2025, Biomarkers and Hemorrhage - Cardiovascular Update

Abstract WP230: Neuroinflammation Biomarker in the Course and Prognosis of Hemorrhagic Strokes

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP230-AWP230, February 1, 2025. Hemorrhagic strokes (HS) are increasingly significant causes of disability and mortality worldwide, making the use of blood biomarkers for their diagnosis and prognosis critical.

Hemorrhage

Hemorrhage Biomarkers Stroke Strokes

Abstract WP227: Physiological Magnetic Resonance Imaging Biomarkers for Early Detection of Microvascular Dysfunction in Acute Intracerebral Hemorrhage

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP227-AWP227, February 1, 2025. Introduction:Intracerebral hemorrhage (ICH) is commonly associated with poor neurologic outcomes. Early intervention has been shown to improve patient prognosis, highlighting the necessity of sensitive biomarkers. Specifically, functional parameters (i.e.,

Biomarkers

Biomarkers Physiology Hemorrhage Stroke

Abstract WP35: Neutrophil Extracellular Traps As a Biomarker for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP35-AWP35, February 1, 2025. Neutrophils are reported to be critical mediators of to poor outcome after subarachnoid hemorrhage (SAH). Finally, as neutrophil counts (and the ratio of neutrophils to lymphocytes) are reported to be a biomarker for DCI, we assessed these measures too.

Aneurysm

Aneurysm Biomarkers Ischemia Hemorrhage

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Abstract TP44: Alpha-1-acid glycoprotein is a potential serum Biomarker for Cerebral Amyloid Angiopathy

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP44-ATP44, February 1, 2025. It is closely linked to Alzheimer's disease (AD) and predisposes elderly patients to intracerebral hemorrhage and cognitive impairment. However, no effective serum biomarker has been established for early diagnosis or prediction of the disease progression.

Biomarkers

Biomarkers Hemorrhage Stroke Strokes

Abstract WMP32: Cross-Platform Proteomics and Machine Learning Algorithms Nominate Biomarkers of Stroke Diagnosis: An Exploratory Study

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP32-AWMP32, February 1, 2025. Our outcomes were differentially expressed protein (DEP) levels between patients with acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), transient ischemic attack (TIA), and stroke mimics (MIM). For pairwise comparisons, we identified the DEPs using 1.5-fold

Biomarkers

Biomarkers Stroke Strokes Hemorrhage

Abstract TMP4: Serum Protein Biomarekrs and Cell Suptypes Linked to Reduced Cerebral Edema in Aneurysmal Subarachnoid Hemorrhage

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP4-ATMP4, February 1, 2025. Introduction:Early brain injury (EBI), a complex collection of pathophysiological processes occurring within 72 hours aneurysmal subarachnoid hemorrhage (aSAH), is the key link connecting the initial event to the delayed and long-term complications.

Aneurysm

Aneurysm Hemorrhage Biomarkers Stroke

Abstract TP310: The Shifting Evidence for Statin Use in the Setting of Intracerebral Hemorrhage

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP310-ATP310, February 1, 2025. Introduction:Intracerebral Hemorrhage (ICH) is associated with a high case fatality and survivors of ICH are at increased risk for ICH recurrence. Roughly 20-30% of patients with ICH take a statin at the time of ICH onset.

Hemorrhage

Hemorrhage Cholesterol Biomarkers Article

Abstract WP370: Platelet morphology but not coagulation markers predicts delayed cerebral ischemia after subarachnoid hemorrhage

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP370-AWP370, February 1, 2025. Approximately 30% of aneurysmal subarachnoid hemorrhage (aSAH) patients who survive the rupture develop delayed cerebral ischemia (DCI) 4 to 10 days following aSAH.

Ischemia

Ischemia Hemorrhage Biomarkers Aneurysm

Abstract WP224: Hematoma location and symptom onset to sampling time are predictors of GFAP release into plasma in acute intracerebral hemorrhage

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP224-AWP224, February 1, 2025. Background:The astroglial protein GFAP (glial fibrillary acidic protein) is a promising biomarker candidate for prehospital differentiation between intracerebral hemorrhage (ICH) and ischemic stroke.

Hemorrhage

Hemorrhage Biomarkers Stroke Strokes

Abstract TP377: A Biomarker Based on Aneurysm Wall Enhancement and Blood Gene Expression to Identify Symptomatic Intracranial Aneurysms

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP377-ATP377, February 1, 2025. Introduction:Intracranial aneurysms (IAs) are weak outpouchings on cerebral vessels that can rupture, causing subarachnoid hemorrhage.

Aneurysm

Aneurysm Biomarkers Hemorrhage Stroke

Abstract WP232: Prediction Value of Intravenous Contrast Extravasation for Mortality and Poor Functional Outcomes in Intracerebral Hemorrhage: An Accuracy Meta-analysis

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP232-AWP232, February 1, 2025. Background:Intracerebral hemorrhage (ICH) is a critical neurological condition with high rates of mortality and morbidity. However, fully adopting this biomarker for mortality outcome prediction requires further analysis of heterogeneity sources.

Hemorrhage

Hemorrhage Outcomes Biomarkers Stroke

Abstract TP343: Co-Expression Modules In The Periphreal Blood Transcriptome Following Subarachnoid Hemorrhage Associate With 90-Day Outcome

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP343-ATP343, February 1, 2025. Background:Subarachnoid Hemorrhage (SAH) accounts for 2-7% of strokes and has high mortality and morbidity. The identified genes and networks may guide the search for potential biomarkers of outcome and novel treatment targets.

Hemorrhage

Hemorrhage Outcomes Biomarkers Stroke

Abstract WMP79: Biologic mechanisms of Early Exercise After Acute Ischemic Stroke and Intracerebral Hemorrhage (BEACH): A Pilot Randomized Controlled Trial of Cycle Ergometry after Stroke

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP79-AWMP79, February 1, 2025. Background and Purpose:The inflammatory response after ischemic and hemorrhagic stroke is associated with worse clinical outcomes through immune mediated production of pro- inflammatory cytokines. Of 25 enrolled patients, mean age was 65.8 (SD,

Exercise

Exercise Hemorrhage Stroke Strokes

Abstract 47: Rapid prehospital diagnosis of intracerebral hemorrhage in acute stroke patients by measuring GFAP on a point-of-care platform (DETECT study)

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A47-A47, February 1, 2025. Introduction:The rapid identification of acute intracerebral hemorrhage (ICH) in patients with symptoms of acute stroke is decisive for prehospital triage and initiation of targeted therapies.

Hemorrhage

Hemorrhage Stroke Strokes Blood Pressure

Abstract WP338: Proteomic Analysis of Carotid Artery Plaques With and Without Vulnerable Features on Magnetic Resonance Angiography with Vessel Wall Imaging: A Pilot Study

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP338-AWP338, February 1, 2025. From those, intraplaque hemorrhage was the most common feature (81.1%).Proteomic Furthermore, these patients could benefit from early surgical intervention if these biomarkers were to be detected. of patients had symptomatic disease.

Plaque

Plaque Biomarkers Stroke Strokes

Abstract TP209: Improving Neuroimaging Data Processing in Clinical Trials Through Automated Cloud-based Analysis

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP209-ATP209, February 1, 2025. This workflow, which involves downloading imaging data from a clinical trials electronic data capture (EDC) system, performing biomarker analyses, and then re-entering data into the EDC, can be cumbersome when performed manually.

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Download Biomarkers Hemorrhage Research

Abstract TP320: The Kynurenine pathway and its metabolites in stroke: A systematic review and meta-analysis of clinical studies

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP320-ATP320, February 1, 2025. Further subgroup analysis revealed significant differences between ischemic stroke and hemorrhagic stroke subgroups (P=0.03).Conclusions:These The alterations in this pathway have been confirmed in psychiatric disorders, but their role in stroke remains unclear.

Stroke

Stroke Strokes Biomarkers Hemorrhage

Abstract WMP42: Exploring The Neural Basis Of Prognostic Tools For Upper Limb Recovery After Stroke: Lesion Topography Of SAFE And Other Medical Research Council Scale Scores

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP42-AWMP42, February 1, 2025. Males=147; Right Hemisphere=131; Ischemic=199, Hemorrhagic=27). The integrity of the corticospinal tract has frequently been suggested as a biomarker of stroke recovery. PREP-2), and been recommended for use in screening for clinical trials.

Research

Research Stroke Strokes Biomarkers

Abstract TMP25: Potential of Rapid GFAP Levels in Acute Undifferentiated Stroke <24 Hours from Onset Using A Point-Of-Care Platform: An Exploratory Analysis of a Prospective Study

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP25-ATMP25, February 1, 2025. Introduction:Glial fibrillary acidic protein (GFAP), highly brain-specific, is emerging as an attractive blood biomarker in acute stroke.

Stroke

Stroke Strokes Technology Biomarkers

Abstract WMP99: Circulating Plasma Biomarkers Associated with Familial Cerebral Cavernous Malformation, Hereditary Hemorrhagic Telangiectasia and Sturge-Weber Syndrome

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP99-AWMP99, February 1, 2025. Introduction:Circulating plasma protein profiling in individuals with brain vascular disorders may aid in the identification of robust diagnostic biomarkers, stratification of high-risk patients for treatment, and monitoring of disease progression or treatment response.

Biomarkers

Biomarkers Circulation Hemorrhage Stroke

Abstract TMP1: Identification of True Biomarkers for Unruptured Cerebral Aneurysms through Revisiting Cerebral Aneurysm Transcriptomes

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP1-ATMP1, February 1, 2025. A cerebral aneurysm (CA) is an abnormal artery deformation in the brain that may lead to hemorrhagic stroke, brain damage, coma, and even death when a CA ruptures. We hypothesized that increasing CA sample size will allow more robust biomarker identification.

Aneurysm

Aneurysm Biomarkers Hemorrhage Cardiomyopathy

Abstract WP226: Thrombin-Mediated Platelet Activity Predicts Hematoma Expansion After Spontaneous Intracerebral Hemorrhage

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP226-AWP226, February 1, 2025. Objective:Hematoma expansion (HE) predicts disability and death after intracerebral hemorrhage (ICH). Specific biomarkers of platelet activity would improve our understanding of HE and could point towards targeted treatments.

Hemorrhage

Hemorrhage Biomarkers Stroke Strokes

Abstract DP47: The Role of Chronic Kidney Disease and Brain Iron Deposition in Intracerebral Hemorrhage

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP47-ADP47, February 1, 2025. Introduction:Chronic kidney disease (CKD) is a risk factor for intracerebral hemorrhage (ICH) and for worse outcomes following ICH.

Kidney Disease

Kidney Disease Hemorrhage Risk Factors Heart Disease

Abstract WP178: Dual-Phase C-11 PiB PET Images For Detecting Tau Pathology in Cerebral Amyloid Angiopathy

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP178-AWP178, February 1, 2025. Background and Objective:Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage and cognitive dysfunction in the elderly, and frequently coexists with Alzheimers disease (AD) and tau pathology.

Biomarkers

Biomarkers Education Hemorrhage Stroke

Abstract WMP14: Spatial Transcriptomics Glean Homologous Mechanisms in the Pathophysiology of Human and E4FAD Mouse Cerebral Microbleeds

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP14-AWMP14, February 1, 2025. Introduction:Cerebral microbleeds (CMBs) are age-related manifestations of microangiopathies predisposing patients to hemorrhagic stroke (HS) and cognitive decline. Little work has currently been done to elucidate mechanisms in the pathophysiology of CMBs.

Biomarkers

Biomarkers Hemorrhage Stroke Strokes

Abstract TMP3: Identifying Sex-specific Biomarkers of Unruptured Cerebral Aneurysms through Revisiting Cerebral Aneurysm Transcriptomes

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP3-ATMP3, February 1, 2025. Cerebral aneurysms (CA) arise from the sites of weakened artery walls in the brain, and they may cause hemorrhagic stroke, coma, and death when they rupture. Studies have revealed sex differences in ~1.5 times higher prevalence of CA and ~1.5

Biomarkers

Biomarkers Aneurysm Risk Factors Hemorrhage

Abstract WP230: Neuroinflammation Biomarker in the Course and Prognosis of Hemorrhagic Strokes

Abstract WP227: Physiological Magnetic Resonance Imaging Biomarkers for Early Detection of Microvascular Dysfunction in Acute Intracerebral Hemorrhage

Abstract WP35: Neutrophil Extracellular Traps As a Biomarker for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

Webinars

Abstract TP44: Alpha-1-acid glycoprotein is a potential serum Biomarker for Cerebral Amyloid Angiopathy

Abstract WMP32: Cross-Platform Proteomics and Machine Learning Algorithms Nominate Biomarkers of Stroke Diagnosis: An Exploratory Study

Abstract TMP4: Serum Protein Biomarekrs and Cell Suptypes Linked to Reduced Cerebral Edema in Aneurysmal Subarachnoid Hemorrhage

Abstract TP310: The Shifting Evidence for Statin Use in the Setting of Intracerebral Hemorrhage

Abstract WP370: Platelet morphology but not coagulation markers predicts delayed cerebral ischemia after subarachnoid hemorrhage

Abstract WP224: Hematoma location and symptom onset to sampling time are predictors of GFAP release into plasma in acute intracerebral hemorrhage

Abstract TP377: A Biomarker Based on Aneurysm Wall Enhancement and Blood Gene Expression to Identify Symptomatic Intracranial Aneurysms

Abstract WP232: Prediction Value of Intravenous Contrast Extravasation for Mortality and Poor Functional Outcomes in Intracerebral Hemorrhage: An Accuracy Meta-analysis

Abstract TP343: Co-Expression Modules In The Periphreal Blood Transcriptome Following Subarachnoid Hemorrhage Associate With 90-Day Outcome

Abstract WMP79: Biologic mechanisms of Early Exercise After Acute Ischemic Stroke and Intracerebral Hemorrhage (BEACH): A Pilot Randomized Controlled Trial of Cycle Ergometry after Stroke

Abstract 47: Rapid prehospital diagnosis of intracerebral hemorrhage in acute stroke patients by measuring GFAP on a point-of-care platform (DETECT study)

Abstract WP338: Proteomic Analysis of Carotid Artery Plaques With and Without Vulnerable Features on Magnetic Resonance Angiography with Vessel Wall Imaging: A Pilot Study

Abstract TP209: Improving Neuroimaging Data Processing in Clinical Trials Through Automated Cloud-based Analysis

Abstract TP320: The Kynurenine pathway and its metabolites in stroke: A systematic review and meta-analysis of clinical studies

Abstract WMP42: Exploring The Neural Basis Of Prognostic Tools For Upper Limb Recovery After Stroke: Lesion Topography Of SAFE And Other Medical Research Council Scale Scores

Abstract TMP25: Potential of Rapid GFAP Levels in Acute Undifferentiated Stroke <24 Hours from Onset Using A Point-Of-Care Platform: An Exploratory Analysis of a Prospective Study

Abstract WMP99: Circulating Plasma Biomarkers Associated with Familial Cerebral Cavernous Malformation, Hereditary Hemorrhagic Telangiectasia and Sturge-Weber Syndrome

Abstract TMP1: Identification of True Biomarkers for Unruptured Cerebral Aneurysms through Revisiting Cerebral Aneurysm Transcriptomes

Abstract WP226: Thrombin-Mediated Platelet Activity Predicts Hematoma Expansion After Spontaneous Intracerebral Hemorrhage

Abstract DP47: The Role of Chronic Kidney Disease and Brain Iron Deposition in Intracerebral Hemorrhage

Abstract WP178: Dual-Phase C-11 PiB PET Images For Detecting Tau Pathology in Cerebral Amyloid Angiopathy

Abstract WMP14: Spatial Transcriptomics Glean Homologous Mechanisms in the Pathophysiology of Human and E4FAD Mouse Cerebral Microbleeds

Abstract TMP3: Identifying Sex-specific Biomarkers of Unruptured Cerebral Aneurysms through Revisiting Cerebral Aneurysm Transcriptomes

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