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The Weekend Effect Touches TAVR Too

CardiacWire

To uncover the weekend effects impact on TAVR , researchers analyzed over 82k TAVR hospitalizations between 2013 and 2021 and revealed that weekend patients faced a 45% higher risk of in-hospital mortality compared to weekday admissions.

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Aficamten – One More Cardiac Myosin Inhibitor for HOCM

All About Cardiovascular System and Disorders

There was substanital reduction in LVOT gradients and most patients experienced improvement in biomarkers and symptoms [1]. 2013 Jun 18;61(24):2456-2460. Epub 2013 Apr 16. Phase 2 Study of Aficamten in Patients With Obstructive Hypertrophic Cardiomyopathy was published in 2023, with 28 patients on aficamten 13 on placebo.

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Lowering Atherosclerotic Cardiovascular Disease Events by Treating Residual Inflammatory Risk

DAIC

14,15 Similarly, the NLRP3 inflammasome has been implicated in pathogenesis as it leads to the activation of proinflammatory cytokines triggering robust proinflammatory signaling through interleukin-6 (IL-6) and inducing production of C-reactive protein (CRP), a biomarker for inflammation.16 2013;368(21):2004-2013. N Engl J Med.

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Additional Data From SEQUOIA-HCM Presented at HFSA Annual Scientific Meeting

DAIC

vs 24% showed enhanced exercise capacity and 84% vs 8% demonstrated a substantial response in cardiac biomarkers (for all p aficamten achieved one or more clinically relevant outcomes, 62% achieved at least three outcomes and 23% achieved all four outcomes. CVrg: Heart Failure 2020-2029, p 44; Maron et al.

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A Tough ECG, But Learn From It!

Dr. Smith's ECG Blog

These patients have worse outcomes: higher mortality, more CHF, higher biomarkers, and worse ejection fractions than the NonSTEMI patients with open arteries. For clarity in Figure-1 — I've labeled the initial ECG in this June 18, 2013 post. Figure-1: I've labeled the initial ECG from this June 18, 2013 post.

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A man in his 70s with acute chest pain and paced rhythm.

Dr. Smith's ECG Blog

8 , 9 The most recent American College of Cardiology and American Heart Association ST-elevation myocardial infarction (STEMI) guidelines (2013) give no direction on diagnosing occlusion myocardial infarction in patients with ventricular paced rhythm. There are 2 primary reasons for this low sensitivity.

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Temporal trends in concordance between ICD-coded and cardiac biomarker-classified hospitalisation rates for acute coronary syndromes: a linked hospital and biomarker data study

Open Heart

Using person-linked hospitalisation data, we compared International Classification of Diseases (ICD)-coded data with biomarker-classified admission rates for ST-segment elevation MI (STEMI), non-STEMI (NSTEMI) and unstable angina (UA) in Western Australia (WA). Results There were 37 272 ACS admissions in 30 683 patients (64.2%