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Clinical characteristics and mortality risk factors in pediatric hypertrophic, restrictive, and rapidly progressive hypertrophic cardiomyopathy: a retrospective cohort study with follow-up

Frontiers in Cardiovascular Medicine

BackgroundPediatric cardiomyopathies are rare but life-threatening conditions with high mortality. ConclusionsThis study underscores the importance of early diagnosis, genetic testing, and integrated management in pediatric cardiomyopathies. Demographic, clinical, and diagnostic data, as well as follow-up outcomes, were reviewed.

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Factors associated with high-intensity physical activity and sudden cardiac death in hypertrophic cardiomyopathy

Heart BMJ

Background High-intensity physical activity has traditionally been discouraged in patients with hypertrophic cardiomyopathy due to concerns about triggering sudden cardiac death. However, current guidelines adopt a more liberal stance, and evidence on risk factors for exercise-related sudden cardiac death remains limited.

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Aligning With 2023 ESC Guidelines in oHCM Treatment

HCPLive

Anjali Tiku Owens, MD, explores the role of cardiac myosin inhibitors in the treatment strategies for patients with obstructive hypertrophic cardiomyopathy (oHCM), in accordance with the latest European Society of Cardiology (ESC) Guidelines released in 2023.

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Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-? Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice

Circulation: Heart Failure

Circulation: Heart Failure, Volume 16, Issue 12 , Page e010351, December 1, 2023. Recent evidence suggests that loss of PRDM16 expression is associated with cardiomyopathy development in mice, although its role in human cardiomyopathy development is unclear.

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Viz.ai Receives Edison Award for HCM Module

DAIC

Viz HCM, the companys AI software solution designed to detect and triage patients with signs of hypertrophic cardiomyopathy (HCM), was recognized in the Health Medical & Biotech category and Cardiovascular Health Diagnostics and Monitoring subcategory. tim.hodson Mon, 04/07/2025 - 16:15 April 4, 2025 Viz.ai JACC: Clinical Electrophysiology.

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BridgeBio Pharma Announces Publication of Positive Results from Phase 3 ATTRibute-CM Study of Acoramidis for Patients with Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in the New England Journal of Medicine

DAIC

BridgeBio has also presented additional detailed results from ATTRibute-CM at the European Society of Cardiology Congress 2023 in August and at the American Heart Association Scientific Sessions 2023 in November. FDA in 2023 and intends to submit additional marketing authorization applications to regulatory bodies in 2024.

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Torsade in a patient with left bundle branch block: is there a long QT? (And: Left Bundle Pacing).

Dr. Smith's ECG Blog

And of course Ken's comments at the bottom) An elderly obese woman with cardiomyopathy, Left bundle branch block, and chronic hypercapnea presented hypoxic with altered mental status. I do not see OMI here and all trops were only minimally elevated, consistent with either chronic injury from cardiomyopathy or with acute injury from sepsis.