2024, Ischemia and Pharmacology - Cardiovascular Update

N-n-butyl haloperidol iodide mitigates myocardial ischemia/reperfusion injury through activation of SIRT1-Nrf2 signaling loop

Journal of Cardiovascular Pharmacology

APRIL 1, 2024

Abstract: N-n-butyl haloperidol iodide (F2), a derivative of haloperidol developed by our group, exhibits potent antioxidative properties and confers protection against cardiac ischemia/reperfusion (I/R) injury. Copyright © 2024 The Author(s). The protective mechanisms by which F2 ameliorates I/R injury remain obscure.

Ischemia

Ischemia Pharmacology Heart Disease Article

Preventive Percutaneous Coronary Intervention for High-Risk Coronary Plaques Reduces Cardiac Events

DAIC

APRIL 11, 2024

PCI is commonly used to open blocked arteries to treat significant myocardial ischemia , which occurs when the heart muscle does not get enough oxygenated blood. Half of the participants were randomly assigned to receive PCI plus medical therapy and half received medical therapy alone.

Plaque

Plaque Heart Attack Heart attacks Coronary Artery Disease

Immunoglobulin-mediated Cardiac Protection from Ischemia/Reperfusion Injury in Diabetic Rats is associated with Endothelial Nitric Oxide Synthase/Glucose Transporter-4 Signaling Pathway

Journal of Cardiovascular Pharmacology

JULY 15, 2024

The role of intravenous immunoglobulin in protecting the diabetic heart from ischemia/reperfusion (I/R) injury is unclear. Hearts isolated from adult diabetic and non-diabetic Wistar rats (n=8 per group) were treated with intravenous immunoglobulin (IVIG) either two hours before euthanasia, before ischemia, or at reperfusion.

Ischemia

Ischemia Diabetes Article

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New Guidelines on Peripheral Artery Disease Issued by American Heart Association, American College of Cardiology and Leading Medical Societies

DAIC

MAY 16, 2024

Among those ages 65 and older, nearly 50% who underwent limb amputation died within one year after surgery, according to the 2024 Heart Disease and Stroke Statistics: A Report of U.S. Pharmacological and behavioral-based strategies often increase the smoking cessation rate in people with PAD, however, these strategies are underused.

Peripheral Arterial Disease

Peripheral Arterial Disease Exercise Ischemia Quality of Life

Abstract 103: Acute Ischemia Induces Spatially and Transcriptionally Distinct Microglial Subclusters

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A103-A103, February 1, 2024. Finally, the infarct size and neurological deficits were evaluated in MCAO mice after pharmacological manipulation of specific microglial subcluster.Results:We discovered stroke-associated microglial subclusters in MCAO mice.

Ischemia

Ischemia Pharmacology Stroke Strokes

Abstract WP301: STAT3 Inhibition Reduces Infarct and Neuroinflammation in Experimental Stroke

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP301-AWP301, February 1, 2024. Signal Transducer and Activator of Transcription 3 (STAT3) activation is increased in the brain following cerebral ischemia. Interestingly Stattic-treated mice had larger spleens (66.31 ± 5.40 g) compared to vehicle-treated mice (46.43 ± 4.60

Stroke

Stroke Strokes Pharmacology Ischemia

American College of Cardiology ACC.24 Late-breaking Science and Guidelines Session Summary

DAIC

FEBRUARY 29, 2024

Image courtesy: ACC christine.book Thu, 02/29/2024 - 11:22 February 29, 2024 — The American College of Cardiology ( ACC ) will soon be holding its ACC 73rd Annual Scientific Session & Expo , ACC.24 24 from April 6 - 8, 2024 in Atlanta, GA at the Georgia World Congress Center. The Guidelines Sessions at ACC.24

Aortic valve

Aortic valve Myocardial Infarction Aortic Blood Pressure

Abstract WP322: GluN2A-NMDAR Mediated Increased Neuronal Prostaglandin E2 Release and Microglial Activation Exacerbates Ischemic Brain Injury Under Hyperhomocysteinemic Condition

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP322-AWP322, February 1, 2024. The findings also showed that Hhcy triggers GluN2A subunit containing NMDA receptor (GluN2A-NMDAR) stimulation that act in conjunction with ischemia-induced pathways involving GluN2B subunit containing NMDAR (GluN2B-NMDAR) stimulation to enhance stroke pathology.

Ischemia

Ischemia Pharmacology Stroke Strokes

Role of autophagy in myocardial remodeling after myocardial infarction

Journal of Cardiovascular Pharmacology

OCTOBER 24, 2024

In the heart, autophagy is regulated mainly through mitophagy due to the metabolic changes of cardiomyocytes caused by ischemia and hypoxia. In the heart, autophagy is regulated mainly through mitophagy due to the metabolic changes of cardiomyocytes caused by ischemia and hypoxia. Copyright © 2024 Wolters Kluwer Health, Inc.

Myocardial Infarction

Myocardial Infarction Ischemia Heart Failure Heart Disease

Exploring the Possible Role of Cannabinoids in Managing Post-Cardiac Surgery Complications: A Narrative Review of Preclinical Evidence and a Call for Future Research Directions

Journal of Cardiovascular Pharmacology

MARCH 13, 2024

Specifically, CBD has shown promise in managing pain, moderating immune responses, and mitigating ischemia/reperfusion injury, underscoring its potential in postoperative care. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

Open-Heart Surgery

Open-Heart Surgery Research Physiology Ischemia

Transcriptome Analysis Reveals Enhancement of Cardiogenesis-Related Signaling Pathways by S-nitroso-N-pivaloyl-D-penicillamine (SNPiP): Implications for Improved Diastolic Function and Cardiac Performance

Journal of Cardiovascular Pharmacology

FEBRUARY 28, 2024

The NNA-activating effects included increased resilience to ischemia, modulation of energy metabolism preference, and activation of angiogenesis. The NNA-activating effects included increased resilience to ischemia, modulation of energy metabolism preference, and activation of angiogenesis. Copyright © 2024 Wolters Kluwer Health, Inc.

Cardiac Function

Cardiac Function Ischemia Article

Antithrombotic Stewardship: Evaluation of Platelet Reactivity-Guided Cangrelor Dosing Using the VerifyNow® Assay

Journal of Cardiovascular Pharmacology

FEBRUARY 7, 2024

Future randomized controlled trials should evaluate the optimal PRU threshold to balance risks of ischemia and bleeding. Future randomized controlled trials should evaluate the optimal PRU threshold to balance risks of ischemia and bleeding. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

Ischemia

Ischemia Outcomes Article

Lowering Atherosclerotic Cardiovascular Disease Events by Treating Residual Inflammatory Risk

DAIC

JANUARY 23, 2024

mg reduced the risk of cardiovascular death, MI or heart attack, ischemic stroke, or ischemia-driven coronary revascularization by 31% compared with placebo.34 Elsevier; 2024:224-235. Accessed January 8, 2024. Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review. 12 Colchicine, 0.5

Cardiovascular Disease

Cardiovascular Disease Heart Attack Heart attacks Coronary Artery Disease

American Stroke Association to Honor 11 Leading Scientists at International Stroke Conference ISC 2024

DAIC

FEBRUARY 7, 2024

During the American Stroke Association’s International Stroke Conference 2024, ISC24, eleven scientists leading the way in stroke research will be recognized for their exceptional professional achievements. The world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health is being held Feb.

Stroke

Stroke Strokes Research Health Disparities

N-n-butyl haloperidol iodide mitigates myocardial ischemia/reperfusion injury through activation of SIRT1-Nrf2 signaling loop

Preventive Percutaneous Coronary Intervention for High-Risk Coronary Plaques Reduces Cardiac Events

Immunoglobulin-mediated Cardiac Protection from Ischemia/Reperfusion Injury in Diabetic Rats is associated with Endothelial Nitric Oxide Synthase/Glucose Transporter-4 Signaling Pathway

Webinars

New Guidelines on Peripheral Artery Disease Issued by American Heart Association, American College of Cardiology and Leading Medical Societies

Abstract 103: Acute Ischemia Induces Spatially and Transcriptionally Distinct Microglial Subclusters

Abstract WP301: STAT3 Inhibition Reduces Infarct and Neuroinflammation in Experimental Stroke

American College of Cardiology ACC.24 Late-breaking Science and Guidelines Session Summary

Abstract WP322: GluN2A-NMDAR Mediated Increased Neuronal Prostaglandin E2 Release and Microglial Activation Exacerbates Ischemic Brain Injury Under Hyperhomocysteinemic Condition

Role of autophagy in myocardial remodeling after myocardial infarction

Exploring the Possible Role of Cannabinoids in Managing Post-Cardiac Surgery Complications: A Narrative Review of Preclinical Evidence and a Call for Future Research Directions

Transcriptome Analysis Reveals Enhancement of Cardiogenesis-Related Signaling Pathways by S-nitroso-N-pivaloyl-D-penicillamine (SNPiP): Implications for Improved Diastolic Function and Cardiac Performance

Antithrombotic Stewardship: Evaluation of Platelet Reactivity-Guided Cangrelor Dosing Using the VerifyNow® Assay

Lowering Atherosclerotic Cardiovascular Disease Events by Treating Residual Inflammatory Risk

American Stroke Association to Honor 11 Leading Scientists at International Stroke Conference ISC 2024

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