2024, Biomarkers and Dementia - Cardiovascular Update

The Best Way To Prevent Dementia

Dr. Paddy Barrett

APRIL 11, 2025

More than heart disease or cancer, dementia is the primary concern for many of the patients I see. Heart disease and cancer attack your body, but dementia attacks your mind and identity. That is why I believe people fear dementia so much. Thankfully, 45% of all dementia is preventable 1. That factor is exercise.

Dementia

Dementia Exercise Cancer Heart Disease

Davangere Devanand, MD: The State of Dementia Drug Development

HCPLive

MAY 5, 2024

Devanand reviews lecanemab and the advent of blood biomarkers for dementia and Alzheimer's management at APA 2024.

Dementia

Dementia Biomarkers

Soluble Biomarkers of Cerebrovascular Pathologies

Stroke Journal

MARCH 24, 2024

Stroke, Volume 55, Issue 4 , Page 801-811, April 1, 2024. Vascular contributions to cognitive impairment and dementia (VCID) is an all-encompassing term that describes cognitive impairment due to cerebrovascular origins.

Biomarkers

Biomarkers Dementia Hemorrhage Research

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

MORE WEBINARS

Abstract TP238: Blood Brain Barrier Injury Detected in the Serum of Patients With a History of Stroke and Transient Ischemic Attack

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP238-ATP238, February 1, 2024. Introduction:Stroke and transient ischemic attack (TIA) increase risk for cognitive impairment and dementia. Without a lasting infarction, the cause of cognitive decline after TIA remains unknown.

Stroke

Stroke Strokes Dementia Biomarkers

Increased Plasma β‐Secretase 1 Activity Correlates With Neurodegeneration in Cerebral Small Vessel Disease

Journal of the American Heart Association

DECEMBER 14, 2024

Journal of the American Heart Association, Volume 13, Issue 24 , December 17, 2024. During 2year followup, BACE1 activity was independently related to dementia conversion (odds ratio, 17.72;P=0.001) It indicates that BACE1 is a promising biomarker especially for CSVDrelated neurodegeneration.

Dementia

Dementia Biomarkers Hemorrhage Hypertension

Abstract WMP20: Deep Learning Radiomics Identifies White Matter Hyperintensity-Related Cognitive Decline Based on T2-FLAIR

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP20-AWMP20, February 1, 2024. Introduction:Early identification of white matter hyperintensity-related cognitive impairment (WMH-CI) through normal MRI images is of great significance for early clinical intervention to reduce the occurrence of dementia.

Dementia

Dementia Biomarkers Hospital Stroke

The Data For Weight Loss Medications Just Keeps Pouring In.

Dr. Paddy Barrett

FEBRUARY 21, 2025

Recent research suggested that the weight loss market was estimated to be worth $224 billion annually in 2021 and is estimated to exceed $400 billion by 2024 1. Type 2 Diabetes When it comes to the increasing the risk of major chronic diseases such as cardiovascular disease, many cancers and dementia, type 2 diabetes plays a huge role.

Obesity

Obesity Diabetes Cardiovascular Disease Chronic Disease

Have We Turned The Tide On Obesity?

Dr. Paddy Barrett

OCTOBER 11, 2024

I have covered this topic previously here , but it is clear that inflammation plays a major role in the initiation and progression of coronary artery disease, and the inflammatory biomarker hsCRP is tightly connected to this process. Dementia is a leading cause of death and a major concern for most people as they age. 2024 Jun 21.

Obesity

Obesity Cancer Dementia Coronary Artery Disease

Why Insulin Resistance Is The Biggest Silent Risk Factor For Heart Disease.

Dr. Paddy Barrett

SEPTEMBER 13, 2024

Understanding where you sit on this continuum is a key part of defining your future risk of heart disease but also dementia, and many cancers. The further along the line of insulin resistance you sit, the higher your risk of all the leading causes of death, including heart disease, dementia and many cancers 5. 2024 Jun 21:e033997.

Risk Factors

Risk Factors Heart Disease Dementia Diabetes

Abstract 70: Rich-Club Behaviour and Analyses in the Human Brain Connectome as Novel Early Biomarkers of Cognitive Decline

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A70-A70, February 1, 2024. Introduction:Transient ischemic attack (TIA) patients have an increased risk of early dementia, but the mechanism is unclear. One potential mechanism is the damaging effects of microvascular disease on brain networks.

Biomarkers

Biomarkers Dementia Stroke Strokes

Abstract WP255: Association Between Asymptomatic Intracranial Large Artery Stenosis and Neurofilament Light Chain: The Northern Manhattan Study

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP255-AWP255, February 1, 2024. Introduction:The Neurofilament light chain (NfL) is a neuronal cytoplasmic protein and a reliable biomarker for assessing axonal damage in neurological diseases and traumatic brain injury.

Stenosis

Stenosis Dementia Hypertension Biomarkers

Abstract TP39: Multi-Marker Cerebral Small Vessel Disease Score and Risk of Incident Depression: The Framingham Heart Study

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP39-ATP39, February 1, 2024. This is important as depression can mimic cognitive impairment, dementia and is treatable. Introduction:The vascular depression hypothesis postulates that cerebral small vessel disease (CSVD) contributes to the development of depression. years, IQR: 5.3-6.7).

Dementia

Dementia Biomarkers Hypertension Stroke

Chest pain followed by 6 days of increasing dyspnea -- what happened?

Dr. Smith's ECG Blog

FEBRUARY 26, 2025

Written by Magnus Nossen, edits by Smith The patient in today's case is an 85-year-old male with a history of COPD and dementia. Due to very severe dementia, it was impossible to obtain a detailed history. He presented to the emergency department for evaluation. Lets us consider two different clinical presentations. 4] Wang, S.,

Chest Pain

Chest Pain Pericarditis Myocardial Infarction Dementia

Why Muscle Power Is The Key To Healthy Ageing.

Dr. Paddy Barrett

MARCH 14, 2025

A critical component of healthy ageing is the maintenance of cognitive capacity and avoidance of dementia. Muscle power may also play a role in the prevention or progression of dementia. Higher muscle power measures, such as gait (walking) speed, were associated with a 50% reduction in the risk of dementia 6. Am J Prev Med.

Dementia

Dementia Biomarkers Cancer Exercise

The legal case – naming a few names

Dr. Malcolm Kendrick

OCTOBER 30, 2024

Burning torches will be provided to all those who turn up. 1: [link] 2: [link] 3: KINGS BENCH DIVISION IN THE HIGH COURT Claim Nos. plus drug supply Bayer: £1.8M plus drug supply ASCEND PLUS (2021 – ongoing) Novo Nordisk A/S: £39.4M Elinogrel feasibility trial (2010-2011) Novartis: £500K EMPA-KIDNEY (2017-ongoing) Boehringer Ingelheim: £106.3M

Cholesterol

Cholesterol Article Research Diet

The Best Way To Prevent Dementia

Davangere Devanand, MD: The State of Dementia Drug Development

Soluble Biomarkers of Cerebrovascular Pathologies

Webinars

Abstract TP238: Blood Brain Barrier Injury Detected in the Serum of Patients With a History of Stroke and Transient Ischemic Attack

Increased Plasma β‐Secretase 1 Activity Correlates With Neurodegeneration in Cerebral Small Vessel Disease

Abstract WMP20: Deep Learning Radiomics Identifies White Matter Hyperintensity-Related Cognitive Decline Based on T2-FLAIR

The Data For Weight Loss Medications Just Keeps Pouring In.

Have We Turned The Tide On Obesity?

Why Insulin Resistance Is The Biggest Silent Risk Factor For Heart Disease.

Abstract 70: Rich-Club Behaviour and Analyses in the Human Brain Connectome as Novel Early Biomarkers of Cognitive Decline

Abstract WP255: Association Between Asymptomatic Intracranial Large Artery Stenosis and Neurofilament Light Chain: The Northern Manhattan Study

Abstract TP39: Multi-Marker Cerebral Small Vessel Disease Score and Risk of Incident Depression: The Framingham Heart Study

Chest pain followed by 6 days of increasing dyspnea -- what happened?

Why Muscle Power Is The Key To Healthy Ageing.

The legal case – naming a few names

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