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Physiology Friday #245: Fitness Protects against Neurodegenerative Diseases—Even in Those at the Greatest Risk

Physiologically Speaking

dementia and Alzheimer’s) can be assessed using polygenic risk scores, which aggregate the effects of numerous genetic variants to estimate genetic predisposition. Offsetting a high genetic predisposition might require a bit more focus and attention to optimizing your cardiorespiratory fitness.

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Thrombotic Thrombocytopenic Purpura: A Missed Cause in Stroke Prevention Guidelines

Stroke Journal

The 2024 Guidelines for the Primary Prevention of Stroke, recently updated by the American Heart Association and the American Stroke Association, serve as an essential resource for clinicians aiming to reduce the growing impact of cerebrovascular disease. Stroke, Ahead of Print.

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Physiology Friday November Recap

Physiologically Speaking

In case you missed it, here are all of the studies I covered in the November 2024 installments of the Physiology Friday newsletter. Enjoy (or re-enjoy) these summaries, and don’t forget to share them with someone you think might learn from or be interested in them. Thanks for reading!

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Abstract 4112869: Development of a Sitosterolemia Risk Prediction Scale (SRPS): A Screening Tool

Circulation

Circulation, Volume 150, Issue Suppl_1 , Page A4112869-A4112869, November 12, 2024. Introduction:Sitosterolemia, a hereditary disorder marked by elevated plant sterol levels, presents diagnostic challenges due to its similarity to other lipid disorders.

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Abstract TP248: Genetic Predisposition to Diabetes and Risk of Stroke in Native Hawaiians

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page ATP248-ATP248, February 1, 2024. Background:Diabetes is a highly heritable stroke risk factor with numerous known genetic risk variants. However, the role of these genetic risk variants in the development of cerebrovascular disease in Native Hawaiians remains unknown. 2.05; p=0.04).Conclusions:Among

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Abstract 8: Polygenic Resistance to Blood Pressure Treatment and Stroke Risk

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page A8-A8, February 1, 2024. Background:Common genetic variation explains up to 40% of blood pressure variation. Despite this compelling physiological impact, the role of common genetic variation in blood pressure treatment and their sequelae remains understudied. for both analyses).Conclusions:Among

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How To Reduce The Risk Of Heart Disease If You Have Insulin Resistance.

Dr. Paddy Barrett

Yes, there is a genetic predisposition at play. BMC Med 22 , 114 (2024). But I am saying that even if you have developed type 2 diabetes, which is a major driver of risk, there is still a huge amount that can be done to reduce future risk. But why wait? For sure. ( I know because I have some of those genes ). They set the odds.