Dr. S. Venkatesan MD

SEPTEMBER 1, 2024

In this context, we need a movement to revive the pre-hospital thrombolysis. Efficiency of thrombolysis is highly reproducible. Strategy to Reduce Mortality Rates of ST-elevation Acute Myocardial Infarction Using Prehospital Thrombolysis: A Meta-analysis. Circulation 2006;114:2019-25 This is what CAPTIM told us.

Thrombolysis 52

Thrombolysis Myocardial Infarction Academic STEMI 52

Stroke Journal

JANUARY 30, 2025

The secondary objective was to identify post-stroke neurological follow-up and rehab therapies utilized by patients with LEP.Methods:Retrospective data collection of 1,026 charts from 2019-2022 tracking demographic findings, treatments, post-stroke neurological follow-up care, and 90-day mRS scores. There were 55 identified as LEP.

Outcomes 40

Outcomes Thrombolysis Document Outpatient 40

Stroke Journal

JANUARY 30, 2025

from 2019 to 2023. atrial fibrillation) and were not treated with thrombolysis/thrombectomy were included in our study. Methods:We used the GWTG-Stroke registry to describe patterns of DAPT use in the U.S. The use of both DAPT regimens significantly increased over time (Figure 1, p<0.001 for trend).Conclusion:Among

Stroke 40

Stroke Strokes Public Health Atrial Fibrillation 40

Dr. Smith's ECG Blog

DECEMBER 19, 2023

The commonest causes of MINOCA include: atherosclerotic causes such as plaque rupture or erosion with spontaneous thrombolysis, and non-atherosclerotic causes such as coronary vasospasm (sometimes called variant angina or Prinzmetal's angina), coronary embolism or thrombosis, possibly microvascular dysfunction.

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Plaque Angina Blog Stent 127

Stroke Journal

FEBRUARY 1, 2024

Pre-hospital identification may increase and speed study enrollment.Methods:Midway through the Multi-Arm Optimization of Stroke Thrombolysis (MOST) trial, our mobile stroke unit research personnel monitored EMS radio for potential stroke patients en route to our study hospital. patients per month compared to 2.4 In addition, there was a 17.5-minute

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Hospital Stroke Strokes Thrombolysis 40

Frontiers in Cardiovascular Medicine

JANUARY 30, 2024

Methods We retrospectively reviewed children with congenital heart diseases (CHDs) who received trans-axillary arterial catheterizations between January 2019 and February 2023. Background Axillary arterial access (AAA) in pediatric heart catheterizations is undervalued. We administrated intra-arterial verapamil (1.25 mg) months (IQR, 8–17.5).

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Pediatrics Congenital Heart Disease Thrombosis Angioplasty 49

Stroke Journal

JANUARY 30, 2025

Background:MOST (Multi-arm Optimization of Stroke Thrombolysis) was a multicenter, randomized controlled trial of adjuvant argatroban, eptifibatide, or placebo in moderate to severe acute ischemic stroke patients who received intravenous thrombolysis within three hours of stroke onset. protocol deviations).

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Stroke Strokes Thrombolysis Document 40

Stroke Journal

FEBRUARY 1, 2024

National Inpatient Sample (2005-2019) using ICD-9 and ICD-10 codes. Within the concurrent AIS group, the CCAD group also exhibited an increased likelihood for IV thrombolysis (10.7% Our study utilized a comprehensive nationwide database to discern these differences.Method:We examined non-traumatic CAD-diagnosed patients from the U.S.

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Inpatient Outcomes Atrial Fibrillation Thrombolysis 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Among patients with an ischemic stroke, thrombectomy administration decreased by up to 25% in February 2020 compared to February 2019 (Zhao et al., In addition, hospital admissions related to stroke dropped by up to 46% in 2020 compared to 2019 (Sharma et al.,

COVID-19 40

COVID-19 Stroke Strokes Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

We sought to evaluate the spoke hospital door in-door out (DIDO) times for patients transferred to our hub center for EVT.Methods:Individuals who first presented with LVO to a spoke hospital and were then transferred to the hub for EVT were retrospectively identified from a prospectively maintained database from January 2019 to November 2022.

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Stroke Strokes Thrombolysis Atrial Fibrillation 40

Stroke Journal

FEBRUARY 1, 2024

Detailed clinical, laboratory and multimodal imaging data from known AF patients consecutively admitted to 20 stroke centers with an IS between 1/2018-12/2019 were used to define characteristics of AIS-despite-AC and compared to AIS-off-AC.Results:Out of 4456 patients with known AF prior to the AIS, 2051 (46%) were using anticoagulants.

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AFIB Stroke Strokes Embolism 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

We sought to evaluate the spoke hospital door in‐door out (DIDO) times for patients transferred to our hub center for EVT.MethodsIndividuals who first presented with LVO to a spoke hospital and were then transferred to the hub for EVT were retrospectively identified from a prospectively maintained database from January 2019 to November 2022.

Stroke 40

Stroke Strokes Thrombolysis Atrial Fibrillation 40

Stroke Journal

FEBRUARY 1, 2024

For inclusion, patients must have been successfully recanalized by mechanical thrombectomy with or without intravenous thrombolytic and ultimate modified thrombolysis in cerebral infarction (mTICI) score 2B/2C/3.

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Hemorrhage Thrombolysis Diabetes Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:In large vessel occlusion (LVO) ischemic stroke patients, better functional outcomes are associated with achieving modified thrombolysis in cerebral infarction (mTICI) score 2C/3 in comparison to 2B.

Stroke 40

Stroke Strokes Thrombolysis Diabetes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

We aimed to assess whether FPCTP obtained directly after MT could provide additional potentially relevant information on tissue reperfusion status.MethodsQualitative, single‐center analysis of all consecutive acute stroke patients admitted between 06/2019 and 03/2021 who underwent MT and post‐interventional FPCTP (n=26).

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Thrombolysis Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Patients with LVO residing in RAs more likely transferred into hospitals from other facilities than arrived from scene, less likely received thrombolysis, and had higher onset-to-arrival time.

Stroke 40

Stroke Strokes Medicaid Medicare 40

Journal of the American Heart Association

JANUARY 31, 2024

The proportion of patients with mRS 0 or 1 was lower in patients with WUS who underwent thrombolysis versus those with known‐onset stroke (50.4% Thrombolytic treatment in WUS versus known‐onset stroke was compared in 730 patients (365 matched pairs). Functional outcomes were assessed by the modified Rankin Scale (mRS) at 3 months.

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Stroke Strokes Hemorrhage Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Introduction:Significant strides have been made in optimizing thrombolysis and thrombectomy for acute ischemic stroke treatment. Stroke, Volume 56, Issue Suppl_1 , Page AWP303-AWP303, February 1, 2025.

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Stroke Strokes Thrombolysis Hospital 40

Stroke Journal

JANUARY 30, 2025

Patients were divided into pre-RAPID (n =186) and post-RAPID (n =264) groups based on the implementation date of the RAPID system (September 1, 2019).

Stroke 40

Stroke Strokes Patient Care Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

The study focused on adult patients (18 years or older) admitted to Alexian Brothers Medical Center in Illinois between 2019-2022 who were diagnosed with acute ischemic stroke. Primary outcomes were the number of AIS patients treated with thrombolysis (IV tPA or IV TNK) and/or mechanical thrombectomy (MT) and time to treatment.

Outcomes 40

Outcomes Stroke Strokes Technology 40

Stroke Journal

FEBRUARY 1, 2024

Methods:We extracted data from our stroke registry for consecutive patients with acLVO who underwent EVT and subsequent neurocritical care (12/2019-12/2022). Patients were categorized based on dexmedetomidine treatment. While favorable functional outcome was less frequently observed in the dexmedetomidine than in the comparator group (7.9%

Stroke 40

Stroke Strokes Outcomes Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Background:Stroke centers following AHA guidelines for the treatment of acute ischemic stroke, are challenged by compliance with documentation of vital sign, neuro and neurovascular assessments post thrombolysis interventions. Standardizing documentation in the electronic health record (EHR) increases compliance and reduces patient harm.

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Document Nursing Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Pre-transfer variables independently associated with clinical improvement were intravenous thrombolysis use, more distal occlusions, and lower serum glucose; variables associated with deterioration included more proximal occlusions and higher serum glucose.

Hospital 40

Hospital Outcomes Thrombolysis Document 40

Stroke Journal

DECEMBER 28, 2023

Patients with acute ischemic stroke aged between 18 and 80 years who were eligible for standard intravenous thrombolysis were enrolled from 17 centers in China and randomly assigned (1:1:1) to receive intravenous reteplase 12+12 mg, intravenous reteplase 18+18 mg, or intravenous alteplase 0.9 Four patients did not receive the study agent.

Stroke 40

Stroke Strokes Hemorrhage Thrombolysis 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 28, 2023

BACKGROUNDIn patients with acute ischemic stroke secondary to large vessel occlusion, achieving modified Thrombolysis in Cerebral Infarction (mTICI) 2c/3 (excellent recanalization) over mTICI 2b is associated with improved functional outcomes. Stroke: Vascular and Interventional Neurology, Ahead of Print. P=0.050) and prior stroke (aOR, 0.27;P=0.007),

Stroke 40

Stroke Strokes Thrombolysis Diabetes 40

Stroke Journal

JANUARY 30, 2025

There was no difference in pre-stroke modified Rankin scale (mRS), NIHSS on admission, mortality, discharge mRS, or 90-day mRS between these two groups, nor between patients who received intravenous thrombolysis (IVT) vs. those who did not. p=0.028), discharge mRS (1.3 p=0.009), and 90-day mRS (1.0 p=0.038) than those who did not.

Stenosis 40

Stenosis Thrombolysis Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Tenecteplase (TNK) is increasingly being utilized for IV thrombolysis in acute ischemic stroke, including for patients with large vessel occlusion (LVO) prior to transfer to an endovascular thrombectomy (EVT) capable center (TCC). Stroke, Volume 55, Issue Suppl_1 , Page AWP22-AWP22, February 1, 2024.

Outcomes 40

Outcomes Stroke Strokes Thrombolysis 40

Stroke: Vascular and Interventional Neurology

OCTOBER 2, 2023

Secondary end points were successful revascularization (modified thrombolysis in cerebral infarction ≥2b), workflow metrics, National Institutes of Health Stroke Scale score at discharge, and patient disposition at 90 days.ResultsA total of 183 patients (64.9±13.7,

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Stroke Strokes Hemorrhage Thrombolysis 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Additionally, we sought to analyze clinical and mortality outcomes in CAS and MT retrospectively at our institution.MethodsWe searched for patients who underwent emergency cervical ICA stent placement and intracranial thrombectomy with stent‐retriever and/or aspiration devices in our institution between 2019‐2023.

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Stent Stents Hemorrhage Inpatient 40

EMS 12-Lead

AUGUST 14, 2022

A second 12 Lead ECG was recorded: This is a testament to the dynamic nature of coronary thrombosis and thrombolysis. The patient verbalized spontaneous improvement just before 324mg ASA administration. Here the ST segments are not so deep, nor are the T waves so wide and bulky, because of improved coronary flow at the level of the occlusion.

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STEMI Sudden Cardiac Death Thrombosis Thrombolysis 52

Dr. Smith's ECG Blog

NOVEMBER 4, 2022

This has been termed a “STEMI equivalent” and included in STEMI guidelines, suggesting this patient should receive dual anti-platelets, heparin and immediate cath lab activation–or thrombolysis in centres where cath lab is not available. Am J Med 2019, 132(5):622-630. American Journal of Medicine 132(5):622-630; May 2019.

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Ischemia STEMI Stenosis Chest Pain 52

Dr. Anish Koka

JANUARY 18, 2023

The TIMI (Thrombolysis in Myocardial Infarction) Study Group is a Division of Cardiovascular Medicine at the esteemed Brigham and Women’s Hospital and Harvard Medical School. Trials of this size are complex and can’t be done by just anyone, which is why the famed TIMI group was tasked with the job.

Document 52

Document Academic Heart Attack Heart attacks 52

Stroke Journal

JANUARY 30, 2025

Introduction:Because of the risk of infarcted tissue leading to symptomatic intracerebral hemorrhage (sICH) after intravenous thrombolysis for acute ischemic stroke, patients are monitored for at least 24 hours in a critical care setting. We aim to assess incidence and risk factors of sICH following thrombolysis for acute ischemic stroke.

Thrombolysis 40

Thrombolysis Hemorrhage Stroke Strokes 40

Stroke Journal

NOVEMBER 9, 2023

This study investigated whether advances in these treatments improved outcomes in this population.METHODS:Using a prospective multicenter stroke registry in Korea, young adults (aged 18–50 years) with acute ischemic stroke hospitalized between 2008 and 2019 were identified. in 2017–2019) and 3-month modified Rankin Scale scores 0 to 1 (68.3%–69.1%)

Stroke 40

Stroke Strokes Outcomes Atrial Fibrillation 40

Stroke Journal

JANUARY 30, 2025

This study explores the interaction between structural racism, urbanity, and the administration of acute ischemic stroke (AIS) interventionsspecifically, intravenous thrombolysis (TPA) and endovascular thrombectomy (ET).Methods:This

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Stroke Strokes Medicare ICU 40

Stroke Journal

DECEMBER 21, 2023

We then developed a simple EMS quality score based on metrics associated with early CT and examined its associations with hospital stroke evaluation times, treatment, and patient outcomes.RESULTS:Five thousand seven hundred seven EMS-transported stroke cases were linked to prehospital records from January 2018 through June 2019.

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Stroke Strokes Document Thrombolysis 40

Stroke Journal

JANUARY 4, 2024

In this post hoc analysis, baseline characteristics, workflow times, successful reperfusion (extended Thrombolysis in Cerebral Infarction score ≥2b), symptomatic intracerebral hemorrhage, 90-day functional independence (modified Rankin Scale score, 0–1), and 90-day mortality were compared by sex. mg/kg) with alteplase (0.9 hours of onset.

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Stroke Strokes Thrombolysis Outcomes 40