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BACKGROUND:The effectiveness of intravenous thrombolysis (IVT) before endovascular treatment (EVT) has been investigated in randomized trials and meta-analyses. Stroke, Ahead of Print. These studies mainly concerned anterior circulation occlusions. All patients with a posterior circulation occlusion were included.
This has been termed a “STEMI equivalent” and included in STEMI guidelines, suggesting this patient should receive dual anti-platelets, heparin and immediate cath lab activation–or thrombolysis in centres where cath lab is not available. His response: “subendocardial ischemia. Anything more on history? POCUS will be helpful.”
A second 12 Lead ECG was recorded: This is a testament to the dynamic nature of coronary thrombosis and thrombolysis. Accurate identification is absolutely necessary as this pattern can be easily misinterpreted for something less nefarious: for example, generic “subendocardial ischemia.” But the lesion is still active!
08/11, 12:07] Dr S Venkatesan: Is the therapeutic time window for primary PCI and thrombolysis same ? [08/11, Thrombolysis has a broader time window, but efficacy decreases significantly after 6 hours. [ 08/11, 12:13] Dr S Venkatesan: Time windows are related to time taken for myocardial cell death because of ischemia.
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