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Findings from the highly-anticipated MOST (Multi-Arm Optimization of StrokeThrombolysis) trial were presented on the first day of the American Stroke Association’s International Stroke Conference, ISC 2024, being held through Feb. A lot of our approaches in stroke treatment were learned from how we treat heart attacks.
Stroke, Volume 55, Issue Suppl_1 , Page A43-A43, February 1, 2024. hours of ischemic stroke onset from 2003 to 2021. hours of ischemic stroke onset from 2003 to 2021. Thrombolysis rates and speed of treatment during TS phase I (2010-2013), II (2014-2018), and III (2019-2021) were compared with the pre-TS period (2003-2009).Results:Among
Stroke, Ahead of Print. BACKGROUND:Timely intravenous thrombolysis and endovascular thrombectomy are the standard reperfusion treatments for large vessel occlusion stroke. hours of onset) and thrombectomy treatment from January 2019 to April 2023. hours of onset) and thrombectomy treatment from January 2019 to April 2023.
Stroke, Volume 56, Issue Suppl_1 , Page AWP14-AWP14, February 1, 2025. Introduction:The use of IV thrombolysis (IVT) in acute ischemic stroke patients presenting with an NIHSS of 5 has failed to demonstrate benefit, particularly when the symptoms are considered non-disabling. Kappa = 0.26 [95% CI 0.23 0.29]) (Table 1).
Stroke, Volume 55, Issue Suppl_1 , Page ATMP13-ATMP13, February 1, 2024. Introduction:Recent studies report similar outcomes with antiplatelet drugs and intravenous thrombolysis (IVT) in patients with minor nondisabling ischemic stroke. Patients were excluded if they were on anticoagulation, presented beyond 4.5
Stroke, Ahead of Print. BACKGROUND:The effectiveness of intravenous thrombolysis (IVT) before endovascular treatment (EVT) has been investigated in randomized trials and meta-analyses. These studies mainly concerned anterior circulation occlusions. All patients with a posterior circulation occlusion were included.
Stroke, Volume 56, Issue Suppl_1 , Page AWMP60-AWMP60, February 1, 2025. Methods:MOST began in 2019 and was completed in 2023. We compared protocol deviations between participants consented using conventional paper informed consent documents (ICDs) versus electronic informed consent (eConsent).Methods:MOST
Stroke, Volume 55, Issue Suppl_1 , Page A1-A1, February 1, 2024. Background:Enrollment into hyperacute stroke trials may be constrained since candidates are usually not identified until they arrive in the emergency department. patients per month compared to 2.4 after intervention (12/2021 - 07/2023), 2.43, 95% CI: 1.48-4.10,
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionThe goal of this research project is to investigate the impacts and effects of the COVID‐19 pandemic on acute ischemic stroke treatment in North America. The most common way to treat these strokes is a mechanical thrombectomy.
BackgroundPrevious clinical trials found improved outcome of thrombolytic treatment in patients with ischemic wake‐up stroke (WUS) selected by advanced imaging techniques. Thrombolytic treatment in WUS versus known‐onset stroke was compared in 730 patients (365 matched pairs). of patients with known‐onset stroke (OR, 1.14 [95% CI, 0.54–2.41];P=0.726).ConclusionsThrombolytic
Stroke, Volume 56, Issue Suppl_1 , Page AWP303-AWP303, February 1, 2025. Introduction:Significant strides have been made in optimizing thrombolysis and thrombectomy for acute ischemic stroke treatment. Prolonged arrival time was defined as more than 6 hours from the approximate last known well time.
Stroke, Volume 55, Issue Suppl_1 , Page ATP43-ATP43, February 1, 2024. Background:Stroke centers following AHA guidelines for the treatment of acute ischemic stroke, are challenged by compliance with documentation of vital sign, neuro and neurovascular assessments post thrombolysis interventions.
Stroke, Volume 56, Issue Suppl_1 , Page AWP181-AWP181, February 1, 2025. Background:Timely intervention is crucial for patients with acute ischemic stroke. Patients were divided into pre-RAPID (n =186) and post-RAPID (n =264) groups based on the implementation date of the RAPID system (September 1, 2019).
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionThe mantra ‘time is brain’ cannot be overstated for patients suffering from acute ischemic stroke. DIDO was defined as the time between spoke hospital door in arrival and door out exit.
Stroke, Volume 55, Issue Suppl_1 , Page ATMP15-ATMP15, February 1, 2024. Large vessel occlusion (LVO), a quarter of ischemic strokes, portends poor outcomes. Rurality was associated with negative SDH and worse acute stroke metrics, except DTNT for patients post-MT. Rural-urban commuting area codes determined rurality.
Stroke, Volume 55, Issue Suppl_1 , Page AWP126-AWP126, February 1, 2024. Methods:Data for this study were obtained from the Get with the Guidelines Stroke database. Methods:Data for this study were obtained from the Get with the Guidelines Stroke database.
Stroke, Volume 55, Issue Suppl_1 , Page AWP10-AWP10, February 1, 2024. Introduction:While observational data suggest that dexmedetomidine may have neuroprotective effects on ischemic brain, its clinical use in acute ischemic stroke is limited due to concerns about cerebral vasoconstriction. vs. 28.8%; p=0.24).
Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDIn patients with acute ischemic stroke secondary to large vessel occlusion, achieving modified Thrombolysis in Cerebral Infarction (mTICI) 2c/3 (excellent recanalization) over mTICI 2b is associated with improved functional outcomes.
Stroke, Ahead of Print. We aimed to determine the safety dose range of reteplase for patients with acute ischemic stroke within 4.5 We aimed to determine the safety dose range of reteplase for patients with acute ischemic stroke within 4.5 2.06]), 48 of 66 (72.7%) in the reteplase 18+18 mg group (odds ratio, 0.75 [95% CI, 0.32–1.78]),
Stroke: Vascular and Interventional Neurology, Volume 3, Issue 6 , November 1, 2023. BackgroundSoutheast Asia accounts for approximately 10% of stroke‐related mortalities worldwide, yet there are limited data regarding mechanical thrombectomy (MT) outcomes in this region. range 0–10). range 0–10). range −22, 25) and 90 days (−13.0,
Stroke, Volume 55, Issue Suppl_1 , Page AWP191-AWP191, February 1, 2024. Introduction:The mantra ‘time is brain’ cannot be overstated for patients suffering from acute ischemic stroke. The median NIHSS was 16 (10-20), 50% were treated with intravenous thrombolysis at a spoke, and TICI 2B-3 reperfusion was achieved in 87% at the hub.
Stroke, Volume 55, Issue Suppl_1 , Page AWP22-AWP22, February 1, 2024. Introduction:Tenecteplase (TNK) is increasingly being utilized for IV thrombolysis in acute ischemic stroke, including for patients with large vessel occlusion (LVO) prior to transfer to an endovascular thrombectomy (EVT) capable center (TCC).
Stroke, Volume 55, Issue Suppl_1 , Page ATP146-ATP146, February 1, 2024. Introduction:Collateral status imaging parameters are associated with predicting hemorrhagic transformation (HT) in acute ischemic stroke caused by large vessel occlusions. p=0.006); CBV index (aOR 0.0002, 95% CI 0-0.1,
Stroke, Volume 56, Issue Suppl_1 , Page AWP16-AWP16, February 1, 2025. Introduction:Currently, no level A evidence exists for the optimal rescue strategy for cases at high risk for re-occlusion following endovascular thrombectomy (EVT) in acute ischemic stroke. Mean National Institute of Health Stroke Scale (NIHSS) on admission was 16.6;
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionClinical utility and diagnostic sensitivity of new‐generation flat‐panel computed tomography perfusion imaging (FPCTP) performed immediately after mechanical thrombectomy (MT) is unknown.
Stroke, Volume 55, Issue Suppl_1 , Page A13-A13, February 1, 2024. Background:Patients with acute ischemic stroke harboring a large vessel occlusion (LVO) admitted to non endovascular-capable centers often require inter-hospital transfer for thrombectomy.
10, 2024 — Royal Philips and the World Stroke Organization (WSO) have published a policy paper calling for a revolution in stroke care to make a real difference to the lives of millions and bring significant economic benefits worldwide. Yet, access to thrombectomy remains the exception rather than the norm in global stroke care.
Stroke, Volume 56, Issue Suppl_1 , Page AWP24-AWP24, February 1, 2025. Introduction:Because of the risk of infarcted tissue leading to symptomatic intracerebral hemorrhage (sICH) after intravenous thrombolysis for acute ischemic stroke, patients are monitored for at least 24 hours in a critical care setting.
Stroke, Volume 56, Issue Suppl_1 , Page ATMP32-ATMP32, February 1, 2025. Using data from GWTG-Stroke, researchers previously reported that, after minor ischemic stroke (NIHSS 0-3), the use of aspirin-clopidogrel for stroke prevention is highly variable despite guideline recommendations. from 2019 to 2023.
Stroke, Volume 55, Issue Suppl_1 , Page A97-A97, February 1, 2024. vs 19.6%, p=0.002) and a past-history of stroke/TIA (36% vs 25%, p<0.001) when compared to non-AC group. Intravenous thrombolysis was used much less commonly for AIS-despite-AC (10.5% Patients who had AIS-despite-AC were younger (76.8+11 11 vs 77.8+12,
Stroke, Volume 54, Issue 12 , Page 3002-3011, December 1, 2023. BACKGROUND:There is limited information on the delivery of acute stroke therapies and secondary preventive measures and clinical outcomes over time in young adults with acute ischemic stroke. in 2017–2019) and 3-month modified Rankin Scale scores 0 to 1 (68.3%–69.1%)
Stroke, Volume 55, Issue 1 , Page 101-109, January 1, 2024. BACKGROUND:Emergency medical services (EMS) is an important link in the stroke chain of recovery. Various prehospital quality metrics have been proposed for prehospital stroke care, but their individual impact is uncertain. 1.6]), glucose check (1.3 [1.1–1.6]),
Stroke, Volume 56, Issue Suppl_1 , Page AWP152-AWP152, February 1, 2025. Background:Structural racism and disparities between rural and urban healthcare systems significantly impact stroke care delivery in the United States. vs. 88.6%), stroke certification (5.3% vs. 38.4%), and lower rates of TPA (1.6% for TPA, 1.27
Stroke, Volume 56, Issue Suppl_1 , Page AHUP17-AHUP17, February 1, 2025. Patients included in this study received either thrombolysis, thrombectomy, or both and were cared for at Methodist Hospital in Indianapolis, Indiana.Results:Between the years of 2019-2022, there were 2,815 ischemic stroke patients at Methodist Hospital.
Stroke, Ahead of Print. BACKGROUND:Understanding sex differences in stroke care is important in reducing potential disparities. mg/kg) in acute ischemic stroke within 4.5 mg/kg) in acute ischemic stroke within 4.5 METHODS:AcT was a multicenter, registry-linked randomized noninferiority trial comparing tenecteplase (0.25
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. Characteristics of hemorrhagic transformation (HT) according to the European Cooperative Acute Stroke Study (ECASS). Thrombolysis in Cerebral Infarction score of 2B was achieved in 18 patients (66.7%); the rest had a TICI 3 score.
LDL floats around in the blood stream and is thought to incrementally accumulate on blood vessels in the body, ultimately increasing the risk of heart attacks and strokes. Statins inhibit the intracellular liver enzyme HMG-CoA reductase, which then results in up regulation of LDL receptors on the surface of the liver cell.
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