IGFBP7: From Senescence Biomarker to a Vaccine for Heart Failure
Circulation
JULY 28, 2024
Circulation, Volume 150, Issue 5 , Page 390-392, July 30, 2024.
2024 Biomarkers Circulation 
Abstract 4113047: Discovering novel biomarkers and predicting cardiovascular disease using AI/ML techniques for precision medicine
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4113047-A4113047, November 12, 2024. The top ten percent of commonly observed significant biomarkers were evaluated using four unique ML classifiers. The identified biomarkers served as potential indicators for early detection of CVDs.
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Roche's Lp(a) Gen.2 Molarity Assay Receives FDA Clearance
DAIC
FEBRUARY 3, 2025
This clearance comes in advance of disease-modifying therapies on the horizon expected to help clinicians use this biomarker to guide patients to improved cardiovascular health, saidBrad Moore, president and CEO at Roche Diagnostics North America. 2024 May-Jun;18(3):e308-e319. Circulation. J Clin Lipidol. doi: 10.1016/j.jacl.2024.03.001.
The Data For Weight Loss Medications Just Keeps Pouring In.
Dr. Paddy Barrett
FEBRUARY 21, 2025
Recent research suggested that the weight loss market was estimated to be worth $224 billion annually in 2021 and is estimated to exceed $400 billion by 2024 1. npj Metab Health Dis 2 , 31 (2024). 2024 Oct 31;391(17):1573-1583. Circulation. 2024 Jun 21. 2024 Jun 8. Nat Med (2024). NEJM Nov 13 2024
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Cardiometabolic Comorbidity Burden and Circulating Biomarkers in Patients with Chronic Coronary Disease in the ISCHEMIA Trials
The American Journal of Cardiology
JUNE 5, 2024
Publication date: Available online 4 June 2024 Source: The American Journal of Cardiology Author(s): Carine E. Hamo, Richard Liu, Wenbo Wu, Rebecca Anthopolos, Sripal Bangalore, Claes Held, Ifitkhar Kullo, Kreton Mavromatis, Bruce McManus, L. Kristin Newby, Harmony R. Reynolds, Kelly V. Ruggles, Lars Wallentin, David J. Maron, Judith S.
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Abstract 4144785: Identification of ARMCX3 as potential mitochondria-related biomarker for pulmonary arterial hypertension using integrated bioinformatics analysis and machine learning
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4144785-A4144785, November 12, 2024. Exploring potential biomarkers from mitochondrial perspective may be effective in the diagnosis and treatment of PAH. Background:Acquired mitochondrial dysfunction is one of the characteristics of pulmonary arterial hypertension (PAH).
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Artificial Intelligence Applications for Electrocardiography to Define New Digital Biomarkers of Cardiovascular Risk
Circulation: Cardiovascular Quality & Outcomes
NOVEMBER 14, 2024
Circulation: Cardiovascular Quality and Outcomes, Volume 17, Issue 12 , Page e011483, December 1, 2024.
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Abstract TP6: Identification of Circulating Epigenetic Biomarkers for Seizure in Brain Arteriovenous Malformation by Methylome Profiling
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP6-ATP6, February 1, 2024. Background:Brain arteriovenous malformations (bAVMs) are an important cause of intracranial hemorrhage, seizure, or other neurological deficits. Clinical heterogeneity of bAVM suggests a role for genetic modifiers that may associate with seizure risk.
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Abstract 4146638: Comparative Assessment of hsCRP and Apolipoprotein B as ASCVD Risk Biomarkers
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4146638-A4146638, November 12, 2024. Introduction/Background:According to the American Heart Association, the accumulation of plaque in the walls of arteries is identified as the primary cause of atherosclerotic cardiovascular disease (ASCVD).
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Abstract 4136687: VTRNA2-1 Promoter Methylation as a Prognostic Biomarker in Peripheral Artery Disease: Implications for Maternal Nutritional Influence
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4136687-A4136687, November 12, 2024. These findings suggest that VTRNA2-1 promoter methylation status could serve as a valuable biomarker for predicting prognosis and guiding treatment strategies in PAD. 6.97, p=0.024), amputations (HR 2.58, 95% CI 1.02-6.57,
Abstract TP12: Changes in Plasma Metabolites Reflect Lesional Iron Content and Permeability Imaging as Monitoring Biomarkers of Hemorrhage in Cavernous Angiomas
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP12-ATP12, February 1, 2024. Piperine reported the lowest SSE (9.77; 438.33) with respective QSM and DCEQP relative changeConclusion:Changes in circulating metabolites accurately reflect changes in lesional iron content and permeability in CASH during yearly follow-up.
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Abstract 106: Circulating Interleukin-6 Levels Early During Active Stroke Estimate Time of Stroke Onset: Potential New Clinical Biomarker Tool From a Mobile Stroke Unit
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page A106-A106, February 1, 2024. Background:Circulating interleukin-6 (IL-6) concentrations are elevated in acute stroke but the timing of the IL-6 response in humans is unknown. We used a mobile stroke unit (MSU) to identify IL-6 levels within minutes of symptom onset.
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Ultrasound Neuromodulation Shows Promise to Treat Pulmonary Hypertension, Feinstein Institutes Research
DAIC
MAY 8, 2024
Credit: Feinstein Institutes) milla1cf Wed, 05/08/2024 - 10:57 May 8, 2024 — Ultrasound could one day complement or even replace drugs to treat diseases. Feinstein Institutes’ Dr. Stavros Zanos is the senior author on the new bioelectronic medicine ultrasound paper.
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Tenax Therapeutics Announces New U.S. Patent Covering the Use of Levosimendan in Pulmonary Hypertension with Heart Failure with Preserved Ejection Fraction (PH-HFpEF)
DAIC
MAY 6, 2024
Getty Images milla1cf Mon, 05/06/2024 - 10:48 May 6, 2024 — Tenax Therapeutics, Inc. , Results of Tenax Therapeutics’ Phase 2 HELP study of levosimendan in patients with pulmonary hypertension (PH) with heart failure with preserved ejection fraction (HFpEF) demonstrated that I.V.
Abstract 4148010: Evaluation of Echocardiography and Biomarkers for Prognostication of RV Failure in COVID-19 Patients Undergoing Extracorporeal Membrane Oxygenation (ECMO)
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4148010-A4148010, November 12, 2024. Background:Severe COVID-19 infection has been associated with acute respiratory distress syndrome (ARDS) and right ventricular (RV) dysfunction.
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Lowering Atherosclerotic Cardiovascular Disease Events by Treating Residual Inflammatory Risk
DAIC
JANUARY 23, 2024
Inflammation driven by signaling cytokines, circulating immune cells, adhesion molecules, and oxidized low-density lipoprotein cholesterol (LDL-C) leads to atherosclerotic plaque development, plaque progression, and eventual rupture.14,15 2019 Sep 10;140(11):e649-e650] [published correction appears in Circulation. Circulation.
Why Insulin Resistance Is The Biggest Silent Risk Factor For Heart Disease.
Dr. Paddy Barrett
SEPTEMBER 13, 2024
I'm Interested In Case You Missed Them: 1 Association of lipid, inflammatory, and metabolic biomarkers with age at onset for incident coronary heart disease in women. BMC Public Health 24 , 574 (2024). BMC Public Health 24 , 574 (2024). 2024 Jun 21:e033997. Circulation. J Am Heart Assoc.
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Abstract 4145649: Proteomics Characteristics of Patients with Acute Coronary Syndrome
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4145649-A4145649, November 12, 2024. Circulating proteins levels were measured with the Olink-Explore 3072 panel. Spearman correlation was used to examine the associations between proteins and clinical variables.
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Abstract 4147640: Genetic Insights in Dilated Cardiomyopathy: SSPN as a Key Player
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4147640-A4147640, November 12, 2024. This gene holds promise as a potential biomarker that could inform the development of targeted therapies, highlighting its significance in the molecular mechanisms of the disease and warranting further investigation.
American Heart Month Puts Spotlight on Cardiovascular Disease and Stroke Statistics
DAIC
FEBRUARY 1, 2024
February 1, 2024 — As cardiologists, heart disease patients and the organizations that serve them across the country embark on American Heart Month, DAIC has compiled a snapshot of significant cardiovascular disease (CVD) and stroke statistics, along with a review of the atherosclerosis drug market.
Coronary Artery Calcification: Current Concepts and Clinical Implications
Circulation
JANUARY 15, 2024
Circulation, Volume 149, Issue 3 , Page 251-266, January 16, 2024. Coronary artery calcification (CAC) accompanies the development of advanced atherosclerosis. Nevertheless, the relationship between CAC and the susceptibility of a plaque to provoke a thrombotic event remains incompletely understood.
Abstract 4113494: Gut Microbiota Modulation by Immunosuppression and Cardiac Cell Therapy in a Nonhuman Primate Ischemia/Reperfusion Model of Cardiac Regeneration
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4113494-A4113494, November 12, 2024. These observed microbiota changes and metabolic shifts could serve as biomarkers for monitoring cell therapy and immunosuppression outcomes, offering potential therapeutic targets to enhance efficacy.
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Abstract 4142231: Relationship between serum interleukin-6 levels and severity of STEMI undergoing percutaneous coronary intervention
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4142231-A4142231, November 12, 2024. Methods:The descriptive, cross-sectional study was conducted in patients with STEMI with a confirmed diagnosis and percutaneous coronary angiography at 108 Military Central Hospital from April 2023 to April 2024. There was 75% of males.
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Abstract 4125093: Association of Systemic Inflammatory Index and Systemic Inflammatory Response Index with Major Adverse Cardiovascular Events in Patients with Acute Coronary Syndrome Who Had Primary Percutaneous Coronary Intervention
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4125093-A4125093, November 12, 2024. Considering their multidirectional effect on atherosclerosis, new inflammatory biomarkers integrating various leukocyte subgroups have been proposed to calculate the systemic inflammatory response index (SIRI) and systemic inflammatory index (SII).Aim:The
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Abstract TMP75: Histopathologic and Transcriptomic Characterizations of Cerebral Microbleeds in an E4FAD Murine Model
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATMP75-ATMP75, February 1, 2024. The cellular architecture in the lesions and their genetic alterations have not been elucidated, limiting biomarker development and therapeutic targeting. The spatial transcriptomics identified 19 DEGs between CMBs and control tissue (p<0.1,
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Abstract 4139191: ETX-258 - A GalOmic™ siRNA for the Treatment of Heart Failure Following Myocardial Infarction
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4139191-A4139191, November 12, 2024. Introduction:Heart failure with reduced ejection fraction (HFrEF) remains a significant clinical challenge, evidenced by high hospitalization rates and five-year mortality. Cardiac function was assessed by echocardiography at 2-, 4- and 6-weeks post-MI.
Abstract 4148181: Neutrophil and Leucocyte Ratio and LDL to HDL ratios as predictors of Hemorrhagic transformation in ischemic stroke patients : A systematic review
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4148181-A4148181, November 12, 2024. Background:Following an ischemic stroke, a serious complication known as hemorrhagic transformation (HT) might jeopardize patient outcomes.
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Is OMI an ECG Diagnosis?
Dr. Smith's ECG Blog
APRIL 18, 2024
1] European guidelines add "regardless of biomarkers". Circulation 2014 2. Int J Cardiol 2024 3. Eur Heart J Digital Health 2024 5. But only 6.4% of such ‘high risk Non-STEMI’ patients get angiography within 2 hours.[2] Amsterdam et al. Alencar et al. Lupu et al. McLaren and Smith.
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Abstract 4147019: Role of Fractional Excretion of Uric Acid as a Predictor of Cardio-renal Syndrome in Acute Decompensated Heart Failure Patients: An Observational Study
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4147019-A4147019, November 12, 2024. However, multi-parametric techniques and biomarkers which are available for investigating cardiovascular diseases and kidney diseases may offer opportunities for the evaluation of CRS.
Abstract 4141864: Eosinophil Regulated Necrosis in Murine Model of Eosinophilic Heart Disease
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4141864-A4141864, November 12, 2024. Background:Many patients with sustained hypereosinophilia develop cardiac complications, and eosinophilic heart disease (EHD) is the major cause of morbidity and mortality in these patients. The mechanism of EHD is poorly understood.
Additional Data From SEQUOIA-HCM Presented at HFSA Annual Scientific Meeting
DAIC
OCTOBER 2, 2024
tim.hodson Wed, 10/02/2024 - 11:08 Sept. 30, 2024 — Cytokinetics, Inc. vs 24% showed enhanced exercise capacity and 84% vs 8% demonstrated a substantial response in cardiac biomarkers (for all p aficamten achieved one or more clinically relevant outcomes, 62% achieved at least three outcomes and 23% achieved all four outcomes.
Abstract 4142484: Mechanism of miR-203a-3p regulating the proliferation and migration of PASMCs through PIK3CA/PI3K/Akt pathway in PAH
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4142484-A4142484, November 12, 2024. Background:Pulmonary arterial hypertension (PAH) is characterized by an elevation in pulmonary vascular resistance and arterial pressure, culminating in right ventricular failure and mortality.
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40 Abstract 4141170: Impact of Serum 5-Hydroxytryptophan Levels on 15-Year Major Adverse Cardiovascular Events in ST-Elevation Myocardial Infarction Patients
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4141170-A4141170, November 12, 2024. These findings suggest that 5-HTP could potentially be used as a biomarker for cardiovascular risk stratification. Conclusion:Higher 5-HTP levels are independently associated with a reduced risk of MACE in patients after STEMI.
Abstract 4147291: Examination of pre-mRNA from cardiomyocytes at single-cell resolution from post-infarcted mouse hearts
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4147291-A4147291, November 12, 2024. This study could identify new biomarkers to predict the onset of heart failure. Background:RNA-seq provides a powerful tool to dissect cellular heterogeneity in diseased hearts. It generates reads from both mature RNA and pre-mRNA.
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40 Abstract 4134796: Safety of over 1000 consecutive, selected low risk patients with accelerated discharge from a chest pain unit with early generation cardiac troponin use, no cardiac functional or anatomic testing and no clinical risk scores
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4134796-A4134796, November 12, 2024. Early discharge of selected LR CP pts based on history, examination, ECG, and biomarker evaluation was safe and effective.Conclusion:This approach in selected LR pts has the potential to reduce unnecessary diagnostic testing and CPU LOS.
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Abstract TP150: Magnetic Resonance Imaging Predictors of Atrial Fibrillation in Cryptogenic Stroke Cases
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP150-ATP150, February 1, 2024. Introduction:Ischemic stroke is a leading cause of death and disability in the US, with 20-40% of cases, classified as cryptogenic or with an unexplained cause. Adjustment variables were based on univariate logistic regression predictors of AF at P ≤0.1000.Results:Of
46 year old with chest pain develops a wide complex rhythm -- see many examples
Dr. Smith's ECG Blog
AUGUST 9, 2024
Frick -- one wonders about the diagnosis of unstable angina in a patient with significantly elevated biomarkers which would certainly have been rising on repeat measurement.) Circulation Research , 56 (2), 184–194. Circulation , 63 (2), 333–340. Moffat, M. & Lukas, A. studies on isolated canine ventricular tissues.
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International Stroke Conference 2024 to Present High-Profile Late-Breaking Science
DAIC
JANUARY 22, 2024
The International Stroke Conference 2024 will be held Feb. MT) TESLA: The Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke Trial: 1-Year Outcome: Osama Zaidat, Mercy Health St. 7-9 in Phoenix, Arizona. 7-9 in Phoenix, Arizona. 7 Late-Breaking Science Oral Abstracts I (beginning at 2:00 p.m.
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Physiology Friday #218: The Longevity Advantage of Elite Middle Distance Runners
Physiologically Speaking
MAY 17, 2024
Most of the evidence on the harms of extreme exercise is related to a biomarker of cardiovascular disease known as coronary artery calcification or CAC. Exercise and Coronary Atherosclerosis | Circulation What’s lacking, however, is good data on long-term survival and lifespan among “extreme exercisers.”
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98 Abstract 4146478: Women with Acute Heart Failure Have Lower Intracardiac Pressures than Men Despite Similar Symptoms, Physical Findings, and Biomarkers
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4146478-A4146478, November 12, 2024. Background:Sex differences in physiology and presentation have been well established across the heart failure (HF) spectrum. Women had a worse Minnesota Living with Heart Failure physical subscore (34.6±5 p=0.03).
Abstract 4138593: Sex-, Age-and Racial- specific disparities, echocardiographic myocardial mechanics and biomarkers, and 1-year survival among patients with heart failure.
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4138593-A4138593, November 12, 2024. No demonstrated sex differences in functional class and biomarkers including NT-proBNP levels. Men demonstrated significant risk for one-year mortality than women, as was black ethnicity and older age.
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40 Abstract 4141403: Age-, Sex- and/or Ethnic- specific disparities; Biventricular systolic and diastolic strain, and biomarker, prognostic implications in Acute Tuberculous Pericarditis.
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4141403-A4141403, November 12, 2024. Background:Two-dimensional speckle tracking echocardiographic (2D-STE) strain analysis is modern and inovatively useful in overcoming technical echocardiographic limitations.
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Abstract 4114198: Humanin Level is Inversely Correlated with NT-proBNP Level and Mortality in Heart Failure with Reduced Ejection Fraction
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4114198-A4114198, November 12, 2024. However, there has yet to be clinically relevant biomarkers that address mitochondrial-mediated cardiac injury in patients. Conclusions:To the best of our knowledge, this is the first study to describe plasma HN levels in HF patients.
Published Research
Society of Thoracic Surgeons - Research
APRIL 20, 2023
Adult Cardiac Surgery Database Lead Author Title Publication Date Jacob Raphael Red Blood Cell Transfusion and Pulmonary Complications: The Society of Thoracic Surgeons Adult Cardiac Surgery Database Analysis The Annals of Thoracic Surgery January 2024 Joseph Sabik Multi-Arterial versus Single-Arterial Coronary Surgery: Ten Year Follow-up of One Million (..)
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