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Findings from MOST Trial Presented at ISC24: Blood thinners added to clot-busting medication did not improve stroke outcomes

DAIC

Findings from the highly-anticipated MOST (Multi-Arm Optimization of Stroke Thrombolysis) trial were presented on the first day of the American Stroke Association’s International Stroke Conference, ISC 2024, being held through Feb. A lot of our approaches in stroke treatment were learned from how we treat heart attacks.

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Abstract 43: Race-Ethnic Specific Trends in Stroke Thrombolysis Care Metrics in Relation to U.S. Target: Stroke Nationwide Quality Improvement Program 2003-2021

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page A43-A43, February 1, 2024. hours of ischemic stroke onset from 2003 to 2021. hours of ischemic stroke onset from 2003 to 2021. Thrombolysis rates and speed of treatment during TS phase I (2010-2013), II (2014-2018), and III (2019-2021) were compared with the pre-TS period (2003-2009).Results:Among

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Comparing Low- or Standard-Dose Alteplase in Endovascular Thrombectomy: Insights From a Nationwide Registry

Stroke Journal

Stroke, Ahead of Print. BACKGROUND:Timely intravenous thrombolysis and endovascular thrombectomy are the standard reperfusion treatments for large vessel occlusion stroke. hours of onset) and thrombectomy treatment from January 2019 to April 2023. hours of onset) and thrombectomy treatment from January 2019 to April 2023.

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Abstract WP14: Objective Scoring to Reduce Excess Thrombolysis Utilization in Acute Ischemic Stroke Patients with NIHSS ≤ 5

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page AWP14-AWP14, February 1, 2025. Introduction:The use of IV thrombolysis (IVT) in acute ischemic stroke patients presenting with an NIHSS of 5 has failed to demonstrate benefit, particularly when the symptoms are considered non-disabling. Kappa = 0.26 [95% CI 0.23 0.29]) (Table 1).

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Abstract TMP13: Prehospital Stroke Scales Are Non-Inferior to NIHSS in Prediction of Intravenous Thrombolysis Use in a Large Telestroke Network

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page ATMP13-ATMP13, February 1, 2024. Introduction:Recent studies report similar outcomes with antiplatelet drugs and intravenous thrombolysis (IVT) in patients with minor nondisabling ischemic stroke. Patients were excluded if they were on anticoagulation, presented beyond 4.5

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Intravenous Thrombolysis Before Endovascular Treatment in Posterior Circulation Occlusions: A MR CLEAN Registry Study

Stroke Journal

Stroke, Ahead of Print. BACKGROUND:The effectiveness of intravenous thrombolysis (IVT) before endovascular treatment (EVT) has been investigated in randomized trials and meta-analyses. These studies mainly concerned anterior circulation occlusions. All patients with a posterior circulation occlusion were included.

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Abstract WMP60: Consent Deviations in an Acute Ischemic Stroke Clinical Trial

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page AWMP60-AWMP60, February 1, 2025. Methods:MOST began in 2019 and was completed in 2023. We compared protocol deviations between participants consented using conventional paper informed consent documents (ICDs) versus electronic informed consent (eConsent).Methods:MOST

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