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Inflammatory pericarditis can occur in differential fashion. For example, the most common chronic pericarditis tuberculosis affects the fibrinous layer. Post MI pericarditis involves the epicardium. Diastolic Coronary Artery Compression in Constrictive Pericarditis. Angina caused by calcific constrictive pericarditis.
Curr Cardiol Red 2021 3. ST depression in lead AVL differentiates inferior ST-elevation myocardial infarction from pericarditis. J Am Heart Assoc 2021 6. IJC Heart and Vasc 2021 8. Systematic review and meta-analysis of diagnostic test accuracy of ST-segment elevation for acute coronary occlusion. Int J Cardiol 2024 2.
The case reports Case 1 involves a 26 year old man who developed pericarditis after the Pfizer vaccine. Pericarditis, an inflammation of the sac the heart lives in, developed about 7 days after the Pfizer vaccine. The diagnosis was made based on classic findings of inflammation on an electrocardiogram associated with acute chest pain.
BACKGROUND:Pericardial late gadolinium enhancement (LGE) is usually associated with active pericarditis, but it is not infrequently found in patients after cardiac surgery even a long time after the intervention. All patients were asymptomatic, and no specific treatment for pericarditis was started.
Traditionally used as an anti-inflammatory for pericarditis (inflammation of the lining of the heart), it has recently been shown to result in fewer major heart events in those with a recent heart attack. 2021 Oct 19;10(20):e021356. 2021 May 1;397(10285):1625-1636. It is an easy win, frequently missed. J Am Heart Assoc.
Primary adverse events were defined as myocardial infarction, thromboembolism, transient ischemic attack, diaphragmatic paralysis, pneumothorax, heart block, pulmonary edema, vagal nerve injury, pericarditis, major vascular access complication or bleeding, death, stroke, or any other cerebrovascular accident. 2021 Feb;16(2):217-221.
First, many on Twitter said "Pericarditis". This is NOT pericarditis, which virtually NEVER has ST depression any where except aVR. See our publication: ST depression in lead aVL differentiates inferior ST-elevation myocardial infarction from pericarditis There is STE in inferior leads, high lateral leads, and V4-V6.
It was Israeli researchers that first highlighted the novel mRNA vaccines as potentially causing myocarditis in the Spring of 2021, but it has proven difficult to quantify the risk of severe complications beyond scattered case reports of severe morbidity and mortality. Subscribe for free to receive new posts and support my work.
This is a bad ST vector orientation, because it causes widespread STE and one of the most important mistakes that needs to be avoided here is thinking of the diagnosis of pericarditis. Such an out-of-proportion STE is virtually never seen in pericarditis. 2021 Sep;49(6):488-500. Look at the STE in lead II, aVF. 2021.21026.
In August, the CDC reported 29 cases of pericarditis, including five in persons with a history of pericarditis after mRNA COVID-19 vaccine ; 10 Importantly, the Novovax vaccine is a protein based vaccine that was hoped to not be associated with myocarditis as was noted with the mRNA vaccines.
The initial computer and final cardiology interpretation was a differential: “ST elevation, consider early repolarization, pericarditis, or injury.” IJC Heart and Vasc 2021 5. But STEMI criteria ignore all this and look at ST segments in isolation. Ann Emerg Med 2023 4. Meyers, Bracey et al. Herman, Meyers, Smith et al.
Though less prevalent in younger patients, occlusion MI may occur and requires the same early interventions as older patients. - - Pericarditis and myocarditis should be a diagnosis of exclusion. 2021 Aug 10;144(6):e123-e135. Epub 2021 Jul 7. 2021 Aug 10;144(6):e149. 2021 Apr 18;13(4):700. 2021 Aug;17(4):335-340.
The ‘post-vaccination’ cohort comprised vaccinated patients with CHD and matched controls with first-recorded SARS-CoV-2 infection between 1 March 2021 and 1 April 2022, at least 14 days after vaccination (57 550 cases, 225 160 controls). Odds of severe COVID-19 outcomes were compared using conditional logistic regression.
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