2014 and Biomarkers - Cardiovascular Update

Abstract WMP32: Cross-Platform Proteomics and Machine Learning Algorithms Nominate Biomarkers of Stroke Diagnosis: An Exploratory Study

Stroke Journal

JANUARY 30, 2025

We conducted internal validation on the same samples using the PeptiQuant Plus biomarker assessment kits (BAK-270) for targeted protein quantitation (Figure 1).Results:We Blood samples were collected at admission to the ER before any therapeutic intervention. Results:We included 100 patients (mean age 58.6

Biomarkers

Biomarkers Stroke Strokes Hemorrhage

Abstract WP88: Association of renal biomarkers with fast progressor phenotype and related outcomes in anterior circulation large vessel occlusion stroke

Stroke Journal

JANUARY 30, 2025

4.94), but not with 90-day mRS or mortality.Conclusion:Serum creatinine-based biomarkers of renal dysfunction were associated with faster progressor phenotype of ACLVO stroke, higher mRS, and mortality at 90 days. Patients were included if they received baseline MRI or CTP on presentation within 24 hours after stroke onset.

Biomarkers

Biomarkers Circulation Stroke Strokes

Abstract 146: Data Independent Acquisition Mass Spectrometry Identifies Novel Plasma Protein Biomarkers that Distinguish Transient Ischemic Attack from Stroke Mimics

Stroke Journal

JANUARY 30, 2025

Conclusions:Our discovery proteomics study highlights the potential of DIA-MS proteomics as a valuable tool for discovering novel protein biomarkers to distinguish TIA from MIM. While TIA patients are at an increased risk of stroke, MIM do not need stroke-related management. These findings warrant validation in larger, longitudinal studies.

Biomarkers

Biomarkers Stroke Strokes

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

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Interrelation between hypoxic liver injury and Killip classification in ST-segment elevation myocardial infarction patients

Frontiers in Cardiovascular Medicine

JANUARY 19, 2025

This study investigates the interrelationship between hypoxic liver injury (HLI) and Killip classification.Method and resultsA total of 1,537 STEMI patients who underwent percutaneous coronary intervention (PCI) from 2007 to 2014 at four tertiary hospitals in the Incheon-Bucheon province were enrolled in this study.

Myocardial Infarction

Myocardial Infarction STEMI Biomarkers Hospital

Associations between short-term exposure to PM2.5 and cardiomyocyte injury in myocardial infarction survivors in North Carolina

Open Heart

JUNE 24, 2022

on cardiac troponin I, a cardiomyocyte specific biomarker of cellular damage. Troponin I measurements were available from 2014 to 2016, and were required to be at least 1 week away from a clinically diagnosed MI. Here we evaluate the impact of daily PM 2.5

Myocardial Infarction

Myocardial Infarction Biomarkers Cardiovascular Disease

Is OMI an ECG Diagnosis?

Dr. Smith's ECG Blog

APRIL 18, 2024

1] European guidelines add "regardless of biomarkers". 2014 AHA/ACC guideline for the management of patients with non-ST elevation acute coronary syndromes. Circulation 2014 2. But only 6.4% of such ‘high risk Non-STEMI’ patients get angiography within 2 hours.[2] It is not yet available, but this is your way to get on the list.

STEMI

STEMI Chest Pain Myocardial Infarction Blog

Abstract DP16: Plasma Proteomics and Machine Learning Algorithms Nominate Proteins Indicative of Stroke Severity in Acute Ischemic Stroke

Stroke Journal

JANUARY 30, 2025

Conclusions:Our study revealed distinct panels of protein biomarkers capable of classifying AIS patients into NIHSS-defined severity subgroups with high accuracy, particularly for mild, severe, and critical categories. Stroke, Volume 56, Issue Suppl_1 , Page ADP16-ADP16, February 1, 2025. to classify mild NIHSS, 0.66

Stroke

Stroke Strokes Biomarkers Hospital

Persistent Chest Pain, an Elevated Troponin, and a Normal ECG. At midnight.

Dr. Smith's ECG Blog

DECEMBER 14, 2016

This is from the 2014 ACC/AHA guidelines. less than 2 h from hospital admission, analogous to STEMI management) invasive strategy with intent to perform revascularization is recommended, irrespective of ECG or biomarker findings. A patient who has a high clinical suspicion of MI should go to the cath lab. This includes: 1.

Chest Pain

Chest Pain STEMI Aortic Myocardial Infarction

Do Statins Cause Dementia?

Dr. Paddy Barrett

SEPTEMBER 19, 2023

Additionally, access to cholesterol synthesis biomarker testing, including desmosterol and lathosterol levels, can be challenging to obtain. 2014 Feb;25(1):40-7. 9 Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology. My approach for APOE 4 patients. 2012 Aug 11;380(9841):581-90.

Dementia

Dementia Cholesterol Biomarkers Coronary Artery Disease

A Tough ECG, But Learn From It!

Dr. Smith's ECG Blog

JUNE 18, 2013

These patients have worse outcomes: higher mortality, more CHF, higher biomarkers, and worse ejection fractions than the NonSTEMI patients with open arteries. Studies show that 30% of NonSTEMI have an occluded infarct artery at the time of angiography done 24 hours after presentation. This is because of subtle ECG findings. Marti D et al.

STEMI

STEMI Chest Pain Myocardial Infarction Webinar

7 steps to missing posterior Occlusion MI, and how to avoid them

Dr. Smith's ECG Blog

JANUARY 3, 2022

So even without the diagnostic ECGs, they had clinical evidence of refractory ischemia with biomarker (troponin) confirmation. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.

STEMI

STEMI Myocardial Infarction Chest Pain Ischemia

Abstract WP93: Cross-Platform Proteomics and Machine Learning Algorithms Nominate Biomarkers of Atrial Fibrillation in Stroke Patients: An Exploratory Study

Stroke Journal

JANUARY 30, 2025

AFib diagnosis is critical to optimize secondary prevention and reduce the recurrent stroke risk.Objectives:We undertook an exploratory cross-platform proteomics study to discover plasma biomarkers of AFib diagnosis in patients with IS or transient ischemic attack (TIA).Methods:We

Biomarkers

Biomarkers AFIB Atrial Fibrillation Stroke

Occlusion myocardial infarction is a clinical diagnosis

Dr. Smith's ECG Blog

DECEMBER 11, 2023

Both the outdated 2014 AHA/ACC guidelines and the updated 2023 ESC guidelines recommend immediate invasive management of patients with uncontrolled chest pain. The ESC states that patients with suspected ACS should go to the cath lab in ＜2 hours "regardless of ECG or biomarker evidence of MI!!" Kontos, M. Levine, G. Liebson, P.

Myocardial Infarction

Myocardial Infarction Chest Pain STEMI Blood Pressure

Body iron stores had no impact on coronary heart disease outcomes: a middle-aged male cohort from the general population with 21-year follow-up

Open Heart

APRIL 11, 2022

Biomarkers for iron stores (serum ferritin and serum transferrin receptor) was analysed from frozen blood samples in 2014. All hospital admissions were registered through national registers during the entire follow-up from 1993 to 2014. HRs were estimated by Cox proportional-hazard regression analyses.

Heart Disease

Heart Disease Outcomes Biomarkers Cardiovascular Disease

Published Research

Society of Thoracic Surgeons - Research

APRIL 20, 2023

Hunter Mehaffey Distressed communities are associated with worse outcomes after coronary artery bypass surgery The Journal of Thoracic and Cardiovascular Surgery August 2019 Meghana Helder Regional and Temporal Trends in the Outcomes of Repairs for Acute Type A Aortic Dissections The Annals of Thoracic Surgery August 2019 Derrick Tam Surgical valve (..)

Research

Research Coronary Artery Bypass Graft Aortic valve Congenital

Published Research

Society of Thoracic Surgeons - Research

APRIL 20, 2023

Hunter Mehaffey 1 Distressed communities are associated with worse outcomes after coronary artery bypass surgery The Journal of Thoracic and Cardiovascular Surgery August 2019 Meghana Helder 2 Regional and Temporal Trends in the Outcomes of Repairs for Acute Type A Aortic Dissections The Annals of Thoracic Surgery August 2019 Derrick Tam 2 Surgical (..)

Research

Research Coronary Artery Bypass Graft Aortic valve Congenital

The legal case – naming a few names

Dr. Malcolm Kendrick

OCTOBER 30, 2024

plus drug supply BEST-D pilot trial of vitamin D (2012-2014) Tishcon: free drug supply only Big Data Institute (2018-2021) Novartis Pharma AG Switzerland: £272K Can wearables improve the prediction of all-cause mortality, cardiovascular disease, and cancer in UK Biobank? plus drug supply Bayer: £1.8M

Cholesterol

Cholesterol Article Research Diet

Abstract WMP32: Cross-Platform Proteomics and Machine Learning Algorithms Nominate Biomarkers of Stroke Diagnosis: An Exploratory Study

Abstract WP88: Association of renal biomarkers with fast progressor phenotype and related outcomes in anterior circulation large vessel occlusion stroke

Abstract 146: Data Independent Acquisition Mass Spectrometry Identifies Novel Plasma Protein Biomarkers that Distinguish Transient Ischemic Attack from Stroke Mimics

Webinars

Interrelation between hypoxic liver injury and Killip classification in ST-segment elevation myocardial infarction patients

Associations between short-term exposure to PM2.5 and cardiomyocyte injury in myocardial infarction survivors in North Carolina

Is OMI an ECG Diagnosis?

Abstract DP16: Plasma Proteomics and Machine Learning Algorithms Nominate Proteins Indicative of Stroke Severity in Acute Ischemic Stroke

Persistent Chest Pain, an Elevated Troponin, and a Normal ECG. At midnight.

Do Statins Cause Dementia?

A Tough ECG, But Learn From It!

7 steps to missing posterior Occlusion MI, and how to avoid them

Abstract WP93: Cross-Platform Proteomics and Machine Learning Algorithms Nominate Biomarkers of Atrial Fibrillation in Stroke Patients: An Exploratory Study

Occlusion myocardial infarction is a clinical diagnosis

Body iron stores had no impact on coronary heart disease outcomes: a middle-aged male cohort from the general population with 21-year follow-up

Published Research

Published Research

The legal case – naming a few names

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