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Novartis Reclaims Anthos, Reenters Factor XI Race

CardiacWire

Anthos subsequently kicked off three phase 3 trials in 2022, and wrapping up these studies by 2026 will now be Novartis responsibility. Besides the hefty price tag , the re-acquisition puts Novartis back into competition with other big-name Factor XI inhibitor developers, whove faced a series of setbacks.

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How To Reverse Coronary Artery Disease With Lifestyle Measures

Dr. Paddy Barrett

You cannot eliminate the plaque entirely, but multiple clinical trials have shown plaque regression using high-intensity cholesterol-lowering treatments, which I have discussed previously. All of these parameters are important and need to be considered when evaluating plaque regression. REVERSAL Investigators.

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Dynamic OMI ECG. Negative trops and negative angiogram does not rule out coronary ischemia or ACS.

Dr. Smith's ECG Blog

Thus, it has recently become generally accepted that most plaque ruptures resulting in myocardial infarction occur in plaques that narrow the lumen diameter by 40% of the arterial cross section may be involved by plaque. The pathologist may see a plaque that constitutes, for example, 50% of the cross-sectional area.

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Abstract TP176: Radiological Reporting Frequencies of High-Risk Non-Stenosing Carotid Plaque Features: A Follow-Up Observational Study

Stroke Journal

Background:High-risk non-stenosing carotid plaque features are emerging as a possible source of embolism in the setting of ESUS. We utilized Fisher’s exact test to compare the frequencies of reporting each plaque characteristic.Results:We analyzed 152 CTA reports in depth.

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Imaging Biomarkers and Prevalence of Complex Aortic Plaque in Cryptogenic Stroke: A Systematic Review

Journal of the American Heart Association

BackgroundComplex aortic plaque (CAP) is a potential embolic source in patients with cryptogenic stroke (CS). Most studies (74%) used ≥4 mm plaque thickness as the imaging criterion for CAP although ≥1 mm (N=1, CTA), ≥5 mm (N=5, TEE), and ≥6 mm (N=2, CTA) were also reported. 0.41],I2=94%). I2=95%) for TEE; 0.23 (95% CI, 0.15–0.34;I2=87%)

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Roche's Lp(a) Gen.2 Molarity Assay Receives FDA Clearance

DAIC

Lp(a) is emerging as an important, yet under-recognized, potential risk factor for cardiovascular disease due to its ability to promote the development of plaques within artery walls, clot formation and aortic valve calcification. 2022 Aug, 80 (9) 934946 Kronenberg F.

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Filling the Evidence Gaps Toward a Coronary Artery Calcium-Guided Primary Prevention Strategy

JAMA Cardiology

This is because the test is widely available, fast, highly reproducible, low radiation, directly reflective of total coronary plaque burden, and highly predictive of future atherosclerotic cardiovascular disease (ASCVD) events.

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