Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A106-A106, February 1, 2024. Background:Circulating interleukin-6 (IL-6) concentrations are elevated in acute stroke but the timing of the IL-6 response in humans is unknown. We used a mobile stroke unit (MSU) to identify IL-6 levels within minutes of symptom onset.

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Stroke Strokes Circulation Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP58-ATMP58, February 1, 2024. Objectives:To determine the relationship between patient-reported outcome measures (PROMs) and volumetric biomarkers assessed on clinical imaging in acute ischemic stroke (AIS).Background:AIS Background:AIS is a leading cause of long-term disability.

Stroke 40

Stroke Strokes Outcomes Biomarkers 40

Stroke Journal

DECEMBER 21, 2023

Stroke, Volume 55, Issue 1 , Page 31-39, January 1, 2024. Sensitivity and specificity of biomarker changes were analyzed in relation to predefined criteria for recurrent SH or asymptomatic change. Mean QSM and DCEQP of the SH lesion were acquired at baseline and at 1- and 2-year follow-ups.

Biomarkers 40

Biomarkers Hemorrhage Certification Stroke 40

Stroke Journal

MARCH 24, 2024

Stroke, Volume 55, Issue 4 , Page e131-e131, April 1, 2024.

Biomarkers 40

Biomarkers Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP12-ATP12, February 1, 2024. Results are a proof of concept that blood tests could replace more complex and costly imaging biomarkers in monitoring CA hemorrhage. Relative change in Phenylacetylglutamine and LPE.18.0+Piperine

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Biomarkers Hemorrhage Circulation Stroke 40

DAIC

FEBRUARY 1, 2024

February 1, 2024 — As cardiologists, heart disease patients and the organizations that serve them across the country embark on American Heart Month, DAIC has compiled a snapshot of significant cardiovascular disease (CVD) and stroke statistics, along with a review of the atherosclerosis drug market. per 1,000* - 122.4

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Cardiovascular Disease Atherosclerosis Stroke Strokes 104

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP119-ATMP119, February 1, 2024. Some of the biomarkers were unchanged (Table). Diabetes doubles the risk of VCID. The underlying reasons are not understood, and preventive therapeutic strategies are lacking.

Biomarkers 40

Biomarkers Diabetes Cholesterol Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP117-AWMP117, February 1, 2024. Background:Stroke is a significant health issue in the United States, and identifying biomarkers for preventing acute ischemic stroke (AIS) remains the highest priority. Exosomal miR-9-3p showed a 14.7-fold

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Stroke Strokes Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP266-AWP266, February 1, 2024. Background:This population-based study investigated the potential of machine learning algorithms to predict stroke incidence and identify important risk factors. These clusters were categorized into high-, medium-, and low-risk groups.

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Stroke Strokes Blood Pressure Laboratory 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP24-ATP24, February 1, 2024. Background:Post-stroke depression (PSD) is a common neuropsychiatric complication of stroke associated with poor functional outcome and increased mortality. versus 40.7%). to 0.25), p<0.001], and Hcy [SMD 0.14, (95% CI 0.05

Stroke 40

Stroke Strokes Biomarkers Hypertension 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP238-ATP238, February 1, 2024. Both subjects with stroke and subjects with TIA had increased serum PDGFRβ compared to those without history of CVA (6608.4 No significant differences related to PDGFRβ were observed between subjects with stroke vs. TIA (P=0.25). pg/mL and 5337.0

Stroke 40

Stroke Strokes Dementia Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A130-A130, February 1, 2024.

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Biomarkers Stroke Strokes Physiology 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP150-AWP150, February 1, 2024. Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is standard of care for secondary prevention in non-cardioembolic minor acute ischemic stroke (AIS) and high-risk transient ischemic attack (TIA). 95% CI +30.71 to +176.1;

Stroke 40

Stroke Strokes Biomarkers Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP169-AWP169, February 1, 2024. TEG-R time may be a useful biomarker in DOAC reversal with PCC. Prothrombin complex concentrates (PCCs) are used to emergently reverse direct-acting oral anticoagulant (DOAC) activity. TEG R-time rebounds 12 hours after PCC administration.

Biomarkers 40

Biomarkers Hemorrhage Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP150-ATP150, February 1, 2024. Introduction:Ischemic stroke is a leading cause of death and disability in the US, with 20-40% of cases, classified as cryptogenic or with an unexplained cause. Stroke in multiple vascular territories MVT was present in 22/101 (22%) at baseline.

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Atrial Fibrillation Stroke Strokes Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A131-A131, February 1, 2024. The primary outcome was incident ischemic stroke. There were a total of 18 ischemic stroke events among those with LVI (6%) and 65 among those without LVI (3%). Further studies are needed to validate these CMR biomarkers of stroke risk.

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Atherosclerosis Stroke Strokes BMI 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP292-AWP292, February 1, 2024. Introduction:Sleep debt attenuates nitric oxide synthase 3 (NOS3) activity and vasodilation which could diminish brain tissue oxygen (PbtO2) after stroke. S-nitrosylatedβHb-Cys93promotes hypoxic vasodilation to enhance PbtO2.

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Stroke Strokes Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A54-A54, February 1, 2024. Introduction:Studies show that successful reperfusion after large-vessel occlusion (LVO) stroke can lead to reduced mass effect and midline shift (MLS).

Biomarkers 40

Biomarkers Thrombolysis Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP6-ATP6, February 1, 2024. Background:Brain arteriovenous malformations (bAVMs) are an important cause of intracranial hemorrhage, seizure, or other neurological deficits. Clinical heterogeneity of bAVM suggests a role for genetic modifiers that may associate with seizure risk.

Circulation 40

Circulation Biomarkers Hemorrhage Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A133-A133, February 1, 2024. Mendelian randomization (MR) studies suggest a causal effect of Fe status on ischemic stroke (IS).

BMI 40

BMI Risk Factors Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP75-ATMP75, February 1, 2024. Background:Cerebral microbleeds (CMBs) are age-related vascular lesions, predisposing patients to a lifetime risk of hemorrhagic stroke and cognitive decline.

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Biomarkers Hemorrhage Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP146-ATP146, February 1, 2024. Introduction:Collateral status imaging parameters are associated with predicting hemorrhagic transformation (HT) in acute ischemic stroke caused by large vessel occlusions. p=0.006); CBV index (aOR 0.0002, 95% CI 0-0.1,

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Hemorrhage Thrombolysis Diabetes Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A57-A57, February 1, 2024. Background:The rapid differentiation between intracerebral hemorrhage (ICH) and ischemic stroke (IS) in patients with symptoms of acute stroke is decisive for triage and initiation of targeted therapies.

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Hemorrhage Biomarkers Stroke Strokes 40

DAIC

JUNE 4, 2024

I am excited about the potential of the FAI-Score biomarker, which has promising prognostic value beyond existing CT-based methods such as plaque, calcium scoring, and CAD-RADS based interpretation." Details of the study, included in a written statement issued by Caristo Diagnostics, follow. fold higher risk for cardiac mortality and 5.5-fold

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Technology Heart attacks Heart Attack Coronary Artery Disease 116

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A28-A28, February 1, 2024. Introduction:ACTIMIS (NCT03803007) was a randomized phase 1b/2a clinical trial evaluating glenzocimab, a monoclonal antibody fragment targeting platelet receptor glycoprotein VI in patients with acute ischemic stroke treated by thrombolysis.

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Hemorrhage Thrombolysis Biomarkers Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP127-ATP127, February 1, 2024. Background/Purpose:Distal medium vessel occlusions (DMVOs) account for a large percentage of vessel occlusions resulting in acute ischemic stroke (AIS) with disabling symptoms. for optimal sensitivity (71% [52.0-85.8%])

Outcomes 40

Outcomes Thrombolysis Biomarkers Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP64-AWMP64, February 1, 2024. Additionally it can serve as an imaging biomarker for the development of adjunctive therapies to mitigate reperfusion injury. Identification of patients with Late lesion growth could be critical to guide clinical management and inform prognosis post-EVT.

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Hemorrhage Thrombolysis Biomarkers Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP81-AWMP81, February 1, 2024. Malnutrition is common in stroke patients and leads to worse outcomes. Future biomarker studies are needed to better understand this relationship. Introduction:Intracerebral Hemorrhage (ICH) leads to high rates of morbidity and mortality.

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Hemorrhage BMI Outcomes Coronary Artery Disease 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A151-A151, February 1, 2024. Glial fibrillary acidic protein (GFAP) has been recently identified as a biomarker of intracerebral hemorrhage.

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Hemorrhage Biomarkers Stroke Strokes 40

DAIC

MAY 17, 2024

milla1cf Fri, 05/17/2024 - 18:54 May 17, 2024 — Royal Philips , a global leader in health technology, is presenting new retrospective study results demonstrating the clinical and economic benefits of Philips’ AI-powered cardiac care solutions at the Heart Rhythm Annual Meeting in Boston (May 16-19). On Saturday, May 18 at 3 p.m.,

Heart Rhythm 52

Heart Rhythm Technology Arrhythmia Outcomes 52

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP20-AWMP20, February 1, 2024. Introduction:Early identification of white matter hyperintensity-related cognitive impairment (WMH-CI) through normal MRI images is of great significance for early clinical intervention to reduce the occurrence of dementia.

Dementia 40

Dementia Biomarkers Hospital Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP14-AWMP14, February 1, 2024. Background:Cerebral amyloid angiopathy (CAA) is associated with reduced cerebrospinal fluid (CSF) levels of the beta-amyloid (Aβ) 40- and 42-amino acid species, thought to reflect the burden of vascular Aβ deposition in the brain.

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Biomarkers Hemorrhage Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP319-ATP319, February 1, 2024. Recently, a novel hypothalamic protein, Sushi repeat-containing protein X-linked 2 (SRPX2), was reported as a potential biomarker for hypothalamic damage after traumatic brain injury.

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Hemorrhage Biomarkers Physiology Stroke 40

DAIC

JANUARY 23, 2024

3 Patients with ASCVD are at a higher risk for major adverse cardiovascular events (MACE) including heart attack or myocardial infarction (MI), stroke, and cardiovascular (CV) death.4 Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2

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Cardiovascular Disease Heart attacks Heart Attack Coronary Artery Disease 111

All About Cardiovascular System and Disorders

MARCH 7, 2024

Inflammatory biomarkers were also estimated. Primary endpoint of the study was a composite of myocardial infarction, stroke, or death from any cause in those who had micro and nanoplastics in the carotid plaque. 2024 Mar 7;390(10):900-910. Comparison was with those who had no evidence of these plastics in the plaques.

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Plaque Myocardial Infarction Laboratory Cardiac Function 52

Medical Xpress - Cardiology

SEPTEMBER 3, 2024

Mass screening for atrial fibrillation using ECG together with heart failure biomarker does not prevent ischemic stroke or systemic embolism (blood clot) in older adults aged 75–76 years over 5 years follow-up, according to late breaking research presented in a Hot Line Session at this year's ESC Congress 2024 in London, UK (30 Aug–2 Sept).

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Atrial Fibrillation Blood Clot Research Stroke 40

DAIC

APRIL 9, 2024

Although they had no symptoms of heart failure or blockages in arteries carrying blood to the heart, they all had structural heart disease or abnormal cardiac biomarkers that classified them as having “pre-heart failure,” putting them at high risk for developing overt symptoms of the diagnosis.

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Heart Failure Diabetes Cardiomyopathy Exercise 52