Stroke Journal

FEBRUARY 1, 2024

Objective:Investigate the efficacy and safety of proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) on stroke prevention.Background:PCSK9i reduce low-density lipoprotein cholesterol (LDL-Chol) and lipoprotein a (LpA) levels. The primary outcome was total stroke.

Stroke 40

Stroke Strokes Cholesterol Outcomes 40

Circulation

NOVEMBER 11, 2024

VA sites work with an AHA QI consultant to develop and deploy a local quality improvement plan to help overcome site specific barriers preventing Veterans from achieving optimal cholesterol levels. As this program is further implemented in our institution, we expect improvement in patient outcomes and prognosis.

Cardiovascular Disease 40

Cardiovascular Disease Diet Education Cholesterol 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. Understanding the temporal progression of vascular calcification allows for the optimization of surgical strategy and timing, potentially reducing stroke risk and improving patient outcomes.

Risk Factors 40

Risk Factors Cholesterol Cardiovascular Disease Strokes 40

Dr. Paddy Barrett

AUGUST 16, 2024

The outcome in real-world circumstances is known as ‘Efficacy’ Effectiveness tells us what is possible. What do you think would happen to someone's blood pressure, LDL cholesterol, or blood glucose if you were to evaluate what happens after you stop their blood pressure, cholesterol-lowering, or diabetes medication?

Obesity 52

Obesity Blood Pressure Diet Exercise 52

Dr. Paddy Barrett

OCTOBER 31, 2023

If you separate those with a significantly elevated Lp(a) (>50mg/dl) and a normal Lp(a) by levels of healthy lifestyle, you see major differences in outcomes. 2023 Sep 15:e14093. Atherosclerosis. 2017 Jan;256:47-52. 2 Healthy lifestyle, lipoprotein (a) levels and the risk of coronary artery disease. Eur J Clin Invest.

Coronary Artery Disease 52

Coronary Artery Disease Heart Disease Atherosclerosis Cardiovascular Disease 52

Physiologically Speaking

DECEMBER 22, 2023

Clinically, about 1/3 of adults have metabolic syndrome — a cluster of conditions including abdominal obesity, high blood pressure, high blood glucose, high triglycerides, and low HDL cholesterol. Published online November 28, 2023:JP285366. Both groups consumed a meal 1 hour before their exercise sessions.

Exercise 52

Exercise Physiology Blood Pressure Cholesterol 52

Physiologically Speaking

DECEMBER 22, 2023

Clinically, about 1/3 of adults have metabolic syndrome — a cluster of conditions including abdominal obesity, high blood pressure, high blood glucose, high triglycerides, and low HDL cholesterol. Published online November 28, 2023:JP285366. Both groups consumed a meal 1 hour before their exercise sessions.

Exercise 52

Exercise Physiology Blood Pressure Cholesterol 52

DAIC

APRIL 24, 2024

The app also recorded other significant heart health risk factors, such as cholesterol, weight, and physical activity via integration with external sources including electronic medical records and fitness trackers. Participants aged 65+ who enrolled in the Hello Heart app from January through October 2023 were studied retrospectively.

Blood Pressure 116

Blood Pressure Cholesterol Technology Heart attacks 116

Dr. Paddy Barrett

DECEMBER 12, 2023

Low levels of muscle mass are associated with a range of adverse outcomes, and a therapy that causes this would not be a good long-term health strategy. Undoubtedly, if weight reduction can be achieved using lifestyle measures alone, that would be the preferable outcome. 2023 Aug 10;389(6):514-526. 2023 Nov 11.

Obesity 106

Obesity Heart attacks Heart Attack Diet 106

Cardiometabolic Health Congress

JANUARY 15, 2025

The Global Burden of Disease data (2023) highlights a grim reality: while high-income countries have seen some success in managing CVD, LMICs now account for most CVD-related deaths. This shift results from an epidemiologic transition: as infectious diseases decline, chronic conditions like atherosclerosis dominate.

Atherosclerosis 59

Atherosclerosis Plaque Myocardial Infarction Risk Factors 59

Dr. Paddy Barrett

APRIL 26, 2024

Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. But if a retained cholesterol particle is the spark. But they don’t guarantee the outcome. 2023 Oct, 82 (16) 1583–1594. 2023 Jul 6:S0939-4753(23)00273-9. This is the spark that sets the fire. For sure. (

Heart Disease 105

Heart Disease Coronary Artery Disease Diabetes Genetic predisposition 105

Circulation: Genomic and Precision Medicine

MARCH 28, 2025

After 6 months, IRSgparticipants had higher statin initiation and lower low-density lipoprotein cholesterol. METHODS:Participants were followed from randomization in October 2013 to September 2023 to ascertain MACE, testing for CHD, and changes in risk factors. 48% male).

Heart Disease 40

Heart Disease Cholesterol Myocardial Infarction Risk Factors 40

All About Cardiovascular System and Disorders

DECEMBER 15, 2023

CLEAR Trial of Bempedoic Acid Bempedoic acid is an ATP citrate lyase inhibitor, acting upstream of HMGCoA reductase targeted by statins, and reduces LDL cholesterol levels. Thus the effect of bempedoic acid on cardiovascular events in those with lower LDL cholesterol levels and those on therapeutic doses of statins were not evaluated.

Cholesterol 52

Cholesterol Myocardial Infarction Cardiovascular Disease Diabetes 52

DAIC

JANUARY 23, 2024

5 Over my career as a cardiovascular surgeon, as well as an immunologist, I have witnessed how current treatments for ASCVD have led to considerable improvements in outcomes, yet many patients remain vulnerable to life-threatening cardiac events.1,6 As of June 2023, the U.S. The repurposed drug is safe, cost-effective and efficacious.

Cardiovascular Disease 111

Cardiovascular Disease Heart attacks Heart Attack Coronary Artery Disease 111

Dr. Paddy Barrett

MAY 17, 2024

When stress is included in the risk factor profile for a future heart attack, it comes in third on the list after abnormal cholesterol and smoking 1. Regardless of what is driving the effect, it is clear that experiencing high levels of stress is associated with worse outcomes. The link is real. For both acute and chronic stress.

Heart Disease 104

Heart Disease Heart attacks Heart Attack Risk Factors 104

Dr. Paddy Barrett

AUGUST 29, 2023

Share JUPITER In 2008 a landmark paper was published showing that in people without cardiovascular disease and relatively normal LDL-cholesterol (<3.4 Because of the increased risk, I am also quicker to introduce non-statin-based cholesterol-lowering agents such as ezetimibe, bempedoic acid, PCSK9 inhibitors or inclisiran when available.

Diabetes 52

Diabetes Risk Factors Heart attacks Heart Attack 52

Dr. Malcolm Kendrick

OCTOBER 20, 2023

20th October 2023 (With lessons from, and for, all other health services around the world) The Quality and Outcomes Framework The Quality and Outcomes Framework (QOF) was to be the glittering triumph of Evidence Based Medicine. People at risk of cardiovascular disease would have their cholesterol levels checked.

Heart attacks 52

Heart attacks Heart Attack Blood Pressure ACE Inhibitor 52

Dr. Anish Koka

JANUARY 18, 2023

Discovering discrepancies in a major published trial from the pharma-academic complex would be a boost to those seeking to force trial data to be public, and that is exactly what a group of investigators attempted to do with a major cholesterol lowering trial published in 2017. Cholesterol lowering is big business.

Document 52

Document Academic Heart attacks Heart Attack 52

Dr. Paddy Barrett

JANUARY 16, 2024

Subscribe now 1 Life's Essential 8 and risk of non-communicable chronic diseases: Outcome-wide analyses. Chinese Medical Journal ():10.1097/CM9.0000000000002830, October 10, 2023. Keep the odds on your side. Let randomness take the rest.

Cancer 97

Cancer Dementia Diabetes Cardiovascular Disease 97

DAIC

MARCH 8, 2024

The FDA decision is based on the results of the landmark SELECT phase 3 cardiovascular outcomes trial that examined the effect of adding Wegovy 2.4 1,2 The primary composite outcome occurred in 6.5% 1,2 The primary composite outcome occurred in 6.5% Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes.

Obesity 111

Obesity Heart Disease Heart attacks Heart Attack 111

Dr. S. Venkatesan MD

JANUARY 8, 2024

10kg) Out of which just 250 mg of cholesterol is streaming in blood. We must understand Fat, lipid and cholesterol are different entities. While the total body seems to do little in determining cholesterol levels, what is more scientifically shocking is slope of the curve between blood LDL levels and plaque burden is rarely linear.

Cholesterol 52

Cholesterol Atherosclerosis Plaque Physiology 52

Dr. Paddy Barrett

OCTOBER 24, 2023

Optimal lifestyle factors include: Normal weight Normal Cholesterol Good Diet Normal Blood Pressure Not Smoking Being Physically Active Maintaining most or all of the above factors results in a 64% reduction in the risk of diabetes 4. We cannot guarantee outcomes, but we can set up probabilities. 2023 Oct;11(10):731-742.

Diabetes 52

Diabetes Cancer Exercise Cardiovascular Disease 52

Frontiers in Cardiovascular Medicine

DECEMBER 23, 2024

Daily behaviors have strong implications for health outcomes and quality of life. Alcohol consumption (AOR=0.64, 95% CI: 0.420.96), ever-practiced reducing salt intake (AOR=2.48, 95% CI: 1.573.93), and low-density lipoprotein cholesterol levels in the blood (>160mg/dl) (AOR=3.3, BackgroundMore than 23 million deaths and 36.5%

Hypertension 52

Hypertension Quality of Life Cholesterol Education 52

Dr. Malcolm Kendrick

OCTOBER 30, 2024

I, Dr Malcolm Kendrick, with or without other co-conspirators, would be accused of spreading misinformation about cholesterol and statins. The hypothesis that a raised cholesterol level causes heart disease [atherosclerotic cardiovascular disease (ASCVD)] is possibly the single most powerful idea in medicine. With thousands dying.

Cholesterol 145

Cholesterol Article Research Diet 145