2015 and Thrombolysis - Cardiovascular Update

Abstract WP199: Outcomes Following Posterior Cerebral Artery Thrombolysis vs Medical Management in those with Atrial Fibrillation

Stroke Journal

FEBRUARY 1, 2024

Background:The benefits of endovascular thrombectomy (EVT) for posterior cerebral artery (PCA) occlusion remain controversial, but intravenous thrombolysis (IVT) has proven benefit across nearly all ischemic stroke types.

Atrial Fibrillation

Atrial Fibrillation Thrombolysis Outcomes Embolism

Abstract TP115: Differences in the Medical Management of Post-Stroke Sequelae Among Patients Treated with Mechanical Thrombectomy vs Intravenous Thrombolysis

Stroke Journal

JANUARY 30, 2025

Background:Mechanical thrombectomy (MT) as treatment for acute ischemic stroke (AIS) has demonstrated superior functional outcomes compared to intravenous thrombolysis (IVT). Stroke, Volume 56, Issue Suppl_1 , Page ATP115-ATP115, February 1, 2025. Matched propensity scores were used to adjust for baseline differences across 36 factors.

Thrombolysis

Thrombolysis Stroke Strokes Quality of Life

Abstract WMP42: Trends of In-Hospital Strokes Over Time: Results From the Greater Cincinnati and Northern Kentucky Stroke Study

Stroke Journal

FEBRUARY 1, 2024

Background:Prior studies have shown that individuals who have an in-hospital stroke are less likely to receive thrombolysis. We used national death index data to determine death at 30 days post-discharge.Results:Among 13134 strokes from 1993-2015, 1152 (9%) occurred in the hospital. in1993/94 (p=0.003).

Hospital

Hospital Stroke Strokes Thrombolysis

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

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Abstract TP278: Identifying High-Risk Patients With Poor Prognosis in Acute Phase of Ischemic Stroke: Treatment-Specific Risk Scales Developed From the National Neurological Medical Center of China

Stroke Journal

FEBRUARY 1, 2024

Subjects were divided into "intravenous thrombolysis group" and "non-intravenous thrombolysis group". Result:A total of 1971 patients (437 thrombolysis) were included. In the external validation set, the AUC-ROC values of "PAIST Scale" were 0.855 in the non-thrombolysis group and 0.778 in the thrombolysis group.

Thrombolysis

Thrombolysis Thrombosis Stroke Strokes

Nationwide Trends in Reperfusion Therapy and Outcomes of Acute Ischemic Stroke According to Severity: The Japan Stroke Data Bank

Stroke: Vascular and Interventional Neurology

SEPTEMBER 12, 2023

Secular changes were assessed per 5‐year cohorts (2000–2005, 2006–2010, 2011–2015, 2016–2020). In patients with NIHSS score ≥10, intravenous thrombolysis frequency increased from 1.6% In patients with NIHSS score 6–9, intravenous thrombolysis frequency increased from 0.5% to 2.8%.

Stroke

Stroke Strokes Outcomes Thrombolysis

Influence of Comorbidity on Endovascular Thrombectomy Outcomes for Medium‐Vessel Occlusion Stroke: A Nationwide Prospective Observational Study

Stroke: Vascular and Interventional Neurology

JANUARY 3, 2025

In an exploratory analysis, we compared outcomes on the basis of successful recanalization (modified Thrombolysis in Cerebral Infarction 2b3).RESULTSAmong Excellent outcome (modified Rankin Scale 01) and symptomatic intracranial hemorrhage were secondary outcomes.

Outcomes

Outcomes Stroke Strokes Hemorrhage

Abstract TP211: TICI Scoring Reliability in Proximal vs Distal Vessel Thrombectomy: A Comparative Analysis

Stroke Journal

FEBRUARY 1, 2024

Introduction:The extended Thrombolysis in Cerebral Infarction (eTICI) scale has been demonstrated to correlate strongly with clinical outcomes. Stroke, Volume 55, Issue Suppl_1 , Page ATP211-ATP211, February 1, 2024.

Thrombolysis

Thrombolysis Stroke Strokes Outcomes

Abstract TMP91: Clinical Change During Inter-Hospital Transfer for Thrombectomy: Incidence, Associated Factors and Relationship With Outcome

Stroke Journal

FEBRUARY 1, 2024

Pre-transfer variables independently associated with clinical improvement were intravenous thrombolysis use, more distal occlusions, and lower serum glucose; variables associated with deterioration included more proximal occlusions and higher serum glucose.

Hospital

Hospital Outcomes Thrombolysis Document

First?Line Stent Retriever Versus Contact Aspiration or Combined Technique for Endovascular Therapy of Posterior Cerebral Artery Occlusion Stroke: The PLATO Study

Stroke: Vascular and Interventional Neurology

NOVEMBER 17, 2023

Intravenous thrombolysis was administered in 39.6%. The primary outcome was the first‐pass effect (FPE), defined as expanded Treatment in Cerebral Infarction (TICI) 2c/3 on the first pass. male, median age 75 (interquartile range 65–82) years, and median National Institutes of Health Stroke Scale score 8 (5–12).

Stent

Stent Stents Stroke Strokes

Abstract WP248: Endovascular Thrombectomy for Acute Ischemic Stroke in Anticoagulated Patients

Stroke Journal

JANUARY 30, 2025

Method:We searched Pubmed, Cochrane, and Embase from 2015 to August 2024, which compared EVT in OAC and Non-OAC patients with acute ischemic stroke. In such a population, the safety and efficacy of EVT remain uncertain, with emphasis on the risk of intracranial hemorrhage (ICH).Method:We Safety outcomes included ICH and 90 days mortality.

Stroke

Stroke Strokes Thrombolysis Outcomes

Abstract 012: First?line Stent Retriever Versus Contact Aspiration or Combined Technique for Posterior Cerebral Artery Occlusion EVT

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Intravenous thrombolysis was administered in 39.6%. Previous studies in LVO and MeVO have demonstrated a correlation between good clinical outcomes and the first pass effect (FPE, eTICI 2c/3 on the first pass) but no differences in FPE rates or clinical outcomes between first‐line endovascular therapy techniques.1‐6

Stent

Stent Stents Outcomes Thrombolysis

Concerning EKG with a Non-obstructive angiogram. What happened?

Dr. Smith's ECG Blog

DECEMBER 19, 2023

The commonest causes of MINOCA include: atherosclerotic causes such as plaque rupture or erosion with spontaneous thrombolysis, and non-atherosclerotic causes such as coronary vasospasm (sometimes called variant angina or Prinzmetal's angina), coronary embolism or thrombosis, possibly microvascular dysfunction.

Plaque

Plaque Angina Blog Stent

Right precordial ST depression in a patient with chest pain

Dr. Smith's ECG Blog

AUGUST 3, 2017

2015 Nov;20(6):570-7. Matetzky S, Freimark D, Chouraqui P, et al. Emergency Medicine Journal 34(2):119. July 2016. Goldwasser D, Senthlikumar A, Bayes de Luna A. Lateral MI Explains the Presence of Prominent R Wave (R ≥ S) in V1. Ann Noninvasive Electrocardiol. Anand U, Kulkarni MD, Renee B.

Chest Pain

Chest Pain Myocardial Infarction STEMI Ischemia

Abstract WP257: Persistent Racial Disparity Despite Higher Income in Odds of Receiving Mechanical Thrombectomy and Thrombolysis for Acute Ischemic Stroke Admissions 2006-2021

Stroke Journal

JANUARY 30, 2025

Background:Non-Hispanic Black (NHB) and other minority patients in the United States (US) receive intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) less frequently compared with non-Hispanic White (NHW) patients during acute ischemic stroke (AIS) admission. Stroke, Volume 56, Issue Suppl_1 , Page AWP257-AWP257, February 1, 2025.

Thrombolysis

Thrombolysis Stroke Strokes Hospital

What happens when you give morphine for chest pain in ACS? And what is pseudo-normalization of T-waves?

Dr. Smith's ECG Blog

MARCH 14, 2025

Here is an old (2015), but still very relevant, lecture on T-wave inversion by Dr. Smith: 40 minute lecture on T-wave inversion Learning points : T-waves are often dynamic in ACS and may hint at reperfusion and re-occlusion before the ST-segment does.

Chest Pain

Chest Pain STEMI Myocardial Infarction Ischemia

Abstract WP199: Outcomes Following Posterior Cerebral Artery Thrombolysis vs Medical Management in those with Atrial Fibrillation

Abstract TP115: Differences in the Medical Management of Post-Stroke Sequelae Among Patients Treated with Mechanical Thrombectomy vs Intravenous Thrombolysis

Abstract WMP42: Trends of In-Hospital Strokes Over Time: Results From the Greater Cincinnati and Northern Kentucky Stroke Study

Webinars

Abstract TP278: Identifying High-Risk Patients With Poor Prognosis in Acute Phase of Ischemic Stroke: Treatment-Specific Risk Scales Developed From the National Neurological Medical Center of China

Nationwide Trends in Reperfusion Therapy and Outcomes of Acute Ischemic Stroke According to Severity: The Japan Stroke Data Bank

Influence of Comorbidity on Endovascular Thrombectomy Outcomes for Medium‐Vessel Occlusion Stroke: A Nationwide Prospective Observational Study

Abstract TP211: TICI Scoring Reliability in Proximal vs Distal Vessel Thrombectomy: A Comparative Analysis

Abstract TMP91: Clinical Change During Inter-Hospital Transfer for Thrombectomy: Incidence, Associated Factors and Relationship With Outcome

First?Line Stent Retriever Versus Contact Aspiration or Combined Technique for Endovascular Therapy of Posterior Cerebral Artery Occlusion Stroke: The PLATO Study

Abstract WP248: Endovascular Thrombectomy for Acute Ischemic Stroke in Anticoagulated Patients

Abstract 012: First?line Stent Retriever Versus Contact Aspiration or Combined Technique for Posterior Cerebral Artery Occlusion EVT

Concerning EKG with a Non-obstructive angiogram. What happened?

Right precordial ST depression in a patient with chest pain

Abstract WP257: Persistent Racial Disparity Despite Higher Income in Odds of Receiving Mechanical Thrombectomy and Thrombolysis for Acute Ischemic Stroke Admissions 2006-2021

What happens when you give morphine for chest pain in ACS? And what is pseudo-normalization of T-waves?

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