Nature Reviews - Cardiology

JANUARY 25, 2024

Nature Reviews Cardiology, Published online: 26 January 2024; doi:10.1038/s41569-023-00986-9 In this Review, Varga and colleagues provide an overview of the evidence on immune checkpoint inhibitor-induced heart failure and cardiac dysfunction that is unrelated to myocarditis, and discuss how pharmacological targeting of immune checkpoints might be (..)

Heart Failure 90

Heart Failure Physiology Pharmacology 90

DAIC

FEBRUARY 2, 2024

9-11, 2024. Image courtesy: Getty Images christine.book Fri, 02/02/2024 - 11:35 February 2, 2024 — The American College of Cardiology ’s Cardiac Oncology Conference, “ Advancing the Cardiovascular Care of the Oncology Patient ,” will be held in person at the Heart House in Washington, D.C., How to Structure?

Cardio Oncology 95

Cardio Oncology Cancer Pharmacology RN 95

Journal of Cardiovascular Pharmacology

JUNE 3, 2024

A variety of technologies, including network pharmacology, RNA-sequencing, immunohistochemistry, and Western blotting were performed to investigate its underlying mechanisms. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

Pharmacology 40

Pharmacology Hypertension Technology Article 40

DAIC

MAY 14, 2024

Getty Images milla1cf Tue, 05/14/2024 - 13:00 May 14, 2024 — One of the most common genetic heart diseases worldwide, hypertrophic cardiomyopathy (HCM) causes the walls of the left ventricle to become thick and stiff. The late breaking research was presented by principal investigator Martin S.

Cardiomyopathy 126

Cardiomyopathy Exercise Chest Pain Quality of Life 126

DAIC

FEBRUARY 27, 2024

Getty Images milla1cf Tue, 02/27/2024 - 17:24 February 27, 2024 — Biosense Webster, Inc. , The study will compare the safety and efficacy of the Laminar LAAX System to commercially available left atrial appendage (LAA) closure devices, providing a potential non-pharmacologic alternative for eligible patients. 

Atrial Fibrillation 105

Atrial Fibrillation Innovation AFIB Pharmacology 105

HCPLive

APRIL 2, 2024

This month’s rheumatology month in review showcases the efficacy of various medications for the treatment of psoriatic arthritis, underscores the importance of addressing workforce challenges, and explores non-pharmacological interventions.

Pharmacology 40

Pharmacology 40

DAIC

JULY 10, 2024

Getty Images mtaschetta-millane Wed, 07/10/2024 - 08:51 July 10, 2024 — Reviva Pharmaceuticals Holdings, Inc. , Reviva believes that a full battery of regulatory compliant toxicology and safety pharmacology studies has been completed for brilaroxazine.

Pulmonary 111

Pulmonary Hypertension Pharmacology Biomarkers 111

Nature Reviews - Cardiology

FEBRUARY 18, 2024

Nature Reviews Cardiology, Published online: 19 February 2024; doi:10.1038/s41569-024-01000-6 Two studies indicate that a reduction in body mass index as a result of either bariatric surgery or pharmacological therapy is associated with a blood pressure-lowering effect.

Blood Pressure 56

Blood Pressure Pharmacology 56

Circulation

MARCH 17, 2024

Circulation, Volume 149, Issue 12 , Page e996-e996, March 19, 2024.

Pharmacology 45

Pharmacology Arrhythmia Circulation 45

Journal of Cardiovascular Pharmacology

SEPTEMBER 12, 2024

Copyright © 2024 Wolters Kluwer Health, Inc. Therefore, we recapitulate here methodological issues evaluating potential value of the IKur as an antiarrhythmic target when investigated in animal models, in human atrial tissues and finally in atrial hiPSC-CM. All rights reserved.

Pharmacology 40

Pharmacology CMS Electrophysiology Physiology 40

DAIC

APRIL 3, 2024

April 3, 2024 — In gearing up for its Annual Scientific Session, ACC.24, The “Pharmacology Program” will cover hot topics in cardiovascular medicine that are key issues that pharmacists, as well as other health care team members, face in managing complex patients. Notably, 2024 marks the 40th Anniversary of ACC/AHA Guidelines.

Education 105

Education Preserved Ejection Fraction Coronary Artery Disease Cardio Oncology 105

Journal of Cardiovascular Pharmacology

JUNE 24, 2024

A personalised management plan including rationalising medications, patient education, identification, and avoidance of triggers, as well as non-pharmacological therapies such as compression devices, dietary modifications, and postural aids, make the first steps. Copyright © 2024 The Author(s).

Pharmacology 40

Pharmacology Hypertension Education Article 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP315-AWP315, February 1, 2024. Backgrounds:Our prior work demonstrated the potential of targeting miR-141-3p to mitigate ischemic stroke damage.

Pharmacology 40

Pharmacology Strokes Stroke 40

Journal of Cardiovascular Pharmacology

OCTOBER 14, 2024

While concerns about fetal toxicity have traditionally limited the use of lisinopril in women of reproductive age, recent ACOG guidelines promote aggressive treatment of hypertension, which may require the use of pharmacologic agents not previously considered in the postpartum period. Copyright © 2024 Wolters Kluwer Health, Inc.

Pharmacology 40

Pharmacology Heart Failure Hypertension Research 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4146046-A4146046, November 12, 2024. However, there are currently no pharmacological treatments for CAVD, and the discovery of de novo molecules targeting a specific protein is a time-intensive and financially demanding process.

Pharmacology 40

Pharmacology Aortic valve Aortic Circulation 40

The British Journal of Cardiology

AUGUST 14, 2024

Faculty member Affiliation Professor Amitava Banerjee Professor of Clinical Data Science, Institute of Health Informatics, University College London; Consultant Cardiologist, University College London Hospitals and Barts Health NHS Trust Professor Sir Mark Caulfield Professor of Clinical Pharmacology, Queen Mary Un.

Cardiovascular Disease 40

Cardiovascular Disease Patient Care Innovation Pharmacology 40

Stroke Journal

JANUARY 30, 2025

There is no effective pharmacological treatment to decrease ICH mortality, While statin therapy demonstrates promising potential in mitigating post-ICH mortality, this study underscores the necessity for further research to elucidate optimal treatment duration and address existing heterogeneity.

Hemorrhage 40

Hemorrhage Pharmacology Hypertension Outcomes 40

Journal of Cardiovascular Pharmacology

SEPTEMBER 5, 2024

Heparin, the most utilized anticoagulant, carries concerns for heparin-induced thrombocytopenia and possible resistance given its dependence on co-factors and circulating proteins to exert its pharmacologic effect. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

Laboratory 40

Laboratory Thrombosis Pharmacology Pulmonary 40

Journal of Cardiovascular Pharmacology

JUNE 24, 2024

The present viewpoint succinctly illustrates the main features of SGLT2 inhibitors as a pharmacologic class, their ever expanding role as a cardiovascular medication, and the comparative effectiveness of different individual SGLT2 inhibitors, explicitly commenting on the recent data on empagliflozin in patients with acute myocardial infarction.

Myocardial Infarction 40

Myocardial Infarction Heart Failure Pharmacology Diabetes 40

DAIC

FEBRUARY 29, 2024

Image courtesy: ACC christine.book Thu, 02/29/2024 - 11:22 February 29, 2024 — The American College of Cardiology ( ACC ) will soon be holding its ACC 73rd Annual Scientific Session & Expo , ACC.24 24 from April 6 - 8, 2024 in Atlanta, GA at the Georgia World Congress Center. The Guidelines Sessions at ACC.24

Aortic valve 103

Aortic valve Myocardial Infarction Aortic Blood Pressure 103

Journal of Cardiovascular Pharmacology

MAY 19, 2024

The adherence to pharmacological treatment was 99%.Additionally, The adherence to pharmacological treatment was 99%.Additionally, Copyright © 2024 Wolters Kluwer Health, Inc. During a mean follow-up of 664 ± 177 days, the incidence rate of major bleedings and of major cardiovascular events (MACE) was 0.8 Additionally, 13.4%

Peripheral Arterial Disease 40

Peripheral Arterial Disease Pharmacology Article 40

The British Journal of Cardiology

MAY 14, 2024

This review describes the physiological rationale behind FXI/FXIa inhibition and the pharmacological properties of existing FXI/FXIa inhibitors.

Thrombosis 40

Thrombosis Pharmacology Physiology Atrial Fibrillation 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP301-AWP301, February 1, 2024. We hypothesized that pharmacological inhibition of STAT3 activation in mice during the reperfusion phase after middle cerebral artery occlusion (MCAO) will lead to increased infarct size. Interestingly Stattic-treated mice had larger spleens (66.31 ± 5.40

Strokes 40

Strokes Stroke Pharmacology Ischemia 40

Journal of Cardiovascular Pharmacology

APRIL 1, 2024

Importantly, we found F2-induced activation of Nrf2 is SIRT1-dependent, as pharmacologically inhibiting SIRT1 by the specific inhibitor EX527 blocked Nrf2 activation. Importantly, we found F2-induced activation of Nrf2 is SIRT1-dependent, as pharmacologically inhibiting SIRT1 by the specific inhibitor EX527 blocked Nrf2 activation.

Ischemia 40

Ischemia Pharmacology Heart Disease Article 40

Cardiometabolic Health Congress

OCTOBER 25, 2024

The 19th Annual CMHC transformed Boston into the epicenter of cardiometabolic health and risk reduction from October 17-19, 2024, bringing together healthcare professionals from around the globe for the largest event of its kind in the US. Aronne, MD , discussed advances in obesity pharmacology, while Virend K. Experts like Louis J.

CME 64

CME Innovation Education Atherosclerosis 64

The British Journal of Cardiology

AUGUST 21, 2024

In this historical review, we explore its journey from ancient wisdom to becoming a cornerstone of heart failure (HF) therapy, including discovery of its pharmacological properties and an appraisal of early clinical studies.

Atrial Fibrillation 40

Atrial Fibrillation Pharmacology Heart Failure 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4117657-A4117657, November 12, 2024. Pharmacological inhibition of GPR39 may open new frontiers in the treatment of PAH. Background:Primary pulmonary arterial hypertension (PAH) is a disease affecting young subjects. It has very poor prognosis and optimal treatment is not available.

Pulmonary 40

Pulmonary Hypertension Blood Pressure Pharmacology 40

The British Journal of Cardiology

FEBRUARY 20, 2024

Currently, the HF pillars are focused on medications shown to improve the outcomes of people with heart failure with reduced ejection fraction (HFrEF), 3 but other key non-pharmacological interventions are not considered.

Heart Failure 40

Heart Failure Preserved Ejection Fraction Cardiac Rehabilitation Pharmacology 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4141474-A4141474, November 12, 2024. While it is known to increase serotonin levels in the brain and gastrointestinal tract, its pharmacology remains largely unexplored.

Kidney Disease 40

Kidney Disease Risk Factors Pharmacology Diabetes 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4140419-A4140419, November 12, 2024. Current treatments, predominantly pharmacological, target signaling pathways involved in fibroblast activation but often come with side effects such as cardiac toxicities.

Cardiac Function 40

Cardiac Function Pharmacology Innovation Heart Failure 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4137905-A4137905, November 12, 2024. Background:In out-of-hospital cardiac arrest (OHCA) patients with an initial shockable rhythm, epinephrine increases the likelihood of return of spontaneous circulation (ROSC), but its effect on neurological outcome remains uncertain.

Cardiac Arrest 40

Cardiac Arrest Hospital Outcomes Pharmacology 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A103-A103, February 1, 2024. Finally, the infarct size and neurological deficits were evaluated in MCAO mice after pharmacological manipulation of specific microglial subcluster.Results:We discovered stroke-associated microglial subclusters in MCAO mice.

Ischemia 40

Ischemia Pharmacology Strokes Stroke 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4142210-A4142210, November 12, 2024. The importance of transesophageal echocardiogram (TEE) to exclude left atrial (LA) and left atrial appendage (LAA) thrombus prior to cardioversion for atrial fibrillation (AF) has been debated in patients who are anticoagulated prior to cardioversion.

Echocardiogram 40

Echocardiogram Atrial Fibrillation Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP51-AWP51, February 1, 2024. There were pharmacological changes in 21.5% (n= 11) of the patients reviewed. Background:Stroke is a debilitating condition and patients with acute stroke usually stays about a week in the acute hospital.

Nursing 40

Nursing Hospital Outpatient Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP322-AWP322, February 1, 2024. In a subset of Hhcy rats, NVP-AAM077, a pharmacological inhibitor of GluN2A-NMDAR was injected intravenously at the onset of stroke. Hyperhomocysteinemia (Hhcy), a metabolic disorder is recognized as a risk factor for ischemic stroke.

Ischemia 40

Ischemia Pharmacology Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP74-AWMP74, February 1, 2024. TCR activation was pharmacologically inhibited using the TCR-specific inhibitor AX-024, administered (10 mg/kg, i.p.) However, brain-infiltrating T cells precise activation mechanisms and resulting pathological impacts remain largely unexplored.

Hemorrhage 40

Hemorrhage Outcomes Pharmacology Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP114-AWMP114, February 1, 2024. Pharmacological inhibition of EZH2 improved cognitive outcomes in CAA mice, suggesting a possible therapeutic target. Introduction:Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid-β (Aβ) in the leptomeningeal and cortical vessels.

Pharmacology 40

Pharmacology Dementia Strokes Stroke 40