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Journal of the American Heart Association, Volume 12, Issue 23 , December 5, 2023. The expression of GPBAR1 in the human endothelium correlated with the expression of inflammatory biomarkers. BackgroundPatients with nonalcoholic fatty liver disease are at increased risk to develop atherosclerotic cardiovascular diseases.
They have the biomarker of risk but no evidence of the disease , even later in life when you would expect them to have it. A healthy lifestyle, in this instance, is defined by a combination of: BMI Nutrition Smoking Status Activity Levels Blood Pressure Diabetes Status Cholesterol Levels All of which are highly modifiable.
Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. But if a retained cholesterol particle is the spark. 1 Association of lipid, inflammatory, and metabolic biomarkers with age at onset for incident coronary heart disease in women. 2023 Oct, 82 (16) 1583–1594.
Elevated levels of two protein biomarkers that indicate heart damage were associated with undetected or symptomless cardiovascular disease in adults with Type 2 diabetes compared to those without Type 2 diabetes, according to new research published May 31, 2023, in the Journal of the American Heart Association, JAHA. In addition, 115.9
Inflammation driven by signaling cytokines, circulating immune cells, adhesion molecules, and oxidized low-density lipoprotein cholesterol (LDL-C) leads to atherosclerotic plaque development, plaque progression, and eventual rupture.14,15 As of June 2023, the U.S. 21 Luckily, each of these risks can be measured by simple blood tests.
CLEAR Trial of Bempedoic Acid Bempedoic acid is an ATP citrate lyase inhibitor, acting upstream of HMGCoA reductase targeted by statins, and reduces LDL cholesterol levels. Thus the effect of bempedoic acid on cardiovascular events in those with lower LDL cholesterol levels and those on therapeutic doses of statins were not evaluated.
I, Dr Malcolm Kendrick, with or without other co-conspirators, would be accused of spreading misinformation about cholesterol and statins. The hypothesis that a raised cholesterol level causes heart disease [atherosclerotic cardiovascular disease (ASCVD)] is possibly the single most powerful idea in medicine. With thousands dying.
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