18, Issue 1 , Page e011504, January 1, 2025. BACKGROUND:Risk stratification strategies for cancer therapeuticsrelated cardiac dysfunction (CTRCD) rely on serial monitoring by specialized imaging, limiting their scalability.

Cancer 40

Cancer Cardiomyopathy Echocardiogram Biomarkers 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP105-AWMP105, February 1, 2025. Introduction:Accurate prediction of the risk of ischemic stroke (IS) is vital for prevention and would be aided by multimodal biomarkers integrating genetic, clinical, and functional data.

Stroke 40

Stroke Strokes Atrial Fibrillation Biomarkers 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP42-AWMP42, February 1, 2025. Shoulder abduction and finger extension, collectively (SAFE), have been suggested to have prognostic value for stroke outcomes (e.g. The integrity of the corticospinal tract has frequently been suggested as a biomarker of stroke recovery.

Research 40

Research Stroke Strokes Biomarkers 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A25-A25, February 1, 2025. We hypothesize serum biomarker analyses during the hyperacute phase can bridge the gap.Methods:This is a single center study of 20 AIS patients&14 age/sex matched controls enrolled from 3/2022-6/2023. Mortality rate was 10%.

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Biomarkers Stroke Strokes Thrombolysis 40

Journal of the American Heart Association

JANUARY 22, 2025

Journal of the American Heart Association, Volume 14, Issue 2 , January 21, 2025. BackgroundCardiac biomarkers improve risk prediction in patients with atrial fibrillation (AF). Higher levels of all 4 neuroglial biomarkers were correlated with increasing age and female sex. During a median followup of 3.6

Biomarkers 40

Biomarkers Atrial Fibrillation Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP93-AWP93, February 1, 2025. AFib diagnosis is critical to optimize secondary prevention and reduce the recurrent stroke risk.Objectives:We undertook an exploratory cross-platform proteomics study to discover plasma biomarkers of AFib diagnosis in patients with IS or transient ischemic attack (TIA).Methods:We

Biomarkers 40

Biomarkers AFIB Atrial Fibrillation Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP378-ATP378, February 1, 2025. One emerging biomarker able to reliably measure oxidative stress is Malondialdehyde (MDA), a reactive carbonyl compound originating from polyunsaturated fatty acid oxidation and lipid peroxidation.

BMI 40

BMI Biomarkers Dementia Stroke 40

Stroke Journal

MARCH 23, 2025

Stroke, Volume 56, Issue 4 , Page 915-925, April 1, 2025. Work is needed in standardizing imaging protocols to improve the reliability of ADC as an imaging biomarker in stroke management protocols to improve the reliability of ADC as an imaging biomarker in stroke management.

Stroke 40

Stroke Strokes Biomarkers Circulation 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A93-A93, February 1, 2025. Background:Stroke outcomes vary with ethnicity, with immune response markers like interferon-gamma (IFN-) playing a significant role in stroke pathophysiology. This heightened response may contribute to worse stroke outcomes in this population.

Stroke 40

Stroke Strokes Biomarkers Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A102-A102, February 1, 2025. Background and Purpose:Chronic kidney disease (CKD) is associated with an increased risk of stroke and worse outcomes, yet it is often asymptomatic, with an estimated 90% of individuals unaware they have CKD until its later stages.

Atherosclerosis 40

Atherosclerosis Kidney Disease Blood Pressure Biomarkers 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP47-ADP47, February 1, 2025. Introduction:Chronic kidney disease (CKD) is a risk factor for intracerebral hemorrhage (ICH) and for worse outcomes following ICH.

Kidney Disease 40

Kidney Disease Hemorrhage Risk Factors Heart Disease 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP360-AWP360, February 1, 2025. Introduction:Loneliness and social isolation (SI) are associated with both an increased risk of stroke and poor outcomes after stroke. Further, alterations of sex-specific miRNA profiles in isolated post-stroke patients suggest its potential as a biomarker.

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Stroke Strokes Biomarkers Outcomes 40

Cardiometabolic Health Congress

NOVEMBER 14, 2024

With the holiday season approaching and fall in full swing, it’s the perfect time to reaffirm our commitment to delivering excellent care, improving patient outcomes, and making the most of every available resource. cardiometabolic health CME/CE conference: the 19th Annual CMHC. .”

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CME Obesity Heart Failure Biomarkers 103

Dr. Malcolm Kendrick

OCTOBER 30, 2024

(2022-25) Swiss Reinsurance Company: £645K China Kadoorie Biobank (2002-ongoing) AstraZeneca: $300K Bayer AG: £300K GlaxoSmithKline: £3.6M Elinogrel feasibility trial (2010-2011) Novartis: £500K EMPA-KIDNEY (2017-ongoing) Boehringer Ingelheim: £106.3M Establishing Fuwai-Oxford research centre (2010-ongoing) Merck: £1.1M

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Cholesterol Article Research Diet 145

Dr. Smith's ECG Blog

FEBRUARY 26, 2025

Both reperfusion, as judged by the biomarker curve, and patency, as assessed by the angiogram, were correlated with the rapidity and depth of T wave inversion. link] == MY Comment , by K EN G RAUER, MD ( 1/14 /2025 ): == I found today's case highly insightful with regard to many aspects. 2018, July 30). American College of Cardiology.

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Chest Pain Pericarditis Myocardial Infarction Dementia 89