2025, Biomarkers and Diabetes - Cardiovascular Update

Bayer to Present New Investigational Heart Failure Data, Continued Portfolio Research in Chronic Kidney Disease at ACC.25

DAIC

MARCH 25, 2025

tim.hodson Tue, 03/25/2025 - 16:19 March 25, 2025 Bayer plans to present data from 13 new analyses from across the KERENDIA (finerenone) comprehensive clinical trial program at the American College of Cardiology (ACC) 74 th Annual Scientific Session & Expo 2025 , in Chicago, IL, March 29-31, 2025. Additional ACC.25

Preserved Ejection Fraction

Preserved Ejection Fraction Heart Failure Kidney Disease Research

Albuminuria in Cardiovascular, Kidney, and Metabolic Disorders: A State-of-the-Art Review

Circulation

MARCH 9, 2025

Circulation, Volume 151, Issue 10 , Page 716-732, March 11, 2025. Albuminuriaincreased urine albumin excretionis associated with cardiovascular mortality among patients with diabetes, hypertension, chronic kidney disease, or heart failure, as well as among adults with few cardiovascular risk factors.

Kidney Disease

Kidney Disease Biomarkers Heart Failure Risk Factors

Abstract TMP1: Identification of True Biomarkers for Unruptured Cerebral Aneurysms through Revisiting Cerebral Aneurysm Transcriptomes

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP1-ATMP1, February 1, 2025. Studies have searched for biomarkers for CA to provide early and easy diagnosis of unruptured CA through blood transcriptome analysis; however, biomarkers from individual studies cannot be validated across studies due to sample size.

Aneurysm

Aneurysm Biomarkers Cardiomyopathy Hemorrhage

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

MORE WEBINARS

Bayer to Present New Investigational Heart Failure Data, Continued Portfolio Research

DAIC

MARCH 25, 2025

tim.hodson Tue, 03/25/2025 - 16:19 March 25, 2025 Bayer plans to present data from 13 new analyses from across t he KERENDIA (finerenone) comprehensive clinical trial program at the American College of Cardiology (ACC) 74 th Annual Scientific Session & Expo 2025 , in Chicago, IL, March 29-31, 2025. Additional ACC.25

Preserved Ejection Fraction

Preserved Ejection Fraction Heart Failure Research Academic

Abstract WP359: Increased CCL4 and CCL5 following Mechanical Thrombectomy: A Plasma Biomarker Study in Ischemic Stroke Patients

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP359-AWP359, February 1, 2025. years, 54% were women, 87% had hypertension, 44% had diabetes mellitus, and 54% had hyperlipidemia. Background:Mechanical thrombectomy has been associated with improved outcomes in patients with acute ischemic stroke. pg/ml vs. 39.520.6

Biomarkers

Biomarkers Stroke Strokes Ischemia

Abstract WP6: Associations between computed tomography biomarkers of cerebral small vessel disease and early outcomes after intravenous thrombolysis for acute ischemic stroke

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP6-AWP6, February 1, 2025. Patients with increasing CT-CSVD scores were older (p<0.001), more likely to have hypertension (p<0.001), diabetes (p<0.001), coronary artery disease (p=0.044), and a higher baseline systolic blood pressure (p=0.037). 1.95, p = 0.019).Conclusion:This

Thrombolysis

Thrombolysis Outcomes Biomarkers Stroke

Primary Prevention Takes Center Stage at the 19th Annual Cardiometabolic Health Congress (CMHC)

Cardiometabolic Health Congress

OCTOBER 25, 2024

Attendees dove into cutting-edge topics, including FDA updates, resistant hypertension, and cardiac biomarkers. “I Florez, MD, PhD , explored the future of precision medicine in diabetes. The 20th Annual CMHC, an anniversary celebration, is already on the horizon, set for October 23-25, 2025, in Boston. Learn more now!

CME

CME Innovation Education Atherosclerosis

Abstract TP268: Xylitol, Xylose, and MicroRNAs Associated with Thrombosis and the Clotting Cascade in a Multi-Omics Cross-Sectional Study of Adults at Risk for Type 2 Diabetes and Stroke

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP268-ATP268, February 1, 2025. MicroRNAs (miRs) have been associated with thrombosis and the blood clotting cascade and can provide additional insight about pathogenesis or biomarkers to help establish safe dietary intake guidelines.

Thrombosis

Thrombosis Obesity Stroke Strokes

Abstract WP93: Cross-Platform Proteomics and Machine Learning Algorithms Nominate Biomarkers of Atrial Fibrillation in Stroke Patients: An Exploratory Study

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP93-AWP93, February 1, 2025. AFib diagnosis is critical to optimize secondary prevention and reduce the recurrent stroke risk.Objectives:We undertook an exploratory cross-platform proteomics study to discover plasma biomarkers of AFib diagnosis in patients with IS or transient ischemic attack (TIA).Methods:We

Biomarkers

Biomarkers AFIB Atrial Fibrillation Stroke

Abstract WP58: Retinal Optical Coherence Tomography Abnormalities Associated with CADASIL: A Case-Control Study from the UK Biobank

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP58-AWP58, February 1, 2025. Introduction:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebral small vessel disease, yet there is currently no biomarker for early detection.

Biomarkers

Biomarkers Ischemia Diabetes Hypertension

Abstract 93: Increased IFN-γ Levels in African American Women Following Ischemic Stroke: A Study of Ethnic Disparities in Plasma Biomarkers

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A93-A93, February 1, 2025. years, 35% were women, 88% had hypertension, 47% had diabetes mellitus, and 53% had hyperlipidemia. Background:Stroke outcomes vary with ethnicity, with immune response markers like interferon-gamma (IFN-) playing a significant role in stroke pathophysiology.

Stroke

Stroke Strokes Biomarkers Outcomes

Abstract WP61: Automated Retinal Vascular Fractal Analysis Can Screen Presymptomatic Alzheimer’s Disease

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP61-AWP61, February 1, 2025. Amyloid positron emission tomography (PET) and apolipoprotein 4 (APOE4) carrier status are known biomarkers of AD risk. Amyloid positron emission tomography (PET) and apolipoprotein 4 (APOE4) carrier status are known biomarkers of AD risk.

Biomarkers

Biomarkers Risk Factors Diabetes Hypertension

Abstract 102: Association Between Kidney Function and Severity of White Matter Hyperintensity: The Atherosclerosis Risk in Communities Study

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A102-A102, February 1, 2025. Background and Purpose:Chronic kidney disease (CKD) is associated with an increased risk of stroke and worse outcomes, yet it is often asymptomatic, with an estimated 90% of individuals unaware they have CKD until its later stages. female, 22.1%

Atherosclerosis

Atherosclerosis Kidney Disease Blood Pressure Biomarkers

Abstract WP45: MRI-Visible Perivascular Spaces and Cognitive Performance: A Cross-Sectional Analysis from The Framingham Heart Study

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP45-AWP45, February 1, 2025. Multiple linear regression models tested associations between PVS burden and each NP test, adjusting for age, sex, smoking, diabetes, hypertension, and education.Results:Among 3777 participants (mean age 60.6 male, 49% college educated, 17.5% CSO high burden, 9.8%

Dementia

Dementia Biomarkers Education Diabetes

Abstract DP47: The Role of Chronic Kidney Disease and Brain Iron Deposition in Intracerebral Hemorrhage

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP47-ADP47, February 1, 2025. In this study, we examined the relationship between kidney function, ICH, and brain iron deposition, using quantitative susceptibility mapping (QSM) and cerebral microbleeds (CMB) as intermediate biomarkers.

Kidney Disease

Kidney Disease Hemorrhage Risk Factors Heart Disease

5 Most-Cited Takeaways From the 19th Annual Cardiometabolic Health Congress (CMHC)

Cardiometabolic Health Congress

NOVEMBER 14, 2024

42% of adults are considered obese , increasing their risk of diabetes, hypertension, and cardiovascular issues. Additionally, 10% of the global population suffers from chronic kidney disease , with diabetes and hypertension as significant risk factors. In the U.S., SELECT Trial Results : Semaglutide 2.4

CME

CME Obesity Heart Failure Biomarkers

The legal case – naming a few names

Dr. Malcolm Kendrick

OCTOBER 30, 2024

(2022-25) Swiss Reinsurance Company: £645K China Kadoorie Biobank (2002-ongoing) AstraZeneca: $300K Bayer AG: £300K GlaxoSmithKline: £3.6M Elinogrel feasibility trial (2010-2011) Novartis: £500K EMPA-KIDNEY (2017-ongoing) Boehringer Ingelheim: £106.3M Establishing Fuwai-Oxford research centre (2010-ongoing) Merck: £1.1M

Cholesterol

Cholesterol Article Research Diet

Chest pain followed by 6 days of increasing dyspnea -- what happened?

Dr. Smith's ECG Blog

FEBRUARY 26, 2025

Both reperfusion, as judged by the biomarker curve, and patency, as assessed by the angiogram, were correlated with the rapidity and depth of T wave inversion. link] == MY Comment , by K EN G RAUER, MD ( 1/14 /2025 ): == I found today's case highly insightful with regard to many aspects. 2018, July 30). American College of Cardiology.

Chest Pain

Chest Pain Pericarditis Myocardial Infarction Dementia

Bayer to Present New Investigational Heart Failure Data, Continued Portfolio Research in Chronic Kidney Disease at ACC.25

Albuminuria in Cardiovascular, Kidney, and Metabolic Disorders: A State-of-the-Art Review

Abstract TMP1: Identification of True Biomarkers for Unruptured Cerebral Aneurysms through Revisiting Cerebral Aneurysm Transcriptomes

Webinars

Bayer to Present New Investigational Heart Failure Data, Continued Portfolio Research

Abstract WP359: Increased CCL4 and CCL5 following Mechanical Thrombectomy: A Plasma Biomarker Study in Ischemic Stroke Patients

Abstract WP6: Associations between computed tomography biomarkers of cerebral small vessel disease and early outcomes after intravenous thrombolysis for acute ischemic stroke

Primary Prevention Takes Center Stage at the 19th Annual Cardiometabolic Health Congress (CMHC)

Abstract TP268: Xylitol, Xylose, and MicroRNAs Associated with Thrombosis and the Clotting Cascade in a Multi-Omics Cross-Sectional Study of Adults at Risk for Type 2 Diabetes and Stroke

Abstract WP93: Cross-Platform Proteomics and Machine Learning Algorithms Nominate Biomarkers of Atrial Fibrillation in Stroke Patients: An Exploratory Study

Abstract WP58: Retinal Optical Coherence Tomography Abnormalities Associated with CADASIL: A Case-Control Study from the UK Biobank

Abstract 93: Increased IFN-γ Levels in African American Women Following Ischemic Stroke: A Study of Ethnic Disparities in Plasma Biomarkers

Abstract WP61: Automated Retinal Vascular Fractal Analysis Can Screen Presymptomatic Alzheimer’s Disease

Abstract 102: Association Between Kidney Function and Severity of White Matter Hyperintensity: The Atherosclerosis Risk in Communities Study

Abstract WP45: MRI-Visible Perivascular Spaces and Cognitive Performance: A Cross-Sectional Analysis from The Framingham Heart Study

Abstract DP47: The Role of Chronic Kidney Disease and Brain Iron Deposition in Intracerebral Hemorrhage

5 Most-Cited Takeaways From the 19th Annual Cardiometabolic Health Congress (CMHC)

The legal case – naming a few names

Chest pain followed by 6 days of increasing dyspnea -- what happened?

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