Remove 2024 Remove Ischemia Remove Pharmacology
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N-n-butyl haloperidol iodide mitigates myocardial ischemia/reperfusion injury through activation of SIRT1-Nrf2 signaling loop

Journal of Cardiovascular Pharmacology

Abstract: N-n-butyl haloperidol iodide (F2), a derivative of haloperidol developed by our group, exhibits potent antioxidative properties and confers protection against cardiac ischemia/reperfusion (I/R) injury. Copyright © 2024 The Author(s). The protective mechanisms by which F2 ameliorates I/R injury remain obscure.

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Immunoglobulin-mediated Cardiac Protection from Ischemia/Reperfusion Injury in Diabetic Rats is associated with Endothelial Nitric Oxide Synthase/Glucose Transporter-4 Signaling Pathway

Journal of Cardiovascular Pharmacology

The role of intravenous immunoglobulin in protecting the diabetic heart from ischemia/reperfusion (I/R) injury is unclear. Hearts isolated from adult diabetic and non-diabetic Wistar rats (n=8 per group) were treated with intravenous immunoglobulin (IVIG) either two hours before euthanasia, before ischemia, or at reperfusion.

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Abstract WP301: STAT3 Inhibition Reduces Infarct and Neuroinflammation in Experimental Stroke

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page AWP301-AWP301, February 1, 2024. Signal Transducer and Activator of Transcription 3 (STAT3) activation is increased in the brain following cerebral ischemia. Interestingly Stattic-treated mice had larger spleens (66.31 ± 5.40 g) compared to vehicle-treated mice (46.43 ± 4.60

Stroke 40
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Preventive Percutaneous Coronary Intervention for High-Risk Coronary Plaques Reduces Cardiac Events

DAIC

PCI is commonly used to open blocked arteries to treat significant myocardial ischemia , which occurs when the heart muscle does not get enough oxygenated blood. Half of the participants were randomly assigned to receive PCI plus medical therapy and half received medical therapy alone.

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Abstract WP322: GluN2A-NMDAR Mediated Increased Neuronal Prostaglandin E2 Release and Microglial Activation Exacerbates Ischemic Brain Injury Under Hyperhomocysteinemic Condition

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page AWP322-AWP322, February 1, 2024. The findings also showed that Hhcy triggers GluN2A subunit containing NMDA receptor (GluN2A-NMDAR) stimulation that act in conjunction with ischemia-induced pathways involving GluN2B subunit containing NMDAR (GluN2B-NMDAR) stimulation to enhance stroke pathology.

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New Guidelines on Peripheral Artery Disease Issued by American Heart Association, American College of Cardiology and Leading Medical Societies

DAIC

Among those ages 65 and older, nearly 50% who underwent limb amputation died within one year after surgery, according to the 2024 Heart Disease and Stroke Statistics: A Report of U.S. Pharmacological and behavioral-based strategies often increase the smoking cessation rate in people with PAD, however, these strategies are underused.

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Exploring the Possible Role of Cannabinoids in Managing Post-Cardiac Surgery Complications: A Narrative Review of Preclinical Evidence and a Call for Future Research Directions

Journal of Cardiovascular Pharmacology

Specifically, CBD has shown promise in managing pain, moderating immune responses, and mitigating ischemia/reperfusion injury, underscoring its potential in postoperative care. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.