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Pulmonary arterial hypertension, a form of high blood pressure that occurs in the lungs, is a target of research by Cedars-Sinai investigators. Pulmonary arterial hypertension is a rare disease, affecting fewer than 100 people per million. Siegel Family Foundation Distinguished Professor and senior author of the study. “We
Results of Tenax Therapeutics’ Phase 2 HELP study of levosimendan in patients with pulmonary hypertension (PH) with heart failure with preserved ejection fraction (HFpEF) demonstrated that I.V. Getty Images milla1cf Mon, 05/06/2024 - 10:48 May 6, 2024 — Tenax Therapeutics, Inc. ,
The independent risk factors for mortality included left ventricular ejection fraction (LVEF), pulmonary hypertension, and low-density lipoprotein (LDL) levels (P<0.05). LVEF, pulmonary hypertension, and LDL levels are critical prognostic factors, offering insights for risk assessment and management in affected children.
Methods A retrospective analysis was conducted using an AI-based ECG algorithm on patients ≥18 years old presenting with dyspnoea at the ED from February 2006 to September 2023. Patients were categorised into cardiac or pulmonary origin groups based on initial admission.
Transcatheter pulmonary valve replacement (TPVR) continued to dominate the field of interventional cardiology. This year saw exciting developments in the treatment of pediatric and congenital heart disease.
Background Decreased diffusing capacity of the lungs for carbon monoxide (DLco) is associated with microvascular damage in chronic thromboembolic pulmonary hypertension (CTEPH). Methods We retrospectively analysed data from patients with inoperable CTEPH who underwent BPA at the University of Tokyo Hospital from July 2011 to August 2023.
This study aims to present our institutional experience and the outcomes of pulmonary endarterectomy for PAS.MethodsWe gathered clinical characteristics, intraoperative data, postoperative outcomes, and prognosis information from PAS patients who underwent surgical treatment at our institution between December 2016 and September 2023.ResultsA
Event 2023 STS Coding Workshop kchalko Tue, 11/15/2022 - 16:12 Event dates Feb 10–11, 2023 Location Virtual Registrants : To access the library of on-demand content, log into the STS Learning Center. Then go to “In Progress” courses on the dashboard or look in the “My Activities” tab. Missed the event? STS Members receive a discount!
Background Pulmonary hypertension (PH) is linked to higher rates of morbidity and mortality worldwide. The estimated pulmonary artery systolic pressure (ePASP ≥ 35 mmHg) measured by echocardiography helps screen PH patients. Early diagnosis of PH is important for clinical treatment.
Getty Images milla1cf Tue, 02/06/2024 - 20:36 February 6, 2024 — Cortex announced the initiation of its RESOLVE-AF trial ( NCT05883631 ), a study formally launched in late October 2023. AFib is the most common heart rhythm disorder, affecting more than 30 million patients worldwide.
Patients in Group 2 had greater pulmonary artery systolic pressure than those in Group 1 (p-value<0.001). The patients were divided into two groups based on age: Group 1 included children and adolescents (18 years of age; n=42), while Group 2 consisted of adults (>18 years of age; n=57), at the time of device percutaneous closure.
We previously reported that first-pass pulmonary vein (PV) isolation (FPI) is related to the PV isolation (PVI) durability in ablation index (AI) guided catheter ablation for atrial fibrillation (AF) (J Cardiovasc Electrophysiol 2023). However, the impact of obesity on FPI has been scarcely reported.
Methods and Results A total of 323 consecutive FAT patients who underwent electrophysiological study and radiofrequency catheter ablation between January 2011 and March 2023 were selected for this study. Young adults had a higher proportion of FAT originating from the superior vena cava and pulmonary veins.
A company statement reported that its PFA System is indicated for the isolation of pulmonary veins in the treatment of drug-refractory, recurrent, symptomatic, paroxysmal (i.e., The FARAPULSE PFA System is indicated for the isolation of pulmonary veins in the treatment of drug-refractory, recurrent, symptomatic, paroxysmal (i.e.,
Due to the implantation technique, left pulmonary artery (LPA) stents represent a relative contraindication to Venus P-valve. 16/17 (94%) patients were successfully implanted. 3/16 (18.7%) patients underwent Venus P-valve implantation with LPA stents.
Journal of the American Heart Association, Volume 12, Issue 23 , December 5, 2023. BackgroundLeft heart disease is the most common cause of pulmonary hypertension (PH) and is frequently accompanied by increases in pulmonary vascular resistance.
In patients with narrow QRS ( not this patient), this pattern is highly suggestive of acute pulmonary embolism. Although it was technically difficult and the quality therefore leaves a lot to be desired, you can still make out RV dilation and septal flattening which is much more suggestive of pulmonary embolism than OMI.
However, retrograde arterial perfusion from the femoral artery can increase left ventricular (LV) afterload, resulting in LV distention which may hamper myocardial recovery and worsen pulmonary congestion. Impella may be particularly effective in reducing pulmonary congestion. 3.65]; p<0.0001). to 1.96) and VA-ECMO alone (1.94
Journal of the American Heart Association, Volume 12, Issue 23 , December 5, 2023. Transpulmonary exosomal miRs offer valuable insights into pulmonary circulation microenvironments. Using an in vitro flow model simulating the shear stress experienced by pulmonary endothelial cells, we observed a significant upregulation of miR‐21.
Background:Transcatheter pulmonary valve replacement (TPVR) has been acknowledged as a common and beneficial treatment for significant pulmonary regurgitation (PR), but data are still lacking about the mid-term effects of self-expanding valve implantation in patients with pyramidal right ventricular outflow tract (RVOT).Methods:This
Patients in the study will be randomized to undergo pulmonary vein isolation (PVI) and left atrial posterior wall ablation using the FARAPULSE PFA System, or receive AAD treatment, and followed for three years. The randomized AVANT GUARD trial will enroll more than 500 patients diagnosed with persistent AF at up to 75 sites globally.
Animal studies have shown that mice with TBX1 gene mutations have smaller left pulmonary arteries compared to wild type mice, defined by a reduced left pulmonary artery (LPA) to right pulmonary artery (RPA) ratio. A single study has shown this translates to humans with 22q11 and structurally normal hearts.
Background:Neonates with complex congenital heart disease and pulmonary overcirculation have been historically treated surgically. Cox regression was used to evaluate the association between palliation strategy and 6-month mortality.Results:From 2021 to 2023, 17 patients (median age, 4 days; interquartile range [IQR], 2–8; median weight, 2.5
For a 10-minute video review on reading Pulmonary CT Scan — WATCH_this_VIDEO by Dr. Jake Gibbons. Figure-5: CTPA view in today's case — showing large clot burden in the right and left main pulmonary arteries. == C ASE F ollow-Up: The "good news" in today's case — is that the patient received thrombolytics, and ultimately did well.
Getty Images milla1cf Tue, 12/19/2023 - 18:09 December 19, 2023 — BioCardia, Inc. , These trials included 93 patients treated with culture expanded MSCs or dedicated controls using the Helix delivery system with no observed treatment emergent serious adverse events.
large ASD, partial anomalous pulmonary venous return, significant tricuspid regurgitation, carcinoid valvular disease, etc,) 2) Conditions causing pressure overload of the RV. Any cause of pulmonary hypertension. There is normal axis, normal R-wave progression in the precordial leads and no intraventricular conduction abnormalities.
KEY Point: Although true that patients with longstanding, severe pulmonary disease may manifest a QRST complex in standard lead I with marked overall reduction in QRST amplitude ( See ECG Blog #65 — regarding Schamroth’s Sign ) — you should never normally see a completely flat line in any of the standard limb leads.
Background:Chronic obstructive pulmonary disorder (COPD) is a progressive respiratory disorder ranking third in global mortality. The search timeline included the earliest available date until April 2023, including studies that investigated stroke occurrence in COPD patients. The analysis was conducted using CMA v.3
Publication date: Available online 30 November 2023 Source: The American Journal of Cardiology Author(s): Muni Rubens, Venkataraghavan Ramamoorthy, Anshul Saxena, Javier Jimenez, Shebin George, Jiana Baker, Juan Ruiz, Sandra Chaparro
These 2 settings are: i ) In patients with severe , often longstanding pulmonary disease ; and / or , ii ) In acutely ill patients with multi-system disease ( ie, sepsis, shock, electrolyte and/or acid-base disorders ). Hypoxic injury ( from pneumonia or other acute pulmonary complication ). Acute pulmonary embolus.
Smith interpretation: This is highly likely to be due to extreme right heart strain and is nearly diagnostic of pulmonary embolism. It is of course pulmonary embolism. No d-dimer or CT pulmonary angiogram was done when they discovered that she had normal coronary arteries. What is the clear diagnosis and reason for arrest?
Journal of the American Heart Association, Volume 12, Issue 23 , December 5, 2023. BackgroundThe modified Blalock‐Taussig‐Thomas shunt is the gold standard palliation for securing pulmonary blood flow in infants with ductal‐dependent pulmonary blood flow.
CT of the chest showed no pulmonary embolism but bibasilar infiltrates. For more on Torsades de Pointes vs PMVT See My Comment in the October 18, 2023 post and the September 2, 2024 post in Dr. Smith's ECG Blog ). She was intubated. Bedside cardiac ultrasound showed moderately decreased LV function.
Anumana has received FDA Breakthrough Device Designation for four of its algorithms: low ejection fraction, pulmonary hypertension , cardiac amyloidosis, and hyperkalemia. FDA clearance in September 2023 and is currently under review in Europe.
Publication date: Available online 15 December 2023 Source: The American Journal of Cardiology Author(s): Alberto Palazzuoli, Alessandra Cartocci, Filippo Pirrotta, Maria Cristina Tavera, Francesco Morrone, Francesca Vannuccini, Alessandro Campora, Gaetano Ruocco
Most popular method is pulmonary vein isolation using these energy sources as the pulmonary veins harbour the triggers for atrial fibrillation. While myocardial tissue is preferentially ablated, effects on adjacent structures like esophagus, phrenic nerve and pulmonary vein tissue is limited with pulsed field ablation.
Ken (below) is appropriately worried about pulmonary embolism from the ECG. What I had not told him before he made that judgement is that the patient also had ultrasound B-lines of pulmonary edema. I was told that the Queen of Hearts had called it OMI with high confidence. What do you think?
Here is a subsequent rhythm strip: This confirms sinus rhythm == MY Comment , by K EN G RAUER, MD ( 10/21 /2023 ): == It is often challenging to review the charts of complex cases when you lack a detailed sequential account of events that transpired. The heart rate gradually slowed with supportive care.
Methods A retrospective analysis was conducted among children under 18 who were diagnosed with CLM and underwent surgery at Srinagarind Hospital, Khon Kaen University between January 2007 and December 2023. Congenital pulmonary airway malformation was the most common diagnosis, affecting 26 children (68.4%).
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