DAIC

DECEMBER 3, 2024

tim.hodson Tue, 12/03/2024 - 16:52 Nov. 18, 2024 — In November, Esperion presented an analysis from the CLEAR Outcomes study focused on patients with Peripheral Artery Disease (PAD) who were unable or unwilling to take statin medications. Bempedoic acid reduced MALE (e.g.

Outcomes 69

Outcomes Peripheral Arterial Disease Ischemia Research 69

HCPLive

JUNE 5, 2024

Sadda, MD, and promising data from studies on geographic atrophy, diabetic macular ischemia, diabetic retinopathy, and AMD. This month-in-review features an exclusive interview with Srinivas R.

Ischemia 59

Ischemia Diabetes 59

Dr. Smith's ECG Blog

JULY 25, 2024

The ECG shows severe ischemia, possibly posterior OMI. But cardiac arrest is a period of near zero flow in the coronary arteries and causes SEVERE ischemia. It takes time for that ischemia to resolve. The patient was brought to the ED and had this ECG recorded: What do you think? And what do you want to do?

Cardiac Arrest 124

Cardiac Arrest Ischemia Tachycardia Defibrillator 124

DAIC

MARCH 27, 2025

In 2024, the FDA approved Flyrcado for patients with known or suspected coronary artery disease (CAD), delivering higher diagnostic efficacy compared to single-photon emission computed tomography (SPECT) i myocardial perfusion imaging (MPI), the predominant procedure used in nuclear cardiology today. Dorbala, S., Di Carli,M. Bateman, T.

Coronary Artery Disease 52

Coronary Artery Disease CMS Innovation Ischemia 52

DAIC

MAY 8, 2024

6 This novel study marks a significant milestone in the field, evaluating the effectiveness of FFR CT in detecting ischemia-producing coronary stenosis in patients with severe PAD. Diagnosis and treatment of ischemia-producing coronary stenoses improves 5-year survival of patients undergoing major vascular surgery.” 2024, [link].

Coronary Artery Disease 111

Coronary Artery Disease Chest Pain Ischemia Myocardial Infarction 111

DAIC

MARCH 27, 2024

Food and Drug Administration (FDA) for its DynamX BTK System, a novel, adaptive implant for use in the treatment of narrowed or blocked vessels below-the-knee (BTK) in patients with chronic limb-threatening ischemia (CLTI). The natural history of untreated severe or critical limb ischemia. 2013;382(9901):1329-1340. J Vasc Surg.

Peripheral Arterial Disease 111

Peripheral Arterial Disease Ischemia Technology Coronary Artery Disease 111

Journal of the American Heart Association

DECEMBER 13, 2024

Journal of the American Heart Association, Volume 13, Issue 24 , December 17, 2024. BackgroundAlthough there has been limited research into the perturbation of electrophysiological activity in the brain after ischemia, the activity signatures during ischemia and reperfusion remain to be fully elucidated.

Electrophysiology 40

Electrophysiology Ischemia Research 40

The American Journal of Cardiology

JUNE 5, 2024

Publication date: Available online 4 June 2024 Source: The American Journal of Cardiology Author(s): Carine E. Berger, ISCHEMIA Biorepository Research Group Hamo, Richard Liu, Wenbo Wu, Rebecca Anthopolos, Sripal Bangalore, Claes Held, Ifitkhar Kullo, Kreton Mavromatis, Bruce McManus, L. Kristin Newby, Harmony R. Reynolds, Kelly V.

Ischemia 40

Ischemia Circulation Biomarkers Research 40

DAIC

FEBRUARY 13, 2024

25, 2024 in the European Heart Journal Cardiovascular Imaging. 25, 2024 in the European Heart Journal Cardiovascular Imaging 1. 25, 2024 in the European Heart Journal Cardiovascular Imaging 1. In Press European Heart Journal CV Imag 2024.This This study was sponsored by Cleerly, Inc. James Min, M.D. and James Earls, M.D.

Coronary Artery Disease 103

Coronary Artery Disease Ischemia Atherosclerosis Cardiovascular Imaging 103

American College of Cardiology

OCTOBER 27, 2024

New science presented at TCT 2024 and simultaneously published across the family of JACC Journals sheds light on topics including photon-counting detector-computed tomography (PCD-CT), new and emerging technologies for treating patients with cardiovascular diseases, fractional flow reserve (FFR) and resting full-cycle ratio for predicting myocardial (..)

Ultrasound 40

Ultrasound Ischemia Technology Cardiovascular Disease 40

Journal of Cardiovascular Pharmacology

JULY 15, 2024

The role of intravenous immunoglobulin in protecting the diabetic heart from ischemia/reperfusion (I/R) injury is unclear. Hearts isolated from adult diabetic and non-diabetic Wistar rats (n=8 per group) were treated with intravenous immunoglobulin (IVIG) either two hours before euthanasia, before ischemia, or at reperfusion.

Ischemia 40

Ischemia Diabetes Article 40

DAIC

JULY 23, 2024

mtaschetta-millane Tue, 07/23/2024 - 10:59 July 23, 2024 — The Society of Cardiovascular Computed Tomography (SCCT) announced its best original science award winners of the 19th Annual Scientific Meeting (SCCT2024) in Washington, DC.

Chest Pain 105

Chest Pain Plaque Coronary Artery Disease Ischemia 105

DAIC

MARCH 20, 2024

milla1cf Wed, 03/20/2024 - 18:50 March 20, 2024 — Biotronik has been granted Breakthrough Device Designation (BDD) from the US Food and Drug Administration (FDA) for the Freesolve below-the-knee resorbable magnesium scaffold (BTK RMS). For more information: www.biotronik.com References: 1 Kwong M.,

Peripheral Arterial Disease 105

Peripheral Arterial Disease Innovation Technology Coronary Artery Disease 105

DAIC

FEBRUARY 14, 2024

2 An estimated 10% of patients with PAOD have its most severe form: chronic limb-threatening ischemia (CLTI). Determinants of long-term outcomes and costs in the management of critical limb ischemia: A population-based cohort study. Eur J Vasc Endovasc Surg. 2012;43:55-61. J Am Heart Assoc. DOI: 10.1161/JAHA.118.009724. 118.009724.

Heart Attack 111

Heart Attack Heart attacks Peripheral Arterial Disease Ischemia 111

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4147779-A4147779, November 12, 2024. Historically, DRP1 has been targeted through genetic downregulation and small-molecule inhibition, thereby mitigating apoptosis and lethal ischemia-reperfusion (IR).Aim:Our

Ischemia 40

Ischemia Circulation 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP317-ATP317, February 1, 2024. To confirm the time-kinetics of cGK1/2 changes, brain samples were divided ischemia-reperfusion period in SMLC and SMKO mice with and without dipyridamole (60 mg/kg, p.o.).Results:Infarction Not only SMLC but also SMKO were the same.

Ischemia 40

Ischemia Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP325-AWP325, February 1, 2024. miR-155-5p ASO-treated PBMC administration increased VEGF expression 21 d after administration in ischemic rats (28 d after cerebral ischemia).

Ischemia 40

Ischemia Strokes Stroke 40

DAIC

APRIL 11, 2024

PCI is commonly used to open blocked arteries to treat significant myocardial ischemia , which occurs when the heart muscle does not get enough oxygenated blood.

Plaque 111

Plaque Heart attacks Heart Attack Coronary Artery Disease 111

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4113494-A4113494, November 12, 2024. To elucidate this relationship, we investigated gut microbiota dynamics in response to immunosuppression and cell therapy in a nonhuman primate (NHP) cardiac ischemia/reperfusion (IR) model, with controlled genetic, dietary, and environmental factors.

Ischemia 40

Ischemia Transplant Heart Transplant Biomarkers 40

Circulation: Cardiovascular Imaging

AUGUST 19, 2024

Circulation: Cardiovascular Imaging, Volume 17, Issue 8 , Page e017210, August 1, 2024.

Ischemia 40

Ischemia Cardiovascular Imaging Circulation 40

Circulation

APRIL 14, 2024

Circulation, Volume 149, Issue 16 , Page 1254-1257, April 16, 2024.

Quality of Life 49

Quality of Life Ischemia Circulation 49

Dr. Smith's ECG Blog

OCTOBER 20, 2024

The first task when assessing a wide complex QRS for ischemia is to identify the end of the QRS. The ST segment changes are compatible with severe subendocardial ischemia which can be caused by type I MI from ACS or potentially from type II MI (non-obstructive coronary artery disease with supply/demand mismatch). What do you think?

Cardiogenic Shock 128

Cardiogenic Shock Ischemia Chest Pain Cardiac Arrest 128

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP32-ATP32, February 1, 2024. This study aims to understand the role of SIRT3 on ischemia and reperfusion-induced neuronal apoptosis. Ischemic stroke occurs when the blood supply to the brain is interrupted, reducing the access of affected tissue to oxygen and glucose.

Ischemia 40

Ischemia Strokes Stroke 40

DAIC

MAY 16, 2024

Among those ages 65 and older, nearly 50% who underwent limb amputation died within one year after surgery, according to the 2024 Heart Disease and Stroke Statistics: A Report of U.S. If left untreated, PAD may progress to severe forms known as chronic limb-threatening ischemia (CLTI) and acute limb ischemia (ALI).

Peripheral Arterial Disease 105

Peripheral Arterial Disease Exercise Ischemia Quality of Life 105

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP12-AWMP12, February 1, 2024. Background:Malonate, a competitive inhibitor of succinate dehydrogenase, has shown much promise in ameliorating ischemia/reperfusion injury (IRI) in various diseases, including ischemic stroke.

Ischemia 40

Ischemia Strokes Stroke Physiology 40

DAIC

JUNE 25, 2024

Pocket-Sized Kardia 12L ECG System milla1cf Tue, 06/25/2024 - 18:55 June 25, 2024 — AliveCor , the global leader in AI -powered cardiology, today announced the U.S. Food and Drug Administration ( FDA ) clearance and commercial launch of KAI 12L AI technology and the Kardia 12L ECG System.

Technology 116

Technology Heart attacks Heart Attack Innovation 116

Dr. Smith's ECG Blog

SEPTEMBER 29, 2024

This usually represents posterior OMI, but in tachycardia and especially after cardiac arrest, this could simply be demand ischemia, residual subendocardial ischemia due to the low flow state of the cardiac arrest. This rules out subendocardial ischemia and is diagnostic of posterior OMI. V4-5 continue to show STD.

Cardiac Arrest 109

Cardiac Arrest STEMI Ischemia SCAD 109

Journal of Cardiovascular Pharmacology

APRIL 1, 2024

Abstract: N-n-butyl haloperidol iodide (F2), a derivative of haloperidol developed by our group, exhibits potent antioxidative properties and confers protection against cardiac ischemia/reperfusion (I/R) injury. Copyright © 2024 The Author(s). The protective mechanisms by which F2 ameliorates I/R injury remain obscure.

Ischemia 40

Ischemia Pharmacology Heart Disease Article 40

Circulation

FEBRUARY 19, 2024

Circulation, Volume 149, Issue 8 , Page 635-637, February 20, 2024.

Ischemia 53

Ischemia Circulation 53

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP112-AWMP112, February 1, 2024. In this study, our hypothesis was that NETs cause vascular occlusion leading to delayed cerebral ischemia (DCI) and worse outcome after SAH. Neutrophils are reported to be critical mediators of to poor outcome after subarachnoid hemorrhage (SAH).

Ischemia 40

Ischemia Hemorrhage Aneurysm Outcomes 40

Ken Grauer, MD

JANUARY 13, 2024

My written interpretation on a tracing such as this one would read, "Marked LVH and 'strain' and/or ischemia — with need for clinical correlation." BOTTOM LINE: ECG changes of LV "strain" and/or ischemia that we see on today's initial ECG — were not present 9 years earlier. Please see ECG Blog #73 for additional details ).

Blog 159

Blog Ischemia AFIB Hypertension 159

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page ASu104-ASu104, November 12, 2024. The neurovascular unit, particularly the interaction between brain microvascular endothelial cells (BMECs) and neurons, is crucial in cerebral ischemia/reperfusion (I/R) injury.

Ischemia 40

Ischemia Cardiac Arrest Circulation Outcomes 40

Dr. Smith's ECG Blog

MAY 27, 2024

The ECG did not meet STEMI criteria, and the final cardiology interpretation was “ST and T wave abnormality, consider anterior ischemia”. Hence the first ECG was labeled 'anterior ischemia' based on ST depression, rather than identifying this as reciprocal from posterior OMI. Int J Cardiol 2024 2. De Alencar Neto. Nikus et al.

Chest Pain 122

Chest Pain STEMI Myocardial Infarction Ischemia 122

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP309-ATP309, February 1, 2024. Background and Purpose:Neutrophils are the first recruited leukocytes following ischemia/reperfusion injury in the brain; however, when and where neutrophils enter the brain parenchyma to exert their effects is controversial.

Ischemia 40

Ischemia Strokes Stroke 40

The American Journal of Cardiology

JANUARY 1, 2025

Publication date: Available online 31 December 2024 Source: The American Journal of Cardiology Author(s): Takuma Takada, Eiji Shibahashi, Shun Hasegawa, Ayano Yoshida, Makoto Kishihara, Shonosuke Watanabe, Shota Shirotani, Takuro Abe, Masashi Nakao, Junichi Yamaguchi, Kentaro Jujo

Ischemia 40

Ischemia Heart Failure 40

Dr. Smith's ECG Blog

JANUARY 2, 2025

It should be kept in mind that on occasions, beta-one agonist can result in increased ventricular ectopy e.g., in severe myocardial ischemia (by increasing myocardial demand), or sometimes with congenital long-QT syndrome. Smith, this can be accomplished by either using beta-one agonists or temporary transvenous pacing.

Tachycardia 116

Tachycardia Cardiomyopathy Blog Bradycardia 116

DAIC

FEBRUARY 12, 2024

Getty Images milla1cf Mon, 02/12/2024 - 15:14 February 12, 2024 — VST Bio Corp. Histological analysis at 72 hours post-stroke confirmed a significant reduction of edema and area of necrosis in both early and delayed therapy groups.

Strokes 98

Strokes Stroke Innovation Ischemia 98