2024, Biomarkers and Hemorrhage - Cardiovascular Update

Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part II: Biomarkers and Trial Modeling

Stroke Journal

DECEMBER 21, 2023

Stroke, Volume 55, Issue 1 , Page 31-39, January 1, 2024. BACKGROUND:Quantitative susceptibility mapping (QSM) and dynamic contrast-enhanced quantitative perfusion (DCEQP) magnetic resonance imaging sequences assessing iron deposition and vascular permeability were previously correlated with new hemorrhage in cerebral cavernous malformations.

Biomarkers

Biomarkers Hemorrhage Certification Stroke

Soluble Biomarkers of Cerebrovascular Pathologies

Stroke Journal

MARCH 24, 2024

Stroke, Volume 55, Issue 4 , Page 801-811, April 1, 2024. VCID is heterogeneous, comprising many different pathological entities (ischemic, or hemorrhagic), and spatial and temporal differences (acute or chronic).

Biomarkers

Biomarkers Dementia Hemorrhage Research

Abstract TP12: Changes in Plasma Metabolites Reflect Lesional Iron Content and Permeability Imaging as Monitoring Biomarkers of Hemorrhage in Cavernous Angiomas

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP12-ATP12, February 1, 2024. Results are a proof of concept that blood tests could replace more complex and costly imaging biomarkers in monitoring CA hemorrhage. Relative change in Phenylacetylglutamine and LPE.18.0+Piperine

Biomarkers

Biomarkers Hemorrhage Circulation Stroke

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

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Abstract WP169: Thromboelastography as a Biomarker of Emergent Direct-Acting Oral Anticoagulant Reversal With Prothrombin Complex Concentrates for Intracranial Hemorrhage

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP169-AWP169, February 1, 2024. We aimed to determine whether TEG R-time is useful in detecting the impact of PCC administration on anticoagulation activity in patients with anti-factor Xa-associated intracranial hemorrhage (ICH). TEG-R time may be a useful biomarker in DOAC reversal with PCC.

Biomarkers

Biomarkers Hemorrhage Stroke Strokes

Abstract TMP25: Common Molecular Biomarkers in Different Types of Acute Brain Injuries Predicting Outcome

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP25-ATMP25, February 1, 2024. Background:Acute brain injuries, including aneurysmal subarachnoid hemorrhage (aSAH), ischemic stroke (IS), and traumatic brain injury (TBI), entail complex recovery processes involving brain plasticity and synaptic regeneration mechanisms.

Biomarkers

Biomarkers Outcomes Aneurysm Hemorrhage

Abstract WMP81: Overweight Patients Had Higher Odds of Favorable Outcome After Both Deep and Lobar Intracerebral Hemorrhage

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP81-AWMP81, February 1, 2024. Introduction:Intracerebral Hemorrhage (ICH) leads to high rates of morbidity and mortality. There was no association between BMI and ICH volume in patients with deep or lobar hemorrhage. Malnutrition is common in stroke patients and leads to worse outcomes.

Hemorrhage

Hemorrhage BMI Outcomes Coronary Artery Disease

Abstract 151: GFAP Measurements for Rapid Prehospital Identification of Intracranial Hemorrhage in Patients With Acute Coma

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A151-A151, February 1, 2024. Glial fibrillary acidic protein (GFAP) has been recently identified as a biomarker of intracerebral hemorrhage. GFAP values over 1000 pg/ml indicated a primary cerebral cause of coma with 100% certainty (hereof, 86% had intracranial hemorrhage).Conclusion:Increased

Hemorrhage

Hemorrhage Biomarkers Stroke Strokes

Abstract TP146: Collateral Status-Based Model for Hemorrhagic Transformation in Successfully Recanalized Medium Vessel Occlusions

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP146-ATP146, February 1, 2024. Introduction:Collateral status imaging parameters are associated with predicting hemorrhagic transformation (HT) in acute ischemic stroke caused by large vessel occlusions.

Hemorrhage

Hemorrhage Thrombolysis Diabetes Biomarkers

Abstract 57: Rapid Prehospital Diagnosis of Intracerebral Hemorrhage by Measuring GFAP on a Point-of-Care Platform

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A57-A57, February 1, 2024. Background:The rapid differentiation between intracerebral hemorrhage (ICH) and ischemic stroke (IS) in patients with symptoms of acute stroke is decisive for triage and initiation of targeted therapies.

Hemorrhage

Hemorrhage Biomarkers Stroke Strokes

Abstract TP6: Identification of Circulating Epigenetic Biomarkers for Seizure in Brain Arteriovenous Malformation by Methylome Profiling

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP6-ATP6, February 1, 2024. Background:Brain arteriovenous malformations (bAVMs) are an important cause of intracranial hemorrhage, seizure, or other neurological deficits. Clinical heterogeneity of bAVM suggests a role for genetic modifiers that may associate with seizure risk.

Circulation

Circulation Biomarkers Hemorrhage Stroke

Abstract 130: Decompression of Corticospinal Tract (CST): An Imaging Biomarker for Post-Stroke Recovery

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A130-A130, February 1, 2024.

Biomarkers

Biomarkers Stroke Strokes Physiology

Abstract TMP75: Histopathologic and Transcriptomic Characterizations of Cerebral Microbleeds in an E4FAD Murine Model

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP75-ATMP75, February 1, 2024. Background:Cerebral microbleeds (CMBs) are age-related vascular lesions, predisposing patients to a lifetime risk of hemorrhagic stroke and cognitive decline.

Biomarkers

Biomarkers Hemorrhage Stroke Strokes

Increased Plasma β‐Secretase 1 Activity Correlates With Neurodegeneration in Cerebral Small Vessel Disease

Journal of the American Heart Association

DECEMBER 14, 2024

Journal of the American Heart Association, Volume 13, Issue 24 , December 17, 2024. It indicates that BACE1 is a promising biomarker especially for CSVDrelated neurodegeneration. Backgroundsecretase 1 (BACE1) plays a key role in amyloidogenic pathway and is considered a new mechanism for cerebral small vessel disease (CSVD).

Dementia

Dementia Biomarkers Hemorrhage Hypertension

Abstract WMP64: Late Lesion Growth Following Endovascular Therapy: Is 24 Hours Too Early to Assess Acute Infarct Size Including the Effects of Secondary Injury?

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP64-AWMP64, February 1, 2024. These patients had an increased hemorrhagic transformation rate of 68% with only 1 in 3 patients having favorable clinical outcome. Additionally it can serve as an imaging biomarker for the development of adjunctive therapies to mitigate reperfusion injury.

Hemorrhage

Hemorrhage Thrombolysis Biomarkers Outcomes

Abstract WMP14: Cerebrospinal Fluid Beta-Amyloid Concentration and MRI Manifestations of Cerebral Amyloid Angiopathy

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP14-AWMP14, February 1, 2024. Out of 31 patients, 19 were female (61.3%), 20 (64.5%) presented with cognitive impairment, 9 (29%) with intracerebral hemorrhage, and 2 (6.5%) with transient focal neurologic events. Results:Median age of presentation was 69 years (range 56-89).

Biomarkers

Biomarkers Hemorrhage Stroke Strokes

Abstract TP154: Association of Left Ventricular Hypertrophy With Ischemic Lesions After Intracerebral Hemorrhage

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP154-ATP154, February 1, 2024. Background:Ischemic lesions on diffusion weighted imaging (DWI) occur in one-third of intracerebral hemorrhage (ICH). Due to conflicting prior studies, it is uncertain if the degree of systolic blood pressure reduction increases the risk.

Hemorrhage

Hemorrhage Blood Pressure Hypertension Biomarkers

Abstract 4148181: Neutrophil and Leucocyte Ratio and LDL to HDL ratios as predictors of Hemorrhagic transformation in ischemic stroke patients : A systematic review

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4148181-A4148181, November 12, 2024. Background:Following an ischemic stroke, a serious complication known as hemorrhagic transformation (HT) might jeopardize patient outcomes.

Hemorrhage

Hemorrhage Stroke Strokes Myocardial Infarction

Abstract 147: Novel Inflammatory and Pro-Thrombotic mRNA Pathways Associated With Worse 3-month Outcome After Intracerebral Hemorrhage

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A147-A147, February 1, 2024. Background:Intracerebral hemorrhage (ICH) has the highest disability among stroke survivors.

Hemorrhage

Hemorrhage Outcomes Biomarkers Stroke

Abstract TP319: Time Course of Novel Hypothalamic Protein Sushi Repeat-Containing Protein X- Linked 2 Expression in a Rat Model of Subarachnoid Hemorrhage

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP319-ATP319, February 1, 2024. Background:Hypothalamic injury after subarachnoid hemorrhage (SAH) is known to be associated with short- and long-term prognosis.

Hemorrhage

Hemorrhage Physiology Biomarkers Stroke

Abstract WP160: Mechanisms of Brain Hemorrhage in Chronic Kidney Disease

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP160-AWP160, February 1, 2024. Introduction:Chronic kidney disease (CKD) is a risk factor for intracerebral hemorrhage (ICH) and for worse outcomes following ICH.

Kidney Disease

Kidney Disease Hemorrhage Risk Factors Biomarkers

Abstract 28: Patients Randomised to Glenzocimab Suffered Less Haemorrhagic Transformation at 24 Hours Compared to Placebo: AI-Imaging Sub-Analysis of the ACTIMIS Trial

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A28-A28, February 1, 2024. Primary analysis demonstrated a reduction in intracranial hemorrhage occurrence stroke-related mortality. Primary analysis demonstrated a reduction in intracranial hemorrhage occurrence stroke-related mortality.

Hemorrhage

Hemorrhage Thrombolysis Biomarkers Stroke

46 year old with chest pain develops a wide complex rhythm -- see many examples

Dr. Smith's ECG Blog

AUGUST 9, 2024

Frick -- one wonders about the diagnosis of unstable angina in a patient with significantly elevated biomarkers which would certainly have been rising on repeat measurement.) below) Other examples of AIVR: Young man with Gunshot wound to right chest with hemorrhagic shock, but bullet path not near heart. Leave it alone. Bigger et al.

Chest Pain

Chest Pain Arrhythmia Myocardial Infarction STEMI

International Stroke Conference 2024 to Present High-Profile Late-Breaking Science

DAIC

JANUARY 22, 2024

The International Stroke Conference 2024 will be held Feb. 7-9 in Phoenix, Arizona. 7-9 in Phoenix, Arizona. 7 Late-Breaking Science Oral Abstracts I (beginning at 2:00 p.m. MT) TESLA: The Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke Trial: 1-Year Outcome: Osama Zaidat, Mercy Health St.

Stroke

Stroke Strokes Hospital Stents

Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part II: Biomarkers and Trial Modeling

Soluble Biomarkers of Cerebrovascular Pathologies

Abstract TP12: Changes in Plasma Metabolites Reflect Lesional Iron Content and Permeability Imaging as Monitoring Biomarkers of Hemorrhage in Cavernous Angiomas

Webinars

Abstract WP169: Thromboelastography as a Biomarker of Emergent Direct-Acting Oral Anticoagulant Reversal With Prothrombin Complex Concentrates for Intracranial Hemorrhage

Abstract TMP25: Common Molecular Biomarkers in Different Types of Acute Brain Injuries Predicting Outcome

Abstract WMP81: Overweight Patients Had Higher Odds of Favorable Outcome After Both Deep and Lobar Intracerebral Hemorrhage

Abstract 151: GFAP Measurements for Rapid Prehospital Identification of Intracranial Hemorrhage in Patients With Acute Coma

Abstract TP146: Collateral Status-Based Model for Hemorrhagic Transformation in Successfully Recanalized Medium Vessel Occlusions

Abstract 57: Rapid Prehospital Diagnosis of Intracerebral Hemorrhage by Measuring GFAP on a Point-of-Care Platform

Abstract TP6: Identification of Circulating Epigenetic Biomarkers for Seizure in Brain Arteriovenous Malformation by Methylome Profiling

Abstract 130: Decompression of Corticospinal Tract (CST): An Imaging Biomarker for Post-Stroke Recovery

Abstract TMP75: Histopathologic and Transcriptomic Characterizations of Cerebral Microbleeds in an E4FAD Murine Model

Increased Plasma β‐Secretase 1 Activity Correlates With Neurodegeneration in Cerebral Small Vessel Disease

Abstract WMP64: Late Lesion Growth Following Endovascular Therapy: Is 24 Hours Too Early to Assess Acute Infarct Size Including the Effects of Secondary Injury?

Abstract WMP14: Cerebrospinal Fluid Beta-Amyloid Concentration and MRI Manifestations of Cerebral Amyloid Angiopathy

Abstract TP154: Association of Left Ventricular Hypertrophy With Ischemic Lesions After Intracerebral Hemorrhage

Abstract 4148181: Neutrophil and Leucocyte Ratio and LDL to HDL ratios as predictors of Hemorrhagic transformation in ischemic stroke patients : A systematic review

Abstract 147: Novel Inflammatory and Pro-Thrombotic mRNA Pathways Associated With Worse 3-month Outcome After Intracerebral Hemorrhage

Abstract TP319: Time Course of Novel Hypothalamic Protein Sushi Repeat-Containing Protein X- Linked 2 Expression in a Rat Model of Subarachnoid Hemorrhage

Abstract WP160: Mechanisms of Brain Hemorrhage in Chronic Kidney Disease

Abstract 28: Patients Randomised to Glenzocimab Suffered Less Haemorrhagic Transformation at 24 Hours Compared to Placebo: AI-Imaging Sub-Analysis of the ACTIMIS Trial

46 year old with chest pain develops a wide complex rhythm -- see many examples

International Stroke Conference 2024 to Present High-Profile Late-Breaking Science

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