2024, Circulation and Pharmacology - Cardiovascular Update

Correction to: Pharmacological Management of Cardiac Arrhythmias in the Fetal and Neonatal Periods: A Scientific Statement From the American Heart Association

Circulation

MARCH 17, 2024

Circulation, Volume 149, Issue 12 , Page e996-e996, March 19, 2024.

Pharmacology

Pharmacology Arrhythmia Circulation

Abstract 4146046: A Chemical Language Model for the Design of De Novo Molecules Targeting the Inhibition of TLR3

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4146046-A4146046, November 12, 2024. However, there are currently no pharmacological treatments for CAVD, and the discovery of de novo molecules targeting a specific protein is a time-intensive and financially demanding process.

Pharmacology

Pharmacology Aortic valve Aortic Circulation

Bivalirudin in Extracorporeal Membrane Oxygenation

Journal of Cardiovascular Pharmacology

SEPTEMBER 5, 2024

Heparin, the most utilized anticoagulant, carries concerns for heparin-induced thrombocytopenia and possible resistance given its dependence on co-factors and circulating proteins to exert its pharmacologic effect. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

Laboratory

Laboratory Thrombosis Pharmacology Pulmonary

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

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Abstract 4137905: The association between prehospital epinephrine administration and short-term outcomes in patients with shockable out-of-hospital cardiac arrest and extracorporeal cardiopulmonary resuscitation: a propensity matched analysis

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4137905-A4137905, November 12, 2024. Background:In out-of-hospital cardiac arrest (OHCA) patients with an initial shockable rhythm, epinephrine increases the likelihood of return of spontaneous circulation (ROSC), but its effect on neurological outcome remains uncertain.

Cardiac Arrest

Cardiac Arrest Hospital Outcomes Pharmacology

Abstract 4117657: Targeting GPR39 for Hypoxia-induced Pulmonary Hypertension in Mice

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4117657-A4117657, November 12, 2024. Pharmacological inhibition of GPR39 may open new frontiers in the treatment of PAH. Background:Primary pulmonary arterial hypertension (PAH) is a disease affecting young subjects. It has very poor prognosis and optimal treatment is not available.

Pulmonary

Pulmonary Hypertension Blood Pressure Pharmacology

Abstract 4141474: Impact of Serum 5-Hydroxytryptophan Levels on Coronary Artery Calcification Severity in Acute Coronary Syndrome Patients: Insights from the Microbiota-Gut-Brain Axis

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4141474-A4141474, November 12, 2024. While it is known to increase serotonin levels in the brain and gastrointestinal tract, its pharmacology remains largely unexplored.

Kidney Disease

Kidney Disease Risk Factors Pharmacology Diabetes

Abstract 4140419: Targeting Cardiac Fibrosis with Chimeric Antigen Receptor Neutrophils from Human Pluripotent Stem Cells

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4140419-A4140419, November 12, 2024. Current treatments, predominantly pharmacological, target signaling pathways involved in fibroblast activation but often come with side effects such as cardiac toxicities.

Cardiac Function

Cardiac Function Pharmacology Innovation Heart Failure

Abstract 4142210: Stroke Risk in Patients with Cardioversion of Newly Diagnosed Persistent Atrial Fibrillation with and without Transesophageal Echocardiogram for Left Atrial and Left Atrial Appendage Thrombus Assessment

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4142210-A4142210, November 12, 2024. The importance of transesophageal echocardiogram (TEE) to exclude left atrial (LA) and left atrial appendage (LAA) thrombus prior to cardioversion for atrial fibrillation (AF) has been debated in patients who are anticoagulated prior to cardioversion.

Echocardiogram

Echocardiogram Atrial Fibrillation Stroke Strokes

The combination of valsartan and spironolactone mitigated mitral regurgitation induced cardiac dysfunction in a novel rat model

Journal of Cardiovascular Pharmacology

JULY 23, 2024

Mechanistically, combination therapy effectively suppressed circulating and cardiac expression of aldosterone- and apoptosis-associated proteins. Mechanistically, combination therapy effectively suppressed circulating and cardiac expression of aldosterone- and apoptosis-associated proteins.

Bicuspid/Mitral

Bicuspid/Mitral Cardiac Function Heart Failure Circulation

Melatonin attenuates cardiac dysfunction and inflammation in dilated cardiomyopathy via M2 macrophage polarization

Journal of Cardiovascular Pharmacology

NOVEMBER 11, 2024

Circulating melatonin levels were significantly decreased in DCM mice and were associated with LVEF. Circulating melatonin levels were significantly decreased in DCM mice and were associated with LVEF. Copyright © 2024 Wolters Kluwer Health, Inc. M2-type macrophages were analyzed by flow cytometry. All rights reserved.

Cardiomyopathy

Cardiomyopathy Circulation Article

Lowering Atherosclerotic Cardiovascular Disease Events by Treating Residual Inflammatory Risk

DAIC

JANUARY 23, 2024

Inflammation driven by signaling cytokines, circulating immune cells, adhesion molecules, and oxidized low-density lipoprotein cholesterol (LDL-C) leads to atherosclerotic plaque development, plaque progression, and eventual rupture.14,15 2019 Sep 10;140(11):e649-e650] [published correction appears in Circulation. Circulation.

Cardiovascular Disease

Cardiovascular Disease Heart Attack Heart attacks Coronary Artery Disease

Abstract 4145490: Direct Oral Anticoagulants versus Low Molecular Weight Heparins for Prevention of VTE in Active Malignancy: Insights from a Pooled Analysis of RCTs

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4145490-A4145490, November 12, 2024. Background:Cancer is well known to cause a pro-thrombotic state, however, the pharmacologic therapy for prevention of Venous Thromboembolism (VTE) remains under contention.

Pharmacology

Pharmacology Cancer Outcomes Circulation

New Guidelines on Peripheral Artery Disease Issued by American Heart Association, American College of Cardiology and Leading Medical Societies

DAIC

MAY 16, 2024

Among those ages 65 and older, nearly 50% who underwent limb amputation died within one year after surgery, according to the 2024 Heart Disease and Stroke Statistics: A Report of U.S. Pharmacological and behavioral-based strategies often increase the smoking cessation rate in people with PAD, however, these strategies are underused.

Peripheral Arterial Disease

Peripheral Arterial Disease Exercise Ischemia Quality of Life

American College of Cardiology (ACC) and American Heart Association (AHA) Issue New Hypertrophic Cardiomyopathy (HCM) Management Guidelines

DAIC

MAY 9, 2024

Image courtesy: Getty Images christine.book Thu, 05/09/2024 - 15:33 May 9, 2024 — The American College of Cardiology ( ACC ) and the American Heart Association ( AHA ) today released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy (HCM).

Cardiomyopathy

Cardiomyopathy Pediatrics Quality of Life Sudden Cardiac Death

American Stroke Association to Honor 11 Leading Scientists at International Stroke Conference ISC 2024

DAIC

FEBRUARY 7, 2024

During the American Stroke Association’s International Stroke Conference 2024, ISC24, eleven scientists leading the way in stroke research will be recognized for their exceptional professional achievements. The world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health is being held Feb.

Stroke

Stroke Strokes Research Health Disparities

Correction to: Pharmacological Management of Cardiac Arrhythmias in the Fetal and Neonatal Periods: A Scientific Statement From the American Heart Association

Abstract 4146046: A Chemical Language Model for the Design of De Novo Molecules Targeting the Inhibition of TLR3

Bivalirudin in Extracorporeal Membrane Oxygenation

Webinars

Abstract 4137905: The association between prehospital epinephrine administration and short-term outcomes in patients with shockable out-of-hospital cardiac arrest and extracorporeal cardiopulmonary resuscitation: a propensity matched analysis

Abstract 4117657: Targeting GPR39 for Hypoxia-induced Pulmonary Hypertension in Mice

Abstract 4141474: Impact of Serum 5-Hydroxytryptophan Levels on Coronary Artery Calcification Severity in Acute Coronary Syndrome Patients: Insights from the Microbiota-Gut-Brain Axis

Abstract 4140419: Targeting Cardiac Fibrosis with Chimeric Antigen Receptor Neutrophils from Human Pluripotent Stem Cells

Abstract 4142210: Stroke Risk in Patients with Cardioversion of Newly Diagnosed Persistent Atrial Fibrillation with and without Transesophageal Echocardiogram for Left Atrial and Left Atrial Appendage Thrombus Assessment

The combination of valsartan and spironolactone mitigated mitral regurgitation induced cardiac dysfunction in a novel rat model

Melatonin attenuates cardiac dysfunction and inflammation in dilated cardiomyopathy via M2 macrophage polarization

Lowering Atherosclerotic Cardiovascular Disease Events by Treating Residual Inflammatory Risk

Abstract 4145490: Direct Oral Anticoagulants versus Low Molecular Weight Heparins for Prevention of VTE in Active Malignancy: Insights from a Pooled Analysis of RCTs

New Guidelines on Peripheral Artery Disease Issued by American Heart Association, American College of Cardiology and Leading Medical Societies

American College of Cardiology (ACC) and American Heart Association (AHA) Issue New Hypertrophic Cardiomyopathy (HCM) Management Guidelines

American Stroke Association to Honor 11 Leading Scientists at International Stroke Conference ISC 2024

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