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The 5-HT7 receptor contributes to increased hindquarter blood flow caused by skeletal muscle contraction.

Journal of Cardiovascular Pharmacology

Serotonin (5-hydroxytryptamine, 5-HT) at low plasma concentrations reduces blood pressure and dilates some skeletal muscle arterioles in the rat. We hypothesized that the 5-HT7 receptor is essential for both 5-HT-induced changes in blood pressure and skeletal muscle arteriolar function. All rights reserved.