Stroke Journal

FEBRUARY 1, 2024

Introduction:Tenecteplase (TNK) is increasingly being utilized for IV thrombolysis in acute ischemic stroke, including for patients with large vessel occlusion (LVO) prior to transfer to an endovascular thrombectomy (EVT) capable center (TCC). The primary outcome was a favorable 90-day mRS of 0-2. TNK vs. 48.4% no TNK, p=0.35).

Outcomes 40

Outcomes Stroke Strokes Thrombolysis 40

Dr. S. Venkatesan MD

SEPTEMBER 1, 2024

In this context, we need a movement to revive the pre-hospital thrombolysis. best, It has a miniscule 1 % edge in the outcome if performed on time, at a expertise intensive place. Efficiency of thrombolysis is highly reproducible. Circulation 2006;114:2019-25 This is what CAPTIM told us. DOI: 10.4103/rcm.rcm_1_24 2.Nallamothu

Thrombolysis 52

Thrombolysis Myocardial Infarction Academic STEMI 52

Stroke Journal

FEBRUARY 1, 2024

We sought to evaluate the spoke hospital door in-door out (DIDO) times for patients transferred to our hub center for EVT.Methods:Individuals who first presented with LVO to a spoke hospital and were then transferred to the hub for EVT were retrospectively identified from a prospectively maintained database from January 2019 to November 2022.

Stroke 40

Stroke Strokes Thrombolysis Atrial Fibrillation 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

We sought to evaluate the spoke hospital door in‐door out (DIDO) times for patients transferred to our hub center for EVT.MethodsIndividuals who first presented with LVO to a spoke hospital and were then transferred to the hub for EVT were retrospectively identified from a prospectively maintained database from January 2019 to November 2022.

Stroke 40

Stroke Strokes Thrombolysis Atrial Fibrillation 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:In large vessel occlusion (LVO) ischemic stroke patients, better functional outcomes are associated with achieving modified thrombolysis in cerebral infarction (mTICI) score 2C/3 in comparison to 2B. Primary outcome measure was achieving mTICI 2C/3 (i.e., excellent) revascularization. were female.

Stroke 40

Stroke Strokes Thrombolysis Diabetes 40

Journal of the American Heart Association

JANUARY 31, 2024

BackgroundPrevious clinical trials found improved outcome of thrombolytic treatment in patients with ischemic wake‐up stroke (WUS) selected by advanced imaging techniques. Functional outcomes were assessed by the modified Rankin Scale (mRS) at 3 months. Journal of the American Heart Association, Ahead of Print. 1.74];P=0.050).

Stroke 40

Stroke Strokes Hemorrhage Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Introduction:Significant strides have been made in optimizing thrombolysis and thrombectomy for acute ischemic stroke treatment. However, available treatment options and better patient outcomes favor stroke patients with hospital arrivals within earlier time frames relative to symptom onset.

Stroke 40

Stroke Strokes Thrombolysis Hospital 40

Stroke Journal

DECEMBER 28, 2023

Patients with acute ischemic stroke aged between 18 and 80 years who were eligible for standard intravenous thrombolysis were enrolled from 17 centers in China and randomly assigned (1:1:1) to receive intravenous reteplase 12+12 mg, intravenous reteplase 18+18 mg, or intravenous alteplase 0.9 Four patients did not receive the study agent.

Stroke 40

Stroke Strokes Hemorrhage Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

For inclusion, patients must have been successfully recanalized by mechanical thrombectomy with or without intravenous thrombolytic and ultimate modified thrombolysis in cerebral infarction (mTICI) score 2B/2C/3. Occurrence of HT was determined from post-interventional imaging, and HT subtype was defined by the ECASS 2 criteria.

Hemorrhage 40

Hemorrhage Thrombolysis Diabetes Biomarkers 40

Stroke: Vascular and Interventional Neurology

OCTOBER 2, 2023

BackgroundSoutheast Asia accounts for approximately 10% of stroke‐related mortalities worldwide, yet there are limited data regarding mechanical thrombectomy (MT) outcomes in this region. The primary end point was functional independence (modified Rankin scale 0–2) at 90 days. Most patients were discharged to home by 90 days (84.1%, 154/183).ConclusionPROSPR‐SEA

Stroke 40

Stroke Strokes Hemorrhage Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

There was no difference in pre-stroke modified Rankin scale (mRS), NIHSS on admission, mortality, discharge mRS, or 90-day mRS between these two groups, nor between patients who received intravenous thrombolysis (IVT) vs. those who did not. p=0.028), discharge mRS (1.3 p=0.009), and 90-day mRS (1.0 p=0.038) than those who did not.

Stenosis 40

Stenosis Thrombolysis Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Large vessel occlusion (LVO), a quarter of ischemic strokes, portends poor outcomes. Patients with LVO residing in RAs more likely transferred into hospitals from other facilities than arrived from scene, less likely received thrombolysis, and had higher onset-to-arrival time.

Stroke 40

Stroke Strokes Medicaid Medicare 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 28, 2023

BACKGROUNDIn patients with acute ischemic stroke secondary to large vessel occlusion, achieving modified Thrombolysis in Cerebral Infarction (mTICI) 2c/3 (excellent recanalization) over mTICI 2b is associated with improved functional outcomes. Stroke: Vascular and Interventional Neurology, Ahead of Print. P=0.012).

Stroke 40

Stroke Strokes Thrombolysis Diabetes 40

Dr. Smith's ECG Blog

NOVEMBER 4, 2022

This has been termed a “STEMI equivalent” and included in STEMI guidelines, suggesting this patient should receive dual anti-platelets, heparin and immediate cath lab activation–or thrombolysis in centres where cath lab is not available. Am J Med 2019, 132(5):622-630. American Journal of Medicine 132(5):622-630; May 2019.

Ischemia 52

Ischemia STEMI Stenosis Chest Pain 52

DAIC

SEPTEMBER 10, 2024

2. Expand and invest in infrastructures for essential stroke services, including stroke units and intravenous thrombolysis.* 5. For example, an average of around 7 percent of all ischemic stroke patients in the Europe region received this treatment in 2019. 4. Increase the necessary skills in the health workforce.

Stroke 96

Stroke Strokes Blood Clot Thrombolysis 96

Stroke Journal

NOVEMBER 9, 2023

BACKGROUND:There is limited information on the delivery of acute stroke therapies and secondary preventive measures and clinical outcomes over time in young adults with acute ischemic stroke. The observation period was divided into 4 epochs: 2008 to 2010, 2011 to 2013, 2014 to 2016, and 2017 to 2019. men, 71.9%) were registered.

Stroke 40

Stroke Strokes Outcomes Atrial Fibrillation 40

Stroke Journal

FEBRUARY 1, 2024

However, limited studies have compared their clinical features and outcomes. National Inpatient Sample (2005-2019) using ICD-9 and ICD-10 codes. Within the concurrent AIS group, the CCAD group also exhibited an increased likelihood for IV thrombolysis (10.7% vs. 8.7%), atrial fibrillation (6.1% vs. 3.7%), hypertension (58.0%

Inpatient 40

Inpatient Outcomes Atrial Fibrillation Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Background:Stroke patients with limited English proficiency (LEP) in the United States have limited stroke recovery and reduced post-stroke neurological care.Objective:Identify 90-day stroke outcomes using the modified Rankin Score (mRS) for patients discharged from Methodist Hospital with LEP. There were 55 identified as LEP.

Outcomes 40

Outcomes Thrombolysis Document Outpatient 40

Stroke Journal

FEBRUARY 1, 2024

Detailed clinical, laboratory and multimodal imaging data from known AF patients consecutively admitted to 20 stroke centers with an IS between 1/2018-12/2019 were used to define characteristics of AIS-despite-AC and compared to AIS-off-AC.Results:Out of 4456 patients with known AF prior to the AIS, 2051 (46%) were using anticoagulants.

AFIB 40

AFIB Stroke Strokes Embolism 40

Stroke Journal

JANUARY 30, 2025

This study explores the interaction between structural racism, urbanity, and the administration of acute ischemic stroke (AIS) interventionsspecifically, intravenous thrombolysis (TPA) and endovascular thrombectomy (ET).Methods:This These findings suggest a need for targeted interventions to address these inequities in stroke treatment

Stroke 40

Stroke Strokes Medicare ICU 40

Stroke Journal

JANUARY 4, 2024

In this post hoc analysis, baseline characteristics, workflow times, successful reperfusion (extended Thrombolysis in Cerebral Infarction score ≥2b), symptomatic intracerebral hemorrhage, 90-day functional independence (modified Rankin Scale score, 0–1), and 90-day mortality were compared by sex. mg/kg) with alteplase (0.9 hours of onset.

Stroke 40

Stroke Strokes Thrombolysis Outcomes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionCurrent literature suggests a benefit in functional outcomes and reperfusion rates when carotid artery stenting (CAS) and mechanical thrombectomy (MT) are performed emergently. Good clinical outcomes were a < 4 points of NIHSS at 24 hours, mRS (0‐3) at 90 days, and disposition to home or inpatient rehabilitation.

Stents 40

Stents Stent Hemorrhage Inpatient 40

Dr. Anish Koka

JANUARY 18, 2023

The TIMI (Thrombolysis in Myocardial Infarction) Study Group is a Division of Cardiovascular Medicine at the esteemed Brigham and Women’s Hospital and Harvard Medical School. Trials of this size are complex and can’t be done by just anyone, which is why the famed TIMI group was tasked with the job.

Document 52

Document Academic Heart Attack Heart attacks 52

Dr. Smith's ECG Blog

APRIL 9, 2025

REFERENCE Prevention of primary ventricular fibrillation in acute myocardial infarction with prophylactic lidocaine [link] Primary ventricular fibrillation (VF) during an acute myocardial infarction (AMI) occurs with a high incidence and mortality rate with or without thrombolysis. Mortality rates were 10.5% Smida T et al.

Defibrillator 63

Defibrillator Cardiac Arrest Myocardial Infarction STEMI 63

Dr. S. Venkatesan MD

NOVEMBER 8, 2024

08/11, 12:07] Dr S Venkatesan: Is the therapeutic time window for primary PCI and thrombolysis same ? [08/11, Thrombolysis has a broader time window, but efficacy decreases significantly after 6 hours. [ Thrombolysis has a broader time window, but efficacy decreases significantly after 6 hours. [ How can they be different? [08/11,

Thrombolysis 40

Thrombolysis Ischemia Hospital Outcomes 40