Remove 2023 Remove Heart Disease Remove Pulmonary
article thumbnail

Hot Topics in Congenital and Pediatric Cardiology in the Year 2023

American College of Cardiology

This year saw exciting developments in the treatment of pediatric and congenital heart disease. Transcatheter pulmonary valve replacement (TPVR) continued to dominate the field of interventional cardiology.

article thumbnail

Transpulmonary Expression of Exosomal microRNAs in Idiopathic and Congenital Heart Disease–Related Pulmonary Arterial Hypertension

Journal of the American Heart Association

Journal of the American Heart Association, Volume 12, Issue 23 , December 5, 2023. BackgroundPulmonary artery hypertension (PAH) is a fatal disease characterized by a complex pathogenesis. Transpulmonary exosomal miRs offer valuable insights into pulmonary circulation microenvironments.

article thumbnail

Transcatheter Palliation With Pulmonary Artery Flow Restrictors in Neonates With Congenital Heart Disease: Feasibility, Outcomes, and Comparison With a Historical Hybrid Stage 1 Cohort

Circulation: Cardiovascular Interventions

Background:Neonates with complex congenital heart disease and pulmonary overcirculation have been historically treated surgically. Pulmonary arteries grew adequately for age, and devices were easily removed without complications. However, subcohorts may benefit from less invasive procedures. kilograms [IQR, 2.1–3.3])

article thumbnail

Omics and Extreme Phenotyping Reveal Longitudinal Association Between Left Atrial Size and Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension

Journal of the American Heart Association

Journal of the American Heart Association, Volume 12, Issue 23 , December 5, 2023. BackgroundLeft heart disease is the most common cause of pulmonary hypertension (PH) and is frequently accompanied by increases in pulmonary vascular resistance.

article thumbnail

Abstract 4147910: 22q11 Deletion Syndrome: A Potenitial Risk Factor For Left Pulmonary Artery Hypoplasia and Need For Intervention in Patients With Congeital Heart Disease

Circulation

Animal studies have shown that mice with TBX1 gene mutations have smaller left pulmonary arteries compared to wild type mice, defined by a reduced left pulmonary artery (LPA) to right pulmonary artery (RPA) ratio. A single study has shown this translates to humans with 22q11 and structurally normal hearts.

article thumbnail

BioCardia Doses First Patient in CardiALLO Phase I/II Clinical Trial of BCDA-03 Allogeneic Mesenchymal Stem Cells for the Treatment of Ischemic Heart Failure of Reduced Ejection Fraction

DAIC

Getty Images milla1cf Tue, 12/19/2023 - 18:09 December 19, 2023 — BioCardia, Inc. , The initiation of the CardiALLO MSC clinical trial for HFrEF is a significant milestone in our efforts to improve patients’ lives through the development of new treatments that target the underpinnings of heart disease,” said Peter Altman, Ph.D.,

article thumbnail

ECG Blog #366 — Diltiazem didn't work.

Ken Grauer, MD

These 2 settings are: i ) In patients with severe , often longstanding pulmonary disease ; and / or , ii ) In acutely ill patients with multi-system disease ( ie, sepsis, shock, electrolyte and/or acid-base disorders ). Acute Right Heart Strain. Hypoxic injury ( from pneumonia or other acute pulmonary complication ).

Blog 78