Stroke Journal

JANUARY 30, 2025

Introduction:Stroke is a leading cause of disability and mortality worldwide, with thrombolysis as a critical treatment. Studies aiming to assess the outcomes of thrombolysis after ischemic stroke in LMIC were selected. Seven randomized controlled trials (RCTs) were included and analyzed independently.

Thrombolysis 40

Thrombolysis Outcomes Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

hour window, and reperfusion through thrombolysis has been shown to enhance functional outcomes in patients with salvageable brain tissue beyond this timeframe.Objective:The aim of this study is to assess the efficacy and safety of thrombolysis administered more than 4.5 These modalities can identify viable brain tissue beyond the 4.5-hour

Thrombolysis 40

Thrombolysis Strokes Stroke Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A59-A59, February 1, 2024. We evaluated the risk of hemorrhage associated with newer, more potent antiplatelet medications and dual antiplatelet regimens among patients treated with intravenous tissue plasminogen activator (IV-tPA).Methods:Using

Hemorrhage 40

Hemorrhage Thrombolysis Strokes Stroke 40

DAIC

FEBRUARY 7, 2024

Findings from the highly-anticipated MOST (Multi-Arm Optimization of Stroke Thrombolysis) trial were presented on the first day of the American Stroke Association’s International Stroke Conference, ISC 2024, being held through Feb. 9 Phoenix, AZ. Adeoye, M.D.,

Strokes 105

Strokes Stroke Outcomes Thrombolysis 105

Stroke Journal

JANUARY 30, 2025

The effectiveness and safety of intravenous thrombolysis (IVT) for acute ischemic stroke in these cases, particularly those involving large vessel occlusions, are debated. We searched MEDLINE (OVID), EMBASE, web of Science, and SCOPUS from inception to 03/03/2024. Stroke, Volume 56, Issue Suppl_1 , Page AWP9-AWP9, February 1, 2025.

Thrombolysis 40

Thrombolysis Strokes Stroke Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP177-AWP177, February 1, 2024. Definitions of symptomatic HT developed during the intravenous thrombolysis (IVT) era are outdated in the endovascular thrombectomy (EVT) era but continue to be widely used. Background:Hemorrhagic transformation (HT) is the principal adverse event of thrombectomy.

Hemorrhage 40

Hemorrhage Outcomes Thrombolysis Strokes 40

Stroke Journal

JANUARY 30, 2025

Background and Aims:Previous studies indicated the usual dose heparin(5000 IU bolus followed by 500~1250 IU/h) during mechanical thrombectomy(MT) is associated with an increased risk of hemorrhagic conversion without beneficial effect. This trend also seemed to be seen in patients who did not undergo intravenous thrombolysis group.

Hemorrhage 40

Hemorrhage Thrombolysis Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP202-AWP202, February 1, 2024. The role of adjunctive intravenous thrombolysis, such as intravenous tissue plasminogen activator (IVtPA), with MT remains unclear, especially for medium vessel occlusion (MeVO).

Thrombolysis 40

Thrombolysis Academic Hemorrhage Outcomes 40

Stroke Journal

JANUARY 30, 2025

Background:Symptomatic intracranial hemorrhage (sICH) is the most dreaded complication after reperfusion therapy for acute ischemic stroke. Concomitant use of intravenous thrombolysis and the use of MT in the extended therapeutic window do not raise the risk of sICH. 2.07; P = 0.037).

Hemorrhage 40

Hemorrhage Thrombolysis Circulation Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP78-AWMP78, February 1, 2024. Recent landmark trials BEST-MSU and B_PROUD have proven that MSUs facilitate quicker thrombolysis times and improved functional outcomes at 90 days when compared to conventional emergency medical services (EMS) for acute ischemic stroke patients.

Hemorrhage 40

Hemorrhage Blood Pressure Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Direct-to-angiography workflow relies on CBCT to exclude intracranial hemorrhage (ICH) to determine treatment eligibility for intravenous thrombolysis (IVT) and/or mechanical thrombectomy (MT). Systematic searches were last performed on April 1, 2024 in EMBASE, PubMed, Web-of-Science, Scopus, and CINAHL databases.

Hemorrhage 40

Hemorrhage Strokes Stroke Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Introduction:Current guidelines recommend 24-hours of high-intensity monitoring (HIM) for acute ischemic stroke patients post-intravenous thrombolysis (IVT) due to risk of bleeding complications including symptomatic intracranial hemorrhage (sICH).

Thrombolysis 40

Thrombolysis ICU Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP8-AWP8, February 1, 2024. Median time from the onset of visual change to thrombolysis was 6.0 [4.5-10.5] Introduction:Branch retinal artery occlusion (BRAO) results from the blood flow compromise in of the branches of the central retinal artery. VA improvement of ≥0.1 VA improvement of ≥0.1

Thrombolysis 40

Thrombolysis Outcomes Hemorrhage Strokes 40

Stroke Journal

JANUARY 30, 2025

We studied the impact of intravenous thrombolysis (IVT) on the outcomes of EVT in those patients.Methods:We conducted a meta-analysis using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist and the Cochrane Handbook of Systematic Reviews and Interventions.

Thrombolysis 40

Thrombolysis Hemorrhage Outcomes Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A25-A25, February 1, 2024. Introduction:Intravenous thrombolysis (IVT) is efficacious treatment of acute ischemic stroke (AIS). Outcomes of interest were symptomatic intracranial hemorrhage (sICH), any ICH, serious systemic bleeding (SSB), and 90-day functional independence (mRS 0-2).

Thrombolysis 40

Thrombolysis Strokes Stroke Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP146-ATP146, February 1, 2024. Introduction:Collateral status imaging parameters are associated with predicting hemorrhagic transformation (HT) in acute ischemic stroke caused by large vessel occlusions.

Hemorrhage 40

Hemorrhage Thrombolysis Diabetes Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP63-ATMP63, February 1, 2024. We analyzed the temporal trends of BP characteristics and their association with early neurological deterioration (END) and symptomatic intracranial hemorrhage (sICH). All BP readings from ED arrival to 24 hours post TNK were queried. vs 4.9%; p=0.3)

Hemorrhage 40

Hemorrhage Blood Pressure Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP179-AWP179, February 1, 2024. We defined two binary outcomes: (1) functional clinical outcome (modified Rankin Scale 0-2) and (2) early symptomatic intracerebral hemorrhage (sICH).

Stents 40

Stents Stent Thrombolysis Angioplasty 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP154-AWP154, February 1, 2024. vs. 6.1%, p = 0.0326), and symptomatic intracerebral hemorrhage (7.3% Patients receiving thrombolysis prior to thrombectomy were less likely to have a prolonged LOS (27.8% p = 0.0002), not receiving IV thrombolysis (OR 2.3, vs. 1.9%, p = 0.0109).

ICU 40

ICU Thrombolysis Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP86-ATMP86, February 1, 2024. Primary safety outcome was parenchymal hematoma type 2 (PH2) intracerebral hemorrhage. A t-test was used to examine association between outcomes and thrombolysis type. Use of TPA was converted to TNK on 1/11/2022 per hospital policy. were females.

Thrombolysis 40

Thrombolysis Strokes Stroke Hemorrhage 40

Stroke Journal

DECEMBER 21, 2023

Stroke, Volume 55, Issue 1 , Page 78-88, January 1, 2024. METHODS:We conducted an international multicenter retrospective cohort study of consecutive AIS tested for SARS-CoV-2, receiving intravenous thrombolysis and endovascular treatment between 2020 and 2021. 1.99]; aOR, 1.63 [95% CI, 1.14–2.32], 2.32], respectively).

COVID-19 40

COVID-19 Outcomes Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP288-AWP288, February 1, 2024. Rates of Thrombolysis were alarming, but with an increasing tendency: 22969 were performed, from 1.6% Data was obtained through DataSUS, a public database. were Male and 47.6% were Female. were Male and 47.6% were Female. in 2017 to 2.3% of all SAH cases).

Cerebrovascular Disease 40

Cerebrovascular Disease Thrombolysis Public Health Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP21-AWP21, February 1, 2024. Introduction:Although prior antiplatelet therapy (APT) could potentially contribute to bleeding risk, the influence of prior APT on intravenous thrombolysis outcomes remains controversial.

Strokes 40

Strokes Stroke Thrombolysis Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

The transition from Alteplase to Tenecteplase for AIS patients eligible for thrombolysis occurred on June 6, 2022. EHR Alteplase references were changed to thrombolysis. A retrospective review of system Alteplase administrations during 6/2020- 5/2022 was compared to Tenecteplase administrations throughout 6/2022- 5/2024.Results:Thrombolytic

Strokes 40

Strokes Stroke Thrombolysis Nursing 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP42-AWMP42, February 1, 2024. Background:Prior studies have shown that individuals who have an in-hospital stroke are less likely to receive thrombolysis. Overall, in-hospital strokes were more likely to be hemorrhagic in 2015 than in 1993/94; 12 % in 2015 vs. 3.6% in1993/94 (p=0.003).

Hospital 40

Hospital Strokes Stroke Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP282-ATP282, February 1, 2024. No significant differences were observed in baseline characteristics, including gender, National Institutes of Health Stroke Scale score, and the rate of intravenous thrombolysis, between the transferred and direct presentation groups (all p > 0.05).

Strokes 40

Strokes Stroke Thrombolysis ICU 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A28-A28, February 1, 2024. Introduction:ACTIMIS (NCT03803007) was a randomized phase 1b/2a clinical trial evaluating glenzocimab, a monoclonal antibody fragment targeting platelet receptor glycoprotein VI in patients with acute ischemic stroke treated by thrombolysis.

Hemorrhage 40

Hemorrhage Thrombolysis Biomarkers Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP215-AWP215, February 1, 2024. Patients who underwent MT for ICA, M1, or M2 with unsuccessful recanalization (modified Thrombolysis in Cerebral Infarction ≤ 2a) were included. Secondary outcomes included any intracranial hemorrhage (ICH) and symptomatic ICH (sICH).

Strokes 40

Strokes Stroke Thrombolysis Aneurysm 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP182-AWP182, February 1, 2024. Forty-four percent of the no AC group received intravenous thrombolysis (IVT). In the anticoagulated group, only patients on NOACs were included. In the NOAC group, 59.5% of patients achieved 90-day mRS of 0-2 vs 49.3% in the no AC group (aOR=1.32, p=0.57).

Atrial Fibrillation 40

Atrial Fibrillation Outcomes Thrombolysis Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A85-A85, February 1, 2024. Intravenous thrombolysis was administered in 55 patients (22.1%) while general anesthesia was used in 94/248 patients (37.9%). years [SD 11.7], 208 [83.5%] male) were included. The median baseline NIHSS score was 23 (IQR 12-30) and median PC-ASPECTS was 9 (IQR 7-10).

Circulation 40

Circulation Outcomes Thrombolysis Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP5-AWP5, February 1, 2024. While DM can reduce the effect of intravenous thrombolysis, metformin can have a positive outcome on AIS patients. Background:Diabetes mellitus (DM) is one of the risk factors for acute ischemic stroke, usually leading to poor prognosis.

Diabetes 40

Diabetes Strokes Stroke Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP3-AWP3, February 1, 2024. Outcomes included sICH, and inpatient mortality, adjusted for confounders which included age, gender, baseline NIHSS, perfusion grade (TICI) intravenous thrombolysis, history of diabetes and HBA1c.Results:A total of 224 patients (mean age was 68.7 years (±14.3); 44.2%

Inpatient 40

Inpatient Strokes Stroke Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP64-AWMP64, February 1, 2024. These patients had an increased hemorrhagic transformation rate of 68% with only 1 in 3 patients having favorable clinical outcome. Late lesion growth patients had a 26.2mL change in Late lesion volume and 19.9mL change in Early lesion volume.

Hemorrhage 40

Hemorrhage Thrombolysis Biomarkers Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP27-AWMP27, February 1, 2024. Tenecteplase (TNK) is currently being used for IV thrombolysis in acute ischemic stroke. Tenecteplase is the first thrombolytic that can be administered over five seconds in a single dose.” Genetech, 2023).

Myocardial Infarction 40

Myocardial Infarction Strokes Stroke Nursing 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP193-ATP193, February 1, 2024. Successful recanalization was defined as modified Thrombolysis in Cerebral Ischemia Score≥ 2b. Secondary outcomes were symptomatic intracranial hemorrhage and intracranial hemorrhage within 24 hours and mortality at 90 days.

Outcomes 40

Outcomes Strokes Stroke Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP191-AWP191, February 1, 2024. The median NIHSS was 16 (10-20), 50% were treated with intravenous thrombolysis at a spoke, and TICI 2B-3 reperfusion was achieved in 87% at the hub. Introduction:The mantra ‘time is brain’ cannot be overstated for patients suffering from acute ischemic stroke.

Strokes 40

Strokes Stroke Thrombolysis Atrial Fibrillation 40

Stroke Journal

JANUARY 30, 2025

We evaluated whether utilizing an APP in the emergency room affected timing and safety of IV thrombolytic therapy.Methods:Single center academic hospital retrospective analysis on acute ischemic stroke patients given thrombolytic therapy in the emergency department between January 2022 and June 2024. Patients treated greater than 4.5

Academic 40

Academic Thrombolysis Strokes Stroke 40