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dementia and Alzheimer’s) can be assessed using polygenic risk scores, which aggregate the effects of numerous genetic variants to estimate geneticpredisposition. Offsetting a high geneticpredisposition might require a bit more focus and attention to optimizing your cardiorespiratory fitness.
The 2024 Guidelines for the Primary Prevention of Stroke, recently updated by the American Heart Association and the American Stroke Association, serve as an essential resource for clinicians aiming to reduce the growing impact of cerebrovascular disease. Stroke, Ahead of Print.
In case you missed it, here are all of the studies I covered in the November 2024 installments of the Physiology Friday newsletter. Enjoy (or re-enjoy) these summaries, and don’t forget to share them with someone you think might learn from or be interested in them. Thanks for reading!
Circulation, Volume 150, Issue Suppl_1 , Page A4112869-A4112869, November 12, 2024. Introduction:Sitosterolemia, a hereditary disorder marked by elevated plant sterol levels, presents diagnostic challenges due to its similarity to other lipid disorders.
Stroke, Volume 55, Issue Suppl_1 , Page ATP248-ATP248, February 1, 2024. Background:Diabetes is a highly heritable stroke risk factor with numerous known genetic risk variants. However, the role of these genetic risk variants in the development of cerebrovascular disease in Native Hawaiians remains unknown. 2.05; p=0.04).Conclusions:Among
Stroke, Volume 55, Issue Suppl_1 , Page A8-A8, February 1, 2024. Background:Common genetic variation explains up to 40% of blood pressure variation. Despite this compelling physiological impact, the role of common genetic variation in blood pressure treatment and their sequelae remains understudied. for both analyses).Conclusions:Among
Yes, there is a geneticpredisposition at play. BMC Med 22 , 114 (2024). But I am saying that even if you have developed type 2 diabetes, which is a major driver of risk, there is still a huge amount that can be done to reduce future risk. But why wait? For sure. ( I know because I have some of those genes ). They set the odds.
Circulation: Genomic and Precision Medicine, Volume 17, Issue 6 , Page e004685, December 1, 2024. The female-specific positive association of PGSMDwith CAD risk was replicated in BioVU.CONCLUSIONS:Genetic predisposition to MD confers a greater risk of CVDs in females versus males, even in the absence of any depression diagnosis.
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