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Recent research suggested that the weight loss market was estimated to be worth $224 billion annually in 2021 and is estimated to exceed $400 billion by 2024 1. In 2021, the weight loss medication Semaglutide, which you probably know as Ozempic, was approved for the management of excess weight-causing health issues. That is until now.
While I have covered many of these fitness measures individually in previous posts, I wanted to summarise these metrics and how they relate to living longer and preventing major diseases such as cardiovascular disease, cancer and dementia. 2021 Sep 1;4(9):e2124516. The relationship is clear. JAMA Netw Open. J Am Coll Cardiol.
It kills almost twice as many people globally when compared to all cancers combined. Dementia Up to 40% of dementia cases could be prevented by focusing on modifiable risk factors 11. Those with high blood pressure from midlife have twice the risk of developing dementia over a 25-year follow-up 12. 2021 Feb 16;87(1):18.
Aims Heart failure (HF) has a lower public profile compared with other serious health conditions, notably cancer. times per million words (pmw), ‘dementia’ occurs 3.68 times pmw and ‘cancer’ occurs 81.96 times per million words (pmw), ‘dementia’ occurs 3.68 times pmw.
Methods and Results Patients with HF from the Swedish HF Registry between 2000-2021 were included. The highest risk was associated with dementia (hazard ratio [HR] 1.55, 95% confidence interval [CI] 1.45-1.65), In a multivariable Cox model, 12 comorbidities were independently associated with a higher risk of death from any cause.
The world we live in means you are massively incentivised to eat in a way that makes you gain excess weight that will likely result in metabolic dysfunction and an increased risk of not only heart disease but many cancers and also dementia. While this is unfortunate, it is the world we live in. This is a way to tackle that problem.
The final model predicting stroke within 1 year following cancer diagnosis was derived using multivariable Fine-Gray regression with candidate predictors selected via backward elimination. Conclusion:We derived and validated a risk prediction model for ischemic stroke in patients with a new cancer diagnosis with good discrimination.
Such support is provided by a number of government institutions and charities, including the Medical Research Council, National Institute for Health and Care Research, Department of Health and Social Care, British Heart Foundation, Cancer Research UK and Wellcome. plus drug supply ASCEND PLUS (2021 – ongoing) Novo Nordisk A/S: £39.4M
Cognitive Performance & Dementia. There is also mechanistic data to support its role in preventing dementia, but for now, this is more speculative 10. 2021 Jun 2;13(6):1915. Evidence suggests that supplementing with creatine leads to greater total sleep duration on training days 8. 2014 Jun;127(6):547-53. Open Access J.
If you have reduced your risk of heart disease and cancer as you age, other threats rise to the surface. A critical component of healthy ageing is the maintenance of cognitive capacity and avoidance of dementia. Muscle power may also play a role in the prevention or progression of dementia. 2021 Apr-Jun 01;44(2):74-81.
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