Dr. Paddy Barrett

FEBRUARY 21, 2025

Recent research suggested that the weight loss market was estimated to be worth $224 billion annually in 2021 and is estimated to exceed $400 billion by 2024 1. That is severe obstructive sleep apnea (OSA), and with that serious interruption to sleep quality also comes a doubling in the risk of future heart disease, particularly stroke 6.

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Obesity Diabetes Cardiovascular Disease Chronic Disease 79

Medical Xpress - Cardiology

SEPTEMBER 3, 2024

Mass screening for atrial fibrillation using ECG together with heart failure biomarker does not prevent ischemic stroke or systemic embolism (blood clot) in older adults aged 75–76 years over 5 years follow-up, according to late breaking research presented in a Hot Line Session at this year's ESC Congress 2024 in London, UK (30 Aug–2 Sept).

Atrial Fibrillation 40

Atrial Fibrillation Blood Clot Research Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP25-ATMP25, February 1, 2024. Background:Acute brain injuries, including aneurysmal subarachnoid hemorrhage (aSAH), ischemic stroke (IS), and traumatic brain injury (TBI), entail complex recovery processes involving brain plasticity and synaptic regeneration mechanisms.

Biomarkers 40

Biomarkers Outcomes Aneurysm Hemorrhage 40

Stroke Journal

MARCH 24, 2024

Stroke, Volume 55, Issue 4 , Page e131-e131, April 1, 2024.

Biomarkers 40

Biomarkers Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP9-ATMP9, February 1, 2024. Background:FLAIR vascular hyperintensities (FVH) are high signal intensities on MRI resulting from sluggish flow through collateral vessels in patients with acute arterial ischemic stroke (AIS). Data from adults suggest they may be a marker of penumbra.

Pediatrics 40

Pediatrics Biomarkers Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A106-A106, February 1, 2024. Background:Circulating interleukin-6 (IL-6) concentrations are elevated in acute stroke but the timing of the IL-6 response in humans is unknown. We used a mobile stroke unit (MSU) to identify IL-6 levels within minutes of symptom onset.

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Stroke Strokes Circulation Thrombolysis 40

DAIC

JUNE 4, 2024

I am excited about the potential of the FAI-Score biomarker, which has promising prognostic value beyond existing CT-based methods such as plaque, calcium scoring, and CAD-RADS based interpretation." Details of the study, included in a written statement issued by Caristo Diagnostics, follow. fold higher risk for cardiac mortality and 5.5-fold

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Technology Heart Attack Heart attacks Coronary Artery Disease 116

Stroke Journal

DECEMBER 21, 2023

Stroke, Volume 55, Issue 1 , Page 31-39, January 1, 2024. Sensitivity and specificity of biomarker changes were analyzed in relation to predefined criteria for recurrent SH or asymptomatic change. Mean QSM and DCEQP of the SH lesion were acquired at baseline and at 1- and 2-year follow-ups.

Biomarkers 40

Biomarkers Hemorrhage Certification Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP58-ATMP58, February 1, 2024. Objectives:To determine the relationship between patient-reported outcome measures (PROMs) and volumetric biomarkers assessed on clinical imaging in acute ischemic stroke (AIS).Background:AIS Background:AIS is a leading cause of long-term disability.

Stroke 40

Stroke Strokes Outcomes Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A130-A130, February 1, 2024.

Biomarkers 40

Biomarkers Stroke Strokes Physiology 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP12-ATP12, February 1, 2024. Results are a proof of concept that blood tests could replace more complex and costly imaging biomarkers in monitoring CA hemorrhage. Relative change in Phenylacetylglutamine and LPE.18.0+Piperine

Biomarkers 40

Biomarkers Hemorrhage Circulation Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP119-ATMP119, February 1, 2024. Some of the biomarkers were unchanged (Table). Diabetes doubles the risk of VCID. The underlying reasons are not understood, and preventive therapeutic strategies are lacking.

Biomarkers 40

Biomarkers Diabetes Cholesterol Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP117-AWMP117, February 1, 2024. Background:Stroke is a significant health issue in the United States, and identifying biomarkers for preventing acute ischemic stroke (AIS) remains the highest priority. Exosomal miR-9-3p showed a 14.7-fold

Stroke 40

Stroke Strokes Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP266-AWP266, February 1, 2024. Background:This population-based study investigated the potential of machine learning algorithms to predict stroke incidence and identify important risk factors. These clusters were categorized into high-, medium-, and low-risk groups.

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Stroke Strokes Blood Pressure Laboratory 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4148181-A4148181, November 12, 2024. Background:Following an ischemic stroke, a serious complication known as hemorrhagic transformation (HT) might jeopardize patient outcomes.

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Hemorrhage Stroke Strokes Myocardial Infarction 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP24-ATP24, February 1, 2024. Background:Post-stroke depression (PSD) is a common neuropsychiatric complication of stroke associated with poor functional outcome and increased mortality. versus 40.7%). to 0.25), p<0.001], and Hcy [SMD 0.14, (95% CI 0.05

Stroke 40

Stroke Strokes Biomarkers Diabetes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP238-ATP238, February 1, 2024. Both subjects with stroke and subjects with TIA had increased serum PDGFRβ compared to those without history of CVA (6608.4 No significant differences related to PDGFRβ were observed between subjects with stroke vs. TIA (P=0.25). pg/mL and 5337.0

Stroke 40

Stroke Strokes Dementia Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP150-AWP150, February 1, 2024. Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is standard of care for secondary prevention in non-cardioembolic minor acute ischemic stroke (AIS) and high-risk transient ischemic attack (TIA). 95% CI +30.71 to +176.1;

Stroke 40

Stroke Strokes Biomarkers Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP169-AWP169, February 1, 2024. TEG-R time may be a useful biomarker in DOAC reversal with PCC. Prothrombin complex concentrates (PCCs) are used to emergently reverse direct-acting oral anticoagulant (DOAC) activity. TEG R-time rebounds 12 hours after PCC administration.

Biomarkers 40

Biomarkers Hemorrhage Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP150-ATP150, February 1, 2024. Introduction:Ischemic stroke is a leading cause of death and disability in the US, with 20-40% of cases, classified as cryptogenic or with an unexplained cause. Stroke in multiple vascular territories MVT was present in 22/101 (22%) at baseline.

Atrial Fibrillation 40

Atrial Fibrillation Stroke Strokes Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A131-A131, February 1, 2024. The primary outcome was incident ischemic stroke. There were a total of 18 ischemic stroke events among those with LVI (6%) and 65 among those without LVI (3%). Further studies are needed to validate these CMR biomarkers of stroke risk.

Atherosclerosis 40

Atherosclerosis Stroke Strokes Atrial Fibrillation 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A54-A54, February 1, 2024. Introduction:Studies show that successful reperfusion after large-vessel occlusion (LVO) stroke can lead to reduced mass effect and midline shift (MLS).

Biomarkers 40

Biomarkers Thrombolysis Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP6-ATP6, February 1, 2024. Background:Brain arteriovenous malformations (bAVMs) are an important cause of intracranial hemorrhage, seizure, or other neurological deficits. Clinical heterogeneity of bAVM suggests a role for genetic modifiers that may associate with seizure risk.

Circulation 40

Circulation Biomarkers Hemorrhage Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP8-AWMP8, February 1, 2024. Introduction:Thrombolysis in acute ischemic stroke (AIS) using Tenecteplase (TNK) is gaining popularity compared to Alteplase (ALT) for its practical advantages. The baseline demographics, vascular risk factors, and admission stroke severity were similar.

Stroke 40

Stroke Strokes Thrombolysis Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP292-AWP292, February 1, 2024. Introduction:Sleep debt attenuates nitric oxide synthase 3 (NOS3) activity and vasodilation which could diminish brain tissue oxygen (PbtO2) after stroke. S-nitrosylatedβHb-Cys93promotes hypoxic vasodilation to enhance PbtO2.

Stroke 40

Stroke Strokes Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A133-A133, February 1, 2024. Mendelian randomization (MR) studies suggest a causal effect of Fe status on ischemic stroke (IS).

BMI 40

BMI Risk Factors Stroke Strokes 40

DAIC

JANUARY 23, 2024

3 Patients with ASCVD are at a higher risk for major adverse cardiovascular events (MACE) including heart attack or myocardial infarction (MI), stroke, and cardiovascular (CV) death.4 Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2

Cardiovascular Disease 111

Cardiovascular Disease Heart Attack Heart attacks Coronary Artery Disease 111

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP75-ATMP75, February 1, 2024. Background:Cerebral microbleeds (CMBs) are age-related vascular lesions, predisposing patients to a lifetime risk of hemorrhagic stroke and cognitive decline.

Biomarkers 40

Biomarkers Hemorrhage Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP146-ATP146, February 1, 2024. Introduction:Collateral status imaging parameters are associated with predicting hemorrhagic transformation (HT) in acute ischemic stroke caused by large vessel occlusions. p=0.006); CBV index (aOR 0.0002, 95% CI 0-0.1,

Hemorrhage 40

Hemorrhage Thrombolysis Diabetes Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A57-A57, February 1, 2024. Background:The rapid differentiation between intracerebral hemorrhage (ICH) and ischemic stroke (IS) in patients with symptoms of acute stroke is decisive for triage and initiation of targeted therapies.

Hemorrhage 40

Hemorrhage Biomarkers Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A28-A28, February 1, 2024. Introduction:ACTIMIS (NCT03803007) was a randomized phase 1b/2a clinical trial evaluating glenzocimab, a monoclonal antibody fragment targeting platelet receptor glycoprotein VI in patients with acute ischemic stroke treated by thrombolysis.

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Hemorrhage Thrombolysis Biomarkers Stroke 40

DAIC

MAY 17, 2024

milla1cf Fri, 05/17/2024 - 18:54 May 17, 2024 — Royal Philips , a global leader in health technology, is presenting new retrospective study results demonstrating the clinical and economic benefits of Philips’ AI-powered cardiac care solutions at the Heart Rhythm Annual Meeting in Boston (May 16-19). On Saturday, May 18 at 3 p.m.,

Heart Rhythm 52

Heart Rhythm Technology Arrhythmia Outcomes 52

Journal of the American Heart Association

DECEMBER 14, 2024

Journal of the American Heart Association, Volume 13, Issue 24 , December 17, 2024. P=0.001) but not stroke in CSVD.ConclusionsPlasma BACE1 activity is moderately increased and associated with neurodegeneration and cognitive impairment risk in CSVD.

Dementia 40

Dementia Biomarkers Hemorrhage Hypertension 40

DAIC

JANUARY 30, 2024

Clinicians currently use two separate risk models to assess patients’ chances of having heart attacks , strokes , and other major cardiovascular events. The ARIC participants included some cases with established atherosclerotic cardiovascular disease and some without.

Cardiovascular Disease 52

Cardiovascular Disease Research Heart Attack Heart attacks 52

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP127-ATP127, February 1, 2024. Background/Purpose:Distal medium vessel occlusions (DMVOs) account for a large percentage of vessel occlusions resulting in acute ischemic stroke (AIS) with disabling symptoms. for optimal sensitivity (71% [52.0-85.8%])

Outcomes 40

Outcomes Thrombolysis Biomarkers Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP64-AWMP64, February 1, 2024. Additionally it can serve as an imaging biomarker for the development of adjunctive therapies to mitigate reperfusion injury. Identification of patients with Late lesion growth could be critical to guide clinical management and inform prognosis post-EVT.

Hemorrhage 40

Hemorrhage Thrombolysis Biomarkers Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP81-AWMP81, February 1, 2024. Malnutrition is common in stroke patients and leads to worse outcomes. Future biomarker studies are needed to better understand this relationship. Introduction:Intracerebral Hemorrhage (ICH) leads to high rates of morbidity and mortality.

Hemorrhage 40

Hemorrhage BMI Outcomes Coronary Artery Disease 40