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BACKGROUND:Timely intravenous thrombolysis and endovascular thrombectomy are the standard reperfusion treatments for large vessel occlusion stroke. METHODS:We enrolled consecutive patients in the multicenter Taiwan Registry of Endovascular Thrombectomy for Acute Ischemic Stroke who had received combined thrombolysis (within 4.5
BACKGROUND:The effectiveness of intravenous thrombolysis (IVT) before endovascular treatment (EVT) has been investigated in randomized trials and meta-analyses. Although symptomatic intracranial hemorrhages occurred more often in the IVT group (4.8% Stroke, Ahead of Print. These studies mainly concerned anterior circulation occlusions.
Findings from the highly-anticipated MOST (Multi-Arm Optimization of Stroke Thrombolysis) trial were presented on the first day of the American Stroke Association’s International Stroke Conference, ISC 2024, being held through Feb. 9 Phoenix, AZ. Adeoye, M.D.,
Introduction:Collateral status imaging parameters are associated with predicting hemorrhagic transformation (HT) in acute ischemic stroke caused by large vessel occlusions. Stroke, Volume 55, Issue Suppl_1 , Page ATP146-ATP146, February 1, 2024.
The proportion of patients with mRS 0 or 1 was lower in patients with WUS who underwent thrombolysis versus those with known‐onset stroke (50.4% Symptomatic intracranial hemorrhage after thrombolytic treatment occurred in 4.4% Symptomatic intracranial hemorrhage after thrombolytic treatment occurred in 4.4% 2.41];P=0.726).ConclusionsThrombolytic
Patients with acute ischemic stroke aged between 18 and 80 years who were eligible for standard intravenous thrombolysis were enrolled from 17 centers in China and randomly assigned (1:1:1) to receive intravenous reteplase 12+12 mg, intravenous reteplase 18+18 mg, or intravenous alteplase 0.9 Four patients did not receive the study agent.
Safety end points included symptomatic intracerebral hemorrhage, emboli in new territory at 24 hours, and all‐cause mortality at 90 days. Within 24 hours, symptomatic intracerebral hemorrhage occurred in 7.7% (14/183) and emboli in new territory in 3.3% (6/183). range −22, 25) and 90 days (−13.0, range −22, 0).
We sought to evaluate the spoke hospital door in-door out (DIDO) times for patients transferred to our hub center for EVT.Methods:Individuals who first presented with LVO to a spoke hospital and were then transferred to the hub for EVT were retrospectively identified from a prospectively maintained database from January 2019 to November 2022.
We sought to evaluate the spoke hospital door in‐door out (DIDO) times for patients transferred to our hub center for EVT.MethodsIndividuals who first presented with LVO to a spoke hospital and were then transferred to the hub for EVT were retrospectively identified from a prospectively maintained database from January 2019 to November 2022.
This has been termed a “STEMI equivalent” and included in STEMI guidelines, suggesting this patient should receive dual anti-platelets, heparin and immediate cath lab activation–or thrombolysis in centres where cath lab is not available. Am J Med 2019, 132(5):622-630. American Journal of Medicine 132(5):622-630; May 2019.
Introduction:Because of the risk of infarcted tissue leading to symptomatic intracerebral hemorrhage (sICH) after intravenous thrombolysis for acute ischemic stroke, patients are monitored for at least 24 hours in a critical care setting. There were higher odds of sICH with lower ASPECTS score (OR 0.81, 95% CI [0.66, 1], p=0.054).
However, rates of symptomatic intracranial hemorrhages have been inconclusive. There is no standardized data on antithrombotic therapy use during CAS and MT procedures with less associated rates of symptomatic hemorrhagic transformation. Seven (26%) patients had symptomatic intracranial hemorrhages.
In this post hoc analysis, baseline characteristics, workflow times, successful reperfusion (extended Thrombolysis in Cerebral Infarction score ≥2b), symptomatic intracerebral hemorrhage, 90-day functional independence (modified Rankin Scale score, 0–1), and 90-day mortality were compared by sex. mg/kg) with alteplase (0.9
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