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Physiology Friday #245: Fitness Protects against Neurodegenerative Diseases—Even in Those at the Greatest Risk

Physiologically Speaking

Insulin resistance and impaired glucose metabolism are risk factors for Alzheimer's disease, hence why the disease is sometimes referred to as ‘type 3 diabetes.’ And while lifestyle factors play a crucial role in mitigating the risk of dementia, our genetic makeup also plays a part. Moderate: 24.1–31.1 Men Low: 23.7–30.8

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Cholesterol’s Star Role in Dementia Prevention: New Insights from the 2024 Lancet Dementia Report 

Cardiometabolic Health Congress

The 2024 report from the Lancet Standing Commission on Dementia Prevention, Intervention, and Care brings promising developments for healthcare professionals and public health advocates. Key Takeaways: Up to 50% of all dementia cases could potentially be prevented or substantially delayed.

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Abstract WP320: Microemboli Model of Vascular Cognitive Impairment/Dementia (VCID) Presents With Long-Term Brain Tissue Hypoxia: Relevance to Endothelin-1 (ET-1)

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page AWP320-AWP320, February 1, 2024. Diabetes doubles the risk of VCID but the underlying reasons remain unclear. At 10 weeks after the onset of diabetes, control and diabetic rats received cholesterol crystal ME (40-70 μm) injections and were monitored for 16 weeks.

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Highlights from The National Lipid Association (NLA) Scientific Sessions 

Cardiometabolic Health Congress

The NLA Scientific Sessions (May 30-June 2, 2024) has concluded, providing key insights into lipid management and cardiovascular health. He highlighted that cardiovascular health is essential for cognitive health, noting the common occurrence of vascular dementia. Ballantyne , this October 17-19, 2024 in Boston, MA.

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Abstract TP35: A 2-Stage Recruitment Design to Reduce MRI Screening Costs for a Theoretical Clinical Trial of WMH Progression

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page ATP35-ATP35, February 1, 2024. Background:White matter hyperintensities (WMH) are associated with risk of dementia and stroke, so are an important therapeutic target for clinical trials.

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14 Ways To Prevent Dementia

Dr. Paddy Barrett

More than heart disease or cancer, the risk of dementia often creates much greater anxiety in the patients I see. And given that dementia is routinely in the top 5 leading causes of death, this concern is dually warranted. But can dementia be prevented? 14 Ways To Prevent Dementia. 14 Ways To Prevent Dementia.

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The Data For Weight Loss Medications Just Keeps Pouring In.

Dr. Paddy Barrett

Recent research suggested that the weight loss market was estimated to be worth $224 billion annually in 2021 and is estimated to exceed $400 billion by 2024 1. Type 2 Diabetes When it comes to the increasing the risk of major chronic diseases such as cardiovascular disease, many cancers and dementia, type 2 diabetes plays a huge role.

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